Kristine Ensrud

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Estimated GFR and risk of hip fracture in older men: comparison of associations using cystatin C and creatinine
    Kristine E Ensrud
    Department of Medicine, University of Minnesota, Minneapolis, MN Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN Center for Chronic Disease Outcomes Research, VA Health Care System, Minneapolis, MN Electronic address
    Am J Kidney Dis 63:31-9. 2014
  2. doi request reprint Epidemiology of fracture risk with advancing age
    Kristine E Ensrud
    VA Medical Center, One Veterans Drive, General Internal Medicine 111 0, Minneapolis, MN 55417
    J Gerontol A Biol Sci Med Sci 68:1236-42. 2013
  3. pmc Cystatin C and risk of hip fractures in older women
    Kristine E Ensrud
    Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    J Bone Miner Res 28:1275-82. 2013
  4. pmc Sleep disturbances and risk of frailty and mortality in older men
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Health Care System, Minneapolis, MN, USA
    Sleep Med 13:1217-25. 2012
  5. pmc Effect of escitalopram on insomnia symptoms and subjective sleep quality in healthy perimenopausal and postmenopausal women with hot flashes: a randomized controlled trial
    Kristine E Ensrud
    Department of Medicine and Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA
    Menopause 19:848-55. 2012
  6. pmc Renal function and nonvertebral fracture risk in multiethnic women: the Women's Health Initiative (WHI)
    K E Ensrud
    Department of Medicine, University of Minnesota, One Veterans Drive 111 0, Minneapolis, MN 55417, USA
    Osteoporos Int 23:887-99. 2012
  7. pmc Postmenopausal hormones and sleep quality in the elderly: a population based study
    Gregory J Tranah
    CPMC Research Institute, San Francisco, CA, USA
    BMC Womens Health 10:15. 2010
  8. pmc Indicators of "healthy aging" in older women (65-69 years of age). A data-mining approach based on prediction of long-term survival
    William R Swindell
    Department of Pathology, University of Michigan, School of Medicine, Ann Arbor, MI 48109 2200, USA
    BMC Geriatr 10:55. 2010
  9. doi request reprint Frequency and severity of hot flashes and sleep disturbance in postmenopausal women with hot flashes
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Menopause 16:286-92. 2009
  10. pmc Circulating 25-hydroxyvitamin D levels and frailty in older men: the osteoporotic fractures in men study
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 59:101-6. 2011

Detail Information

Publications106 found, 100 shown here

  1. pmc Estimated GFR and risk of hip fracture in older men: comparison of associations using cystatin C and creatinine
    Kristine E Ensrud
    Department of Medicine, University of Minnesota, Minneapolis, MN Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN Center for Chronic Disease Outcomes Research, VA Health Care System, Minneapolis, MN Electronic address
    Am J Kidney Dis 63:31-9. 2014
    ..Whether estimated glomerular filtration rate (eGFR) based on cystatin C (eGFRcys) is superior in predicting hip fracture risk to eGFR based on creatinine (eGFRcr) or the combination (eGFR(cr-cys)) also is uncertain...
  2. doi request reprint Epidemiology of fracture risk with advancing age
    Kristine E Ensrud
    VA Medical Center, One Veterans Drive, General Internal Medicine 111 0, Minneapolis, MN 55417
    J Gerontol A Biol Sci Med Sci 68:1236-42. 2013
    ..Future research focused on identification of older adults at high risk of disabling fractures is warranted. ..
  3. pmc Cystatin C and risk of hip fractures in older women
    Kristine E Ensrud
    Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    J Bone Miner Res 28:1275-82. 2013
    ..These findings suggest that cystatin C may be a promising biomarker for identification of older adults at high risk of hip fracture...
  4. pmc Sleep disturbances and risk of frailty and mortality in older men
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Health Care System, Minneapolis, MN, USA
    Sleep Med 13:1217-25. 2012
    ..To test the hypothesis that non-frail older men with poorer sleep at baseline are at increased risk of frailty and death at follow-up...
  5. pmc Effect of escitalopram on insomnia symptoms and subjective sleep quality in healthy perimenopausal and postmenopausal women with hot flashes: a randomized controlled trial
    Kristine E Ensrud
    Department of Medicine and Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA
    Menopause 19:848-55. 2012
    ..The aim of this study was to determine the effect of escitalopram on insomnia symptoms and subjective sleep quality in healthy perimenopausal and postmenopausal women with hot flashes...
  6. pmc Renal function and nonvertebral fracture risk in multiethnic women: the Women's Health Initiative (WHI)
    K E Ensrud
    Department of Medicine, University of Minnesota, One Veterans Drive 111 0, Minneapolis, MN 55417, USA
    Osteoporos Int 23:887-99. 2012
    ..Reduced renal function appeared to increase fracture risk among Black women, but there was little evidence to support this association among other racial/ethnic groups...
  7. pmc Postmenopausal hormones and sleep quality in the elderly: a population based study
    Gregory J Tranah
    CPMC Research Institute, San Francisco, CA, USA
    BMC Womens Health 10:15. 2010
    ..Using data from the multicenter Study of Osteoporotic Fractures (SOF), we tested the relationship between HT and sleep-wake estimated from actigraphy...
  8. pmc Indicators of "healthy aging" in older women (65-69 years of age). A data-mining approach based on prediction of long-term survival
    William R Swindell
    Department of Pathology, University of Michigan, School of Medicine, Ann Arbor, MI 48109 2200, USA
    BMC Geriatr 10:55. 2010
    ..The aims of this study were to identify predictors of long-term survival in older women and to develop a multivariable model based upon longitudinal data from the Study of Osteoporotic Fractures (SOF)...
  9. doi request reprint Frequency and severity of hot flashes and sleep disturbance in postmenopausal women with hot flashes
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Menopause 16:286-92. 2009
    ..To determine whether greater frequency and severity of hot flashes are independently associated with insomnia symptoms and objective measures of disrupted sleep among healthy postmenopausal women with hot flashes...
  10. pmc Circulating 25-hydroxyvitamin D levels and frailty in older men: the osteoporotic fractures in men study
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 59:101-6. 2011
    ..To determine the cross-sectional and longitudinal associations between 25-hydroxyvitamin D (25(OH)D) levels and frailty status in older men...
  11. pmc A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    J Am Geriatr Soc 57:492-8. 2009
    ....
  12. ncbi request reprint Endogenous sex steroids, weight change and rates of hip bone loss in older men: the MrOS study
    K E Ensrud
    Department of Medicine 111 0, VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
    Osteoporos Int 17:1329-36. 2006
    ..We hypothesized that among older men with weight loss, higher rates of bone loss at the hip would be observed in men with lower baseline bioavailable sex steroids or those with greater declines in these hormones...
  13. pmc Serum 25-hydroxyvitamin D levels and rate of hip bone loss in older men
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, VA Medical Center, One Veterans Drive 111 0, Minneapolis, MN 55417, USA
    J Clin Endocrinol Metab 94:2773-80. 2009
    ..Vitamin D deficiency is common among older adults, but the association between 25-hydroxyvitamin D [25(OH)D] levels and rates of bone loss is uncertain...
  14. doi request reprint Lasofoxifene and cardiovascular events in postmenopausal women with osteoporosis: Five-year results from the Postmenopausal Evaluation and Risk Reduction with Lasofoxifene (PEARL) trial
    Kristine Ensrud
    VA Medical Center, Minneapolis, MN, USA
    Circulation 122:1716-24. 2010
    ..5 mg/d is consistent across different categories of CHD risk...
  15. ncbi request reprint Voluntary weight reduction in older men increases hip bone loss: the osteoporotic fractures in men study
    Kristine E Ensrud
    Department of Medicine 111 0, Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, Minnesota 55417, USA
    J Clin Endocrinol Metab 90:1998-2004. 2005
    ..7%/yr in those with weight loss; test for trend, P < 0.001). Older men who experience weight loss have increased rates of hip bone loss, even among overweight and obese men undergoing voluntary weight reduction...
  16. doi request reprint Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, General Internal Medicine, Minneapolis, MN 55417, USA
    Arch Intern Med 168:382-9. 2008
    ..Frailty, as defined by the index derived from the Cardiovascular Health Study (CHS index), predicts risk of adverse outcomes in older adults. Use of this index, however, is impractical in clinical practice...
  17. pmc Sleep disturbances and frailty status in older community-dwelling men
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    J Am Geriatr Soc 57:2085-93. 2009
    ..To test the hypothesis that sleep disturbances are independently associated with frailty status in older men...
  18. ncbi request reprint Renal function and risk of hip and vertebral fractures in older women
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, MN 55417, USA
    Arch Intern Med 167:133-9. 2007
    ..An increased rate of hip fractures has been reported in patients with end-stage renal disease, but the effect of less severe renal dysfunction on fracture risk is uncertain...
  19. ncbi request reprint Randomized trial of effect of alendronate continuation versus discontinuation in women with low BMD: results from the Fracture Intervention Trial long-term extension
    Kristine E Ensrud
    Department of Medicine, VA Medical Center, Minneapolis, Minnesota 55417, USA
    J Bone Miner Res 19:1259-69. 2004
    ..However, among women who discontinued alendronate and took placebo in the extension, BMD remained higher, and reduction in bone turnover was greater than values at FIT baseline, showing persistence of alendronate's effects on bone...
  20. pmc Antiepileptic drug use and rates of hip bone loss in older men: a prospective study
    K E Ensrud
    VA Medical Center, One Veterans Drive 111 0, Minneapolis, MN 55417, USA
    Neurology 71:723-30. 2008
    ..To test the hypotheses that older community dwelling men taking non-enzyme-inducing antiepileptic drugs (NEIAEDs) and those taking enzyme-inducing antiepileptic drugs (EIAEDs) have increased rates of hip bone loss...
  21. pmc Circulating 25-hydroxyvitamin D levels and frailty status in older women
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, VA Medical Center, and Department of Medicine, University of Minnesota, M P H, One Veterans Drive 111 0, Minneapolis, Minnesota 55417, USA
    J Clin Endocrinol Metab 95:5266-73. 2010
    ..Vitamin D deficiency and frailty are common with aging, but the association between these conditions is uncertain...
  22. ncbi request reprint Frailty and risk of falls, fracture, and mortality in older women: the study of osteoporotic fractures
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, and Department of Medicine, University of Minnesota, Minneapolis, MN 55417, USA
    J Gerontol A Biol Sci Med Sci 62:744-51. 2007
    ..However, the predictive validity of this phenotype for fracture outcomes and across risk subgroups is uncertain...
  23. ncbi request reprint Central nervous system active medications and risk for fractures in older women
    Kristine E Ensrud
    Department of Medicine and Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, MN 55417, USA
    Arch Intern Med 163:949-57. 2003
    ..Use of central nervous system (CNS) active medications may increase the risk for fractures. Prior studies are limited by incomplete control of confounders...
  24. pmc A comparison of prediction models for fractures in older women: is more better?
    Kristine E Ensrud
    Department of Medicine, Minneapolis Veterans Affairs Medical Center, MN 55417, USA
    Arch Intern Med 169:2087-94. 2009
    ..However, it is uncertain whether prediction with FRAX models is superior to that based on parsimonious models...
  25. ncbi request reprint Long-term prediction of incident hip fracture risk in elderly white women: study of osteoporotic fractures
    Brent C Taylor
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 52:1479-86. 2004
    ..To identify independent risk factors for first hip fracture over 10 years of follow-up...
  26. pmc Association of provider-patient visit frequency and patient outcomes on hemodialysis
    Yelena Slinin
    Veterans Administration Health Care System, Minneapolis, Minnesota, USA
    J Am Soc Nephrol 23:1560-7. 2012
    ..In summary, greater frequency of provider visits to hemodialysis patients associates with a small but significant reduction in hospitalizations, but it does not consistently associate with lower risk for death...
  27. pmc Association between sleep and physical function in older men: the osteoporotic fractures in men sleep study
    Thuy Tien L Dam
    Department of Medicine, University of California at San Diego, La Jolla, California, USA
    J Am Geriatr Soc 56:1665-73. 2008
    ..To determine whether sleep quality is associated with physical function in older men...
  28. ncbi request reprint BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures
    Katie L Stone
    Department of Medicine, University of California, San Francisco, California 94105, USA
    J Bone Miner Res 18:1947-54. 2003
    ..Although we found almost all fracture types to be related to low BMD, the overall proportion of fractures attributable to low BMD is modest...
  29. doi request reprint Prehemodialysis care by dietitians and first-year mortality after initiation of hemodialysis
    Yelena Slinin
    Veterans Administration Medical Center, Minneapolis, MN 55417, USA
    Am J Kidney Dis 58:583-90. 2011
    ..Few patients receive dietary counseling before end-stage renal disease onset; whether such counseling is associated with improved outcomes is unknown...
  30. doi request reprint Predictors of provider-patient visit frequency during hemodialysis
    Yelena Slinin
    Veterans Administration Health Care System, University of Minnesota, Minneapolis, Minn 55417, USA
    Am J Nephrol 38:91-8. 2013
    ..We aimed to identify patient, provider, and dialysis facility characteristics associated with provider visit frequency...
  31. doi request reprint BMD changes and predictors of increased bone loss in postmenopausal women after a 5-year course of alendronate
    Brian Louis McNabb
    Division of Endocrinology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    J Bone Miner Res 28:1319-27. 2013
    ..Although about one-third of women who discontinued ALN after 5 years experienced >5% bone loss at the total hip, predicting which women will lose at a higher rate was not possible...
  32. doi request reprint Provider and care characteristics associated with timing of dialysis initiation
    Yelena Slinin
    Primary Care Service Line, Veterans Administration Health Care System, Minneapolis, Minnesota, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, Minnesota
    Clin J Am Soc Nephrol 9:310-7. 2014
    ..This study aimed to determine whether provider characteristics and pre-ESRD nephrology care and vascular access are independently associated with higher estimated GFR at initiation...
  33. ncbi request reprint Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs
    Steven R Cummings
    Department of Medicine, University of California, San Francisco, California, USA
    Am J Med 112:281-9. 2002
    ..To estimate how much the improvement in bone mass accounts for the reduction in risk of vertebral fracture that has been observed in randomized trials of antiresorptive treatments for osteoporosis...
  34. ncbi request reprint Association between Parkinson's disease and low bone density and falls in older men: the osteoporotic fractures in men study
    Howard A Fink
    Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    J Am Geriatr Soc 53:1559-64. 2005
    ..To examine the association between Parkinson's disease (PD) and bone mineral density (BMD) and risk of falls...
  35. ncbi request reprint Association of low bone mineral density with selective serotonin reuptake inhibitor use by older men
    Elizabeth M Haney
    Department of Medicine, Oregon Health and Science University, Mailcode L 475, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Arch Intern Med 167:1246-51. 2007
    ..Osteoblasts and osteocytes express functional serotonin transporters; serotonin transporter gene disruption in mice results in osteopenia; and SSRI use has been associated with increased risk of hip fracture...
  36. ncbi request reprint Effects of ultralow-dose transdermal estradiol on postmenopausal symptoms in women aged 60 to 80 years
    Susan Diem
    Department of Medicine, University of Minnesota, Minneapolis, 55415, USA
    Menopause 13:130-8. 2006
    ..To investigate the effect of ultralow-dose transdermal estradiol on postmenopausal symptoms and side effects in a cohort of largely asymptomatic postmenopausal women aged 60 to 80 years...
  37. ncbi request reprint Association of endothelial nitric oxide synthase genotypes with bone mineral density, bone loss, hip structure, and risk of fracture in older women: the SOF study
    Brent C Taylor
    Center for Chronic Disease Outcomes Research 152 2E, Minneapolis VA Medical Center, and Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA
    Bone 39:174-80. 2006
    ..Confirmation of these findings is needed in other populations and with additional markers within and flanking the NOS3 gene region...
  38. ncbi request reprint Association between prior non-spine non-hip fractures or prevalent radiographic vertebral deformities known to be at least 10 years old and incident hip fracture
    John T Schousboe
    Park Nicollet Health Services, Minneapolis, Minnesota 55416, USA
    J Bone Miner Res 21:1557-64. 2006
    ....
  39. ncbi request reprint Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older women
    Diana M Antoniucci
    Division of Endocrinology, Department of Medicine, University of California, San Francisco, California 94105, USA
    J Bone Miner Res 20:741-7. 2005
    ..There was no association between postmenopausal oophorectomy and the risk of hip or vertebral fractures...
  40. pmc Meeting KDOQI guideline goals at hemodialysis initiation and survival during the first year
    Yelena Slinin
    VA Medical Center 111J, One Veteran s Drive, Minneapolis, MN 55417, USA
    Clin J Am Soc Nephrol 5:1574-81. 2010
    ....
  41. ncbi request reprint Association between self-reported prior wrist fractures and risk of subsequent hip and radiographic vertebral fractures in older women: a prospective study
    John T Schousboe
    Section of Rheumatology, Park Nicollet Health Services, Minneapolis, Minnesota 55416, USA
    J Bone Miner Res 20:100-6. 2005
    ..Validation of such an approach would require intervention trials in patients with prior wrist fracture...
  42. pmc Association of osteocalcin and abdominal aortic calcification in older women: the study of osteoporotic fractures
    Benjamin D Parker
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, San Diego, CA 92093, USA
    Calcif Tissue Int 86:185-91. 2010
    ..87). In conclusion, among community-living older women, serum OC is not associated with AAC. These findings suggest that serum OC levels may more closely reflect bone formation than vascular calcification in humans...
  43. ncbi request reprint Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. men
    Lynn M Marshall
    Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Bone Miner Res 21:1197-206. 2006
    ..Relations of femoral neck dimensions and vBMD to age differed from those in the shaft, indicating that patterns of bone modeling and remodeling in the neck and shaft are distinct...
  44. pmc Muscle power and physical activity are associated with bone strength in older men: The osteoporotic fractures in men study
    Julie M Cousins
    School of Kinesiology, Laboratory for Musculoskeletal Health, University of Minnesota, Minneapolis, MN 55455, USA
    Bone 47:205-11. 2010
    ..008). Similar results were found at both the distal and midshaft of the radius. The findings of this study suggest the importance of maintaining levels of physical activity and muscle strength in older men to prevent bone fragility...
  45. ncbi request reprint Cost-effectiveness of vertebral fracture assessment to detect prevalent vertebral deformity and select postmenopausal women with a femoral neck T-score>-2.5 for alendronate therapy: a modeling study
    John T Schousboe
    Park Nicollet Health Services, Minneapolis, MN 55416, USA
    J Clin Densitom 9:133-43. 2006
    ..5. These conclusions are robust to reasonable changes in fracture rates, assumed fracture disutility, discount rates, relative risk of fracture attributable to vertebral deformity, alendronate cost, and drug adherence...
  46. ncbi request reprint Universal bone densitometry screening combined with alendronate therapy for those diagnosed with osteoporosis is highly cost-effective for elderly women
    John T Schousboe
    Park Nicollet Health Services, Minneapolis, Minnesota 55416, USA
    J Am Geriatr Soc 53:1697-704. 2005
    ..To investigate the cost-effectiveness of universal bone densitometry in women aged 65 and older combined with alendronate treatment for those diagnosed with osteoporosis (femoral neck T-score < or = -2.5)...
  47. ncbi request reprint Abdominal aortic calcification detected on lateral spine images from a bone densitometer predicts incident myocardial infarction or stroke in older women
    John T Schousboe
    Park Nicollet Health Services, Minneapolis, Minnesota 55416, USA
    J Bone Miner Res 23:409-16. 2008
    ....
  48. pmc Differences in site-specific fracture risk among older women with discordant results for osteoporosis at hip and spine: study of osteoporotic fractures
    Howard A Fink
    Geriatric Research Education and Clinical Center, VA Medical Center, Minneapolis, MN 55417, USA
    J Clin Densitom 11:250-9. 2008
    ..Women osteoporotic only at spine would not have been identified from hip BMD measurement alone, and may have a sufficiently high fracture risk to warrant preventive treatment...
  49. pmc Renal function and sleep-disordered breathing in older men
    Muna T Canales
    Department of Medicine, University of Florida, Division of Nephrology, Hypertension and Renal Transplantation, Gainesville, FL 32610, USA
    Nephrol Dial Transplant 23:3908-14. 2008
    ..Sleep-disordered breathing (SDB) is common in severe chronic kidney disease (CKD) and may contribute to morbidity and mortality in this population. However, the association between mild to moderate CKD and likelihood of SDB is uncertain...
  50. ncbi request reprint Effect of raloxifene on cardiovascular adverse events in postmenopausal women with osteoporosis
    Kristine Ensrud
    Veterans Affairs Medical Center, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Cardiol 97:520-7. 2006
    ....
  51. ncbi request reprint Bone outcomes and technical measurement issues of bone health among children and adolescents: considerations for nutrition and physical activity intervention trials
    Jayne A Fulkerson
    Division of Epidemiology, School of Public Health, University of Minnesota, MN, USA
    Osteoporos Int 15:929-41. 2004
    ..It describes the implications of these issues for the interpretation of intervention effects observed in intervention trials, and provides recommendations for future research...
  52. pmc Rest/activity rhythms and mortality rates in older men: MrOS Sleep Study
    Misti L Paudel
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
    Chronobiol Int 27:363-77. 2010
    ..Older men with less robust RAR and earlier acrophase timing have modestly higher all-cause and CVD-related mortality rates. Further research should examine potential biological mechanisms underlying this association...
  53. pmc Peripheral arterial disease is associated with higher rates of hip bone loss and increased fracture risk in older men
    Tracie C Collins
    University of Minnesota, Department of Medicine, 717 Delaware St SE, Suite 166, Minneapolis, MN 55414, USA
    Circulation 119:2305-12. 2009
    ..Peripheral arterial disease (PAD) and osteoporosis are chronic illnesses that increase in prevalence with aging and certain metabolic disorders. The association between PAD, rates of bone loss, and fracture risk in older men is uncertain...
  54. doi request reprint The magnitude of acute serum creatinine increase after cardiac surgery and the risk of chronic kidney disease, progression of kidney disease, and death
    Areef Ishani
    Center for Epidemiology and Clinical Research, Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota 55417, USA
    Arch Intern Med 171:226-33. 2011
    ..We determined the association between the magnitude of creatinine increase after cardiac surgery and the risk of incident chronic kidney disease (CKD), CKD progression, and death...
  55. pmc Reduced renal function and sleep-disordered breathing in community-dwelling elderly men
    Muna T Canales
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    Sleep Med 9:637-45. 2008
    ..Sleep-disordered breathing (SDB) may increase the risk of cardiovascular disease (CVD) and death in chronic kidney disease (CKD). However, the association between mild reductions in renal function and SDB is uncertain...
  56. pmc Bone mass and strength in older men with type 2 diabetes: the Osteoporotic Fractures in Men Study
    Moira A Petit
    School of Kinesiology, Laboratory for Musculoskeletal Health, University of Minnesota, Minneapolis, MN, USA
    J Bone Miner Res 25:285-91. 2010
    ..These data demonstrate that older men with T2DM have bone strength that is low relative to body weight at the cortical-rich midshaft of the radius despite no difference in cortical vBMD...
  57. pmc The effect of raloxifene treatment in postmenopausal women with CKD
    Areef Ishani
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, and Department of Medicine and Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55417, USA
    J Am Soc Nephrol 19:1430-8. 2008
    ..In conclusion, raloxifene increases BMD at both the hip and the spine and reduces the risk for vertebral fractures among individuals with CKD. The effect ofraloxifene on hip BMD is greater among those with mild to moderate CKD...
  58. pmc Association between depressive symptoms and sleep disturbances in community-dwelling older men
    Misti L Paudel
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 56:1228-35. 2008
    ..To examine the association between depressive symptoms and subjective and objective measures of sleep in community-dwelling older men...
  59. pmc Kidney function and cognitive performance and decline in older men
    Yelena Slinin
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 56:2082-8. 2008
    ..To examine the association between kidney function and cognitive impairment and decline in elderly men...
  60. ncbi request reprint Effects of raloxifene on fracture risk in postmenopausal women: the Raloxifene Use for the Heart Trial
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    J Bone Miner Res 23:112-20. 2008
    ..Treatment with raloxifene for 5 yr reduced the risk of clinical vertebral fractures, but not nonvertebral fractures, irrespective of the presence or absence of risk factors for fracture...
  61. ncbi request reprint Central nervous system-active medications and risk for falls in older women
    Kristine E Ensrud
    Department of Medicine, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 50:1629-37. 2002
    ..To determine whether current use of central nervous system (CNS)-active medications, including benzodiazepines, antidepressants, anticonvulsants, and narcotics, increases the risk for subsequent falls...
  62. ncbi request reprint Depressive symptoms and rates of bone loss at the hip in older women
    Susan J Diem
    Department of Medicine, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55415, USA
    J Am Geriatr Soc 55:824-31. 2007
    ..To ascertain whether depressive symptoms are associated with increased rates of bone loss at the hip...
  63. ncbi request reprint Use of selective serotonin reuptake inhibitors and sleep disturbances in community-dwelling older women
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, and Department of Medicine and Division of Epidemiology, University of Minnesota 55417, USA
    J Am Geriatr Soc 54:1508-15. 2006
    ..To determine the association between use of selective serotonin reuptake inhibitors (SSRIs) and objective measures of sleep disturbances in older community-dwelling women, including women without evidence of depression...
  64. ncbi request reprint Use of antidepressants and rates of hip bone loss in older women: the study of osteoporotic fractures
    Susan J Diem
    Department of Medicine, University of Minnesota, and Center for Chronic Disease Outcomes Research, Minneapolis Veterans Affairs Medical Center, 1100 Washington Ave S, Suite 201, Minneapolis, MN 55415, USA
    Arch Intern Med 167:1240-5. 2007
    ..Serotonin transporters have recently been described in bone, raising the possibility that medications that block serotonin reuptake could affect bone metabolism...
  65. ncbi request reprint Risk factors for motor vehicle crashes in older women
    Karen L Margolis
    Division of Clinical Epidemiology, Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA
    J Gerontol A Biol Sci Med Sci 57:M186-91. 2002
    ..Identifying elderly drivers who are at risk for automobile crashes may help direct interventions to reduce their high rate of injuries and deaths...
  66. ncbi request reprint Intentional and unintentional weight loss increase bone loss and hip fracture risk in older women
    Kristine E Ensrud
    Department of Medicine and Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, Minnesota 55417, USA
    J Am Geriatr Soc 51:1740-7. 2003
    ..To test the hypothesis that unintentional weight loss increases the rate of bone loss and risk of hip fracture more than intentional weight loss...
  67. ncbi request reprint What proportion of incident radiographic vertebral deformities is clinically diagnosed and vice versa?
    Howard A Fink
    Geriatric Research Education and Clinical Center, VA Medical Center, Minneapolis, Minnesota 55417, USA
    J Bone Miner Res 20:1216-22. 2005
    ..The proportion of deformities clinically diagnosed ranged from <15% for milder deformities to nearly 30% for more severe deformities...
  68. ncbi request reprint Effect of isoflavones on lipids and bone turnover markers in menopausal women
    Tamara M Knudson Schult
    Center for Chronic Disease Outcomes Research, Minneapolis VA Medical Center, MN 55417, USA
    Maturitas 48:209-18. 2004
    ..The purpose of this analysis was to compare the effects of two dietary supplements derived from red clover to placebo on lipids and bone turnover markers in symptomatic menopausal women...
  69. pmc Trochanteric soft tissue thickness and hip fracture in older men
    Carrie M Nielson
    Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Clin Endocrinol Metab 94:491-6. 2009
    ..The effect of trochanteric soft tissue thickness on the risk of incident hip fracture has not been evaluated in men...
  70. ncbi request reprint Potential cost-effective use of spine radiographs to detect vertebral deformity and select osteopenic post-menopausal women for amino-bisphosphonate therapy
    John T Schousboe
    Park Nicollet Health Services, Minneapolis, MN, USA
    Osteoporos Int 16:1883-93. 2005
    ....
  71. pmc Race and ethnic variation in proximal femur structure and BMD among older men
    Lynn M Marshall
    Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland Oregon, USA
    J Bone Miner Res 23:121-30. 2008
    ..All had similar stature-adjusted mean femoral neck volume, but black and Asian men had thicker cortices and higher trabecular vBMD, which may increase bone strength...
  72. ncbi request reprint Endogenous estrogen levels and the effects of ultra-low-dose transdermal estradiol therapy on bone turnover and BMD in postmenopausal women
    Alison J Huang
    Veterans Affairs Medical Center, San Francisco, California, USA
    J Bone Miner Res 22:1791-7. 2007
    ..This suggests that the protective effects of ultra-low-dose estrogen therapy on the postmenopausal skeletal health may depend critically on women's endogenous estrogen levels before treatment...
  73. ncbi request reprint Cost-effectiveness of bone densitometry followed by treatment of osteoporosis in older men
    John T Schousboe
    Rheumatology, Park Nicollet Health Services, Minneapolis, MN 55416, USA
    JAMA 298:629-37. 2007
    ..Osteoporotic fractures are common among elderly men...
  74. ncbi request reprint Cost-effectiveness of alendronate therapy for osteopenic postmenopausal women
    John T Schousboe
    Park Nicollet Health Services, University of Minnesota, and Veterans Administration Medical Center, Minneapolis, Minnesota 55416, USA
    Ann Intern Med 142:734-41. 2005
    ..Treatment guidelines recommend drug treatment to prevent fractures for some postmenopausal women who have low bone mass (osteopenia) but do not have osteoporosis or a history of clinical fractures...
  75. ncbi request reprint Use of statins and fracture: results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trials
    Douglas C Bauer
    Department of Medicine, University of California, San Francisco 94105, USA
    Arch Intern Med 164:146-52. 2004
    ....
  76. ncbi request reprint Hip fracture in women without osteoporosis
    Stacey A Wainwright
    Bone and Mineral Research Unit, Department of Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Mail Code CR113, Portland, Oregon 97239, USA
    J Clin Endocrinol Metab 90:2787-93. 2005
    ..These findings call attention to the many older women who suffer hip fracture but do not have particularly low antecedent BMD measures and help begin to identify risk factors associated with higher bone density levels...
  77. ncbi request reprint Association of testosterone and estradiol deficiency with osteoporosis and rapid bone loss in older men
    Howard A Fink
    Geriatric Research Eduction and Clinical Center, Veterans Affairs Medical Center, One Veterans Drive, Box 11G, Minneapolis, MN 55417, USA
    J Clin Endocrinol Metab 91:3908-15. 2006
    ..The clinical value of measuring testosterone and estradiol in older men with osteoporosis and of measuring bone mineral density (BMD) in older men with testosterone or estradiol deficiency is uncertain...
  78. pmc Elevations in serum and urinary calcium with parathyroid hormone (1-84) with and without alendronate for osteoporosis
    Diana M Antoniucci
    Division of Endocrinology, Department of Medicine, University of California, San Francisco, California 94107, USA
    J Clin Endocrinol Metab 92:942-7. 2007
    ..The effect of PTH therapy on serum and urinary calcium levels and the risk of hypercalcemia or hypercalciuria has not been formally evaluated...
  79. doi request reprint Carvedilol versus controlled-release metoprolol for elderly veterans with heart failure
    Thomas S Rector
    Minneapolis Veterans Affairs Medical Center and Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55417, USA
    J Am Geriatr Soc 56:1021-7. 2008
    ..To characterize prescribing of carvedilol and controlled-release (CR) metoprolol for veterans with heart failure who were predominantly elderly (aged > or = 65) and to compare the time to first hospitalization or death...
  80. ncbi request reprint Phytoestrogens for treatment of menopausal symptoms: a systematic review
    Erin E Krebs
    Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    Obstet Gynecol 104:824-36. 2004
    ..To assess the efficacy and tolerability of phytoestrogens for treatment of menopausal symptoms...
  81. ncbi request reprint The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA
    N Engl J Med 349:1207-15. 2003
    ..We conducted a randomized, double-blind clinical study of parathyroid hormone and alendronate to test the hypothesis that the concurrent administration of the two agents would increase bone density more than the use of either one alone...
  82. ncbi request reprint Risk factors for a first-incident radiographic vertebral fracture in women > or = 65 years of age: the study of osteoporotic fractures
    Michael C Nevitt
    Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94105, USA
    J Bone Miner Res 20:131-40. 2005
    ..Risk factors and low BMD should be useful to help focus efforts to prevent these fractures...
  83. ncbi request reprint Oral daily ibandronate prevents bone loss in early postmenopausal women without osteoporosis
    Michael R McClung
    Oregon Osteoporosis Center, Portland, Oregon 97213, USA
    J Bone Miner Res 19:11-8. 2004
    ..1% and 1.8%, respectively; p < or = 0.0001 versus placebo) with 2.5 mg ibandronate after 24 months. Oral ibandronate is a promising option for the prevention of postmenopausal bone loss...
  84. ncbi request reprint Vision impairment and combined vision and hearing impairment predict cognitive and functional decline in older women
    Michael Y Lin
    Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    J Am Geriatr Soc 52:1996-2002. 2004
    ..To determine the association between vision and hearing impairment and subsequent cognitive and functional decline in community-residing older women...
  85. ncbi request reprint Body mass index and mortality among older breast cancer survivors in the Study of Osteoporotic Fractures
    Katherine W Reeves
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 516A Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Cancer Epidemiol Biomarkers Prev 16:1468-73. 2007
    ..This study investigated the association between BMI and mortality after breast cancer diagnosis in a cohort of older Caucasian women enrolled in the Study of Osteoporotic Fractures...
  86. ncbi request reprint Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis: four-year results from a randomized clinical trial
    Pierre D Delmas
    University of Claude Bernard of Lyon, Hopital Edouard Herriot, Service de Rhumatologie et de Pathologie Osseuse, Lyon 69437, France
    J Clin Endocrinol Metab 87:3609-17. 2002
    ..The decreased vertebral fracture risk in yr 4 alone was not different from that observed in the first 3 yr...
  87. ncbi request reprint Frailty in older men: prevalence, progression, and relationship with mortality
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107 1762, USA
    J Am Geriatr Soc 55:1216-23. 2007
    ..To describe the association between frailty and health status, the progression of frailty, and the relationship between frailty and mortality in older men...
  88. ncbi request reprint Older women with diabetes have a higher risk of falls: a prospective study
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA
    Diabetes Care 25:1749-54. 2002
    ..To determine whether older women with diabetes have an increased risk of falls and whether known risk factors for falls account for any increased risk...
  89. ncbi request reprint Relationship of changes in physical activity and mortality among older women
    Edward W Gregg
    Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    JAMA 289:2379-86. 2003
    ..Physical activity has been related to reduced mortality, but it is not clear whether changes in physical activity affect mortality among older women...
  90. ncbi request reprint Post hoc analysis of data from the Multiple Outcomes of Raloxifene Evaluation (MORE) trial on the effects of three years of raloxifene treatment on glycemic control and cardiovascular disease risk factors in women with and without type 2 diabetes
    Elizabeth Barrett-Connor
    Department of Family and Preventive Medicine, School of Medicine, University of California at San Diego, La Jolla, California 92093 0607, USA
    Clin Ther 25:919-30. 2003
    ..The long-term effects of the selective estrogen-receptor modulator raloxifene hydrochloride on glycemic control and markers of cardiovascular disease risk in postmenopausal women with type 2 diabetes mellitus are unknown...
  91. doi request reprint Loop diuretic use and increased rates of hip bone loss in older men: the Osteoporotic Fractures in Men Study
    Lionel S Lim
    Department of Internal Medicine, Griffin Hospital, 130 Division St, Derby, CT 06418, USA
    Arch Intern Med 168:735-40. 2008
    ..Studies examining the association between loop diuretics and bone mineral density (BMD) are lacking, particularly those involving men...
  92. ncbi request reprint beta-Blocker use, BMD, and fractures in the study of osteoporotic fractures
    Ian R Reid
    Department of Medicine, University of Auckland, Auckland, New Zealand
    J Bone Miner Res 20:613-8. 2005
    ..We studied the association of beta-blocker use with BMD and fractures in the Study of Osteoporotic Fractures. beta-blocker use and BMD are unrelated in this cohort, and associations with fracture risk are inconsistent...
  93. ncbi request reprint Bone mineral density and age-related maculopathy in older women
    Robin L Seitzman
    Department of Ophthalmology, Jules Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Am Geriatr Soc 55:740-6. 2007
    ..To determine whether bone mineral density (BMD) is associated with age-related maculopathy (ARM) risk in older women...
  94. ncbi request reprint Alendronate treatment in women with normal to severely impaired renal function: an analysis of the fracture intervention trial
    Sophie A Jamal
    Division of Endocrinology, St Michael s Hospital and the University of Toronto, Toronto, Ont, Canada
    J Bone Miner Res 22:503-8. 2007
    ..There was no increase in adverse events among women with impaired renal function treated with alendronate. Alendronate is safe and effective among this group of women with reduced renal function...
  95. ncbi request reprint Evaluating the value of repeat bone mineral density measurement and prediction of fractures in older women: the study of osteoporotic fractures
    Teresa A Hillier
    Center for Health Research, Kaiser Permanente Northwest Hawaii, Portland, OR 97227, USA
    Arch Intern Med 167:155-60. 2007
    ..Whether repeat bone mineral density (BMD) measurement adds benefit beyond the initial BMD measurement in predicting fractures in older women is unknown...
  96. ncbi request reprint Visual acuity, contrast sensitivity, and mortality in older women: Study of osteoporotic fractures
    Kathryn L Pedula
    Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon 97227, USA
    J Am Geriatr Soc 54:1871-7. 2006
    ..To determine whether poorer visual acuity and contrast sensitivity are independent risk factors for all-cause and traumatic mortality in older women...
  97. ncbi request reprint Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial
    Dennis M Black
    San Francisco Coordinating Center, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94107, USA
    JAMA 296:2927-38. 2006
    ..The optimal duration of treatment of women with postmenopausal osteoporosis is uncertain...
  98. pmc Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
    J Bone Miner Res 23:1326-33. 2008
    ....
  99. ncbi request reprint BMD and risk of hip and nonvertebral fractures in older men: a prospective study and comparison with older women
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
    J Bone Miner Res 21:1550-6. 2006
    ..The relationship between hip BMD and hip fracture risk seemed to be stronger than observed in a large prospective study of women. Hip BMD is an excellent test for predicting fracture risk in men...
  100. ncbi request reprint Self-reported sleep and nap habits and risk of falls and fractures in older women: the study of osteoporotic fractures
    Katie L Stone
    Research Institute, California Pacific Medical Center, San Francisco, 94107, USA
    J Am Geriatr Soc 54:1177-83. 2006
    ..To test the association between self-reported sleep and nap habits and risk of falls and fractures in a large cohort of older women...
  101. ncbi request reprint Measures of adiposity and risk of breast cancer in older postmenopausal women
    Erin E Krebs
    Robert Wood Johnson Clinical Scholars Program and Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Am Geriatr Soc 54:63-9. 2006
    ..To determine whether higher adiposity is associated with greater breast cancer risk in older postmenopausal women...