Elissa S Epel

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Accelerated telomere shortening in response to life stress
    Elissa S Epel
    Department of Psychiatry, University of California, 3333 California Street, Suite 465, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:17312-5. 2004
  2. ncbi Cell aging in relation to stress arousal and cardiovascular disease risk factors
    Elissa S Epel
    UCSF Department of Psychiatry, San Francisco, CA, USA
    Psychoneuroendocrinology 31:277-87. 2006
  3. pmc Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity
    Elissa S Epel
    Department of Psychiatry, University of California, San Francisco
    J Gerontol A Biol Sci Med Sci 69:S10-6. 2014
  4. doi How "reversible" is telomeric aging?
    Elissa Epel
    University of California, San Francisco, San Francisco, CA 94143, USA
    Cancer Prev Res (Phila) 5:1163-8. 2012
  5. pmc Dynamics of telomerase activity in response to acute psychological stress
    Elissa S Epel
    Department of Psychiatry, University of California, San Francisco, 3333 Calif St, Suite 465, San Francisco, CA 94143, USA
    Brain Behav Immun 24:531-9. 2010
  6. pmc Dietary restraint and telomere length in pre- and postmenopausal women
    Amy Kiefer
    UCSF Department of Psychiatry, University of California, San Francisco, California, USA
    Psychosom Med 70:845-9. 2008
  7. pmc Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres
    Elissa Epel
    University of California San Francisco, Department of Psychiatry, San Francisco, California 94143, USA
    Ann N Y Acad Sci 1172:34-53. 2009
  8. pmc The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men
    Elissa S Epel
    University of California, San Francisco, Department of Psychiatry, San Francisco, CA, 94143, USA
    Aging (Albany NY) 1:81-8. 2009
  9. ncbi Psychological and metabolic stress: a recipe for accelerated cellular aging?
    Elissa S Epel
    University of California, Department of Psychiatry, San Francisco, CA 94143, USA
    Hormones (Athens) 8:7-22. 2009
  10. ncbi Depression gets old fast: do stress and depression accelerate cell aging?
    Owen M Wolkowitz
    Department of Psychiatry, University of California School of Medicine, San Francisco, California, USA
    Depress Anxiety 27:327-38. 2010

Research Grants

Detail Information

Publications41

  1. pmc Accelerated telomere shortening in response to life stress
    Elissa S Epel
    Department of Psychiatry, University of California, 3333 California Street, Suite 465, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:17312-5. 2004
    ..These findings have implications for understanding how, at the cellular level, stress may promote earlier onset of age-related diseases...
  2. ncbi Cell aging in relation to stress arousal and cardiovascular disease risk factors
    Elissa S Epel
    UCSF Department of Psychiatry, San Francisco, CA, USA
    Psychoneuroendocrinology 31:277-87. 2006
    ..These findings may implicate telomerase as a novel and important mediator of the effects of psychological stress on physical health and disease...
  3. pmc Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity
    Elissa S Epel
    Department of Psychiatry, University of California, San Francisco
    J Gerontol A Biol Sci Med Sci 69:S10-6. 2014
    ..This will require interdisciplinary novel approaches that hold much promise for understanding and intervening in human chronic disease. ..
  4. doi How "reversible" is telomeric aging?
    Elissa Epel
    University of California, San Francisco, San Francisco, CA 94143, USA
    Cancer Prev Res (Phila) 5:1163-8. 2012
    ..Cancer Prev Res; 5(10); 1163-8. ©2012 AACR...
  5. pmc Dynamics of telomerase activity in response to acute psychological stress
    Elissa S Epel
    Department of Psychiatry, University of California, San Francisco, 3333 Calif St, Suite 465, San Francisco, CA 94143, USA
    Brain Behav Immun 24:531-9. 2010
    ....
  6. pmc Dietary restraint and telomere length in pre- and postmenopausal women
    Amy Kiefer
    UCSF Department of Psychiatry, University of California, San Francisco, California, USA
    Psychosom Med 70:845-9. 2008
    ....
  7. pmc Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres
    Elissa Epel
    University of California San Francisco, Department of Psychiatry, San Francisco, California 94143, USA
    Ann N Y Acad Sci 1172:34-53. 2009
    ..Aspects of this model are currently being tested in ongoing trials of mindfulness meditation...
  8. pmc The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men
    Elissa S Epel
    University of California, San Francisco, Department of Psychiatry, San Francisco, CA, 94143, USA
    Aging (Albany NY) 1:81-8. 2009
    ..0 (95% CI: 1.1 - 8.2). This is the first demonstration that rate of telomere length change (TLC) predicts mortality and thus may be a useful prognostic factor for longevity...
  9. ncbi Psychological and metabolic stress: a recipe for accelerated cellular aging?
    Elissa S Epel
    University of California, Department of Psychiatry, San Francisco, CA 94143, USA
    Hormones (Athens) 8:7-22. 2009
    ..Certain psychological temperaments at high risk of this stress cascade (mainly anxiety prone), gene-environment interactions, and potential interventions for interrupting the stress-aging cascade are discussed...
  10. ncbi Depression gets old fast: do stress and depression accelerate cell aging?
    Owen M Wolkowitz
    Department of Psychiatry, University of California School of Medicine, San Francisco, California, USA
    Depress Anxiety 27:327-38. 2010
    ....
  11. doi Chronic psychological stress and racial disparities in body mass index change between Black and White girls aged 10-19
    A Janet Tomiyama
    Department of Psychology, University of California, Los Angeles, 90095 1563, USA
    Ann Behav Med 45:3-12. 2013
    ..One of the largest health disparities in the USA is in obesity rates between Black and White females...
  12. pmc Multisystem resiliency moderates the major depression-telomere length association: findings from the Heart and Soul Study
    Eli Puterman
    University of California San Francisco, 3333 California Street Suite 465, San Francisco, CA 94143 0848, United States Electronic address
    Brain Behav Immun 33:65-73. 2013
    ..Further research should explore the cognitive, neural, and other physiological pathways through which multisystem resiliency may confer biological benefit...
  13. pmc Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings
    Owen M Wolkowitz
    Department of Psychiatry, University of California San Francisco School of Medicine, San Francisco, California, United States of America
    PLoS ONE 6:e17837. 2011
    ..We sought to determine if leukocyte telomeres are shortened in Major Depressive Disorder (MDD), whether this is a function of lifetime depression exposure and whether this is related to putative mediators, oxidation and inflammation...
  14. pmc Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere length
    Aoife O'Donovan
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Brain Behav Immun 26:573-9. 2012
    ..Exaggerated anticipatory threat appraisals may be a common and modifiable psychological mechanism of psychological stress effects on cellular aging...
  15. pmc Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study
    Aoife O'Donovan
    Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e19687. 2011
    ..However, in spite of the proposed causal links between inflammatory activity and LTL, there is little clinical evidence in support of their covariation and interaction...
  16. pmc Gender differences in the prospective associations of self-reported sleep quality with biomarkers of systemic inflammation and coagulation: findings from the Heart and Soul Study
    Aric A Prather
    Department of Psychiatry, University of California, 3333 California St, Suite 465, San Francisco, CA 94118, United States
    J Psychiatr Res 47:1228-35. 2013
    ..Further research is necessary to elucidate the pathways that underlie gender-specific associations between subjective sleep quality and markers of inflammation and coagulation as this may help clarify gender disparities in CHD. ..
  17. pmc Serum BDNF levels before treatment predict SSRI response in depression
    Owen M Wolkowitz
    Department of Psychiatry, University of California, San Francisco School of Medicine, San Francisco, CA 94143, United States
    Prog Neuropsychopharmacol Biol Psychiatry 35:1623-30. 2011
    ..It is also unknown whether pre-treatment serum BDNF levels predict antidepressant response...
  18. pmc Accelerated cell aging in female APOE-ε4 carriers: implications for hormone therapy use
    Emily G Jacobs
    Robert Wood Johnson Foundation Health and Society Scholars Program, Center for Health and Community, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e54713. 2013
    ..The results suggest that hormone use might buffer against accelerated cell aging in mid-life women at risk for dementia. Importantly, for non-carrier women there was no evidence that HT conferred protective effects on telomere dynamics...
  19. pmc Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length
    Sonja Entringer
    Department of Pediatrics, University of California, Irvine, School of Medicine, Irvine, CA 92697, USA
    Am J Obstet Gynecol 208:134.e1-7. 2013
    ..The objective of the present study was to determine how early in life this effect of stress on LTL is apparent by quantifying the association of maternal psychosocial stress during pregnancy with newborn telomere length...
  20. ncbi The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men
    Elissa S Epel
    University of California, San Francisco, Department of Psychiatry, San Francisco, CA, 94143, USA
    Aging (Albany NY) 1:81-8. 2008
    ..0 (95% CI: 1.1 - 8.2). This is the first demonstration that rate of telomere length change (TLC) predicts mortality and thus may be a useful prognostic factor for longevity...
  21. pmc Indirect effect of financial strain on daily cortisol output through daily negative to positive affect index in the Coronary Artery Risk Development in Young Adults Study
    Eli Puterman
    Department of Psychiatry, University of California, San Francisco, United States Electronic address
    Psychoneuroendocrinology 38:2883-9. 2013
    ..A combined affect index may be a more sensitive and powerful measure than either negative or positive affect alone, tapping the burden of chronic financial strain, and its effects on biology. ..
  22. doi Posttraumatic stress disorder is associated with emotional eating
    Lisa S Talbot
    San Francisco VA Medical Center, San Francisco, California 94121, USA
    J Trauma Stress 26:521-5. 2013
    ..Findings suggest the importance of future longitudinal research to understand whether emotional eating contributes to the high rates of obesity, diabetes, and heart disease in PTSD. ..
  23. pmc Leptin concentrations in response to acute stress predict subsequent intake of comfort foods
    A Janet Tomiyama
    Department of Psychology, UCLA, Los Angeles, CA, USA
    Physiol Behav 107:34-9. 2012
    ..Increasing leptin during the stressor predicted lower intake of comfort food. These initial findings suggest that acute changes in leptin may be one of the factors modulating down the consumption of comfort food following stress...
  24. pmc Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease
    Ramin Farzaneh-Far
    Division of Cardiology, Room 5G1, San Francisco General Hospital, 1001 Potrero Ave, San Francisco, CA 94110, USA
    JAMA 303:250-7. 2010
    ..Increased dietary intake of marine omega-3 fatty acids is associated with prolonged survival in patients with coronary heart disease. However, the mechanisms underlying this protective effect are poorly understood...
  25. pmc Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood
    Sonja Entringer
    Department of Pediatrics, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 108:E513-8. 2011
    ..This observation may help shed light on an important biological pathway underlying the developmental origins of adult health and disease risk...
  26. pmc The reward-based eating drive scale: a self-report index of reward-based eating
    Elissa S Epel
    Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America UCSF Center for Obesity Assessment, Study, and Treatment, San Francisco, California, United States of America
    PLoS ONE 9:e101350. 2014
    ..Given the heterogeneity of obesity, unique brief profiling of the reward-based aspect of obesity using a self-report instrument such as the RED scale may be critical for customizing effective treatments in the general population. ..
  27. doi Exaggerated neurobiological sensitivity to threat as a mechanism linking anxiety with increased risk for diseases of aging
    Aoife O'Donovan
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Neurosci Biobehav Rev 37:96-108. 2013
    ..Chronic inflammation, in turn, increases risk for diseases of aging. Exaggerated neurobiological sensitivity to threat may thus be a treatment target for reducing disease risk in anxious individuals...
  28. pmc Chronic stress elevates telomerase activity in rats
    Annaliese K Beery
    Robert Wood Johnson Health and Society Scholar at University of California at San Francisco, San Francisco, CA 04143, USA
    Biol Lett 8:1063-6. 2012
    ..This significant increase suggests a potential mechanism for resilience to stress-related replicative senescence...
  29. pmc Telomere shortening in formerly abused and never abused women
    Janice Humphreys
    Department of Family Health Care Nursing, School of Nursing, University of California, San Francisco, CA 94143, USA
    Biol Res Nurs 14:115-23. 2012
    ..Findings from this descriptive study suggest a link between IPV exposure, duration of IPV-related stress, and telomere length molecular mechanisms that regulate cellular aging...
  30. pmc Shorter leukocyte telomere length in midlife women with poor sleep quality
    Aric A Prather
    Robert Wood Johnson Foundation Health and Society Scholars Program, Center for Health and Community, University of California San Francisco, 3333 California Street, Suite 465, San Francisco, CA 94118, USA
    J Aging Res 2011:721390. 2011
    ..Conclusions. This study provides the first evidence that poor sleep quality explains significant variation in LTL, a marker of cellular aging...
  31. ncbi Flattened cortisol rhythms in metastatic breast cancer patients
    Heather C Abercrombie
    Department of Psychiatry, University of Wisconsin Medical School, 6001 Research Park Blvd, Madison, WI 53719, USA
    Psychoneuroendocrinology 29:1082-92. 2004
    ..These findings suggest that the cortisol diurnal slope may have important but different correlates in healthy women versus those with breast cancer...
  32. doi Glucocorticoids. Mood, memory, and mechanisms
    Owen M Wolkowitz
    Department of Psychiatry, University of California San Francisco UCSF School of Medicine, San Francisco, California, USA
    Ann N Y Acad Sci 1179:19-40. 2009
    ..The article concludes with a conceptual model of glucocorticoid actions in the brain that may lead to novel therapeutic opportunities...
  33. pmc Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)
    Nicole Maninger
    Department of Psychiatry, University of California San Francisco, School of Medicine, San Francisco 94143, USA
    Front Neuroendocrinol 30:65-91. 2009
    ..Accumulating data suggest abnormal DHEA and/or DHEAS concentrations in several neuropsychiatric conditions. The evidence that DHEA and DHEAS may be fruitful targets for pharmacotherapy in some conditions is reviewed...
  34. doi Positive affect uniquely predicts lower risk of mortality in people with diabetes
    Judith Tedlie Moskowitz
    Osher Center for Integrative Medicine, University of California, San Francisco, CA 94115, USA
    Health Psychol 27:S73-82. 2008
    ..To determine whether positive affect predicts mortality among people with diabetes and among a comparison group of people with no chronic health conditions...
  35. pmc Black sheep get the blues: a psychobiological model of social rejection and depression
    George M Slavich
    Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143 0848, USA
    Neurosci Biobehav Rev 35:39-45. 2010
    ..This response also may be moderated by several factors, including prior life stress, prior depression, and genes implicated in stress reactivity...
  36. doi Socioeconomic status in relation to early menarche among black and white girls
    Dejana Braithwaite
    Department of Epidemiology and Biostatistics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 185 Berry Street, Lobby 4 Suite 5700, San Francisco, CA 94107, USA
    Cancer Causes Control 20:713-20. 2009
    ..Early menarche is a risk factor for breast cancer. We investigated the variation in age at menarche by socioeconomic status (SES) and race...
  37. ncbi Clues to maintaining calorie restriction? Psychosocial profiles of successful long-term restrictors
    Angela C Incollingo Belsky
    Department of Psychology, University of California, Los Angeles, CA, USA
    Appetite 79:106-12. 2014
    ..Paralleling a movement toward personalized medicine, this study points toward a personalized behavioral medicine model in behavioral nutrition and treatment of overweight/obesity...
  38. ncbi Stress, eating and the reward system
    Tanja C Adam
    University of California, San Francisco, Department of Psychiatry, United States
    Physiol Behav 91:449-58. 2007
    ....
  39. ncbi When blue turns to grey: do stress and depression accelerate cell aging?
    Owen M Wolkowitz
    World J Biol Psychiatry 9:2-5. 2008
  40. ncbi Sex differences in stress responses: social rejection versus achievement stress
    Laura R Stroud
    Brown University Centers for Behavioral and Preventive Medicine, Providence, Rhode Island 02903, USA
    Biol Psychiatry 52:318-27. 2002
    ..In particular, we predicted that women would show greater responses to social rejection stressors, whereas men would demonstrate greater responses to achievement stressors...
  41. pmc Why egalitarianism might be good for your health: physiological thriving during stressful intergroup encounters
    Wendy Berry Mendes
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Psychol Sci 18:991-8. 2007
    ..Egalitarianism may have physical and psychological benefits for people living in a diverse society...

Research Grants4

  1. Depression, Stress & Health: Role of Anabolic Hormones
    Elissa Epel; Fiscal Year: 2006
    ..If warranted, future research will compare effects of stress reduction and hormonal supplementation on mood and disease risk. ..
  2. Social status, cellular aging, and mortality
    Elissa S Epel; Fiscal Year: 2010
    ....
  3. Chronic and Acute Psychosocial Stress and Impaired Cell Aging
    Elissa S Epel; Fiscal Year: 2010
    ....