Research Topics
| FREDERICK EPSTEINSummaryAffiliation: University of Virginia Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Mapping right ventricular myocardial mechanics using 3D cine DENSE cardiovascular magnetic resonanceDaniel A Auger
MRC UCT Medical Imaging Research Unit, Department of Human Biology, University of Cape Town, Cape Town, South Africa
J Cardiovasc Magn Reson 14:4. 2012..This study aims to describe the complex mechanics of the healthy RV using three dimensional (3D) cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance (CMR)...- Comprehensive cardiovascular magnetic resonance of myocardial mechanics in mice using three-dimensional cine DENSEXiaodong Zhong
MR R and D Collaborations, Siemens Healthcare, Atlanta, USA
J Cardiovasc Magn Reson 13:83. 2011..Quantitative noninvasive imaging of myocardial mechanics in mice enables studies of the roles of individual genes in cardiac function. We sought to develop comprehensive three-dimensional methods for imaging myocardial mechanics in mice... 
Multislice first-pass cardiac perfusion MRI: validation in a model of myocardial infarctionFrederick H Epstein
Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Magn Reson Med 47:482-91. 2002..Additionally, analysis of myocardial time-intensity curves (TICs) indicated that 15.8 +/- 6 sectors, corresponding to 260 microl of endocardium, can be analyzed (R(2) > 0.95)...- Displacement-encoded cardiac MRI using cosine and sine modulation to eliminate (CANSEL) artifact-generating echoesFrederick H Epstein
Department of Radiology, University of Virginia, Charlottesville, Virginia 22908, USA
Magn Reson Med 52:774-81. 2004..For applications that employ DENSE imaging with multiple acquisitions, the CANSEL technique can suppress artifact-generating echoes without placing constraints on the displacement-encoding frequency and direction... - The angiotensin II type 2 receptor and improved adjacent region function post-MIChristina M Bove
Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
J Cardiovasc Magn Reson 7:459-64. 2005..Thus, myocardial tagging can detect regional differences in contractile function post-MI in TG mice, and AT2-R overexpression is associated with improved contractile function in adjacent noninfarcted myocardium... - Complementary displacement-encoded MRI for contrast-enhanced infarct detection and quantification of myocardial function in miceWesley D Gilson
Department of Radiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Magn Reson Med 51:744-52. 2004..03 +/- 0.04 in infarcted regions, whereas E(cc) was -0.12 +/- 0.02 and E(rr) was 0.38 +/- 0.09 in noninfarcted regions. In vivo E(cc) as determined by DENSE correlated well with E(cc) obtained by conventional tag analysis (R = 0.90)... - Interaction between bradykinin subtype 2 and angiotensin II type 2 receptors during post-MI left ventricular remodelingDavid C Isbell
Cardiovascular Division, Department of Medicine, University of Virginia Health System, 1215 Lee Street, Charlottesville, VA 22908, USA
Am J Physiol Heart Circ Physiol 293:H3372-8. 2007..However, B(2)R does appear to have a role in the smaller cavity size and hyperdynamic function observed at baseline in AT(2)TG mice and in limiting collagen deposition during postinfarct remodeling... - Quantification and MRI validation of regional contractile dysfunction in mice post myocardial infarction using high resolution ultrasoundYinbo Li
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908 0759, USA
Ultrasound Med Biol 33:894-904. 2007..85 for radial and circumferential strain, respectively). Therefore, ultrasound imaging, followed by 2D image tracking, provides an effective, low cost, mobile method to quantify murine cardiac function accurately and reliably... 
Postinfarction myocardial scarring in mice: molecular MR imaging with use of a collagen-targeting contrast agentPatrick A Helm
Department of Radiology, University of Virginia, 409 Lane Rd, MR4 Bldg, Room 1186, Charlottesville, VA 22908, USA
Radiology 247:788-96. 2008..To prospectively evaluate a gadolinium-based collagen-targeting contrast agent, EP-3533, for in vivo magnetic resonance (MR) imaging of myocardial fibrosis in a mouse model of healed myocardial infarction (MI)...- Stunned, infarcted, and normal myocardium in dogs: simultaneous differentiation by using gadolinium-enhanced cine MR imaging with magnetization transfer contrastClifford R Weiss
Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, 10 Center Dr, Bldg 10, Rm B1D416, MSC 1061, Bethesda, MD 20892-1061, USA
Radiology 226:723-30. 2003..CONCLUSION: One day after myocardial ischemia, MTET during one MR imaging examination enabled simultaneous differentiation of infarcted, stunned, and normal myocardial regions on the basis of gadolinium enhancement and regional function... - Multi-parameter in vivo cardiac magnetic resonance imaging demonstrates normal perfusion reserve despite severely attenuated beta-adrenergic functional response in neuronal nitric oxide synthase knockout miceMoriel H Vandsburger
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
Eur Heart J 28:2792-8. 2007..We used magnetic resonance imaging (MRI) to phenotype nNOS(-/-) and wild-type (WT) mice regarding left ventricular (LV) structure, baseline function, beta-adrenergic responsiveness, and perfusion reserve... - Magnetic resonance imaging identifies the fibrous cap in atherosclerotic abdominal aortic aneurysmChristopher M Kramer
Department of Radiology, University of Virginia Health System, Lee Street, Box 800170, Charlottesville, VA 22908, USA
Circulation 109:1016-21. 2004..MRI can distinguish components of atherosclerotic plaque. We hypothesized that contrast enhancement with gadolinium-DTPA (Gd-DTPA) could aid in the differentiation of plaque components in abdominal aortic aneurysm (AAA)... - Cardiac motion recovery via active trajectory field modelsAndrew D Gilliam
C L Brown Department of Electrical and ComputerEngineering, University of Virginia, Charlottesville, VA 22904, USA
IEEE Trans Inf Technol Biomed 13:226-35. 2009.... - MR tagging early after myocardial infarction in mice demonstrates contractile dysfunction in adjacent and remote regionsFrederick H Epstein
Department of Radiology, University of Virginia, Charlottesville 22908, USA
Magn Reson Med 48:399-403. 2002..2% in the remote zone. %CS was statistically different for all comparisons between the infarcted, adjacent, remote, and baseline groups (P < 0.01). MR tagging can detect regional differences in myocardial function post-MI in mice... - MRI of left ventricular functionFrederick H Epstein
Departments of Radiology and Biomedical, University of Virginia Health System, Charlottesville, VA 22908, USA
J Nucl Cardiol 14:729-44. 2007..When used together with other CMR techniques such as first-pass perfusion imaging or late gadolinium enhancement, CMR of LV function provides a wealth of information in a single imaging study... - MR in mouse models of cardiac diseaseFrederick H Epstein
Departments of Radiology and Biomedical Engineering, and the Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
NMR Biomed 20:238-55. 2007.... - Importance of k-space trajectory in echo-planar myocardial tagging at rest and during dobutamine stressDaniel Kim
Department of Radiology, University of Virginia, Charlottesville, Virginia 22908, USA
Magn Reson Med 50:813-20. 2003..For the specific imaging protocol used, the repetition time of the improved trajectory increased by 36% compared to the conventional trajectory... - Selective suppression of artifact-generating echoes in cine DENSE using through-plane dephasingXiaodong Zhong
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
Magn Reson Med 56:1126-31. 2006..The use of dephasing with CSPAMM required two acquisitions, but demonstrated greater artifact suppression than CSPAMM alone or dephasing alone... - Nitric oxide mediates benefits of angiotensin II type 2 receptor overexpression during post-infarct remodelingChristina M Bove
University of Virginia Health System, Departments of Medicine and Radiology, Lee Street, Box 800170, Charlottesville, VA 22908, USA
Hypertension 43:680-5. 2004..Noninfarcted region interstitial collagen was similar between groups. Thus, the NO pathway may mediate much of the benefits of cardiac AT(2)-R overexpression during post-MI remodeling... - Myocardial tissue tracking with two-dimensional cine displacement-encoded MR imaging: development and initial evaluationDaniel Kim
Department of Radiology, University of Virginia Health System, Rm 1175, MR-4 Bldg, 409 Lane Rd, Charlottesville, VA 22908, USA
Radiology 230:862-71. 2004..7 x 2.7 mm and 60 msec, respectively. E(cc) measured at cine DENSE MR imaging correlated well with that measured at conventional MR imaging tagging (slope = 0.88, intercept = 0.00, R = 0.87)... - Borderzone contractile dysfunction is transiently attenuated and left ventricular structural remodeling is markedly reduced following reperfused myocardial infarction in inducible nitric oxide synthase knockout miceWesley D Gilson
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22903, USA
J Am Coll Cardiol 50:1799-807. 2007..We sought to determine the effect of inducible nitric oxide synthase (iNOS) expression on regional contractile function and left ventricular (LV) remodeling after reperfused myocardial infarction (MI)... - Increasing the signal-to-noise ratio in DENSE MRI by combining displacement-encoded echoesDaniel Kim
Department of Radiology, New York University, New York, New York 10016, USA
Magn Reson Med 52:188-92. 2004..The breath-hold sav-DENSE technique yielded relatively accurate and precise quantification of 2D intramyocardial function, with a 40.2-ms temporal resolution and a 3.5 x 3.5 mm2 spatial resolution... - Interaction between AT1 and AT2 receptors during postinfarction left ventricular remodelingSzilard Voros
Department of Medicine, University of Virginia Health System, Lee St, Box 800170, Charlottesville, Virginia 22908, USA
Am J Physiol Heart Circ Physiol 290:H1004-10. 2006..Pharmacological blockade of AT1-R is equivalent to AT2-R overexpression in attenuating post-MI remodeling. Genetic knockout of the AT1a-R is additive to AT2-R overexpression, due, at least in part, to blood pressure lowering... - Infarct involution and improved function during healing of acute myocardial infarction: the role of microvascular obstructionC Joon Choi
Department of Medicine, Cardiovascular Division, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Cardiovasc Magn Reson 6:917-25. 2004.... - Black blood gradient echo cine magnetic resonance imaging of the mouse heartStuart S Berr
Department of Radiology, University of Virginia, Charlottesville, USA
Magn Reson Med 53:1074-9. 2005..Black blood cine MRI in mice provides reduced interobserver variability and improved accuracy for the measurement of myocardial volumes and mass compared to the conventional bright blood technique... - Tracking brain motion during the cardiac cycle using spiral cine-DENSE MRIXiaodong Zhong
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
Med Phys 36:3413-9. 2009..These preliminary results demonstrated that the spiral cine-DENSE MRI technique can be used to measure cardiac-synchronized pulsatile brain motion on the pixel-by-pixel basis with high temporal/spatial resolution and sensitivity... - Improved arterial spin labeling after myocardial infarction in mice using cardiac and respiratory gated look-locker imaging with fuzzy C-means clusteringMoriel H Vandsburger
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
Magn Reson Med 63:648-57. 2010..This technique, when applied to genetically engineered mice, will allow for the investigation of the roles of specific genes in myocardial perfusion during infarct healing... - Calf muscle perfusion at peak exercise in peripheral arterial disease: measurement by first-pass contrast-enhanced magnetic resonance imagingDavid C Isbell
Department of Medicine, University of Virginia Health System, University of Virginia, Lee Street, Charlottesville, VA 22908, USA
J Magn Reson Imaging 25:1013-20. 2007..To develop a contrast-enhanced magnetic resonance (MR) technique to measure skeletal muscle perfusion in peripheral arterial disease (PAD)... - Measurement of myocardial mechanics in mice before and after infarction using multislice displacement-encoded MRI with 3D motion encodingWesley D Gilson
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
Am J Physiol Heart Circ Physiol 288:H1491-7. 2005..07 +/- 0.54 degrees /mm (R = 0.96, P < 0.05). DENSE MRI can assess the 3D myocardial mechanics of the murine heart in <1 h of scan time at 4.7 T and may be applied to studies of myocardial mechanics in genetically engineered mice... - Multifactorial determinants of functional capacity in peripheral arterial disease: uncoupling of calf muscle perfusion and metabolismJustin D Anderson
Department of Medicine, University of Virginia Health System, University of Virginia, Charlottesville, VA 22908, USA
J Am Coll Cardiol 54:628-35. 2009..We aimed to investigate the pathophysiology of peripheral arterial disease (PAD) by examining magnetic resonance imaging (MRI) and spectroscopic (MRS) correlates of functional capacity... - Assessment of regional systolic and diastolic dysfunction in familial hypertrophic cardiomyopathy using MR taggingDaniel B Ennis
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Magn Reson Med 50:638-42. 2003..03). The combination of CSPAMM and CAPTOR allows regional indices of myocardial function to be quantified throughout the cardiac cycle. This technique reveals regional differences in systolic and diastolic impairment in FHC patients... - Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imagingPatrick F Antkowiak
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
Am J Physiol Endocrinol Metab 296:E573-8. 2009.... - Balanced multipoint displacement encoding for DENSE MRIXiaodong Zhong
Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
Magn Reson Med 61:981-8. 2009..Reduced phase noise and improved displacement and strain maps using balanced methods were visually observed in phantom and volunteer images. Balanced multipoint encoding can also be applied to PC MRI... - Imaging two-dimensional displacements and strains in skeletal muscle during joint motion by cine DENSE MRXiaodong Zhong
Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
J Biomech 41:532-40. 2008..This study demonstrates the utility of cine DENSE MRI for analyzing skeletal muscle mechanics and provides data describing the in vivo mechanics of muscle tissue to a level of detail that has not been previously possible... - Spatial and spectral heterogeneity of time-varying shear stress profiles in the carotid bifurcation by phase-contrast MRIBradley D Gelfand
Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Magn Reson Imaging 24:1386-92. 2006..CONCLUSION: These findings indicate that the time and frequency dependent parameters of in vivo shear stress have important implications for regional development of atherosclerosis... - Reproducibility and reliability of atherosclerotic plaque volume measurements in peripheral arterial disease with cardiovascular magnetic resonanceDavid C Isbell
Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Cardiovasc Magn Reson 9:71-6. 2007..27 +/- 3.73 cm3. Intra-observer intraclass correlation was R = 0.997, inter-observer was R = 0.987, and test-retest reproducibility was R = 0.996. Thus, high resolution measurement of plaque volume in PAD is reliable and reproducible... - Delayed calf muscle phosphocreatine recovery after exercise identifies peripheral arterial diseaseDavid C Isbell
Department of Medicine, University of Virginia Health System, University of Virginia, Charlottesville, Virginia 22908, USA
J Am Coll Cardiol 47:2289-95. 2006..The method is reproducible and may be useful in the identification of disease. Further study of this parameter's ability to track response to therapy as well as its prognostic capability is warranted... - Myocardial first-pass perfusion cardiovascular magnetic resonance: history, theory, and current state of the artBernhard L Gerber
Department of Cardiovascular Diseases, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
J Cardiovasc Magn Reson 10:18. 2008..This comprehensive overview includes a summary of the past clinical performance of first-pass perfusion CMR and current clinical applications using state-of-the-art methodologies... - Collagen-targeted MRI contrast agent for molecular imaging of fibrosisPeter Caravan
EPIX Pharmaceuticals, Inc. 4 Maguire Road, Lexington, MA 02421, USA
Angew Chem Int Ed Engl 46:8171-3. 2007 - 3D myocardial tissue tracking with slice followed cine DENSE MRIBruce S Spottiswoode
UCT MRC Medical Imaging Research Unit, University of Cape Town, South Africa
J Magn Reson Imaging 27:1019-27. 2008..To track three-dimensional (3D) myocardial tissue motion using slice followed cine displacement encoded imaging with stimulated echoes (DENSE)... - Tracking myocardial motion from cine DENSE images using spatiotemporal phase unwrapping and temporal fittingB S Spottiswoode
MRC UCT Medical Imaging Research Unit, University of Cape Town, Cape Town 7925, South Africa
IEEE Trans Med Imaging 26:15-30. 2007..0% in mid-diastole. The improvement in intra-myocardial strain measurements due to temporal fitting is apparent in strain histograms, and also in identifying regions of dysfunctional myocardium in studies of patients with infarcts... - Angiotensin II type 2 receptor overexpression preserves left ventricular function after myocardial infarctionZequan Yang
Department of Medicine and the Cardiovascular Research Center, University of Virginia Health System, Charlottesville 22908, USA
Circulation 106:106-11. 2002..At day 28, blood pressure and LV dP/dt were higher in TG. CONCLUSIONS: Cardiac AT2-R overexpression improves LV systolic function at baseline and preserves function during post-MI remodeling... - Reperfused myocardial infarction in mice: 3D mapping of late gadolinium enhancement and strainAlistair A Young
Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
J Cardiovasc Magn Reson 8:685-92. 2006..3D mapping of late enhancement and strain allows registration of multiple studies in a consistent framework... - Effects of phase encode order and segment interpolation methods on the quality and accuracy of myocardial tags during assessment of left ventricular contractionTiffany B Salido
Department of Medical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
J Cardiovasc Magn Reson 4:245-54. 2002....
Research Grants
- MRI of Myocardial Function in Post-Infarct Knockout MiceFREDERICK EPSTEIN; Fiscal Year: 2006..abstract_text> ..
- MRI of Myocardial Function in Post-Infarct Knockout MiceFREDERICK EPSTEIN; Fiscal Year: 2009....
- MRI of Myocardial Function in Post-Infarct Knockout MiceFrederick H Epstein; Fiscal Year: 2010....