Perenlei Enkhbaatar

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. pmc Anticoagulant therapy in acute lung injury: a useful tool without proper operating instruction?
    Sebastian Rehberg
    Department of Anesthesiology, The University of Texas Medical Branch, 301 University Blvd, 77555 Galveston, TX, USA
    Crit Care 12:179. 2008
  2. pmc Arginine vasopressin in septic shock: supplement or substitute for norepinephrine?
    Sebastian Rehberg
    Investigational Intensive Care Unit, Department of Anesthesiology, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Crit Care 13:178. 2009
  3. pmc Inhibition of neuronal nitric oxide synthase in ovine model of acute lung injury
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 37:208-14. 2009
  4. ncbi request reprint Aerosolized anticoagulants ameliorate acute lung injury in sheep after exposure to burn and smoke inhalation
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 35:2805-10. 2007
  5. doi request reprint Role of neuronal nitric oxide synthase in ovine sepsis model
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Shock 32:253-7. 2009
  6. ncbi request reprint Novel ovine model of methicillin-resistant Staphylococcus aureus-induced pneumonia and sepsis
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, and Shriners Hospital for Children, Galveston, TX 77551, USA
    Shock 29:642-9. 2008
  7. doi request reprint Mechanistic aspects of inducible nitric oxide synthase-induced lung injury in burn trauma
    Perenlei Enkhbaatar
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA
    Burns 37:638-45. 2011
  8. ncbi request reprint Combined anticoagulants ameliorate acute lung injury in sheep after burn and smoke inhalation
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Clin Sci (Lond) 114:321-9. 2008
  9. doi request reprint Antithrombin attenuates vascular leakage via inhibiting neutrophil activation in acute lung injury
    Sebastian Rehberg
    1Investigational Intensive Care Unit, Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX 2Department of Anesthesiology, Intensive Care and Pain Medicine, University of Muenster, Muenster, Germany 3Department of Pathology, The University of Texas Medical Branch, Galveston, TX 4Shriners Hospital for Children, Galveston, TX
    Crit Care Med 41:e439-46. 2013
  10. pmc Pulmonary microvascular hyperpermeability and expression of vascular endothelial growth factor in smoke inhalation- and pneumonia-induced acute lung injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, Galveston, TX 77550, USA
    Burns 38:1072-8. 2012

Detail Information

Publications86

  1. pmc Anticoagulant therapy in acute lung injury: a useful tool without proper operating instruction?
    Sebastian Rehberg
    Department of Anesthesiology, The University of Texas Medical Branch, 301 University Blvd, 77555 Galveston, TX, USA
    Crit Care 12:179. 2008
    ..Anticoagulant therapy might be a useful tool in the treatment of ALI; however the proper operating instruction remains to be defined...
  2. pmc Arginine vasopressin in septic shock: supplement or substitute for norepinephrine?
    Sebastian Rehberg
    Investigational Intensive Care Unit, Department of Anesthesiology, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Crit Care 13:178. 2009
    ..In addition, future studies are warranted to evaluate whether a first-line therapy of AVP is superior to a last-resort administration...
  3. pmc Inhibition of neuronal nitric oxide synthase in ovine model of acute lung injury
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 37:208-14. 2009
    ..In this study, we have tested the hypothesis that inhibition of neuronal nitric oxide synthase could ameliorate the severity of acute lung injury using our well-established ovine model of cutaneous burn and smoke inhalation...
  4. ncbi request reprint Aerosolized anticoagulants ameliorate acute lung injury in sheep after exposure to burn and smoke inhalation
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 35:2805-10. 2007
    ....
  5. doi request reprint Role of neuronal nitric oxide synthase in ovine sepsis model
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Shock 32:253-7. 2009
    ..The above results suggest that the nNOS-derived NO may be involved in the pathophysiology of sepsis-related multiorgan dysfunction...
  6. ncbi request reprint Novel ovine model of methicillin-resistant Staphylococcus aureus-induced pneumonia and sepsis
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, and Shriners Hospital for Children, Galveston, TX 77551, USA
    Shock 29:642-9. 2008
    ..The smoke inhalation alone had a little or no effect on these variables. This model closely mimics hyperdynamic human sepsis. The excessive production of NO may be extensively involved in the pathogenic process...
  7. doi request reprint Mechanistic aspects of inducible nitric oxide synthase-induced lung injury in burn trauma
    Perenlei Enkhbaatar
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA
    Burns 37:638-45. 2011
    ....
  8. ncbi request reprint Combined anticoagulants ameliorate acute lung injury in sheep after burn and smoke inhalation
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Clin Sci (Lond) 114:321-9. 2008
    ..In conclusion, the results provide definitive evidence that anticoagulant therapy may be a novel and effective treatment tool in the management of burn patients with concomitant smoke inhalation injury...
  9. doi request reprint Antithrombin attenuates vascular leakage via inhibiting neutrophil activation in acute lung injury
    Sebastian Rehberg
    1Investigational Intensive Care Unit, Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX 2Department of Anesthesiology, Intensive Care and Pain Medicine, University of Muenster, Muenster, Germany 3Department of Pathology, The University of Texas Medical Branch, Galveston, TX 4Shriners Hospital for Children, Galveston, TX
    Crit Care Med 41:e439-46. 2013
    ..To test the hypothesis that restoration of antithrombin plasma concentrations attenuates vascular leakage by inhibiting neutrophil activation through syndecan-4 receptor inhibition in an established ovine model of acute lung injury...
  10. pmc Pulmonary microvascular hyperpermeability and expression of vascular endothelial growth factor in smoke inhalation- and pneumonia-induced acute lung injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, Galveston, TX 77550, USA
    Burns 38:1072-8. 2012
    ..The current study was designed further evaluate the mechanism of pulmonary vascular hyperpermeability in sheep with these injuries...
  11. ncbi request reprint Recombinant human activated protein C improves pulmonary function in ovine acute lung injury resulting from smoke inhalation and sepsis
    Marc O Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, and Shriners Burn Hospital for Children, Galveston, USA
    Crit Care Med 34:2432-8. 2006
    ..To investigate the effects of recombinant human activated protein C (rhAPC) on pulmonary function in acute lung injury (ALI) resulting from smoke inhalation in association with a bacterial challenge...
  12. ncbi request reprint Ceftazidime improves hemodynamics and oxygenation in ovine smoke inhalation injury and septic shock
    Marc O Maybauer
    Investigational Intensive Care Unit, University of Texas Medical Branch and Shriners Burns Hospital, 301 University Blvd, Galveston, TX 77555 0833, USA
    Intensive Care Med 33:1219-27. 2007
    ..To investigate ceftazidime in acute lung injury (ALI) and sepsis...
  13. ncbi request reprint Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis
    Kazunori Murakami
    Department of Anesthesiology, The University of Texas Medical Branch and Shriners Burns Hospital, Galveston, Texas, 77555, USA
    Shock 21:126-33. 2004
    ..In conclusion, inhibition of PARP improved the ALI after smoke inhalation and pneumonia. The results suggest that the activation of PARP plays a role in the pathophysiology of ALI in sheep...
  14. doi request reprint Cardiopulmonary effects of low-dose arginine vasopressin in ovine acute lung injury
    Martin Westphal
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 39:357-63. 2011
    ..To elucidate the effects of low-dose arginine vasopressin on cardiopulmonary functions and nitrosative stress using an established model of acute lung injury...
  15. pmc Molecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injury
    Fiona D Saunders
    Investigational Intensive Care Unit, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Am J Physiol Lung Cell Mol Physiol 298:L427-36. 2010
    ....
  16. pmc Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity
    Dirk M Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children at Galveston, 301 University Blvd, Galveston, TX 77555 0833, USA
    Biochem Biophys Res Commun 377:786-91. 2008
    ..These findings suggest that ONOO(-) plays a pivotal role in the pathology of IL-2-induced pulmonary VLS, and that WW-85 may become a useful treatment option...
  17. pmc Beneficial pulmonary effects of a metalloporphyrinic peroxynitrite decomposition catalyst in burn and smoke inhalation injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The Univ of Texas Medical Branch, Shriners Hospitals for Children, Galveston, 77550, USA
    Am J Physiol Lung Cell Mol Physiol 300:L167-75. 2011
    ..Administration of an ONOO(-) decomposition catalyst may represent a potential treatment option for this injury...
  18. ncbi request reprint Gentamicin improves hemodynamics in ovine septic shock after smoke inhalation injury
    Marc O Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, Texas 77555 0833, USA
    Shock 24:226-31. 2005
    ....
  19. doi request reprint Assessment of combined muscarinic antagonist and fibrinolytic therapy for inhalation injury
    Collette Jonkam
    Shriners Hospitals for Children and Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, USA
    J Burn Care Res 33:524-31. 2012
    ..There was no additive benefit to the inclusion of nebulized TPA with TIO...
  20. doi request reprint Time profile of oxidative stress and neutrophil activation in ovine acute lung injury and sepsis
    Matthias Lange
    Investigational Intensive Care Unit, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Shock 37:468-72. 2012
    ....
  21. ncbi request reprint Vitamin E attenuates acute lung injury in sheep with burn and smoke inhalation injury
    Naoki Morita
    The University of Texas Medical Branch, Department of Anaesthesiology and Shriners Burns Hospital for Children, Galveston, Texas, USA
    Redox Rep 11:61-70. 2006
    ..We hypothesized that vitamin E supplementation (alpha-tocopherol) would attenuate acute lung injury induced by burn and smoke inhalation injury...
  22. pmc Role of calcitonin gene-related peptide (CGRP) in ovine burn and smoke inhalation injury
    Matthias Lange
    Investigational Intensive Care Unit, Dept of Anesthesiology, The Univ of Texas Medical Branch, 301 Univ Blvd, Galveston, TX 77550, USA
    J Appl Physiol (1985) 107:176-84. 2009
    ..Future studies will be needed to clarify the potential therapeutic benefit for patients with this injury...
  23. doi request reprint Muscarinic receptor antagonist therapy improves acute pulmonary dysfunction after smoke inhalation injury in sheep
    Collette Jonkam
    Shriners Hospitals for Children and The University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 38:2339-44. 2010
    ....
  24. ncbi request reprint L-arginine attenuates acute lung injury after smoke inhalation and burn injury in sheep
    Kazunori Murakami
    Department of Anesthesiology, University of Texas Medical Branch, TX 77555 0833, USA
    Shock 28:477-83. 2007
    ..Therefore, L-Arg supplementation improved gas exchange and pulmonary function in ovine after B + S injury via its, at least in part, effect on reduction of oxidative stress through the peroxynitrite pathway...
  25. pmc Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis model
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, 301 University Boulevard, Galveston, Texas 77550, USA
    Crit Care 14:R129. 2010
    ..However, the time changes of these pathogenic factors are largely undetermined...
  26. pmc Pulmonary expression of nitric oxide synthase isoforms in sheep with smoke inhalation and burn injury
    Robert A Cox
    Department of Pathology, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Exp Lung Res 35:104-18. 2009
    ..In the parenchyma, a slight increase in iNOS immunostaining was seen in type I cells at 12 and 24 hours after injury only. Virtually no change in eNOS or nNOS was seen after injury...
  27. ncbi request reprint The inducible nitric oxide synthase inhibitor BBS-2 prevents acute lung injury in sheep after burn and smoke inhalation injury
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, 610 Texas Ave, Galveston, TX 77555, USA
    Am J Respir Crit Care Med 167:1021-6. 2003
    ..The results provide definitive evidence that iNOS is a key mediator of pulmonary pathology in sheep with ARDS resulting from combined burn and smoke inhalation injury...
  28. pmc Beneficial effects of concomitant neuronal and inducible nitric oxide synthase inhibition in ovine burn and inhalation injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, and Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Shock 35:626-31. 2011
    ..This novel treatment strategy may represent a useful therapeutic adjunct for patients with these injuries...
  29. ncbi request reprint Combined burn and smoke inhalation injury impairs ovine hypoxic pulmonary vasoconstriction
    Martin Westphal
    Investigational Intensive Care Unit, Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 34:1428-36. 2006
    ..To examine the effects of combined burn and smoke inhalation injury on hypoxic pulmonary vasoconstriction, 3-nitrotyrosine formation, and respiratory function in adult sheep...
  30. doi request reprint Cardiovascular collapse and vascular permeability changes in an ovine model of methicillin-resistant Staphylococcus aureus sepsis
    Collette C Jonkam
    Department of Anesthesiology, The University of Texas Medical Branch and Shriners Hospital for Children, Galveston, Texas, USA
    Shock 32:621-5. 2009
    ..These results evidence that excessive production of reactive radicals and VEGF may play a major role in cardiovascular collapse and vascular hyperpermeability in MRSA sepsis...
  31. pmc Selective V(1a) agonism attenuates vascular dysfunction and fluid accumulation in ovine severe sepsis
    Sebastian Rehberg
    Investigational Intensive Care Unit, Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA
    Am J Physiol Heart Circ Physiol 303:H1245-54. 2012
    ..Highly selective V(1a)-agonism appears to be superior to unselective vasopressin analogs for the treatment of sepsis-induced vascular dysfunction...
  32. pmc Development of a long-term ovine model of cutaneous burn and smoke inhalation injury and the effects of early excision and skin autografting
    Yusuke Yamamoto
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, Shriners Burns Hospital for Children, 601 Harborside Drive, Galveston, TX 77555 1102, USA
    Burns 38:908-16. 2012
    ....
  33. ncbi request reprint Aerosolized alpha-tocopherol ameliorates acute lung injury following combined burn and smoke inhalation injury in sheep
    Naoki Morita
    Department of Anaesthesiology, The University of Texas Medical Branch, Galveston, Texas 77555 0833, USA
    Shock 25:277-82. 2006
    ..Vitamin E nebulization therapy improved the clinical responses to burn and smoke inhalation-induced acute lung injury...
  34. ncbi request reprint The inhibition of inducible nitric oxide synthase in ovine sepsis model
    Perenlei Enkhbaatar
    Department of Anesthesiology, Pathology, Pediatrics and Surgery, University Texas Medical Branch, Galveston, TX 77555, USA
    Shock 25:522-7. 2006
    ..The results of present study show that iNOS may be partially involved in the pathogenesis of acute lung injury induced by smoke inhalation followed by bacterial instillation in the airway...
  35. pmc gamma-Tocopherol nebulization by a lipid aerosolization device improves pulmonary function in sheep with burn and smoke inhalation injury
    Atsumori Hamahata
    University of Texas Medical Branch, Galveston, TX 77555, USA
    Free Radic Biol Med 45:425-33. 2008
    ..Pulmonary gT delivery along with a FO source may be a novel effective treatment strategy in management of patients with acute lung injury...
  36. ncbi request reprint Ketorolac attenuates cardiopulmonary derangements in sheep with combined burn and smoke inhalation injury
    Perenlei Enkhbaatar
    Department of Anesthesiology, University Texas Medical Branch and Shriners Hospital for Children Burn Unit, Galveston, TX 77555 0833, USA
    Clin Sci (Lond) 105:621-8. 2003
    ..These results suggest that ketorolac may ameliorate cardiopulmonary morbidity, at least in part, by inhibiting excessive NO...
  37. doi request reprint Assessment of vascular permeability in an ovine model of acute lung injury and pneumonia-induced Pseudomonas aeruginosa sepsis
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX, USA
    Crit Care Med 36:1284-9. 2008
    ..To assess the time changes and mechanism of pulmonary and peripheral vascular permeability in sheep with acute lung injury and sepsis...
  38. pmc γ-tocopherol nebulization decreases oxidative stress, arginase activity, and collagen deposition after burn and smoke inhalation in the ovine model
    Yusuke Yamamoto
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Shock 38:671-6. 2012
    ....
  39. doi request reprint Pulmonary changes in a mouse model of combined burn and smoke inhalation-induced injury
    Akio Mizutani
    Investigative Intensive Care Unit, Department of Anesthesiology, University of Texas Medical Branch and Shriners Hospital for Children, 610 Texas Ave, Galveston, TX 77555 0833, USA
    J Appl Physiol (1985) 105:678-84. 2008
    ..The murine model of burn and smoke inhalation injury allows us to better understand pathophysiological mechanisms underlying cardiopulmonary morbidity secondary to burn and smoke inhalation injury...
  40. ncbi request reprint Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep
    Katsumi Shimoda
    Department of Anesthesiology, The University of Texas Medical Branch, Shriners Burns Hospital, Galveston, Texas 77555 0833, USA
    Am J Physiol Lung Cell Mol Physiol 285:L240-9. 2003
    ..We conclude that PARS inhibition attenuates various aspects of the pathophysiological response in a clinically relevant experimental model of burn/smoke inhalation injury...
  41. ncbi request reprint High-dose heparin fails to improve acute lung injury following smoke inhalation in sheep
    Kazunori Murakami
    Department of Anesthesiology, The University of Texas Medical Branch and Shriners Burns Hospital, Galveston, TX 77555, U S A
    Clin Sci (Lond) 104:349-56. 2003
    ..There was a decrease in the arterial partial pressure of O(2). In conclusion, high-dose heparin did not prevent lung dysfunction in this model, in which acute lung injury was induced by combined smoke and septic challenge...
  42. doi request reprint Effects of early neuronal and delayed inducible nitric oxide synthase blockade on cardiovascular, renal, and hepatic function in ovine sepsis
    Matthias Lange
    Department of Anesthesiology, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas, USA
    Anesthesiology 113:1376-84. 2010
    ..We hypothesized that early neuronal and delayed inducible nitric oxide synthase blockade attenuates multiple organ dysfunctions during sepsis...
  43. doi request reprint Role of different nitric oxide synthase isoforms in a murine model of acute lung injury and sepsis
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX 77550, USA
    Biochem Biophys Res Commun 399:286-91. 2010
    ..Future studies should investigate the effects of specific pharmacological inhibition of nNOS and iNOS at different time points during the disease process...
  44. pmc Combined neuronal and inducible nitric oxide synthase inhibition in ovine acute lung injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX, USA
    Crit Care Med 37:223-9. 2009
    ....
  45. pmc Impact of bronchial circulation on bronchial exudates following combined burn and smoke inhalation injury in sheep
    Naoki Morita
    Department of Anesthesiology, The University of Texas Medical Branch and Shriners Hospital for Children, Galveston, TX 77555, USA
    Burns 37:465-73. 2011
    ..We hypothesized reduction of bronchial blood flow reduces exudation to the airway and ameliorates lung injury from combined burn and smoke insults (B&S injury)...
  46. doi request reprint Predictive role of arterial carboxyhemoglobin concentrations in ovine burn and smoke inhalation-induced lung injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, Texas 77550, USA
    Exp Lung Res 37:239-45. 2011
    ..Arterial carboxyhemoglobin in sheep with combined burn and inhalation injury are correlated with the degree of pulmonary failure and edema formation, but not with certain histological alterations including airway obstruction scores...
  47. doi request reprint Multiple versus single injections of fluorescent microspheres for the determination of regional organ blood flow in septic sheep
    Matthias Lange
    Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, Texas 77555, USA
    Lab Anim 47:203-9. 2013
    ..015). In conclusion, the results indicate that multiple versus single microsphere injections induced no or negligible alterations during ovine sepsis. This finding may help reduce the quantity of animals needed in future experiments...
  48. doi request reprint Time course of early histopathological lung changes in an ovine model of acute lung injury and pulmonary infection
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, Texas 77555, USA
    Exp Lung Res 39:201-6. 2013
    ....
  49. ncbi request reprint Inducible nitric oxide synthase dimerization inhibitor prevents cardiovascular and renal morbidity in sheep with combined burn and smoke inhalation injury
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, 610 Texas Ave, Galveston, TX 77555, USA
    Am J Physiol Heart Circ Physiol 285:H2430-6. 2003
    ..The results identify a major role for iNOS in mediating extrapulmonary comorbidity in a clinically relevant and severe trauma model and support the use of highly selective iNOS inhibitors as novel treatments in critical care medicine...
  50. ncbi request reprint Effect of inhaled nitric oxide on pulmonary vascular hyperpermeability in sheep following smoke inhalation
    Perenlei Enkhbaatar
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch at Galveston, 610 Texas Avenue, Galveston, TX 77555 0833, USA
    Burns 31:1013-9. 2005
    ..Nitric oxide inhalation ameliorated the above-mentioned pathological changes. The results suggest that nitric oxide inhalation has potential for beneficial effect in the treatment of patients suffering from smoke inhalation...
  51. doi request reprint A murine model of sepsis following smoke inhalation injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX 77550, USA
    Biochem Biophys Res Commun 391:1555-60. 2010
    ..In conclusion, bacterial pneumonia is predominantly responsible for mortality and morbidity in this novel murine model of smoke inhalation and pulmonary sepsis. Reactive oxygen and nitrogen species mediate the severity of lung injury...
  52. doi request reprint Activated nuclear factor kappa B and airway inflammation after smoke inhalation and burn injury in sheep
    Robert A Cox
    Department of Pathology, University of Texas Medical Branch, Galvetston, Texas, USA
    J Burn Care Res 30:489-98. 2009
    ....
  53. pmc Preclinical evaluation of epinephrine nebulization to reduce airway hyperemia and improve oxygenation after smoke inhalation injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX, USA
    Crit Care Med 39:718-24. 2011
    ....
  54. doi request reprint Advantages and pitfalls of combining intravenous antithrombin with nebulized heparin and tissue plasminogen activator in acute respiratory distress syndrome
    Sebastian Rehberg
    From the Investigational Intensive Care Unit S R, Y Y, L E S, C J, D S P, P E, Department of Anesthesiology, and Department of Pathology R A C, The University of Texas Medical Branch and Shriners Hospital for Children R A C, P E, Galveston, Texas and Department of Anesthesiology, Intensive Care and Pain Medicine S R, University of Muenster, Muenster, Germany
    J Trauma Acute Care Surg 76:126-33. 2014
    ..Therefore, the present prospective, randomized experiment was conducted using an established ovine model...
  55. ncbi request reprint Aerosolized tissue plasminogen inhibitor improves pulmonary function in sheep with burn and smoke inhalation
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Shock 22:70-5. 2004
    ..The results provide evidence that clearance of airway obstructive cast material is crucial in managing acute respiratory distress syndrome resulting from combined burn and smoke inhalation injury...
  56. doi request reprint Direct delivery of low-dose 7-nitroindazole into the bronchial artery attenuates pulmonary pathophysiology after smoke inhalation and burn injury in an ovine model
    Atsumori Hamahata
    Department of Plastic and Reconstructive Surgery, Tokyo Woman s Medical University, Tokyo, Japan
    Shock 36:575-9. 2011
    ..Our data strongly suggest that local airway production of NO contributes to pulmonary dysfunction following smoke inhalation and burn injury. Most mechanisms that drive this pathophysiology reside in the airway...
  57. pmc Pseudomonas aeruginosa is associated with increased lung cytokines and asymmetric dimethylarginine compared with methicillin-resistant Staphylococcus aureus
    Linda E Sousse
    Department of Anesthesiology, University of Texas Medical Branch, 610 Harborside Drive, Galveston, TX 77555, USA
    Shock 36:466-70. 2011
    ..aeruginosa sepsis. The lack of arginase activity may explain the greater nitric oxide production in MRSA sepsis...
  58. ncbi request reprint Effects of manganese superoxide dismutase nebulization on pulmonary function in an ovine model of acute lung injury
    Marc O Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Shock 23:138-43. 2005
    ..Although Mn-SOD nebulization attenuated the loss of protein, it failed to improve lung edema and pulmonary gas exchange, thereby limiting its clinical use...
  59. ncbi request reprint The role of nitric oxide and reactive nitrogen species in experimental ARDS
    Sebastian Rehberg
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555 0833, USA
    Front Biosci (Schol Ed) 2:18-29. 2010
    ..In addition, current large animal models of ARDS are described and future therapeutic approaches are discussed...
  60. ncbi request reprint Acute bronchial obstruction in sheep: histopathology and gland cytokine expression
    Robert A Cox
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Exp Lung Res 31:819-37. 2005
    ..05...
  61. pmc Beneficial effect of a hydrogen sulphide donor (sodium sulphide) in an ovine model of burn- and smoke-induced acute lung injury
    Aimalohi Esechie
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, 77550, USA
    Br J Pharmacol 158:1442-53. 2009
    ..The present study investigated whether the pathophysiological changes induced by burn and smoke inhalation are modulated by parenteral administration of Na(2)S, a H(2)S donor...
  62. ncbi request reprint Pyridoxalated haemoglobin polyoxyethylene conjugate, a nitric oxide scavenger, decreases dose-limiting hypotension associated with interleukin-2 (IL-2) therapy
    Kazunori Murakami
    Department of Anesthesiology, University of Texas Medical Branch and Shriners Hospital for Children, Galveston, TX 77555, USA
    Clin Sci (Lond) 105:629-35. 2003
    ..Scavenging NO by PHP prevented the hyperdynamic reaction induced by IL-2 administration in sheep. This activity of PHP may prevent the early discontinuation of IL-2 therapy that results because of these adverse events...
  63. pmc Nebulization with γ-tocopherol ameliorates acute lung injury after burn and smoke inhalation in the ovine model
    Yusuke Yamamoto
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Shock 37:408-14. 2012
    ..Delivery of g-T into the lungs may be a safe, novel, and efficient approach for management of acute lung injury patients who have sustained oxidative damage to the airway...
  64. ncbi request reprint Effects of the bradykinin B2 receptor antagonist icatibant on microvascular permeability after thermal injury in sheep
    Collette C Jonkam
    Department of Anesthesiology, University of Texas Medical Branch and Shriners Hospital for Children, 610 Texas Avenue, Galveston, TX 77551, USA
    Shock 28:704-9. 2007
    ....
  65. ncbi request reprint Inhibition of neuronal nitric oxide synthase by 7-nitroindazole attenuates acute lung injury in an ovine model
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555 0833, USA
    Am J Physiol Regul Integr Comp Physiol 285:R366-72. 2003
    ..The results of the present study show that nNOS may be involved in the pathogenesis of ALI after smoke inhalation injury followed by bacterial instillation in the airway...
  66. ncbi request reprint Skin nitric oxide and its metabolites are increased in nonburned skin after thermal injuries
    Gisele V Oliveira
    Department of Surgery, Shriners Hospital for Children, Galveston, Texas 77555, USA
    Shock 22:278-82. 2004
    ..The increase of NO and its metabolites after burn in noninjured skin is followed by a significant increase in peroxynitrite, a potent cytotoxic mediator...
  67. doi request reprint Time course of the inflammatory and oxidative stress response to pulmonary infection in mice
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Exp Lung Res 38:157-63. 2012
    ..In addition, the identification of the time changes of the described pathogenetic factors may enhance the timing of innovate therapeutic approaches in future experiments...
  68. pmc The Angiotensin-converting enzyme inhibitor captopril inhibits poly(adp-ribose) polymerase activation and exerts beneficial effects in an ovine model of burn and smoke injury
    Sven Asmussen
    Departments of Anesthesiology, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555, USA
    Shock 36:402-9. 2011
    ..Angiotensin-converting enzyme inhibition may also exert additional beneficial effects by inhibiting the expression of the profibrotic mediator transforming growth factor β...
  69. pmc Pulmonary vascular permeability changes in an ovine model of methicillin-resistant Staphylococcus aureus sepsis
    Collette C Jonkam
    Department of Anesthesiology, The University of Texas Medical Branch and Shriners Hospital for Children, Galveston, TX 77555 1102, USA
    Crit Care 13:R19. 2009
    ..We tested the hypothesis that methicillin-resistant Staphylococcus aureus (MRSA) sepsis following smoke inhalation increases pulmonary transvascular fluid flux via excessive nitric oxide (NO) production...
  70. ncbi request reprint Acute effects of combined burn and smoke inhalation injury on carboxyhemoglobin formation, tissue oxygenation, and cardiac performance
    Martin Westphal
    Investigational Intensive Care Unit, Department of Anesthesiology, University of Texas Medical Branch, and Shriners Burns Hospital for Children, Galveston, TX, USA
    Biochem Biophys Res Commun 317:945-9. 2004
    ....
  71. doi request reprint Specific inhibition of nitric oxide synthases at different time points in a murine model of pulmonary sepsis
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX 77550, USA
    Biochem Biophys Res Commun 404:877-81. 2011
    ..Future investigations should identify the time changes of the expression and activation of NOS isoforms...
  72. pmc A novel antibiotic based long-term model of ovine smoke inhalation injury and septic shock
    Yoshimitsu Nakano
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, Shriners Burns Hospital for Children, 601 Harborside Drive, Galveston, TX 77555 1102, USA
    Burns 36:1050-8. 2010
    ..80.5 h in AB6h, and 65 h in AB12h animals. Combined ciprofloxacin and piperacillin therapy was effective, reduced nitric oxide production and mortality, and will allow future long-term studies in this model...
  73. pmc Acute lung injury-induced collagen deposition is associated with elevated asymmetric dimethylarginine and arginase activity
    Linda E Sousse
    Departments of Anesthesiology and Pathology, University of Texas Medical Branch, Galveston, TX 77555 0833, USA
    Shock 35:282-8. 2011
    ..These data support that excess lung collagen deposition and reduced pulmonary function in acute lung injury after burn and inhalation injury are mediated through the arginase pathway...
  74. ncbi request reprint P-selectin blockade fails to improve acute lung injury in sheep
    Abhijit Chandra
    Department of Anesthesiology, The University of Texas Medical Branch and Shriners Burns Hospital, Galveston, TX 77555, USA
    Clin Sci (Lond) 104:313-21. 2003
    ..In conclusion, although the anti-(P-selectin) antibody did not protect against lung injury during the initial 48 h of burn and smoke, it decreased some aspects of injury in the peripheral microcirculation...
  75. ncbi request reprint Role of nitric oxide in shock: the large animal perspective
    Matthias Lange
    Investigational Intensive Care Unit, University of Texas Medical Branch, 610 Texas Avenue, Galveston, Texas 77550, USA
    Front Biosci (Landmark Ed) 14:1979-89. 2009
    ..Further investigation in large animal models is warranted to clarify the time course of increased expression and/or activity of different NOS isoenzymes and the effects of specific inhibition of the NOS isoforms at different time points...
  76. ncbi request reprint Carboxyhemoglobin formation following smoke inhalation injury in sheep is interrelated with pulmonary shunt fraction
    Martin Westphal
    Department of Investigational Intensive Care Unit and Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX, USA
    Biochem Biophys Res Commun 311:754-8. 2003
    ..96 and -0.93). Although the arteriovenous COHb gradient successively decreased over time, COHb determined in venous blood underestimated the arterial content...
  77. ncbi request reprint Upper airway mucus deposition in lung tissue of burn trauma victims
    Robert A Cox
    Shriners Hospital for Children and the University of Texas Medical Branch, Galveston, Texas 77550, USA
    Shock 29:356-61. 2008
    ..Increased mucus synthesis and/or impaired mucociliary function may contribute to the pulmonary pathophysiology associated with burn injury...
  78. ncbi request reprint Pathophysiology of acute lung injury in combined burn and smoke inhalation injury
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, 610 Texas Ave, Galveston, TX 77555, USA
    Clin Sci (Lond) 107:137-43. 2004
    ..In the present review, we will describe the pathophysiological aspects of acute lung injury induced by combined burn and smoke inhalation and examine various therapeutic approaches...
  79. ncbi request reprint Cardiovascular distribution of the calcium sensing receptor before and after burns
    Gordon L Klein
    Department of Pediatrics, University of Texas Medical Branch Galveston, Galveston, TX, United States
    Burns 34:370-5. 2008
    ..We suggest that CaR has a local, tissue-specific role, and functions in vascular calcium sensing for intravascular calcium deposition or regulation of other calcium channels after trauma or burn...
  80. doi request reprint Neuronal nitric oxide synthase inhibition attenuates cardiopulmonary dysfunctions after combined burn and smoke inhalation injury in sheep
    Martin Westphal
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Crit Care Med 36:1196-204. 2008
    ..Therefore, we aimed to examine the effects of selective neuronal NOS inhibition on cardiopulmonary functions and cellular injury in sheep with acute respiratory distress syndrome secondary to combined burn and smoke inhalation injury...
  81. ncbi request reprint Effects of severe smoke inhalation injury and septic shock on global hemodynamics and microvascular blood flow in sheep
    Dirk M Maybauer
    Departments of Anesthesiology and Surgery, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, Texas, U S A
    Shock 26:489-95. 2006
    ..aeruginosa infusion. The results of this study reflect the complex pathophysiological variances of the combined injury and may provide a basis for future investigations for the treatment of this kind of injury...
  82. ncbi request reprint Continuous nebulized albuterol attenuates acute lung injury in an ovine model of combined burn and smoke inhalation
    Tina L Palmieri
    Shriners Hospitals for Children Northern California and University of California Davis, Sacramento, CA, USA
    Crit Care Med 34:1719-24. 2006
    ..We hypothesized that albuterol administered via continuous nebulization would mitigate acute lung injury after smoke inhalation injury and burn...
  83. ncbi request reprint Protective role of myocardial heat shock protein 70 in burn trauma: another brick in the wall?
    Martin Westphal
    Crit Care Med 32:1425-6. 2004
  84. ncbi request reprint Interleukin-1 in thermal injury: what is next?
    Perenlei Enkhbaatar
    Crit Care Med 35:1212-3. 2007
  85. ncbi request reprint Sepsis: emerging role of nitric oxide and selectins
    Abhijit Chandra
    Department of Surgery, King George Medical University Lucknow, India
    Clinics (Sao Paulo) 61:71-6. 2006
    ..This review briefly describes the role of selectins and nitric oxide in experimental and clinical sepsis as well as the therapeutic outcomes of blocking therapies...
  86. ncbi request reprint Whole-body hypothermia: another option in smoke inhalation management?
    Perenlei Enkhbaatar
    Crit Care Med 34:1280-1. 2006