FREDERICK EPSTEIN

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Reproducibility of rest and exercise stress contrast-enhanced calf perfusion magnetic resonance imaging in peripheral arterial disease
    Ronny S Jiji
    Departments of Medicine and the Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, VA, USA
    J Cardiovasc Magn Reson 15:14. 2013
  2. pmc Mapping right ventricular myocardial mechanics using 3D cine DENSE cardiovascular magnetic resonance
    Daniel A Auger
    MRC UCT Medical Imaging Research Unit, Department of Human Biology, University of Cape Town, Cape Town, South Africa
    J Cardiovasc Magn Reson 14:4. 2012
  3. pmc Comprehensive cardiovascular magnetic resonance of myocardial mechanics in mice using three-dimensional cine DENSE
    Xiaodong Zhong
    MR R and D Collaborations, Siemens Healthcare, Atlanta, USA
    J Cardiovasc Magn Reson 13:83. 2011
  4. ncbi request reprint Multislice first-pass cardiac perfusion MRI: validation in a model of myocardial infarction
    Frederick H Epstein
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Magn Reson Med 47:482-91. 2002
  5. ncbi request reprint Displacement-encoded cardiac MRI using cosine and sine modulation to eliminate (CANSEL) artifact-generating echoes
    Frederick H Epstein
    Department of Radiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Magn Reson Med 52:774-81. 2004
  6. ncbi request reprint The angiotensin II type 2 receptor and improved adjacent region function post-MI
    Christina M Bove
    Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
    J Cardiovasc Magn Reson 7:459-64. 2005
  7. ncbi request reprint Complementary displacement-encoded MRI for contrast-enhanced infarct detection and quantification of myocardial function in mice
    Wesley D Gilson
    Department of Radiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Magn Reson Med 51:744-52. 2004
  8. ncbi request reprint Interaction between bradykinin subtype 2 and angiotensin II type 2 receptors during post-MI left ventricular remodeling
    David C Isbell
    Cardiovascular Division, Department of Medicine, University of Virginia Health System, 1215 Lee Street, Charlottesville, VA 22908, USA
    Am J Physiol Heart Circ Physiol 293:H3372-8. 2007
  9. doi request reprint Postinfarction myocardial scarring in mice: molecular MR imaging with use of a collagen-targeting contrast agent
    Patrick A Helm
    Department of Radiology, University of Virginia, 409 Lane Rd, MR4 Bldg, Room 1186, Charlottesville, VA 22908, USA
    Radiology 247:788-96. 2008
  10. pmc Quantification and MRI validation of regional contractile dysfunction in mice post myocardial infarction using high resolution ultrasound
    Yinbo Li
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908 0759, USA
    Ultrasound Med Biol 33:894-904. 2007

Research Grants

Collaborators

Detail Information

Publications45

  1. pmc Reproducibility of rest and exercise stress contrast-enhanced calf perfusion magnetic resonance imaging in peripheral arterial disease
    Ronny S Jiji
    Departments of Medicine and the Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, VA, USA
    J Cardiovasc Magn Reson 15:14. 2013
    ....
  2. pmc Mapping right ventricular myocardial mechanics using 3D cine DENSE cardiovascular magnetic resonance
    Daniel A Auger
    MRC UCT Medical Imaging Research Unit, Department of Human Biology, University of Cape Town, Cape Town, South Africa
    J Cardiovasc Magn Reson 14:4. 2012
    ..This study aims to describe the complex mechanics of the healthy RV using three dimensional (3D) cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance (CMR)...
  3. pmc Comprehensive cardiovascular magnetic resonance of myocardial mechanics in mice using three-dimensional cine DENSE
    Xiaodong Zhong
    MR R and D Collaborations, Siemens Healthcare, Atlanta, USA
    J Cardiovasc Magn Reson 13:83. 2011
    ..Quantitative noninvasive imaging of myocardial mechanics in mice enables studies of the roles of individual genes in cardiac function. We sought to develop comprehensive three-dimensional methods for imaging myocardial mechanics in mice...
  4. ncbi request reprint Multislice first-pass cardiac perfusion MRI: validation in a model of myocardial infarction
    Frederick H Epstein
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Magn Reson Med 47:482-91. 2002
    ..Additionally, analysis of myocardial time-intensity curves (TICs) indicated that 15.8 +/- 6 sectors, corresponding to 260 microl of endocardium, can be analyzed (R(2) > 0.95)...
  5. ncbi request reprint Displacement-encoded cardiac MRI using cosine and sine modulation to eliminate (CANSEL) artifact-generating echoes
    Frederick H Epstein
    Department of Radiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Magn Reson Med 52:774-81. 2004
    ..For applications that employ DENSE imaging with multiple acquisitions, the CANSEL technique can suppress artifact-generating echoes without placing constraints on the displacement-encoding frequency and direction...
  6. ncbi request reprint The angiotensin II type 2 receptor and improved adjacent region function post-MI
    Christina M Bove
    Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
    J Cardiovasc Magn Reson 7:459-64. 2005
    ..Thus, myocardial tagging can detect regional differences in contractile function post-MI in TG mice, and AT2-R overexpression is associated with improved contractile function in adjacent noninfarcted myocardium...
  7. ncbi request reprint Complementary displacement-encoded MRI for contrast-enhanced infarct detection and quantification of myocardial function in mice
    Wesley D Gilson
    Department of Radiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Magn Reson Med 51:744-52. 2004
    ..03 +/- 0.04 in infarcted regions, whereas E(cc) was -0.12 +/- 0.02 and E(rr) was 0.38 +/- 0.09 in noninfarcted regions. In vivo E(cc) as determined by DENSE correlated well with E(cc) obtained by conventional tag analysis (R = 0.90)...
  8. ncbi request reprint Interaction between bradykinin subtype 2 and angiotensin II type 2 receptors during post-MI left ventricular remodeling
    David C Isbell
    Cardiovascular Division, Department of Medicine, University of Virginia Health System, 1215 Lee Street, Charlottesville, VA 22908, USA
    Am J Physiol Heart Circ Physiol 293:H3372-8. 2007
    ..However, B(2)R does appear to have a role in the smaller cavity size and hyperdynamic function observed at baseline in AT(2)TG mice and in limiting collagen deposition during postinfarct remodeling...
  9. doi request reprint Postinfarction myocardial scarring in mice: molecular MR imaging with use of a collagen-targeting contrast agent
    Patrick A Helm
    Department of Radiology, University of Virginia, 409 Lane Rd, MR4 Bldg, Room 1186, Charlottesville, VA 22908, USA
    Radiology 247:788-96. 2008
    ..To prospectively evaluate a gadolinium-based collagen-targeting contrast agent, EP-3533, for in vivo magnetic resonance (MR) imaging of myocardial fibrosis in a mouse model of healed myocardial infarction (MI)...
  10. pmc Quantification and MRI validation of regional contractile dysfunction in mice post myocardial infarction using high resolution ultrasound
    Yinbo Li
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908 0759, USA
    Ultrasound Med Biol 33:894-904. 2007
    ..85 for radial and circumferential strain, respectively). Therefore, ultrasound imaging, followed by 2D image tracking, provides an effective, low cost, mobile method to quantify murine cardiac function accurately and reliably...
  11. ncbi request reprint Multi-parameter in vivo cardiac magnetic resonance imaging demonstrates normal perfusion reserve despite severely attenuated beta-adrenergic functional response in neuronal nitric oxide synthase knockout mice
    Moriel H Vandsburger
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    Eur Heart J 28:2792-8. 2007
    ..We used magnetic resonance imaging (MRI) to phenotype nNOS(-/-) and wild-type (WT) mice regarding left ventricular (LV) structure, baseline function, beta-adrenergic responsiveness, and perfusion reserve...
  12. ncbi request reprint Stunned, infarcted, and normal myocardium in dogs: simultaneous differentiation by using gadolinium-enhanced cine MR imaging with magnetization transfer contrast
    Clifford R Weiss
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, 10 Center Dr, Bldg 10, Rm B1D416, MSC 1061, Bethesda, MD 20892 1061, USA
    Radiology 226:723-30. 2003
    ..To simultaneously differentiate stunned, infarcted, and normal myocardial regions by using gadolinium-enhanced cine magnetic resonance (MR) imaging with magnetization transfer contrast...
  13. ncbi request reprint MR in mouse models of cardiac disease
    Frederick H Epstein
    Departments of Radiology and Biomedical Engineering, and the Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    NMR Biomed 20:238-55. 2007
    ....
  14. ncbi request reprint MRI of left ventricular function
    Frederick H Epstein
    Departments of Radiology and Biomedical, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Nucl Cardiol 14:729-44. 2007
    ..When used together with other CMR techniques such as first-pass perfusion imaging or late gadolinium enhancement, CMR of LV function provides a wealth of information in a single imaging study...
  15. ncbi request reprint Selective suppression of artifact-generating echoes in cine DENSE using through-plane dephasing
    Xiaodong Zhong
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
    Magn Reson Med 56:1126-31. 2006
    ..The use of dephasing with CSPAMM required two acquisitions, but demonstrated greater artifact suppression than CSPAMM alone or dephasing alone...
  16. ncbi request reprint Importance of k-space trajectory in echo-planar myocardial tagging at rest and during dobutamine stress
    Daniel Kim
    Department of Radiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Magn Reson Med 50:813-20. 2003
    ..For the specific imaging protocol used, the repetition time of the improved trajectory increased by 36% compared to the conventional trajectory...
  17. ncbi request reprint MR tagging early after myocardial infarction in mice demonstrates contractile dysfunction in adjacent and remote regions
    Frederick H Epstein
    Department of Radiology, University of Virginia, Charlottesville 22908, USA
    Magn Reson Med 48:399-403. 2002
    ..2% in the remote zone. %CS was statistically different for all comparisons between the infarcted, adjacent, remote, and baseline groups (P < 0.01). MR tagging can detect regional differences in myocardial function post-MI in mice...
  18. ncbi request reprint Nitric oxide mediates benefits of angiotensin II type 2 receptor overexpression during post-infarct remodeling
    Christina M Bove
    University of Virginia Health System, Departments of Medicine and Radiology, Lee Street, Box 800170, Charlottesville, VA 22908, USA
    Hypertension 43:680-5. 2004
    ..Noninfarcted region interstitial collagen was similar between groups. Thus, the NO pathway may mediate much of the benefits of cardiac AT(2)-R overexpression during post-MI remodeling...
  19. ncbi request reprint Myocardial tissue tracking with two-dimensional cine displacement-encoded MR imaging: development and initial evaluation
    Daniel Kim
    Department of Radiology, University of Virginia Health System, Rm 1175, MR 4 Bldg, 409 Lane Rd, Charlottesville, VA 22908, USA
    Radiology 230:862-71. 2004
    ..7 x 2.7 mm and 60 msec, respectively. E(cc) measured at cine DENSE MR imaging correlated well with that measured at conventional MR imaging tagging (slope = 0.88, intercept = 0.00, R = 0.87)...
  20. pmc Magnetic resonance imaging identifies the fibrous cap in atherosclerotic abdominal aortic aneurysm
    Christopher M Kramer
    Department of Radiology, University of Virginia Health System, Lee Street, Box 800170, Charlottesville, VA 22908, USA
    Circulation 109:1016-21. 2004
    ..MRI can distinguish components of atherosclerotic plaque. We hypothesized that contrast enhancement with gadolinium-DTPA (Gd-DTPA) could aid in the differentiation of plaque components in abdominal aortic aneurysm (AAA)...
  21. pmc Cardiac motion recovery via active trajectory field models
    Andrew D Gilliam
    C L Brown Department of Electrical and ComputerEngineering, University of Virginia, Charlottesville, VA 22904, USA
    IEEE Trans Inf Technol Biomed 13:226-35. 2009
    ....
  22. ncbi request reprint Borderzone contractile dysfunction is transiently attenuated and left ventricular structural remodeling is markedly reduced following reperfused myocardial infarction in inducible nitric oxide synthase knockout mice
    Wesley D Gilson
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22903, USA
    J Am Coll Cardiol 50:1799-807. 2007
    ..We sought to determine the effect of inducible nitric oxide synthase (iNOS) expression on regional contractile function and left ventricular (LV) remodeling after reperfused myocardial infarction (MI)...
  23. pmc Tracking brain motion during the cardiac cycle using spiral cine-DENSE MRI
    Xiaodong Zhong
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Med Phys 36:3413-9. 2009
    ..These preliminary results demonstrated that the spiral cine-DENSE MRI technique can be used to measure cardiac-synchronized pulsatile brain motion on the pixel-by-pixel basis with high temporal/spatial resolution and sensitivity...
  24. pmc Improved arterial spin labeling after myocardial infarction in mice using cardiac and respiratory gated look-locker imaging with fuzzy C-means clustering
    Moriel H Vandsburger
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Magn Reson Med 63:648-57. 2010
    ..This technique, when applied to genetically engineered mice, will allow for the investigation of the roles of specific genes in myocardial perfusion during infarct healing...
  25. ncbi request reprint Infarct involution and improved function during healing of acute myocardial infarction: the role of microvascular obstruction
    C Joon Choi
    Department of Medicine, Cardiovascular Division, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Cardiovasc Magn Reson 6:917-25. 2004
    ....
  26. ncbi request reprint Increasing the signal-to-noise ratio in DENSE MRI by combining displacement-encoded echoes
    Daniel Kim
    Department of Radiology, New York University, New York, New York 10016, USA
    Magn Reson Med 52:188-92. 2004
    ..The breath-hold sav-DENSE technique yielded relatively accurate and precise quantification of 2D intramyocardial function, with a 40.2-ms temporal resolution and a 3.5 x 3.5 mm2 spatial resolution...
  27. ncbi request reprint Interaction between AT1 and AT2 receptors during postinfarction left ventricular remodeling
    Szilard Voros
    Department of Medicine, University of Virginia Health System, Lee St, Box 800170, Charlottesville, Virginia 22908, USA
    Am J Physiol Heart Circ Physiol 290:H1004-10. 2006
    ..Pharmacological blockade of AT1-R is equivalent to AT2-R overexpression in attenuating post-MI remodeling. Genetic knockout of the AT1a-R is additive to AT2-R overexpression, due, at least in part, to blood pressure lowering...
  28. ncbi request reprint Black blood gradient echo cine magnetic resonance imaging of the mouse heart
    Stuart S Berr
    Department of Radiology, University of Virginia, Charlottesville, USA
    Magn Reson Med 53:1074-9. 2005
    ..Black blood cine MRI in mice provides reduced interobserver variability and improved accuracy for the measurement of myocardial volumes and mass compared to the conventional bright blood technique...
  29. ncbi request reprint Measurement of myocardial mechanics in mice before and after infarction using multislice displacement-encoded MRI with 3D motion encoding
    Wesley D Gilson
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Am J Physiol Heart Circ Physiol 288:H1491-7. 2005
    ..07 +/- 0.54 degrees /mm (R = 0.96, P < 0.05). DENSE MRI can assess the 3D myocardial mechanics of the murine heart in <1 h of scan time at 4.7 T and may be applied to studies of myocardial mechanics in genetically engineered mice...
  30. pmc Calf muscle perfusion at peak exercise in peripheral arterial disease: measurement by first-pass contrast-enhanced magnetic resonance imaging
    David C Isbell
    Department of Medicine, University of Virginia Health System, University of Virginia, Lee Street, Charlottesville, VA 22908, USA
    J Magn Reson Imaging 25:1013-20. 2007
    ..To develop a contrast-enhanced magnetic resonance (MR) technique to measure skeletal muscle perfusion in peripheral arterial disease (PAD)...
  31. pmc Multifactorial determinants of functional capacity in peripheral arterial disease: uncoupling of calf muscle perfusion and metabolism
    Justin D Anderson
    Department of Medicine, University of Virginia Health System, University of Virginia, Charlottesville, VA 22908, USA
    J Am Coll Cardiol 54:628-35. 2009
    ..We aimed to investigate the pathophysiology of peripheral arterial disease (PAD) by examining magnetic resonance imaging (MRI) and spectroscopic (MRS) correlates of functional capacity...
  32. pmc Balanced multipoint displacement encoding for DENSE MRI
    Xiaodong Zhong
    Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Magn Reson Med 61:981-8. 2009
    ..Reduced phase noise and improved displacement and strain maps using balanced methods were visually observed in phantom and volunteer images. Balanced multipoint encoding can also be applied to PC MRI...
  33. pmc Assessment of regional systolic and diastolic dysfunction in familial hypertrophic cardiomyopathy using MR tagging
    Daniel B Ennis
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Magn Reson Med 50:638-42. 2003
    ..03). The combination of CSPAMM and CAPTOR allows regional indices of myocardial function to be quantified throughout the cardiac cycle. This technique reveals regional differences in systolic and diastolic impairment in FHC patients...
  34. pmc Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging
    Patrick F Antkowiak
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Endocrinol Metab 296:E573-8. 2009
    ....
  35. pmc Reproducibility and reliability of atherosclerotic plaque volume measurements in peripheral arterial disease with cardiovascular magnetic resonance
    David C Isbell
    Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Cardiovasc Magn Reson 9:71-6. 2007
    ..27 +/- 3.73 cm3. Intra-observer intraclass correlation was R = 0.997, inter-observer was R = 0.987, and test-retest reproducibility was R = 0.996. Thus, high resolution measurement of plaque volume in PAD is reliable and reproducible...
  36. ncbi request reprint Spatial and spectral heterogeneity of time-varying shear stress profiles in the carotid bifurcation by phase-contrast MRI
    Bradley D Gelfand
    Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Magn Reson Imaging 24:1386-92. 2006
    ..To determine the heterogeneity of the time-varying shear stress profiles in the human carotid bifurcation, a region prone to atherosclerosis...
  37. pmc Imaging two-dimensional displacements and strains in skeletal muscle during joint motion by cine DENSE MR
    Xiaodong Zhong
    Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
    J Biomech 41:532-40. 2008
    ..This study demonstrates the utility of cine DENSE MRI for analyzing skeletal muscle mechanics and provides data describing the in vivo mechanics of muscle tissue to a level of detail that has not been previously possible...
  38. pmc Delayed calf muscle phosphocreatine recovery after exercise identifies peripheral arterial disease
    David C Isbell
    Department of Medicine, University of Virginia Health System, University of Virginia, Charlottesville, Virginia 22908, USA
    J Am Coll Cardiol 47:2289-95. 2006
    ....
  39. ncbi request reprint Effects of phase encode order and segment interpolation methods on the quality and accuracy of myocardial tags during assessment of left ventricular contraction
    Tiffany B Salido
    Department of Medical Engineering, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Cardiovasc Magn Reson 4:245-54. 2002
    ....
  40. ncbi request reprint Angiotensin II type 2 receptor overexpression preserves left ventricular function after myocardial infarction
    Zequan Yang
    Department of Medicine and the Cardiovascular Research Center, University of Virginia Health System, Charlottesville 22908, USA
    Circulation 106:106-11. 2002
    ..We hypothesized that cardiac AT2-R overexpression in transgenic (TG) mice would attenuate remodeling after myocardial infarction (MI)...
  41. ncbi request reprint Tracking myocardial motion from cine DENSE images using spatiotemporal phase unwrapping and temporal fitting
    B S Spottiswoode
    MRC UCT Medical Imaging Research Unit, University of Cape Town, Cape Town 7925, South Africa
    IEEE Trans Med Imaging 26:15-30. 2007
    ..0% in mid-diastole. The improvement in intra-myocardial strain measurements due to temporal fitting is apparent in strain histograms, and also in identifying regions of dysfunctional myocardium in studies of patients with infarcts...
  42. ncbi request reprint Reperfused myocardial infarction in mice: 3D mapping of late gadolinium enhancement and strain
    Alistair A Young
    Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    J Cardiovasc Magn Reson 8:685-92. 2006
    ..3D mapping of late enhancement and strain allows registration of multiple studies in a consistent framework...
  43. pmc Myocardial first-pass perfusion cardiovascular magnetic resonance: history, theory, and current state of the art
    Bernhard L Gerber
    Department of Cardiovascular Diseases, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
    J Cardiovasc Magn Reson 10:18. 2008
    ..This comprehensive overview includes a summary of the past clinical performance of first-pass perfusion CMR and current clinical applications using state-of-the-art methodologies...
  44. ncbi request reprint Collagen-targeted MRI contrast agent for molecular imaging of fibrosis
    Peter Caravan
    EPIX Pharmaceuticals, Inc 4 Maguire Road, Lexington, MA 02421, USA
    Angew Chem Int Ed Engl 46:8171-3. 2007
  45. doi request reprint 3D myocardial tissue tracking with slice followed cine DENSE MRI
    Bruce S Spottiswoode
    UCT MRC Medical Imaging Research Unit, University of Cape Town, South Africa
    J Magn Reson Imaging 27:1019-27. 2008
    ..To track three-dimensional (3D) myocardial tissue motion using slice followed cine displacement encoded imaging with stimulated echoes (DENSE)...

Research Grants7

  1. MRI of Myocardial Function in Post-Infarct Knockout Mice
    FREDERICK EPSTEIN; Fiscal Year: 2006
    ..abstract_text> ..
  2. MRI of Myocardial Function in Post-Infarct Knockout Mice
    FREDERICK EPSTEIN; Fiscal Year: 2009
    ....
  3. MRI of Myocardial Function in Post-Infarct Knockout Mice
    Frederick H Epstein; Fiscal Year: 2010
    ....