PAMELA ENGLAND

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Rapid photoinactivation of native AMPA receptors on live cells using ANQX
    Pamela M England
    Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, USA
    Sci STKE 2006:pl1. 2006
  2. ncbi request reprint A subtype-selective, use-dependent inhibitor of native AMPA receptors
    Aaron Nilsen
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158 2517, USA
    J Am Chem Soc 129:4902-3. 2007
  3. ncbi request reprint Unnatural amino acid mutagenesis: a precise tool for probing protein structure and function
    Pamela M England
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 2280, USA
    Biochemistry 43:11623-9. 2004
  4. doi request reprint Bridging the gaps between synapses, circuits, and behavior
    Pamela M England
    Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA
    Chem Biol 17:607-15. 2010
  5. ncbi request reprint Photochemically knocking out glutamate receptors in vivo
    James J Chambers
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 2280, USA
    J Am Chem Soc 126:13886-7. 2004
  6. ncbi request reprint Photoinactivation of native AMPA receptors reveals their real-time trafficking
    Hillel Adesnik
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Neuron 48:977-85. 2005
  7. pmc 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor
    Leslie A Cruz
    Graduate Program in Chemistry and Chemical Biology, University of California San Francisco, San Francisco, California 94158 2517, USA
    J Med Chem 51:5856-60. 2008
  8. pmc Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area
    Emanuela Argilli
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:9092-100. 2008
  9. doi request reprint AMPA receptors and synaptic plasticity: a chemist's perspective
    James J Fleming
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California, USA
    Nat Chem Biol 6:89-97. 2010
  10. doi request reprint Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands
    James J Fleming
    Department of Pharmaceutical Chemistry and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
    Bioorg Med Chem 18:1381-7. 2010

Research Grants

  1. Chemical Basis for Potassium Channel Modulation
    PAMELA ENGLAND; Fiscal Year: 2006

Collaborators

  • Roger A Nicoll
  • Robert Malenka
  • Irwin Kuntz
  • Antonello Bonci
  • James J Fleming
  • Leslie A Cruz
  • Emanuela Argilli
  • Aaron Nilsen
  • Hillel Adesnik
  • Xi Chen
  • James J Chambers
  • David R Sibley
  • Eva Estebanez-Perpina
  • Sabine Borngraeber
  • Ning Bao
  • Sam Pfaff
  • Justin Blethrow
  • Robert J Fletterick
  • Katherine W Scangos
  • Narendrakumar Ramanan
  • Kevan M Shokat
  • Rejji Kuruvilla
  • David D Ginty
  • Haihong Ye
  • Nicolas M Johnson
  • Chao Zhang
  • Hiroaki Gouda
  • David M Young

Detail Information

Publications11

  1. ncbi request reprint Rapid photoinactivation of native AMPA receptors on live cells using ANQX
    Pamela M England
    Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, USA
    Sci STKE 2006:pl1. 2006
    ..Combined with a functional AMPA receptor assay, such as continuous recording of AMPA receptor-mediated ionic currents, ANQX provides a means of directly monitoring native AMPA receptor trafficking in real time...
  2. ncbi request reprint A subtype-selective, use-dependent inhibitor of native AMPA receptors
    Aaron Nilsen
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158 2517, USA
    J Am Chem Soc 129:4902-3. 2007
  3. ncbi request reprint Unnatural amino acid mutagenesis: a precise tool for probing protein structure and function
    Pamela M England
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 2280, USA
    Biochemistry 43:11623-9. 2004
    ..The future will likely see many more investigators utilizing this approach to manipulate proteins as it realizes its promise of becoming a tool with enormous potential...
  4. doi request reprint Bridging the gaps between synapses, circuits, and behavior
    Pamela M England
    Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA
    Chem Biol 17:607-15. 2010
    ..These technologies and the design principles underlying them are reviewed herein...
  5. ncbi request reprint Photochemically knocking out glutamate receptors in vivo
    James J Chambers
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 2280, USA
    J Am Chem Soc 126:13886-7. 2004
    ..ANQX provides a means of directly evaluating the trafficking of native AMPA receptors with unparalleled spatiotemporal resolution...
  6. ncbi request reprint Photoinactivation of native AMPA receptors reveals their real-time trafficking
    Hillel Adesnik
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Neuron 48:977-85. 2005
    ....
  7. pmc 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor
    Leslie A Cruz
    Graduate Program in Chemistry and Chemical Biology, University of California San Francisco, San Francisco, California 94158 2517, USA
    J Med Chem 51:5856-60. 2008
    ..Upon photostimulation, ANQX reacts intramolecularly to form FQX or intermolecularly to form a covalent adduct with Glu705...
  8. pmc Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area
    Emanuela Argilli
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:9092-100. 2008
    ....
  9. doi request reprint AMPA receptors and synaptic plasticity: a chemist's perspective
    James J Fleming
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California, USA
    Nat Chem Biol 6:89-97. 2010
    ..Here we review these chemical tools and their application to unraveling the molecular basis of synaptic plasticity...
  10. doi request reprint Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands
    James J Fleming
    Department of Pharmaceutical Chemistry and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
    Bioorg Med Chem 18:1381-7. 2010
    ..Here we provide a perspective on opportunities for developing a complete pharmacology for AMPA receptors...
  11. ncbi request reprint A chemical-genetic approach to studying neurotrophin signaling
    Xi Chen
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 46:13-21. 2005
    ..Thus, Trk knockin mice provide valuable tools for selective, rapid, and reversible inhibition of neurotrophin signaling in vitro and in vivo...

Research Grants4

  1. Chemical Basis for Potassium Channel Modulation
    PAMELA ENGLAND; Fiscal Year: 2006
    ..To determine the site(s) in HERG that interact with other proteins, photoreactive amino acids capable of forming protein cross-links will be site-specifically incorporated into the HERG. ..