David J Erle

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Use of spotted oligonucleotide arrays for large-scale analysis of mammalian gene expression
    David J Erle
    Functional Genomics Core Facility, UCSF Sandler Center for Basic Research in Asthma, University of California, San Francisco, San Francisco, CA, USA
    Chest 121:80S. 2002
  2. pmc Asthma investigators begin to reap the fruits of genomics
    David J Erle
    Lung Biology Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Genome Biol 4:232. 2003
  3. pmc The epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma model
    Yasuhiro Nakagami
    Lung Biology Center, Department of Medicine, University of California, San Francisco, CA 94158, USA
    J Immunol 181:2203-10. 2008
  4. pmc AGR2 is induced in asthma and promotes allergen-induced mucin overproduction
    Bradley W Schroeder
    Lung Biology Center, Department of Medicine, University of California San Francisco, USA
    Am J Respir Cell Mol Biol 47:178-85. 2012
  5. pmc Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma
    Sung Woo Park
    Lung Biology Center, University of California San Francisco, San Francisco, California 94143, USA
    Am J Respir Crit Care Med 180:603-10. 2009
  6. pmc A distinctive alveolar macrophage activation state induced by cigarette smoking
    Prescott G Woodruff
    UCSF Mission Bay Rock Hall, Room 545, 1550 4th Street, San Francisco, CA 94158, USA
    Am J Respir Crit Care Med 172:1383-92. 2005
  7. pmc The protein disulfide isomerase AGR2 is essential for production of intestinal mucus
    Sung Woo Park
    Lung Biology Center and Program in Immunology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:6950-5. 2009
  8. ncbi request reprint Dissecting asthma using focused transgenic modeling and functional genomics
    Douglas A Kuperman
    Department of Medicine, Allergy Immunology Division, Northwestern University Feinberg School of Medicine, Chicago, USA
    J Allergy Clin Immunol 116:305-11. 2005
  9. pmc IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production
    Guohua Zhen
    Department of Medicine, University of California, San Francisco, CA 94143 2922, USA
    Am J Respir Cell Mol Biol 36:244-53. 2007
  10. pmc Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:15858-63. 2007

Detail Information

Publications33

  1. ncbi request reprint Use of spotted oligonucleotide arrays for large-scale analysis of mammalian gene expression
    David J Erle
    Functional Genomics Core Facility, UCSF Sandler Center for Basic Research in Asthma, University of California, San Francisco, San Francisco, CA, USA
    Chest 121:80S. 2002
  2. pmc Asthma investigators begin to reap the fruits of genomics
    David J Erle
    Lung Biology Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Genome Biol 4:232. 2003
    ..Microarray experiments have identified novel candidate genes in animal models of asthma. In the near future, genomics may have a profound impact on the way we think about this common and complex disease...
  3. pmc The epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma model
    Yasuhiro Nakagami
    Lung Biology Center, Department of Medicine, University of California, San Francisco, CA 94158, USA
    J Immunol 181:2203-10. 2008
    ..We conclude that pendrin regulates ASL thickness and may be an important contributor to asthma exacerbations induced by viral infections or allergens...
  4. pmc AGR2 is induced in asthma and promotes allergen-induced mucin overproduction
    Bradley W Schroeder
    Lung Biology Center, Department of Medicine, University of California San Francisco, USA
    Am J Respir Cell Mol Biol 47:178-85. 2012
    ..AGR2 interacts with immature mucin in the ER and loss of AGR2 impairs allergen-induced MUC5AC and MUC5B overproduction...
  5. pmc Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma
    Sung Woo Park
    Lung Biology Center, University of California San Francisco, San Francisco, California 94143, USA
    Am J Respir Crit Care Med 180:603-10. 2009
    ..IL-13-driven mucous cell metaplasia is associated with decreased expression of the transcription factor FOXA2 and increased expression of the related transcription factor FOXA3 in animal and cell culture models...
  6. pmc A distinctive alveolar macrophage activation state induced by cigarette smoking
    Prescott G Woodruff
    UCSF Mission Bay Rock Hall, Room 545, 1550 4th Street, San Francisco, CA 94158, USA
    Am J Respir Crit Care Med 172:1383-92. 2005
    ..Macrophages are believed to play a central role in emphysema based largely on data from mouse models. However, the relevance of these models to smoking-related lung disease in humans is uncertain...
  7. pmc The protein disulfide isomerase AGR2 is essential for production of intestinal mucus
    Sung Woo Park
    Lung Biology Center and Program in Immunology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:6950-5. 2009
    ..We conclude that AGR2 is a unique member of the PDI family, with a specialized and nonredundant role in intestinal mucus production...
  8. ncbi request reprint Dissecting asthma using focused transgenic modeling and functional genomics
    Douglas A Kuperman
    Department of Medicine, Allergy Immunology Division, Northwestern University Feinberg School of Medicine, Chicago, USA
    J Allergy Clin Immunol 116:305-11. 2005
    ..These mice develop airway hyperreactivity and mucus overproduction but not airway inflammation...
  9. pmc IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production
    Guohua Zhen
    Department of Medicine, University of California, San Francisco, CA 94143 2922, USA
    Am J Respir Cell Mol Biol 36:244-53. 2007
    ....
  10. pmc Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:15858-63. 2007
    ....
  11. pmc The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells
    Kotaro Sugimoto
    Lung Biology Center, Department of Medicine, UCSF, San Francisco, California, USA
    J Clin Invest 122:748-58. 2012
    ....
  12. pmc Systemically dispersed innate IL-13-expressing cells in type 2 immunity
    April E Price
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, CA 94143 0795, USA
    Proc Natl Acad Sci U S A 107:11489-94. 2010
    ..Widely dispersed innate type 2 helper cells, which we designate Ih2 cells, play an integral role in type 2 immune responses...
  13. pmc T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire
    Yelena Bronevetsky
    Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 210:417-32. 2013
    ....
  14. pmc Airway epithelial miRNA expression is altered in asthma
    Owen D Solberg
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA
    Am J Respir Crit Care Med 186:965-74. 2012
    ..Changes in airway epithelial cell differentiation, driven in part by IL-13, are important in asthma. Micro-RNAs (miRNAs) regulate cell differentiation in many systems and could contribute to epithelial abnormalities in asthma...
  15. pmc Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1
    Laura L Koth
    Lung Biology Center, Department of Medicine, San Francisco General Hospital, California, USA
    Am J Respir Cell Mol Biol 37:651-9. 2007
    ..These findings show that alphavbeta6 and TGF-beta1 regulate homeostasis of phospholipids and collectins in adult mouse lungs and may have implications for anti-fibrotic therapeutics that inhibit active TGF-beta in the lung...
  16. ncbi request reprint IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production
    Douglas A Kuperman
    Lung Biology Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    J Immunol 175:3746-52. 2005
    ..Because only IL-13 and IL-4 are thought to signal via IL-4Ralpha, we conclude that direct effects of IL-4 and/or IL-13 on Clara cells are required for allergen-induced mucus production in the airway epithelium...
  17. ncbi request reprint Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    Douglas A Kuperman
    Lung Biology Center, Department of Medicine and Cardiovascular Research Institute, University of California San Francisco School of Medicine, San Francisco, California, USA
    Nat Med 8:885-9. 2002
    ..These results demonstrate the importance of direct effects of IL-13 on epithelial cells in causing two central features of asthma...
  18. pmc Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1
    Dolkun Rahmutula
    Division of Cardiology and Cardiovascular Research Institute, University of California, 505 Parnassus Avenue, M1182, Box 0124, San Francisco, CA 94143, USA
    Cardiovasc Res 99:769-79. 2013
    ..This study investigated the role of TGF-β1 in human AF and the mechanism of atrial-selective fibrosis...
  19. pmc Differential gene expression by integrin beta 7+ and beta 7- memory T helper cells
    Madeleine W Rodriguez
    Department of Medicine, University of California, San Francisco, CA 94143 0854, USA
    BMC Immunol 5:13. 2004
    ..We hypothesized that beta 7+ and beta 7- blood memory T helper cells differ in their expression of genes that play a role in the adhesion or migration of T cells...
  20. pmc Increased DNA microarray hybridization specificity using sscDNA targets
    Christopher S Barker
    Gladstone Institute of Cardiovascular Disease, The J David Gladstone Institutes, San Francisco, California 94158, USA
    BMC Genomics 6:57. 2005
    ....
  21. pmc Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients
    Jun Araya
    Department of Pathology, Lung Biology Center, UCSF, San Francisco, California 94110, USA
    J Clin Invest 117:3551-62. 2007
    ..Our findings have identified TGF-beta as a potential therapeutic target for COPD...
  22. ncbi request reprint The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells
    Rajeev Venkayya
    Lung Biology Center, Program in Immunology, University of California San Francisco, Box 0854, San Francisco, CA 94143 0854, USA
    Am J Respir Cell Mol Biol 26:202-8. 2002
    ..These results strongly suggest that products of activated Th2 lymphocytes can rapidly perturb airway function through direct effects on resident airway cells...
  23. pmc Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2
    Laura L Koth
    Lung Biology Center, Department of Medicine, University of California, San Francisco, California, USA
    Respir Res 5:12. 2004
    ..Furthermore, MCP-1-deficient mice have not previously been studied in models of experimental allergic asthma...
  24. pmc The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile
    Beatrice T Wang
    Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:15201-6. 2011
    ..PP242 caused 1,666 genes to be differentially expressed whereas rapamycin affected only 88 genes. Our analysis provides a genomewide view of the transcriptional outputs of mTOR signaling that are insensitive to rapamycin...
  25. pmc Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking
    Joong Kyu Kim
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA
    PLoS ONE 4:e6580. 2009
    ..The results make clear multiple aspects of Treg cell homeostasis and phenotype that are dependent on a sustained capacity to signal through the TCR...
  26. pmc Spotted long oligonucleotide arrays for human gene expression analysis
    Andrea Barczak
    Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    Genome Res 13:1775-85. 2003
    ..The approach described here involves far more gene expression measurements and provides a useful method for comparing existing and emerging techniques for genome-scale expression analysis...
  27. pmc Toward a systematic understanding of mRNA 3' untranslated regions
    Wenxue Zhao
    Department of Medicine, University of California, San Francisco, CA, USA
    Proc Am Thorac Soc 8:163-6. 2011
    ..Application of new data sets and experimental approaches should provide powerful insights into how 3' UTR-mediated regulatory events contribute to disease and may inspire novel therapeutic approaches...
  28. ncbi request reprint Abnormal alveolar development associated with elevated adenine nucleosides
    Suman K Banerjee
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
    Am J Respir Cell Mol Biol 30:38-50. 2004
    ..These studies provide evidence that elevated lung adenosine can lead to abnormal alveogenesis by disrupting patterns of cell proliferation and apoptosis...
  29. ncbi request reprint The asthma channel? Stay tuned . .
    David J Erle
    Am J Respir Crit Care Med 173:1181-2. 2006
  30. pmc Disease-specific gene expression profiling in multiple models of lung disease
    Christina C Lewis
    Cincinnati Children s Hospital Medical Center Division of Immunobiology, 3333 Burnet Avenue, MLC 7038, Cincinnati, OH 45229, USA
    Am J Respir Crit Care Med 177:376-87. 2008
    ..However, analyses of individual diseases or models of diseases frequently yield extensive lists of differentially expressed genes with uncertain relationships to disease pathogenesis...
  31. ncbi request reprint Influenza virus infection causes global respiratory tract B cell response modulation via innate immune signals
    W L William Chang
    Center for Comparative Medicine and
    J Immunol 178:1457-67. 2007
    ....
  32. ncbi request reprint Genomics and proteomics of lung disease: conference summary
    J Usha Raj
    Division of Neonatology, Harbor UCLA Medical Center, Geffen School of Medicine at University of California, and Los Angeles Biomedical Research Institute, Los Angeles, California, USA
    Am J Physiol Lung Cell Mol Physiol 293:L45-51. 2007
  33. ncbi request reprint Progress toward a systems biology approach to acute lung injury
    James A Frank
    Am J Physiol Lung Cell Mol Physiol 293:L290-1. 2007