Research Topics
| A ErdelySummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
Renal disease in rats with type 2 diabetes is associated with decreased renal nitric oxide productionA Erdely
Department of Physiology, West Virginia University, Morgantown, West Virginia, USA
Diabetologia 47:1672-6. 2004..Here, we studied diabetic obese Zucker (ZDF Gmi fa/fa) rats that develop severe hyperglycaemia and renal disease, together with their lean control animals, to determine if renal nitric oxide deficiency also occurs in this model...
Protection against puromycin aminonucleoside-induced chronic renal disease in the Wistar-Furth ratAaron Erdely
Department of Physiology, West Virginia University, Morgantown, West Virginia 26506, USA
Am J Physiol Renal Physiol 287:F81-9. 2004..In conclusion, WF showed resistance to a second model of CRD with maintained renal NOS activity compared with SD...
Uremic levels of BUN do not cause nitric oxide deficiency in rats with normal renal functionS Xiao
Department of Physiology, West Virginia University, Morgantown, West Virginia 26506, USA
Am J Physiol Renal Physiol 280:F996-F1000. 2001..Further studies are needed to evaluate the effect of high BUN on the NO system in rats with progressive renal functional insufficiency...
Protection of wistar furth rats from chronic renal disease is associated with maintained renal nitric oxide synthaseAaron Erdely
Department of Physiology, West Virginia University, Morgantown, West Virginia 26506 9229, USA
J Am Soc Nephrol 14:2526-33. 2003..NOS inhibition rendered WF rats susceptible to progression, suggesting a possible critical threshold for NO production, below which renal injury occurs...
DOCA/NaCl-induced chronic kidney disease: a comparison of renal nitric oxide production in resistant and susceptible rat strainsAaron Erdely
Department of Physiology and Pharmacology, West Virginia University, USA
Am J Physiol Renal Physiol 292:F192-6. 2007..Further studies are needed to evaluate how WF rats maintain renal NO production despite similar changes in abundance as the vulnerable SD strain...
The nitric oxide pathway is amplified in venular vs arteriolar cultured rat mesenteric endothelial cellsL Wagner
Department of Physiology, West Virginia University, Morgantown, West Virginia 26506, USA
Microvasc Res 62:401-9. 2001....
Reduced nitric oxide synthase activity in rats with chronic renal disease due to glomerulonephritisLaszlo Wagner
Division of Exercise Physiology, Department of Physiology, West Virginia University, Morgantown, West Virginia, USA
Kidney Int 62:532-6. 2002..CONCLUSIONS: Total and renal NOS activity is reduced in the GN model of CRD due to increased circulating endogenous NOS inhibitors and decreased renal nNOS abundance...
Renal neuronal nitric oxide synthase protein expression as a marker of renal injuryAttila J Szabo
Department of Physiology, West Virginia University, Morgantown, West Virginia 26506, USA
Kidney Int 64:1765-71. 2003..CONCLUSION: Renal nNOS abundance was reduced in the 5/6 A/I model of renal disease when plasma creatinine> approximately 1 mg/dL and when> approximately 20% of remaining glomeruli were sclerosed...
Sexual dimorphism in the aging kidney: Effects on injury and nitric oxide systemAaron Erdely
Department of Physiology, West Virginia University, Morgantown, West Virginia 26506-9229, USA
Kidney Int 63:1021-6. 2003..This, together with the marked age-dependent kidney damage seen in the male, suggests that the renal NO deficiency in the aging male rat may contribute to the age-dependent kidney damage...
Inhibition of inducible nitric oxide synthase during high dietary salt intakeJoan Bloch
Department of Physiology, West Virginia University, Morgantown 26506-9229, USA
Am J Hypertens 15:230-5. 2002..CONCLUSION: We conclude that NO from an iNOS source is not essential for the regulation of sodium excretion and BP in the presence of a high-salt diet in a normal rat...
Resistance to renal damage by chronic nitric oxide synthase inhibition in the Wistar-Furth ratAaron Erdely
Department of Physiology and Functional Genomics, 1600 SW Archer Rd, P. O. Box 100274, University of Florida, Gainesville, FL 32610-0274, USA
Am J Physiol Regul Integr Comp Physiol 290:R66-72. 2006..In conclusion, WF rats do not develop renal injury after chronic NOSI at, or above, a dose that causes significant injury in the SD rat. This protection may be associated with protection from glomerular hypertension...
Renal cortex neuronal nitric oxide synthase in response to rapamycin in kidney transplantationYou Lin Tain
Department of Physiology and Functional Genomics, 1600 SW Archer Road, Room M544, University of Florida, POB 100274, Gainesville, FI 32667, USA
Nitric Oxide 18:80-6. 2008..In male ALLO RAPA decreased renal cortical nNOSalpha but increased nNOSbeta expression. This may represent compensatory upregulation of nNOSbeta when nNOSalpha-derived NO is deficient...
