PAMELA ENGLAND

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Rapid photoinactivation of native AMPA receptors on live cells using ANQX
    Pamela M England
    Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, USA
    Sci STKE 2006:pl1. 2006
  2. ncbi request reprint A subtype-selective, use-dependent inhibitor of native AMPA receptors
    Aaron Nilsen
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158 2517, USA
    J Am Chem Soc 129:4902-3. 2007
  3. ncbi request reprint Unnatural amino acid mutagenesis: a precise tool for probing protein structure and function
    Pamela M England
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 2280, USA
    Biochemistry 43:11623-9. 2004
  4. doi request reprint Bridging the gaps between synapses, circuits, and behavior
    Pamela M England
    Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA
    Chem Biol 17:607-15. 2010
  5. ncbi request reprint Photochemically knocking out glutamate receptors in vivo
    James J Chambers
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 2280, USA
    J Am Chem Soc 126:13886-7. 2004
  6. ncbi request reprint Photoinactivation of native AMPA receptors reveals their real-time trafficking
    Hillel Adesnik
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Neuron 48:977-85. 2005
  7. pmc 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor
    Leslie A Cruz
    Graduate Program in Chemistry and Chemical Biology, University of California San Francisco, San Francisco, California 94158 2517, USA
    J Med Chem 51:5856-60. 2008
  8. pmc Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area
    Emanuela Argilli
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:9092-100. 2008
  9. doi request reprint AMPA receptors and synaptic plasticity: a chemist's perspective
    James J Fleming
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California, USA
    Nat Chem Biol 6:89-97. 2010
  10. doi request reprint Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands
    James J Fleming
    Department of Pharmaceutical Chemistry and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
    Bioorg Med Chem 18:1381-7. 2010

Collaborators

  • Roger A Nicoll
  • Robert Malenka
  • Irwin Kuntz
  • Antonello Bonci
  • James J Fleming
  • Emanuela Argilli
  • Leslie A Cruz
  • Aaron Nilsen
  • Xi Chen
  • Hillel Adesnik
  • James J Chambers
  • Eva Estebanez-Perpina
  • Ning Bao
  • Justin Blethrow
  • Sam Pfaff
  • Robert J Fletterick
  • Sabine Borngraeber
  • David R Sibley
  • Katherine W Scangos
  • Nicolas M Johnson
  • David D Ginty
  • Narendrakumar Ramanan
  • Haihong Ye
  • Kevan M Shokat
  • Chao Zhang
  • Rejji Kuruvilla
  • Hiroaki Gouda
  • David M Young

Detail Information

Publications11

  1. ncbi request reprint Rapid photoinactivation of native AMPA receptors on live cells using ANQX
    Pamela M England
    Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, USA
    Sci STKE 2006:pl1. 2006
    ..Combined with a functional AMPA receptor assay, such as continuous recording of AMPA receptor-mediated ionic currents, ANQX provides a means of directly monitoring native AMPA receptor trafficking in real time...
  2. ncbi request reprint A subtype-selective, use-dependent inhibitor of native AMPA receptors
    Aaron Nilsen
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158 2517, USA
    J Am Chem Soc 129:4902-3. 2007
  3. ncbi request reprint Unnatural amino acid mutagenesis: a precise tool for probing protein structure and function
    Pamela M England
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 2280, USA
    Biochemistry 43:11623-9. 2004
    ..The future will likely see many more investigators utilizing this approach to manipulate proteins as it realizes its promise of becoming a tool with enormous potential...
  4. doi request reprint Bridging the gaps between synapses, circuits, and behavior
    Pamela M England
    Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA
    Chem Biol 17:607-15. 2010
    ..These technologies and the design principles underlying them are reviewed herein...
  5. ncbi request reprint Photochemically knocking out glutamate receptors in vivo
    James J Chambers
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 2280, USA
    J Am Chem Soc 126:13886-7. 2004
    ..ANQX provides a means of directly evaluating the trafficking of native AMPA receptors with unparalleled spatiotemporal resolution...
  6. ncbi request reprint Photoinactivation of native AMPA receptors reveals their real-time trafficking
    Hillel Adesnik
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Neuron 48:977-85. 2005
    ....
  7. pmc 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor
    Leslie A Cruz
    Graduate Program in Chemistry and Chemical Biology, University of California San Francisco, San Francisco, California 94158 2517, USA
    J Med Chem 51:5856-60. 2008
    ..Upon photostimulation, ANQX reacts intramolecularly to form FQX or intermolecularly to form a covalent adduct with Glu705...
  8. pmc Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area
    Emanuela Argilli
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:9092-100. 2008
    ....
  9. doi request reprint AMPA receptors and synaptic plasticity: a chemist's perspective
    James J Fleming
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California, USA
    Nat Chem Biol 6:89-97. 2010
    ..Here we review these chemical tools and their application to unraveling the molecular basis of synaptic plasticity...
  10. doi request reprint Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands
    James J Fleming
    Department of Pharmaceutical Chemistry and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
    Bioorg Med Chem 18:1381-7. 2010
    ..Here we provide a perspective on opportunities for developing a complete pharmacology for AMPA receptors...
  11. ncbi request reprint A chemical-genetic approach to studying neurotrophin signaling
    Xi Chen
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 46:13-21. 2005
    ..Thus, Trk knockin mice provide valuable tools for selective, rapid, and reversible inhibition of neurotrophin signaling in vitro and in vivo...