Affiliation: University of Chicago
- Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinityBoris Engels
Department of Pathology, Committee on Immunology and Committee on Cancer Biology, The University of Chicago, Chicago, IL 60637, USA
Cancer Cell 23:516-26. 2013..These findings highlight the importance of targeting peptides with high affinity for MHC class I when designing T cell-based immunotherapy...
- Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinityBoris Engels
Department of Pathology, Committee on Immunology, The University of Chicago, Chicago, Illinois 60637 5420, USA
Mol Ther 20:652-60. 2012....
- Targeting stroma to treat cancersBoris Engels
Department of Pathology, Committee on Cancer Biology, Committee on Immunology, The University of Chicago, Chicago, IL 60637 5420, USA
Semin Cancer Biol 22:41-9. 2012..Therefore, we will also discuss conditions where stromal targeting can eradicate large established tumors. Finally, we will examine still unanswered questions of this promising and exciting area of cancer research...
- Spleen cells from young but not old immunized mice eradicate large established cancersKarin Schreiber
Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
Clin Cancer Res 18:2526-33. 2012..However, TCR-transgenic T cells and/or tumor cells overexpressing antigens are frequently used in these experiments. Here we studied the requirements for destroying clinical size, unmanipulated 8101 tumors by adoptive cell therapy...
- IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent mannerRebecca Berlant Liu
Committee on Immunology and Departments of Pathology, Medicine, and Pediatrics, University of Chicago, Chicago, IL 60637
Proc Natl Acad Sci U S A 110:8158-63. 2013....
- Densely granulated murine NK cells eradicate large solid tumorsRebecca B Liu
Committee on Immunology, Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
Cancer Res 72:1964-74. 2012..These results indicate that IL-15 released at the cancer site induces highly activated NK cells that lead to eradication of large solid tumors...