Keith M Erikson

Summary

Affiliation: University of North Carolina at Greensboro
Country: USA

Publications

  1. ncbi request reprint Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter
    Keith M Erikson
    Department of Nutrition, University of North Carolina Greensboro, 318 Stone Building, UNCG, POB 26170, Greensboro, NC 27402 6170, USA
    Neurotoxicology 27:125-30. 2006
  2. ncbi request reprint Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity
    Keith M Erikson
    Department of Nutrition, University of North Carolina Greensboro, Greensboro, NC 27402 6170, USA
    Toxicol Sci 97:459-66. 2007
  3. ncbi request reprint Manganese exposure and induced oxidative stress in the rat brain
    Keith M Erikson
    Department of Nutrition, The University of North Carolina Greensboro, Greensboro, NC 27402 6170, USA
    Sci Total Environ 334:409-16. 2004
  4. pmc Manganese neurotoxicity: a focus on the neonate
    Keith M Erikson
    Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC, USA
    Pharmacol Ther 113:369-77. 2007
  5. ncbi request reprint Duration of airborne-manganese exposure in rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity
    Keith M Erikson
    Department of Nutrition, University of North Carolina Greensboro, Greensboro, NC 27402 6170, USA
    Neurotoxicology 29:377-85. 2008
  6. ncbi request reprint Persistent alterations in biomarkers of oxidative stress resulting from combined in utero and neonatal manganese inhalation
    Keith M Erikson
    Department of Nutrition, University of North Carolina Greensboro, Greensboro, NC 27402 6170, USA
    Biol Trace Elem Res 104:151-63. 2005
  7. ncbi request reprint Airborne manganese exposure differentially affects end points of oxidative stress in an age- and sex-dependent manner
    Keith M Erikson
    Department of Physiology and Pharmacology and Interdisciplinary Program in Neuroscience, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Biol Trace Elem Res 100:49-62. 2004
  8. pmc Manganese exposure inhibits the clearance of extracellular GABA and influences taurine homeostasis in the striatum of developing rats
    Steve C Fordahl
    Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27402, USA
    Neurotoxicology 31:639-46. 2010
  9. ncbi request reprint Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese
    Keith M Erikson
    Department of Nutrition, University of North Carolina Greensboro, NC, USA
    Biol Trace Elem Res 111:199-215. 2006
  10. pmc Manganese exposure alters extracellular GABA, GABA receptor and transporter protein and mRNA levels in the developing rat brain
    Joel G Anderson
    Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27402, USA
    Neurotoxicology 29:1044-53. 2008

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter
    Keith M Erikson
    Department of Nutrition, University of North Carolina Greensboro, 318 Stone Building, UNCG, POB 26170, Greensboro, NC 27402 6170, USA
    Neurotoxicology 27:125-30. 2006
    ..The decreased TfR associated with +Fe treatment and the increased DMT-1 levels suggest that DMT-1 is a likely putative transporter of Mn in astrocytes...
  2. ncbi request reprint Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity
    Keith M Erikson
    Department of Nutrition, University of North Carolina Greensboro, Greensboro, NC 27402 6170, USA
    Toxicol Sci 97:459-66. 2007
    ..g., GSH was increased in the frontal cortex and decreased in the caudate despite two- to threefold increases in Mn concentrations in these regions)...
  3. ncbi request reprint Manganese exposure and induced oxidative stress in the rat brain
    Keith M Erikson
    Department of Nutrition, The University of North Carolina Greensboro, Greensboro, NC 27402 6170, USA
    Sci Total Environ 334:409-16. 2004
    ..g., glutamine synthetase) have been commonly used as biomarkers of oxidative stress, particularly in rat brain tissue. This paper examines the link between manganese neurotoxicity in the rat brain and common pathways to oxidative stress...
  4. pmc Manganese neurotoxicity: a focus on the neonate
    Keith M Erikson
    Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC, USA
    Pharmacol Ther 113:369-77. 2007
    ..We will briefly review some of the mechanisms of Mn neurotoxicity and conclude with a discussion of ripe areas for research in this underreported area of neurotoxicity...
  5. ncbi request reprint Duration of airborne-manganese exposure in rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity
    Keith M Erikson
    Department of Nutrition, University of North Carolina Greensboro, Greensboro, NC 27402 6170, USA
    Neurotoxicology 29:377-85. 2008
    ..Overall, the nonhuman primate brain responds to airborne Mn in a heterogeneous manner and most alterations in these biomarkers of neurotoxicity are reversible upon cessation of Mn exposure...
  6. ncbi request reprint Persistent alterations in biomarkers of oxidative stress resulting from combined in utero and neonatal manganese inhalation
    Keith M Erikson
    Department of Nutrition, University of North Carolina Greensboro, Greensboro, NC 27402 6170, USA
    Biol Trace Elem Res 104:151-63. 2005
    ....
  7. ncbi request reprint Airborne manganese exposure differentially affects end points of oxidative stress in an age- and sex-dependent manner
    Keith M Erikson
    Department of Physiology and Pharmacology and Interdisciplinary Program in Neuroscience, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Biol Trace Elem Res 100:49-62. 2004
    ..1-mg/m3 manganese phosphate exposure. These results demonstrate that age and sex are variables that must be considered when assessing the neurotoxicity of manganese...
  8. pmc Manganese exposure inhibits the clearance of extracellular GABA and influences taurine homeostasis in the striatum of developing rats
    Steve C Fordahl
    Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27402, USA
    Neurotoxicology 31:639-46. 2010
    ....
  9. ncbi request reprint Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese
    Keith M Erikson
    Department of Nutrition, University of North Carolina Greensboro, NC, USA
    Biol Trace Elem Res 111:199-215. 2006
    ..It is important to note that the doses of Mn utilized represent levels that are a hundred- to a thousand-fold higher than the inhalation reference concentration set by the United States Environmental Protection Agency...
  10. pmc Manganese exposure alters extracellular GABA, GABA receptor and transporter protein and mRNA levels in the developing rat brain
    Joel G Anderson
    Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27402, USA
    Neurotoxicology 29:1044-53. 2008
    ..These data suggest that Mn exposure results in an increase in extracellular GABA concentrations via altered expression of transport and receptor proteins, which may be the basis of the neurological characteristics of manganism...
  11. ncbi request reprint Oxidative stress is induced in the rat brain following repeated inhalation exposure to manganese sulfate
    Allison W Dobson
    Department of Physiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Biol Trace Elem Res 93:113-26. 2003
    ....
  12. pmc Extracellular norepinephrine, norepinephrine receptor and transporter protein and mRNA levels are differentially altered in the developing rat brain due to dietary iron deficiency and manganese exposure
    Joel G Anderson
    Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27402 6170, USA
    Brain Res 1281:1-14. 2009
    ..These data suggest that Mn exposure results in a decrease in NE uptake and extracellular NE concentrations via altered expression of transport and receptor proteins...
  13. ncbi request reprint Brain manganese accumulation is inversely related to gamma-amino butyric acid uptake in male and female rats
    Joel G Anderson
    Department of Nutrition, The University of North Carolina at Greensboro, Greensboro, North Carolina 27402, USA
    Toxicol Sci 95:188-95. 2007
    ..05). In conclusion, ID-associated Mn accumulation is similar in both sexes, with Mn levels affecting GABA uptake in both sexes in a comparable fashion...
  14. pmc Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors
    Steve Fordahl
    Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27402 6170, USA
    Neurotoxicol Teratol 34:27-36. 2012
    ..These data provide putative biomarkers for Mn-neurotoxicity and suggest that Mn disrupts the circadian cycle in rats...
  15. pmc Inhibition of DAT function attenuates manganese accumulation in the globus pallidus
    Joel G Anderson
    Department of Nutrition, The University of North Carolina at Greensboro, Greensboro, NC 27402
    Environ Toxicol Pharmacol 23:179-84. 2007
    ..05). Our data show that inhibition of DAT exclusively inhibits Mn accumulation in the globus pallidus during chronic exposure...
  16. doi request reprint Iron overload alters iron-regulatory genes and proteins, down-regulates osteoblastic phenotype, and is associated with apoptosis in fetal rat calvaria cultures
    Jonathan G Messer
    Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27412, USA
    Bone 45:972-9. 2009
    ..These results provide evidence that iron overload alters iron metabolism and suppresses differentiation and function of cells in the osteoblast lineage associated with increased apoptosis...
  17. ncbi request reprint Depleted uranium is not toxic to rat brain endothelial (RBE4) cells
    Allison W Dobson
    Department of Life Sciences, Winston Salem State University, Winston Salem, NC, USA
    Biol Trace Elem Res 110:61-72. 2006
    ..Thus, the present experimental paradigm is rather reassuring and provides no indication for overt cytotoxicity in endothelial cells exposed to DU...
  18. ncbi request reprint Manganese accumulation in membrane fractions of primary astrocytes is associated with decreased γ-aminobutyric acid (GABA) uptake, and is exacerbated by oleic acid and palmitate
    Steve C Fordahl
    Department of Nutrition, University of North Carolina at Greensboro, 318 Stone Building, P O Box 26170, Greensboro, NC 27402 6170, United States Electronic address
    Environ Toxicol Pharmacol 37:1148-56. 2014
    ..These data indicate that reduced GAT function in astrocytes is influenced by Mn and fatty acids accumulating at or interacting with the plasma membrane...
  19. ncbi request reprint Neurobehavioral analysis of developmental iron deficiency in rats
    John L Beard
    Graduate Program in Nutrition, Department of Nutrition, The Pennsylvania State University, S 126 Henderson Bldg, University Park, PA 16802, USA
    Behav Brain Res 134:517-24. 2002
    ..These observations also strengthen the argument that the Fe-dopamine link is fundamental to understanding biobehavioral difficulties seen in children with ID anemia...
  20. ncbi request reprint Effects of inhaled manganese on biomarkers of oxidative stress in the rat brain
    Michael D Taylor
    Environmental Science, Afton Chemical Corporation, 500 Spring Street, Richmond, VA 23219, USA
    Neurotoxicology 27:788-97. 2006
    ..There are, however, instances of changes in individual endpoints consistent with oxidative stress in certain brain tissues...
  21. ncbi request reprint Glutamate/aspartate transporter (GLAST), taurine transporter and metallothionein mRNA levels are differentially altered in astrocytes exposed to manganese chloride, manganese phosphate or manganese sulfate
    Keith M Erikson
    Department of Physiology and Pharmacology, School of Medicine, Wake Forest University, Winston Salem 27157 1083, USA
    Neurotoxicology 23:281-8. 2002
    ....
  22. ncbi request reprint Neonatal iron deficiency results in irreversible changes in dopamine function in rats
    John Beard
    Graduate Program in Nutrition, Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 133:1174-9. 2003
    ..Changes in DA-related behaviors that were persistent after postweaning iron repletion suggest the existence of a critical neonatal developmental period that is expressed by alterations in DA functioning...
  23. ncbi request reprint Manganese neurotoxicity
    Allison W Dobson
    Department of Physiology and Pharmacology, and Interdisciplinary Program in Neuroscience, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Ann N Y Acad Sci 1012:115-28. 2004
    ..Additionally, evidence for the role of oxidative stress in the progression of manganism is reviewed here...
  24. ncbi request reprint Globus pallidus: a target brain region for divalent metal accumulation associated with dietary iron deficiency
    Keith M Erikson
    Department of Physiology Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    J Nutr Biochem 15:335-41. 2004
    ..Therefore, the globus pallidus appears to be a target for divalent metal accumulation that is associated with dietary iron deficiency, potentially caused by increased transporter protein levels...
  25. doi request reprint Measuring brain manganese and iron accumulation in rats following 14 weeks of low-dose manganese treatment using atomic absorption spectroscopy and magnetic resonance imaging
    Vanessa A Fitsanakis
    Department of Biology, King College, Bristol, Tennessee 37620, USA
    Toxicol Sci 103:116-24. 2008
    ..These data suggest that dietary Fe manipulation, whether increased or decreased, may contribute to brain Mn deposition in populations vulnerable to increased Mn exposure...
  26. ncbi request reprint Manganese neurotoxicity and glutamate-GABA interaction
    Keith M Erikson
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neurochem Int 43:475-80. 2003
    ..Collectively, these data suggest that excitotoxicity may occur due to manganese-induced altered glutamate metabolism, representing a proximate mechanism for manganese-induced neurotoxicity...
  27. ncbi request reprint Manganese dosimetry: species differences and implications for neurotoxicity
    Michael Aschner
    Vanderbilt University, Nashville, Tennessee, USA
    Crit Rev Toxicol 35:1-32. 2005
    ..g., pre-parkinsonian state, aging), may have altered manganese metabolism and could be at greater risk for manganese toxicity...
  28. ncbi request reprint The effects of manganese on glutamate, dopamine and gamma-aminobutyric acid regulation
    Vanessa A Fitsanakis
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neurochem Int 48:426-33. 2006
    ..Finally, we suggest that current research focus on the interdependence of these basal ganglial neurochemicals, with a greater emphasis on the GABAergic and glutamatergic systems...
  29. ncbi request reprint Manganese accumulates in iron-deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations
    Keith M Erikson
    Department of Physiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Biol Trace Elem Res 87:143-56. 2002
    ..These data show that ID is a significant risk factor for central nervous system Mn accumulation and that some of the neurochemical alterations associated with ID are specifically attributable to Mn accumulation...
  30. ncbi request reprint Genetic differences in hepatic lipid peroxidation potential and iron levels in mice
    Glenn S Gerhard
    Department of Pathology, Penn State College of Medicine, Hershey, PA, USA
    Mech Ageing Dev 123:167-76. 2002
    ..0006. At least two potentially relevant candidate genes reside close to this chromosomal position. Hepatic lipid peroxidation potential appears to be a strain related trait in mice that is amenable to QTL analysis...

Research Grants2

  1. Neurotoxicology of dietary iron/manganese interactions
    Keith Erikson; Fiscal Year: 2005
    ..If successful, these studies will lay the foundation for the development of a pharmacological therapy aimed at the prevention of manganese-accumulation in vulnerable populations. ..
  2. The link between lipid peroxidation and manganese induced glutathione depletion
    Keith Erikson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..