Kristine Ensrud

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Low fractional calcium absorption increases the risk for hip fracture in women with low calcium intake. Study of Osteoporotic Fractures Research Group
    K E Ensrud
    Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    Ann Intern Med 132:345-53. 2000
  2. ncbi request reprint Antiepileptic drug use increases rates of bone loss in older women: a prospective study
    K E Ensrud
    Department of Medicine and Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, MN 55417, USA
    Neurology 62:2051-7. 2004
  3. ncbi request reprint Intentional and unintentional weight loss increase bone loss and hip fracture risk in older women
    Kristine E Ensrud
    Department of Medicine and Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, Minnesota 55417, USA
    J Am Geriatr Soc 51:1740-7. 2003
  4. ncbi request reprint Central nervous system-active medications and risk for falls in older women
    Kristine E Ensrud
    Department of Medicine, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 50:1629-37. 2002
  5. pmc Association of provider-patient visit frequency and patient outcomes on hemodialysis
    Yelena Slinin
    Veterans Administration Health Care System, Minneapolis, Minnesota, USA
    J Am Soc Nephrol 23:1560-7. 2012
  6. doi request reprint Prehemodialysis care by dietitians and first-year mortality after initiation of hemodialysis
    Yelena Slinin
    Veterans Administration Medical Center, Minneapolis, MN 55417, USA
    Am J Kidney Dis 58:583-90. 2011
  7. doi request reprint Predictors of Provider-Patient Visit Frequency during Hemodialysis
    Yelena Slinin
    Veterans Administration Health Care System, University of Minnesota, Minneapolis, Minn, USA
    Am J Nephrol 38:91-8. 2013
  8. doi request reprint BMD changes and predictors of increased bone loss in postmenopausal women after a 5-year course of alendronate
    Brian Louis McNabb
    Division of Endocrinology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    J Bone Miner Res 28:1319-27. 2013
  9. doi request reprint Lasofoxifene and cardiovascular events in postmenopausal women with osteoporosis: Five-year results from the Postmenopausal Evaluation and Risk Reduction with Lasofoxifene (PEARL) trial
    Kristine Ensrud
    VA Medical Center, Minneapolis, MN, USA
    Circulation 122:1716-24. 2010
  10. ncbi request reprint BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures
    Katie L Stone
    Department of Medicine, University of California, San Francisco, California 94105, USA
    J Bone Miner Res 18:1947-54. 2003

Research Grants

  1. STUDY OF OSTEOPOROTIC FRACTURES
    Kristine Ensrud; Fiscal Year: 2005
  2. Outcomes of Sleep Disorders in Older Men-Minneapolis
    Kristine Ensrud; Fiscal Year: 2007
  3. OSTEOPOROSIS IN MEN
    Kristine Ensrud; Fiscal Year: 2007
  4. STUDY OF OSTEOPOROTIC FRACTURES
    Kristine Ensrud; Fiscal Year: 2007
  5. FRACTURES IN OLDER WOMEN
    Kristine Ensrud; Fiscal Year: 1993
  6. FRACTURES IN OLDER WOMEN
    Kristine Ensrud; Fiscal Year: 2000
  7. STUDY OF OSTEOPOROTIC FRACTURES
    Kristine Ensrud; Fiscal Year: 2009

Detail Information

Publications75

  1. ncbi request reprint Low fractional calcium absorption increases the risk for hip fracture in women with low calcium intake. Study of Osteoporotic Fractures Research Group
    K E Ensrud
    Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    Ann Intern Med 132:345-53. 2000
    ..However, the associations between fractional calcium absorption, dietary calcium intake, and risk for fracture have never been studied...
  2. ncbi request reprint Antiepileptic drug use increases rates of bone loss in older women: a prospective study
    K E Ensrud
    Department of Medicine and Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, MN 55417, USA
    Neurology 62:2051-7. 2004
    ..To test the hypothesis that older women with antiepileptic drug (AED) use have increased rates of bone loss...
  3. ncbi request reprint Intentional and unintentional weight loss increase bone loss and hip fracture risk in older women
    Kristine E Ensrud
    Department of Medicine and Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, Minnesota 55417, USA
    J Am Geriatr Soc 51:1740-7. 2003
    ..To test the hypothesis that unintentional weight loss increases the rate of bone loss and risk of hip fracture more than intentional weight loss...
  4. ncbi request reprint Central nervous system-active medications and risk for falls in older women
    Kristine E Ensrud
    Department of Medicine, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 50:1629-37. 2002
    ..To determine whether current use of central nervous system (CNS)-active medications, including benzodiazepines, antidepressants, anticonvulsants, and narcotics, increases the risk for subsequent falls...
  5. pmc Association of provider-patient visit frequency and patient outcomes on hemodialysis
    Yelena Slinin
    Veterans Administration Health Care System, Minneapolis, Minnesota, USA
    J Am Soc Nephrol 23:1560-7. 2012
    ..In summary, greater frequency of provider visits to hemodialysis patients associates with a small but significant reduction in hospitalizations, but it does not consistently associate with lower risk for death...
  6. doi request reprint Prehemodialysis care by dietitians and first-year mortality after initiation of hemodialysis
    Yelena Slinin
    Veterans Administration Medical Center, Minneapolis, MN 55417, USA
    Am J Kidney Dis 58:583-90. 2011
    ..Few patients receive dietary counseling before end-stage renal disease onset; whether such counseling is associated with improved outcomes is unknown...
  7. doi request reprint Predictors of Provider-Patient Visit Frequency during Hemodialysis
    Yelena Slinin
    Veterans Administration Health Care System, University of Minnesota, Minneapolis, Minn, USA
    Am J Nephrol 38:91-8. 2013
    ..Conclusion: After the Medicare reimbursement policy change, several patient, provider, and facility characteristics were independently associated with greater dialysis provider-patient visit frequency. ..
  8. doi request reprint BMD changes and predictors of increased bone loss in postmenopausal women after a 5-year course of alendronate
    Brian Louis McNabb
    Division of Endocrinology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    J Bone Miner Res 28:1319-27. 2013
    ..Although about one-third of women who discontinued ALN after 5 years experienced >5% bone loss at the total hip, predicting which women will lose at a higher rate was not possible...
  9. doi request reprint Lasofoxifene and cardiovascular events in postmenopausal women with osteoporosis: Five-year results from the Postmenopausal Evaluation and Risk Reduction with Lasofoxifene (PEARL) trial
    Kristine Ensrud
    VA Medical Center, Minneapolis, MN, USA
    Circulation 122:1716-24. 2010
    ..5 mg/d is consistent across different categories of CHD risk...
  10. ncbi request reprint BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures
    Katie L Stone
    Department of Medicine, University of California, San Francisco, California 94105, USA
    J Bone Miner Res 18:1947-54. 2003
    ..Although we found almost all fracture types to be related to low BMD, the overall proportion of fractures attributable to low BMD is modest...
  11. ncbi request reprint Bone outcomes and technical measurement issues of bone health among children and adolescents: considerations for nutrition and physical activity intervention trials
    Jayne A Fulkerson
    Division of Epidemiology, School of Public Health, University of Minnesota, MN, USA
    Osteoporos Int 15:929-41. 2004
    ..It describes the implications of these issues for the interpretation of intervention effects observed in intervention trials, and provides recommendations for future research...
  12. pmc Association between sleep and physical function in older men: the osteoporotic fractures in men sleep study
    Thuy Tien L Dam
    Department of Medicine, University of California at San Diego, La Jolla, California, USA
    J Am Geriatr Soc 56:1665-73. 2008
    ..To determine whether sleep quality is associated with physical function in older men...
  13. ncbi request reprint Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs
    Steven R Cummings
    Department of Medicine, University of California, San Francisco, California, USA
    Am J Med 112:281-9. 2002
    ..To estimate how much the improvement in bone mass accounts for the reduction in risk of vertebral fracture that has been observed in randomized trials of antiresorptive treatments for osteoporosis...
  14. pmc Meeting KDOQI guideline goals at hemodialysis initiation and survival during the first year
    Yelena Slinin
    VA Medical Center 111J, One Veteran s Drive, Minneapolis, MN 55417, USA
    Clin J Am Soc Nephrol 5:1574-81. 2010
    ....
  15. ncbi request reprint Effects of ultralow-dose transdermal estradiol on postmenopausal symptoms in women aged 60 to 80 years
    Susan Diem
    Department of Medicine, University of Minnesota, Minneapolis, 55415, USA
    Menopause 13:130-8. 2006
    ..To investigate the effect of ultralow-dose transdermal estradiol on postmenopausal symptoms and side effects in a cohort of largely asymptomatic postmenopausal women aged 60 to 80 years...
  16. ncbi request reprint Effect of raloxifene on cardiovascular adverse events in postmenopausal women with osteoporosis
    Kristine Ensrud
    Veterans Affairs Medical Center, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Cardiol 97:520-7. 2006
    ....
  17. ncbi request reprint Use of antidepressants and rates of hip bone loss in older women: the study of osteoporotic fractures
    Susan J Diem
    Department of Medicine, University of Minnesota, and Center for Chronic Disease Outcomes Research, Minneapolis Veterans Affairs Medical Center, 1100 Washington Ave S, Suite 201, Minneapolis, MN 55415, USA
    Arch Intern Med 167:1240-5. 2007
    ..Serotonin transporters have recently been described in bone, raising the possibility that medications that block serotonin reuptake could affect bone metabolism...
  18. ncbi request reprint Association of low bone mineral density with selective serotonin reuptake inhibitor use by older men
    Elizabeth M Haney
    Department of Medicine, Oregon Health and Science University, Mailcode L 475, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Arch Intern Med 167:1246-51. 2007
    ..Osteoblasts and osteocytes express functional serotonin transporters; serotonin transporter gene disruption in mice results in osteopenia; and SSRI use has been associated with increased risk of hip fracture...
  19. ncbi request reprint Bone mineral density and age-related maculopathy in older women
    Robin L Seitzman
    Department of Ophthalmology, Jules Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Am Geriatr Soc 55:740-6. 2007
    ..To determine whether bone mineral density (BMD) is associated with age-related maculopathy (ARM) risk in older women...
  20. ncbi request reprint Alendronate treatment in women with normal to severely impaired renal function: an analysis of the fracture intervention trial
    Sophie A Jamal
    Division of Endocrinology, St Michael s Hospital and the University of Toronto, Toronto, Ont, Canada
    J Bone Miner Res 22:503-8. 2007
    ..There was no increase in adverse events among women with impaired renal function treated with alendronate. Alendronate is safe and effective among this group of women with reduced renal function...
  21. ncbi request reprint Evaluating the value of repeat bone mineral density measurement and prediction of fractures in older women: the study of osteoporotic fractures
    Teresa A Hillier
    Center for Health Research, Kaiser Permanente Northwest Hawaii, Portland, OR 97227, USA
    Arch Intern Med 167:155-60. 2007
    ..Whether repeat bone mineral density (BMD) measurement adds benefit beyond the initial BMD measurement in predicting fractures in older women is unknown...
  22. ncbi request reprint Depressive symptoms and rates of bone loss at the hip in older women
    Susan J Diem
    Department of Medicine, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55415, USA
    J Am Geriatr Soc 55:824-31. 2007
    ..To ascertain whether depressive symptoms are associated with increased rates of bone loss at the hip...
  23. ncbi request reprint Renal function and risk of hip and vertebral fractures in older women
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, MN 55417, USA
    Arch Intern Med 167:133-9. 2007
    ..An increased rate of hip fractures has been reported in patients with end-stage renal disease, but the effect of less severe renal dysfunction on fracture risk is uncertain...
  24. ncbi request reprint Visual acuity, contrast sensitivity, and mortality in older women: Study of osteoporotic fractures
    Kathryn L Pedula
    Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon 97227, USA
    J Am Geriatr Soc 54:1871-7. 2006
    ..To determine whether poorer visual acuity and contrast sensitivity are independent risk factors for all-cause and traumatic mortality in older women...
  25. ncbi request reprint Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial
    Dennis M Black
    San Francisco Coordinating Center, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94107, USA
    JAMA 296:2927-38. 2006
    ..The optimal duration of treatment of women with postmenopausal osteoporosis is uncertain...
  26. pmc Elevations in serum and urinary calcium with parathyroid hormone (1-84) with and without alendronate for osteoporosis
    Diana M Antoniucci
    Division of Endocrinology, Department of Medicine, University of California, San Francisco, California 94107, USA
    J Clin Endocrinol Metab 92:942-7. 2007
    ..The effect of PTH therapy on serum and urinary calcium levels and the risk of hypercalcemia or hypercalciuria has not been formally evaluated...
  27. ncbi request reprint Use of selective serotonin reuptake inhibitors and sleep disturbances in community-dwelling older women
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, and Department of Medicine and Division of Epidemiology, University of Minnesota 55417, USA
    J Am Geriatr Soc 54:1508-15. 2006
    ..To determine the association between use of selective serotonin reuptake inhibitors (SSRIs) and objective measures of sleep disturbances in older community-dwelling women, including women without evidence of depression...
  28. ncbi request reprint Endogenous estrogen levels and the effects of ultra-low-dose transdermal estradiol therapy on bone turnover and BMD in postmenopausal women
    Alison J Huang
    Veterans Affairs Medical Center, San Francisco, California, USA
    J Bone Miner Res 22:1791-7. 2007
    ..This suggests that the protective effects of ultra-low-dose estrogen therapy on the postmenopausal skeletal health may depend critically on women's endogenous estrogen levels before treatment...
  29. ncbi request reprint Body mass index and mortality among older breast cancer survivors in the Study of Osteoporotic Fractures
    Katherine W Reeves
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 516A Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Cancer Epidemiol Biomarkers Prev 16:1468-73. 2007
    ..This study investigated the association between BMI and mortality after breast cancer diagnosis in a cohort of older Caucasian women enrolled in the Study of Osteoporotic Fractures...
  30. pmc Association between depressive symptoms and sleep disturbances in community-dwelling older men
    Misti L Paudel
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 56:1228-35. 2008
    ..To examine the association between depressive symptoms and subjective and objective measures of sleep in community-dwelling older men...
  31. doi request reprint Loop diuretic use and increased rates of hip bone loss in older men: the Osteoporotic Fractures in Men Study
    Lionel S Lim
    Department of Internal Medicine, Griffin Hospital, 130 Division St, Derby, CT 06418, USA
    Arch Intern Med 168:735-40. 2008
    ..Studies examining the association between loop diuretics and bone mineral density (BMD) are lacking, particularly those involving men...
  32. pmc The effect of raloxifene treatment in postmenopausal women with CKD
    Areef Ishani
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, and Department of Medicine and Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55417, USA
    J Am Soc Nephrol 19:1430-8. 2008
    ..In conclusion, raloxifene increases BMD at both the hip and the spine and reduces the risk for vertebral fractures among individuals with CKD. The effect ofraloxifene on hip BMD is greater among those with mild to moderate CKD...
  33. doi request reprint Estrogen receptor alpha and matrix metalloproteinase 2 polymorphisms and age-related maculopathy in older women
    Robin L Seitzman
    Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 92122, USA
    Am J Epidemiol 167:1217-25. 2008
    ..02). The MMP2 rs2287074 A allele may be associated with a lower likelihood of ARM in older Caucasian women, particularly those who have never used hormone therapy. The role of MMP2 rs2287074 in ARM should be further elucidated...
  34. pmc Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
    J Bone Miner Res 23:1326-33. 2008
    ....
  35. doi request reprint Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, General Internal Medicine, Minneapolis, MN 55417, USA
    Arch Intern Med 168:382-9. 2008
    ..Frailty, as defined by the index derived from the Cardiovascular Health Study (CHS index), predicts risk of adverse outcomes in older adults. Use of this index, however, is impractical in clinical practice...
  36. pmc Differences in site-specific fracture risk among older women with discordant results for osteoporosis at hip and spine: study of osteoporotic fractures
    Howard A Fink
    Geriatric Research Education and Clinical Center, VA Medical Center, Minneapolis, MN 55417, USA
    J Clin Densitom 11:250-9. 2008
    ..Women osteoporotic only at spine would not have been identified from hip BMD measurement alone, and may have a sufficiently high fracture risk to warrant preventive treatment...
  37. doi request reprint Long-term risk of incident vertebral fractures
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    JAMA 298:2761-7. 2007
    ..Women with low bone mineral density (BMD) and prevalent vertebral fractures have a greater risk of incident vertebral fractures over the short-term, but their absolute risk of vertebral fracture over the long-term is uncertain...
  38. ncbi request reprint Abdominal aortic calcification detected on lateral spine images from a bone densitometer predicts incident myocardial infarction or stroke in older women
    John T Schousboe
    Park Nicollet Health Services, Minneapolis, Minnesota 55416, USA
    J Bone Miner Res 23:409-16. 2008
    ....
  39. ncbi request reprint Effects of raloxifene on fracture risk in postmenopausal women: the Raloxifene Use for the Heart Trial
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    J Bone Miner Res 23:112-20. 2008
    ..Treatment with raloxifene for 5 yr reduced the risk of clinical vertebral fractures, but not nonvertebral fractures, irrespective of the presence or absence of risk factors for fracture...
  40. ncbi request reprint Cost-effectiveness of bone densitometry followed by treatment of osteoporosis in older men
    John T Schousboe
    Rheumatology, Park Nicollet Health Services, Minneapolis, MN 55416, USA
    JAMA 298:629-37. 2007
    ..Osteoporotic fractures are common among elderly men...
  41. ncbi request reprint Frailty and risk of falls, fracture, and mortality in older women: the study of osteoporotic fractures
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, and Department of Medicine, University of Minnesota, Minneapolis, MN 55417, USA
    J Gerontol A Biol Sci Med Sci 62:744-51. 2007
    ..However, the predictive validity of this phenotype for fracture outcomes and across risk subgroups is uncertain...
  42. ncbi request reprint Frailty in older men: prevalence, progression, and relationship with mortality
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107 1762, USA
    J Am Geriatr Soc 55:1216-23. 2007
    ..To describe the association between frailty and health status, the progression of frailty, and the relationship between frailty and mortality in older men...
  43. ncbi request reprint Association between prior non-spine non-hip fractures or prevalent radiographic vertebral deformities known to be at least 10 years old and incident hip fracture
    John T Schousboe
    Park Nicollet Health Services, Minneapolis, Minnesota 55416, USA
    J Bone Miner Res 21:1557-64. 2006
    ....
  44. ncbi request reprint Association between self-reported prior wrist fractures and risk of subsequent hip and radiographic vertebral fractures in older women: a prospective study
    John T Schousboe
    Section of Rheumatology, Park Nicollet Health Services, Minneapolis, Minnesota 55416, USA
    J Bone Miner Res 20:100-6. 2005
    ..Validation of such an approach would require intervention trials in patients with prior wrist fracture...
  45. ncbi request reprint Vision impairment and combined vision and hearing impairment predict cognitive and functional decline in older women
    Michael Y Lin
    Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    J Am Geriatr Soc 52:1996-2002. 2004
    ..To determine the association between vision and hearing impairment and subsequent cognitive and functional decline in community-residing older women...
  46. ncbi request reprint Long-term prediction of incident hip fracture risk in elderly white women: study of osteoporotic fractures
    Brent C Taylor
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 52:1479-86. 2004
    ..To identify independent risk factors for first hip fracture over 10 years of follow-up...
  47. ncbi request reprint Post hoc analysis of data from the Multiple Outcomes of Raloxifene Evaluation (MORE) trial on the effects of three years of raloxifene treatment on glycemic control and cardiovascular disease risk factors in women with and without type 2 diabetes
    Elizabeth Barrett-Connor
    Department of Family and Preventive Medicine, School of Medicine, University of California at San Diego, La Jolla, California 92093 0607, USA
    Clin Ther 25:919-30. 2003
    ..The long-term effects of the selective estrogen-receptor modulator raloxifene hydrochloride on glycemic control and markers of cardiovascular disease risk in postmenopausal women with type 2 diabetes mellitus are unknown...
  48. ncbi request reprint Randomized trial of effect of alendronate continuation versus discontinuation in women with low BMD: results from the Fracture Intervention Trial long-term extension
    Kristine E Ensrud
    Department of Medicine, VA Medical Center, Minneapolis, Minnesota 55417, USA
    J Bone Miner Res 19:1259-69. 2004
    ..However, among women who discontinued alendronate and took placebo in the extension, BMD remained higher, and reduction in bone turnover was greater than values at FIT baseline, showing persistence of alendronate's effects on bone...
  49. ncbi request reprint Effect of isoflavones on lipids and bone turnover markers in menopausal women
    Tamara M Knudson Schult
    Center for Chronic Disease Outcomes Research, Minneapolis VA Medical Center, MN 55417, USA
    Maturitas 48:209-18. 2004
    ..The purpose of this analysis was to compare the effects of two dietary supplements derived from red clover to placebo on lipids and bone turnover markers in symptomatic menopausal women...
  50. ncbi request reprint Oral daily ibandronate prevents bone loss in early postmenopausal women without osteoporosis
    Michael R McClung
    Oregon Osteoporosis Center, Portland, Oregon 97213, USA
    J Bone Miner Res 19:11-8. 2004
    ..1% and 1.8%, respectively; p < or = 0.0001 versus placebo) with 2.5 mg ibandronate after 24 months. Oral ibandronate is a promising option for the prevention of postmenopausal bone loss...
  51. ncbi request reprint Use of statins and fracture: results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trials
    Douglas C Bauer
    Department of Medicine, University of California, San Francisco 94105, USA
    Arch Intern Med 164:146-52. 2004
    ....
  52. ncbi request reprint The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA
    N Engl J Med 349:1207-15. 2003
    ..We conducted a randomized, double-blind clinical study of parathyroid hormone and alendronate to test the hypothesis that the concurrent administration of the two agents would increase bone density more than the use of either one alone...
  53. ncbi request reprint Relationship of changes in physical activity and mortality among older women
    Edward W Gregg
    Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    JAMA 289:2379-86. 2003
    ..Physical activity has been related to reduced mortality, but it is not clear whether changes in physical activity affect mortality among older women...
  54. ncbi request reprint Central nervous system active medications and risk for fractures in older women
    Kristine E Ensrud
    Department of Medicine and Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, MN 55417, USA
    Arch Intern Med 163:949-57. 2003
    ..Use of central nervous system (CNS) active medications may increase the risk for fractures. Prior studies are limited by incomplete control of confounders...
  55. ncbi request reprint Older women with diabetes have a higher risk of falls: a prospective study
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA
    Diabetes Care 25:1749-54. 2002
    ..To determine whether older women with diabetes have an increased risk of falls and whether known risk factors for falls account for any increased risk...
  56. ncbi request reprint Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis: four-year results from a randomized clinical trial
    Pierre D Delmas
    University of Claude Bernard of Lyon, Hopital Edouard Herriot, Service de Rhumatologie et de Pathologie Osseuse, Lyon 69437, France
    J Clin Endocrinol Metab 87:3609-17. 2002
    ..The decreased vertebral fracture risk in yr 4 alone was not different from that observed in the first 3 yr...
  57. ncbi request reprint Risk factors for motor vehicle crashes in older women
    Karen L Margolis
    Division of Clinical Epidemiology, Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA
    J Gerontol A Biol Sci Med Sci 57:M186-91. 2002
    ..Identifying elderly drivers who are at risk for automobile crashes may help direct interventions to reduce their high rate of injuries and deaths...
  58. ncbi request reprint Risk factors for a first-incident radiographic vertebral fracture in women > or = 65 years of age: the study of osteoporotic fractures
    Michael C Nevitt
    Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94105, USA
    J Bone Miner Res 20:131-40. 2005
    ..Risk factors and low BMD should be useful to help focus efforts to prevent these fractures...
  59. ncbi request reprint Voluntary weight reduction in older men increases hip bone loss: the osteoporotic fractures in men study
    Kristine E Ensrud
    Department of Medicine 111 0, Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, Minnesota 55417, USA
    J Clin Endocrinol Metab 90:1998-2004. 2005
    ..7%/yr in those with weight loss; test for trend, P < 0.001). Older men who experience weight loss have increased rates of hip bone loss, even among overweight and obese men undergoing voluntary weight reduction...
  60. ncbi request reprint beta-Blocker use, BMD, and fractures in the study of osteoporotic fractures
    Ian R Reid
    Department of Medicine, University of Auckland, Auckland, New Zealand
    J Bone Miner Res 20:613-8. 2005
    ..We studied the association of beta-blocker use with BMD and fractures in the Study of Osteoporotic Fractures. beta-blocker use and BMD are unrelated in this cohort, and associations with fracture risk are inconsistent...
  61. ncbi request reprint BMD and risk of hip and nonvertebral fractures in older men: a prospective study and comparison with older women
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
    J Bone Miner Res 21:1550-6. 2006
    ..The relationship between hip BMD and hip fracture risk seemed to be stronger than observed in a large prospective study of women. Hip BMD is an excellent test for predicting fracture risk in men...
  62. ncbi request reprint Self-reported sleep and nap habits and risk of falls and fractures in older women: the study of osteoporotic fractures
    Katie L Stone
    Research Institute, California Pacific Medical Center, San Francisco, 94107, USA
    J Am Geriatr Soc 54:1177-83. 2006
    ..To test the association between self-reported sleep and nap habits and risk of falls and fractures in a large cohort of older women...
  63. ncbi request reprint Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. men
    Lynn M Marshall
    Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Bone Miner Res 21:1197-206. 2006
    ..Relations of femoral neck dimensions and vBMD to age differed from those in the shaft, indicating that patterns of bone modeling and remodeling in the neck and shaft are distinct...
  64. ncbi request reprint Cost-effectiveness of vertebral fracture assessment to detect prevalent vertebral deformity and select postmenopausal women with a femoral neck T-score>-2.5 for alendronate therapy: a modeling study
    John T Schousboe
    Park Nicollet Health Services, Minneapolis, MN 55416, USA
    J Clin Densitom 9:133-43. 2006
    ..5. These conclusions are robust to reasonable changes in fracture rates, assumed fracture disutility, discount rates, relative risk of fracture attributable to vertebral deformity, alendronate cost, and drug adherence...
  65. ncbi request reprint Association of endothelial nitric oxide synthase genotypes with bone mineral density, bone loss, hip structure, and risk of fracture in older women: the SOF study
    Brent C Taylor
    Center for Chronic Disease Outcomes Research 152 2E, Minneapolis VA Medical Center, and Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA
    Bone 39:174-80. 2006
    ..Confirmation of these findings is needed in other populations and with additional markers within and flanking the NOS3 gene region...
  66. ncbi request reprint Measures of adiposity and risk of breast cancer in older postmenopausal women
    Erin E Krebs
    Robert Wood Johnson Clinical Scholars Program and Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Am Geriatr Soc 54:63-9. 2006
    ..To determine whether higher adiposity is associated with greater breast cancer risk in older postmenopausal women...
  67. ncbi request reprint Universal bone densitometry screening combined with alendronate therapy for those diagnosed with osteoporosis is highly cost-effective for elderly women
    John T Schousboe
    Park Nicollet Health Services, Minneapolis, Minnesota 55416, USA
    J Am Geriatr Soc 53:1697-704. 2005
    ..To investigate the cost-effectiveness of universal bone densitometry in women aged 65 and older combined with alendronate treatment for those diagnosed with osteoporosis (femoral neck T-score < or = -2.5)...
  68. ncbi request reprint Association between Parkinson's disease and low bone density and falls in older men: the osteoporotic fractures in men study
    Howard A Fink
    Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    J Am Geriatr Soc 53:1559-64. 2005
    ..To examine the association between Parkinson's disease (PD) and bone mineral density (BMD) and risk of falls...
  69. ncbi request reprint Potential cost-effective use of spine radiographs to detect vertebral deformity and select osteopenic post-menopausal women for amino-bisphosphonate therapy
    John T Schousboe
    Park Nicollet Health Services, Minneapolis, MN, USA
    Osteoporos Int 16:1883-93. 2005
    ....
  70. ncbi request reprint One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosis
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94105, USA
    N Engl J Med 353:555-65. 2005
    ..In the continuation of this trial, we asked whether antiresorptive therapy is required to maintain gains in bone mineral density after one year of therapy with parathyroid hormone (1-84)...
  71. ncbi request reprint What proportion of incident radiographic vertebral deformities is clinically diagnosed and vice versa?
    Howard A Fink
    Geriatric Research Education and Clinical Center, VA Medical Center, Minneapolis, Minnesota 55417, USA
    J Bone Miner Res 20:1216-22. 2005
    ..The proportion of deformities clinically diagnosed ranged from <15% for milder deformities to nearly 30% for more severe deformities...
  72. ncbi request reprint Bone mineral density and the risk of incident nonspinal fractures in black and white women
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    JAMA 293:2102-8. 2005
    ..Black women have a lower rate of fracture than white women, but whether bone mineral density (BMD) predicts fracture risk as well in black women as it does in white women is not established...
  73. ncbi request reprint Cost-effectiveness of alendronate therapy for osteopenic postmenopausal women
    John T Schousboe
    Park Nicollet Health Services, University of Minnesota, and Veterans Administration Medical Center, Minneapolis, Minnesota 55416, USA
    Ann Intern Med 142:734-41. 2005
    ..Treatment guidelines recommend drug treatment to prevent fractures for some postmenopausal women who have low bone mass (osteopenia) but do not have osteoporosis or a history of clinical fractures...
  74. ncbi request reprint Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older women
    Diana M Antoniucci
    Division of Endocrinology, Department of Medicine, University of California, San Francisco, California 94105, USA
    J Bone Miner Res 20:741-7. 2005
    ..There was no association between postmenopausal oophorectomy and the risk of hip or vertebral fractures...
  75. ncbi request reprint Diabetes and incidence of functional disability in older women
    Edward W Gregg
    Division of Diabetes Translation, National Center for Chronic Disease and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Diabetes Care 25:61-7. 2002
    ..To examine the relationship between diabetes and the incidence of functional disability and to determine the predictors of functional disability among older women with diabetes...

Research Grants26

  1. STUDY OF OSTEOPOROTIC FRACTURES
    Kristine Ensrud; Fiscal Year: 2005
    ....
  2. Outcomes of Sleep Disorders in Older Men-Minneapolis
    Kristine Ensrud; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
  3. OSTEOPOROSIS IN MEN
    Kristine Ensrud; Fiscal Year: 2007
    ....
  4. STUDY OF OSTEOPOROTIC FRACTURES
    Kristine Ensrud; Fiscal Year: 2007
    ....
  5. FRACTURES IN OLDER WOMEN
    Kristine Ensrud; Fiscal Year: 1993
    ..Continued study of this unique cohort is likely to produce important advances in understanding and preventing fractures in older women...
  6. FRACTURES IN OLDER WOMEN
    Kristine Ensrud; Fiscal Year: 2000
    ..We propose using our archived DNA specimens and existing data about hip and vertebral fractures, breast cancer, bone mass, serum sex hormones and lipoproteins to determine whether these ER variations have biological importance. ..
  7. STUDY OF OSTEOPOROTIC FRACTURES
    Kristine Ensrud; Fiscal Year: 2009
    ..The SOF Coordinating Center was funded for 5 years; SOF clinical centers for 3 years. In order to meet these aims, two years of support is requested for the SOF clinical centers. ..