S J Enna

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. ncbi GABA(B) receptor alterations as indicators of physiological and pharmacological function
    S J Enna
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical School, 3901 Rainbow Boulevard, Mail Stop 1018, Kansas City, Kansas 66160 0227, USA
    Biochem Pharmacol 68:1541-8. 2004
  2. ncbi A legacy of discovery: from monoamines to GABA
    S J Enna
    Departments of Molecular and Integrative Physiology, and of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Neuropharmacology 60:1050-7. 2011
  3. ncbi A GABA(B) mystery: the search for pharmacologically distinct GABA(B) receptors
    S J Enna
    Department of Pharmacology, Toxicology and Therapeutics, Kansas University School of Medicine, 3901 Rainbow Blvd, Kansas City, Kansas 66160, USA
    Mol Interv 1:208-18. 2001
  4. ncbi Challenges in the search for drugs to treat central nervous system disorders
    S J Enna
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Pharmacol Exp Ther 329:404-11. 2009
  5. ncbi GABA(B) receptor function and subunit expression in the rat spinal cord as indicators of stress and the antinociceptive response to antidepressants
    Kenneth E McCarson
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Brain Res 1068:109-17. 2006
  6. ncbi Developmental regulation of GABA(B) receptor function in rat spinal cord
    J M Moran
    Department of Pharmacology, University of Kansas Medical Center, Kansas City 66160-7417, USA
    Life Sci 68:2287-95. 2001
  7. ncbi Differential regulation of GABA B receptor subunit expression and function
    S A Sands
    Department of Pharmacology, Toxicology and Therapeutics, Kansas University School of Medicine, Kansas City, Kansas 66160 7424, USA
    J Pharmacol Exp Ther 305:191-6. 2003
  8. ncbi Relationship between the antinociceptive response to desipramine and changes in GABAB receptor function and subunit expression in the dorsal horn of the rat spinal cord
    Scott A Sands
    Department Pharmacology, Toxicology and Therapeutics, Kansas University School of Medicine, 3901 Rainbow Blvd, Mail Code 1018, Kansas City, KS 66160, USA
    Biochem Pharmacol 67:743-9. 2004
  9. ncbi Ontogeny of GABA(B) receptor subunit expression and function in the rat spinal cord
    Scott A Sands
    Department of Pharmacology, Toxicology, and Therapeutics, School of Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7147, USA
    Brain Res 972:197-206. 2003
  10. ncbi Effect of antidepressants on GABA(B) receptor function and subunit expression in rat hippocampus
    Scott A Sands
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical School, 3901 Rainbow Boulevard, Mail Stop 1018, Kansas City, KS 66160 7417, USA
    Biochem Pharmacol 68:1489-95. 2004

Collaborators

Detail Information

Publications22

  1. ncbi GABA(B) receptor alterations as indicators of physiological and pharmacological function
    S J Enna
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical School, 3901 Rainbow Boulevard, Mail Stop 1018, Kansas City, Kansas 66160 0227, USA
    Biochem Pharmacol 68:1541-8. 2004
    ..This, together with results from other types of studies, indicates the potential therapeutic value of developing drugs capable of selectively activating, inhibiting, or modulating GABA(B) receptor function...
  2. ncbi A legacy of discovery: from monoamines to GABA
    S J Enna
    Departments of Molecular and Integrative Physiology, and of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Neuropharmacology 60:1050-7. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  3. ncbi A GABA(B) mystery: the search for pharmacologically distinct GABA(B) receptors
    S J Enna
    Department of Pharmacology, Toxicology and Therapeutics, Kansas University School of Medicine, 3901 Rainbow Blvd, Kansas City, Kansas 66160, USA
    Mol Interv 1:208-18. 2001
    ..Accordingly, the therapeutic promise of GABA(B) receptor manipulation depends upon the identification of subtypes than can be specifically targeted...
  4. ncbi Challenges in the search for drugs to treat central nervous system disorders
    S J Enna
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Pharmacol Exp Ther 329:404-11. 2009
    ..Efforts must also be directed toward defining the sites of action of existing CNS drugs to aid in the design of second-generation agents with improved efficacy and safety...
  5. ncbi GABA(B) receptor function and subunit expression in the rat spinal cord as indicators of stress and the antinociceptive response to antidepressants
    Kenneth E McCarson
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Brain Res 1068:109-17. 2006
    ..The data also suggest that GABA(B) subunit gene expression may serve as a preclinical marker of antidepressant efficacy and of drug- or stress-induced modifications in central nervous system activity...
  6. ncbi Developmental regulation of GABA(B) receptor function in rat spinal cord
    J M Moran
    Department of Pharmacology, University of Kansas Medical Center, Kansas City 66160-7417, USA
    Life Sci 68:2287-95. 2001
    ..The results indicate that GABA(B) receptors may not be coupled to G-proteins in the adult rat spinal cord, or couple in a way that differs from that in newborns or adult cerebral cortex...
  7. ncbi Differential regulation of GABA B receptor subunit expression and function
    S A Sands
    Department of Pharmacology, Toxicology and Therapeutics, Kansas University School of Medicine, Kansas City, Kansas 66160 7424, USA
    J Pharmacol Exp Ther 305:191-6. 2003
    ..Moreover, these findings indicate that nongenomic mechanisms are primarily responsible for the GABA(B) receptor desensitization that occurs during prolonged exposure to receptor agonist...
  8. ncbi Relationship between the antinociceptive response to desipramine and changes in GABAB receptor function and subunit expression in the dorsal horn of the rat spinal cord
    Scott A Sands
    Department Pharmacology, Toxicology and Therapeutics, Kansas University School of Medicine, 3901 Rainbow Blvd, Mail Code 1018, Kansas City, KS 66160, USA
    Biochem Pharmacol 67:743-9. 2004
    ..These findings suggest the antinociceptive effect of desipramine is accompanied by a change in spinal cord GABAB receptor sensitivity that could be an important component in the analgesic response to this agent...
  9. ncbi Ontogeny of GABA(B) receptor subunit expression and function in the rat spinal cord
    Scott A Sands
    Department of Pharmacology, Toxicology, and Therapeutics, School of Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7147, USA
    Brain Res 972:197-206. 2003
    ....
  10. ncbi Effect of antidepressants on GABA(B) receptor function and subunit expression in rat hippocampus
    Scott A Sands
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical School, 3901 Rainbow Boulevard, Mail Stop 1018, Kansas City, KS 66160 7417, USA
    Biochem Pharmacol 68:1489-95. 2004
    ....
  11. ncbi CGP 56999A, a GABA(B) receptor antagonist, enhances expression of brain-derived neurotrophic factor and attenuates dopamine depletion in the rat corpus striatum following a 6-hydroxydopamine lesion of the nigrostriatal pathway
    S J Enna
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Neurosci Lett 406:102-6. 2006
    ..These findings suggest that GABA(B) receptor antagonists may be of value in the treatment of Parkinson's disease and other conditions that would benefit from an enhanced production of neurotrophic factors in brain...
  12. ncbi The role of GABA in the mediation and perception of pain
    S J Enna
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Adv Pharmacol 54:1-27. 2006
    ..Continued research in this area is warranted given the limited choices, and clinical difficulties, associated with conventional analgesics...
  13. ncbi Amitriptyline prevents thermal hyperalgesia and modifications in rat spinal cord GABA(B) receptor expression and function in an animal model of neuropathic pain
    Kenneth E McCarson
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Mail Stop 1018, Kansas City, KS 66160, USA
    Biochem Pharmacol 71:196-202. 2005
    ..These findings indicate that the efficacy of amitriptyline as a treatment for neuropathic pain may be related to an ability to maintain spinal cord GABA(B) receptor activity...
  14. ncbi Defining the role of pharmacology in the emerging world of translational research
    S J Enna
    Department of Molecular and Integrative Physiology, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA
    Adv Pharmacol 57:1-30. 2009
    ....
  15. ncbi Evidence for pharmacologically distinct GABAB receptors associated with cAMP production in rat brain
    M D Cunningham
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical School, Kansas City 66160 7417, USA
    Brain Res 720:220-4. 1996
    ..The results suggest at least two pharmacologically distinct subclasses of GABAB receptors regulate cAMP production in brain...
  16. ncbi Effects of stress and tranylcypromine on amphetamine-induced locomotor activity and GABA(B) receptor function in rat brain
    S A Sands
    Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Life Sci 72:1085-92. 2003
    ....
  17. ncbi GABA pharmacology: the search for analgesics
    Kenneth E McCarson
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Mail Stop 1018, Kansas City, KS, 66160, USA
    Neurochem Res 39:1948-63. 2014
    ..As subtype selective positive allosteric modulators may accomplish these goals, such compounds might represent a new class of analgesic drugs...
  18. pmc Characterization of GABA receptors
    S J Enna
    University of Kansas Medical Center, Kansas City, Kansas
    Curr Protoc Pharmacol 63:Unit 1.7.. 2013
    ..Excluded from the unit are ligand-binding assays for other components of the GABAA receptor complex, such as the benzodiazepine or ion-channel binding sites...
  19. ncbi Fifty years of Biochemical Pharmacology: the discipline and the journal
    S J Enna
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA
    Biochem Pharmacol 76:1-10. 2008
    ..Together with chemical, molecular, genetic, physiological, and clinical sciences, biochemical pharmacology will in the coming decades continue to be a critical component of the drug discovery process...
  20. ncbi Constitutive expression of functional GABA(B) receptors in mIL-tsA58 cells requires both GABA(B(1)) and GABA(B(2)) genes
    B M Chronwall
    School of Biological Sciences, University of Missouri Kansas City, Kansas City, Missouri 64110, USA
    J Neurochem 77:1237-47. 2001
    ..This is a physiologic validation of results from recombinant overexpression in naive cells and shows that the mIL cell line is a useful model for studying GABA(B) receptor expression, regulation and function...
  21. ncbi Binding of [3H]desglycinyl remacemide to rat brain membranes: association with the benzomorphan attachment site of the N-methyl-D-aspartic acid receptor channel
    M S Ahmed
    Schools of Pharmacy and Medicine, University of Missouri Kansas City, 2411 Holmes Street, Kansas City, MO, 64108, USA
    Brain Res 827:46-50. 1999
    ..In contrast, haloperidol, and other sigma receptor-active agents, were relatively inactive at this site. These data suggest that DGR interacts with a channel blocking site on the NMDA receptor...
  22. ncbi International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function
    N G Bowery
    Department of Pharmacology, Medical School, University of Birmingham, Edgbaston, United Kingdom
    Pharmacol Rev 54:247-64. 2002
    ..The advent of GABA(B1) knockout mice has also failed to provide support for multiple receptor types...