Research Topics
Species | Elissa S EpelSummaryAffiliation: University of California Country: USA Publications
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Publications
Accelerated telomere shortening in response to life stressElissa S Epel
Department of Psychiatry, University of California, 3333 California Street, Suite 465, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 101:17312-5. 2004..These findings have implications for understanding how, at the cellular level, stress may promote earlier onset of age-related diseases...
Cell aging in relation to stress arousal and cardiovascular disease risk factorsElissa S Epel
UCSF Department of Psychiatry, San Francisco, CA, USA
Psychoneuroendocrinology 31:277-87. 2006..These findings may implicate telomerase as a novel and important mediator of the effects of psychological stress on physical health and disease...
How "reversible" is telomeric aging?Elissa Epel
University of California, San Francisco, San Francisco, CA 94143, USA
Cancer Prev Res (Phila) 5:1163-8. 2012..Cancer Prev Res; 5(10); 1163-8. ©2012 AACR...- The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly menElissa S Epel
University of California, San Francisco, Department of Psychiatry, San Francisco, CA, 94143, USA
Aging (Albany NY) 1:81-8. 2009..0 (95% CI: 1.1 - 8.2). This is the first demonstration that rate of telomere length change (TLC) predicts mortality and thus may be a useful prognostic factor for longevity... - Dynamics of telomerase activity in response to acute psychological stressElissa S Epel
Department of Psychiatry, University of California, San Francisco, 3333 Calif St, Suite 465, San Francisco, CA 94143, USA
Brain Behav Immun 24:531-9. 2010.... - Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeresElissa Epel
University of California San Francisco, Department of Psychiatry, San Francisco, California 94143, USA
Ann N Y Acad Sci 1172:34-53. 2009..Aspects of this model are currently being tested in ongoing trials of mindfulness meditation... - Psychological and metabolic stress: a recipe for accelerated cellular aging?Elissa S Epel
University of California, Department of Psychiatry, San Francisco, CA 94143, USA
Hormones (Athens) 8:7-22. 2009..Certain psychological temperaments at high risk of this stress cascade (mainly anxiety prone), gene-environment interactions, and potential interventions for interrupting the stress-aging cascade are discussed... - Dietary restraint and telomere length in pre- and postmenopausal womenAmy Kiefer
UCSF Department of Psychiatry, University of California, San Francisco, California, USA
Psychosom Med 70:845-9. 2008.... - Depression gets old fast: do stress and depression accelerate cell aging?Owen M Wolkowitz
Department of Psychiatry, University of California School of Medicine, San Francisco, California, USA
Depress Anxiety 27:327-38. 2010.... - Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findingsOwen M Wolkowitz
Department of Psychiatry, University of California San Francisco School of Medicine, San Francisco, California, United States of America
PLoS ONE 6:e17837. 2011..We sought to determine if leukocyte telomeres are shortened in Major Depressive Disorder (MDD), whether this is a function of lifetime depression exposure and whether this is related to putative mediators, oxidation and inflammation... - Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere lengthAoife O'Donovan
Department of Psychiatry, University of California, San Francisco, CA, USA
Brain Behav Immun 26:573-9. 2012..Exaggerated anticipatory threat appraisals may be a common and modifiable psychological mechanism of psychological stress effects on cellular aging... - Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition StudyAoife O'Donovan
Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 6:e19687. 2011..However, in spite of the proposed causal links between inflammatory activity and LTL, there is little clinical evidence in support of their covariation and interaction... - Serum BDNF levels before treatment predict SSRI response in depressionOwen M Wolkowitz
Department of Psychiatry, University of California, San Francisco School of Medicine, San Francisco, CA 94143, United States
Prog Neuropsychopharmacol Biol Psychiatry 35:1623-30. 2011..It is also unknown whether pre-treatment serum BDNF levels predict antidepressant response... - Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere lengthSonja Entringer
Department of Pediatrics, University of California, Irvine, School of Medicine, Irvine, CA 92697, USA
Am J Obstet Gynecol 208:134.e1-7. 2013..The objective of the present study was to determine how early in life this effect of stress on LTL is apparent by quantifying the association of maternal psychosocial stress during pregnancy with newborn telomere length... - The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly menElissa S Epel
University of California, San Francisco, Department of Psychiatry, San Francisco, CA, 94143, USA
Aging (Albany NY) 1:81-8. 2008..0 (95% CI: 1.1 - 8.2). This is the first demonstration that rate of telomere length change (TLC) predicts mortality and thus may be a useful prognostic factor for longevity... - Leptin concentrations in response to acute stress predict subsequent intake of comfort foodsA Janet Tomiyama
Department of Psychology, UCLA, Los Angeles, CA, USA
Physiol Behav 107:34-9. 2012..Increasing leptin during the stressor predicted lower intake of comfort food. These initial findings suggest that acute changes in leptin may be one of the factors modulating down the consumption of comfort food following stress... - Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart diseaseRamin Farzaneh-Far
Division of Cardiology, Room 5G1, San Francisco General Hospital, 1001 Potrero Ave, San Francisco, CA 94110, USA
JAMA 303:250-7. 2010..Increased dietary intake of marine omega-3 fatty acids is associated with prolonged survival in patients with coronary heart disease. However, the mechanisms underlying this protective effect are poorly understood... - Stress exposure in intrauterine life is associated with shorter telomere length in young adulthoodSonja Entringer
Department of Pediatrics, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 108:E513-8. 2011..This observation may help shed light on an important biological pathway underlying the developmental origins of adult health and disease risk... - Chronic stress elevates telomerase activity in ratsAnnaliese K Beery
Robert Wood Johnson Health and Society Scholar at University of California at San Francisco, San Francisco, CA 04143, USA
Biol Lett 8:1063-6. 2012..This significant increase suggests a potential mechanism for resilience to stress-related replicative senescence... - Telomere shortening in formerly abused and never abused womenJanice Humphreys
Department of Family Health Care Nursing, School of Nursing, University of California, San Francisco, CA 94143, USA
Biol Res Nurs 14:115-23. 2012..Findings from this descriptive study suggest a link between IPV exposure, duration of IPV-related stress, and telomere length molecular mechanisms that regulate cellular aging... - Shorter leukocyte telomere length in midlife women with poor sleep qualityAric A Prather
Robert Wood Johnson Foundation Health and Society Scholars Program, Center for Health and Community, University of California San Francisco, 3333 California Street, Suite 465, San Francisco, CA 94118, USA
J Aging Res 2011:721390. 2011..Conclusions. This study provides the first evidence that poor sleep quality explains significant variation in LTL, a marker of cellular aging... - Flattened cortisol rhythms in metastatic breast cancer patientsHeather C Abercrombie
Department of Psychiatry, University of Wisconsin Medical School, 6001 Research Park Blvd, Madison, WI 53719, USA
Psychoneuroendocrinology 29:1082-92. 2004..These findings suggest that the cortisol diurnal slope may have important but different correlates in healthy women versus those with breast cancer... - Chronic psychological stress and racial disparities in body mass index change between Black and White girls aged 10-19A Janet Tomiyama
Department of Psychology, University of California, Los Angeles, 90095 1563, USA
Ann Behav Med 45:3-12. 2013..One of the largest health disparities in the USA is in obesity rates between Black and White females... - Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)Nicole Maninger
Department of Psychiatry, University of California San Francisco, School of Medicine, San Francisco 94143, USA
Front Neuroendocrinol 30:65-91. 2009..Accumulating data suggest abnormal DHEA and/or DHEAS concentrations in several neuropsychiatric conditions. The evidence that DHEA and DHEAS may be fruitful targets for pharmacotherapy in some conditions is reviewed... - Positive affect uniquely predicts lower risk of mortality in people with diabetesJudith Tedlie Moskowitz
Osher Center for Integrative Medicine, University of California, San Francisco, CA 94115, USA
Health Psychol 27:S73-82. 2008..To determine whether positive affect predicts mortality among people with diabetes and among a comparison group of people with no chronic health conditions... - Glucocorticoids. Mood, memory, and mechanismsOwen M Wolkowitz
Department of Psychiatry, University of California San Francisco UCSF School of Medicine, San Francisco, California, USA
Ann N Y Acad Sci 1179:19-40. 2009..The article concludes with a conceptual model of glucocorticoid actions in the brain that may lead to novel therapeutic opportunities... - Accelerated cell aging in female APOE-ε4 carriers: implications for hormone therapy useEmily G Jacobs
Robert Wood Johnson Foundation Health and Society Scholars Program, Center for Health and Community, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 8:e54713. 2013..The results suggest that hormone use might buffer against accelerated cell aging in mid-life women at risk for dementia. Importantly, for non-carrier women there was no evidence that HT conferred protective effects on telomere dynamics... - Exaggerated neurobiological sensitivity to threat as a mechanism linking anxiety with increased risk for diseases of agingAoife O'Donovan
Department of Psychiatry, University of California, San Francisco, CA, USA
Neurosci Biobehav Rev 37:96-108. 2013..Chronic inflammation, in turn, increases risk for diseases of aging. Exaggerated neurobiological sensitivity to threat may thus be a treatment target for reducing disease risk in anxious individuals... - Black sheep get the blues: a psychobiological model of social rejection and depressionGeorge M Slavich
Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143 0848, USA
Neurosci Biobehav Rev 35:39-45. 2010..This response also may be moderated by several factors, including prior life stress, prior depression, and genes implicated in stress reactivity... - Socioeconomic status in relation to early menarche among black and white girlsDejana Braithwaite
Department of Epidemiology and Biostatistics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 185 Berry Street, Lobby 4 Suite 5700, San Francisco, CA 94107, USA
Cancer Causes Control 20:713-20. 2009..Early menarche is a risk factor for breast cancer. We investigated the variation in age at menarche by socioeconomic status (SES) and race... - Stress, eating and the reward systemTanja C Adam
University of California, San Francisco, Department of Psychiatry, United States
Physiol Behav 91:449-58. 2007.... - When blue turns to grey: do stress and depression accelerate cell aging?Owen M Wolkowitz
World J Biol Psychiatry 9:2-5. 2008 - Why egalitarianism might be good for your health: physiological thriving during stressful intergroup encountersWendy Berry Mendes
Department of Psychology, Harvard University, Cambridge, MA 02138, USA
Psychol Sci 18:991-8. 2007..Egalitarianism may have physical and psychological benefits for people living in a diverse society... - Sex differences in stress responses: social rejection versus achievement stressLaura R Stroud
Brown University Centers for Behavioral and Preventive Medicine, Providence, Rhode Island 02903, USA
Biol Psychiatry 52:318-27. 2002..Women's greater reactivity to rejection stress may contribute to the increased rates of affective disorders in women...
Research Grants
- Depression, Stress & Health: Role of Anabolic HormonesElissa Epel; Fiscal Year: 2006..If warranted, future research will compare effects of stress reduction and hormonal supplementation on mood and disease risk. ..
- Social status, cellular aging, and mortalityElissa S Epel; Fiscal Year: 2010....
- Chronic and Acute Psychosocial Stress and Impaired Cell AgingElissa S Epel; Fiscal Year: 2010....