Research Topics
| JEROME J ENGELSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Connectomics and epilepsyJerome Engel
Department of Neurology, The Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Curr Opin Neurol 26:186-94. 2013..Epilepsy is such a disease, and our understanding of the mechanisms underlying the development of epilepsy and the generation of epileptic seizures will undoubtedly benefit from research utilizing these connectomic approaches...
High-frequency oscillations - where we are and where we need to goJerome Engel
Departments of Neurology, Neurobiology, and Psychiatry and Biobehavioral Sciences, and the Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Prog Neurobiol 98:316-8. 2012..The complexity of these processes makes the development of relevant computational models of dynamical neuronal networks most compelling...- Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trialJerome Engel
Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
JAMA 307:922-30. 2012..Despite reported success, surgery for pharmacoresistant seizures is often seen as a last resort. Patients are typically referred for surgery after 20 years of seizures, often too late to avoid significant disability and premature death... - Progress in epilepsy: reducing the treatment gap and the promise of biomarkersJerome Engel
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1769, USA
Curr Opin Neurol 21:150-4. 2008..People with epilepsy have benefited substantially from results of modern basic and clinical research; however, serious challenges remain. Two programs begun in the past decade offer the promise of even greater progress in the future... 
Practice parameter: temporal lobe and localized neocortical resections for epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology, in association with the American Epilepsy Society and the American Association of NeuroJ Engel
Neurological Research Center, Department of Neurology 1250, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
Neurology 60:538-47. 2003..To examine evidence for effectiveness of anteromesial temporal lobe and localized neocortical resections for disabling complex partial seizures by systematic review and analysis of the literature since 1990...- Practice parameter: temporal lobe and localized neocortical resections for epilepsyJerome Engel
Reed Neurological Research Center, Department of Neurology, Los Angeles, CA 90095 1769, USA
Epilepsia 44:741-51. 2003..To examine evidence for effectiveness of anteromesial temporal lobe and localized neocortical resections for disabling complex partial seizures... - Report of the ILAE classification core groupJerome Engel
Reed Neurological Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, USA
Epilepsia 47:1558-68. 2006..A major purpose of this approach is to identify research necessary to clarify remaining issues of uncertainty, and to pave the way for new classifications... - Advances in understanding the process of epileptogenesis based on patient material: what can the patient tell us?Jerome Engel
Departments of Neurology and Neurobiology, David Geffen School of Medicine at UCLA, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095 1769, U S A
Epilepsia 44:60-71. 2003..Further research is needed to determine if these observations are relevant to other types of epilepsies... - Models of focal epilepsyJerome Engel
Department of Neurology, Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
Suppl Clin Neurophysiol 57:392-9. 2004..Appropriate use of markers such as FR could greatly reduce the expense, and time required, to produce the necessary research results... - High-frequency oscillations: what is normal and what is not?Jerome Engel
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1769, USA
Epilepsia 50:598-604. 2009..The potential for pHFOs to act as biomarkers for epileptogenesis and epileptogenicity is also discussed... - So what can we conclude--do seizures damage the brain?Jerome Engel
Departments of Neurology and Neurobiology, Brain Research Institute, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
Prog Brain Res 135:509-12. 2002.... - Mesial temporal lobe epilepsy: what have we learned?J Engel
Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
Neuroscientist 7:340-52. 2001.... - Commentary: hormones, diet, and botanicalsJerome Engel
Department of Neurology, and the Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1769, USA
Neurotherapeutics 6:421-3. 2009..Clear advantages of these largely adjunctive therapies are discussed, as well as unique obstacles to bringing these alternative interventions into the mainstream... - Design considerations for a multicenter randomized controlled trial of early surgery for mesial temporal lobe epilepsyJerome Engel
Department of Neurology, UCLA, Los Angeles, California 90095 1769, USA
Epilepsia 51:1978-86. 2010..ERSET was designed to assess the safety and efficacy of early surgical intervention compared to continued pharmacotherapy... - Biomarkers in epilepsy: introductionJerome Engel
Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
Biomark Med 5:537-44. 2011..Recent advances in electrophysiology, neuroimaging, molecular biology and genetics promise to reveal clinically useful biomarkers for epilepsy in the near future... - When is imaging enough?J Engel
Department of Neurology, Reed Neurological Research Center, UCLA School of Medicine, USA
Epileptic Disord 1:249-53. 1999..Retrospective studies should be carried out to determine when long-term, in-patient, video-EEG monitoring in these conditions add information that appropriately changes the therapeutic approach... - Research on the human brain in an epilepsy surgery settingJ Engel
Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
Epilepsy Res 32:1-11. 1998.... - ILAE classification of epilepsy syndromesJerome Engel
Department of Neurology and the Brain Research Institute, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
Epilepsy Res 70:S5-10. 2006..Consequently, the Task Force has agreed not to propose a replacement until a clearly better classification can be created... - Paired pulse suppression and facilitation in human epileptogenic hippocampal formationC L Wilson
Department of Neurology, Reed Neurological Research Center, UCLA School of Medicine, Los Angeles, CA 90024, USA
Epilepsy Res 31:211-30. 1998.... - Cerebral microdialysis combined with single-neuron and electroencephalographic recording in neurosurgical patients. Technical noteI Fried
Department of Psychiatry, University of California at Los Angeles School of Medicine, 90095 7039, USA
J Neurosurg 91:697-705. 1999..The technique described here could be used in developing novel approaches for evaluation and treatment in a variety of neurological conditions such as head injury, subarachnoid hemorrhage, epilepsy, and movement disorders... - Multiple site silicon-based probes for chronic recordings in freely moving rats: implantation, recording and histological verificationA Bragin
Department of Neurology, UCLA School of Medicine, 2147 RNRC, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
J Neurosci Methods 98:77-82. 2000..Successful recordings of single and multiunit activity with parallel depth profiles of spontaneous and evoked field potentials are shown. The procedure for histological verification of the position of the silicon probe is described... - Chronic epileptogenesis requires development of a network of pathologically interconnected neuron clusters: a hypothesisA Bragin
Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
Epilepsia 41:S144-52. 2000.... - Acquiring simultaneous EEG and functional MRIR I Goldman
UCLA Brain Mapping Division, Ahmanson Lovelace Brain Mapping Center, 660 Charles E Young Drive South, Los Angeles, CA 90095 7085, USA
Clin Neurophysiol 111:1974-80. 2000..However, truly concurrent EEG/fMRI recording has great potential for clinical and scientific neurological applications. We have devised a method for acquiring EEG simultaneously with fMRI that minimizes contamination of the EEG signals... - Total sleep deprivation increases extracellular serotonin in the rat hippocampusF Lopez-Rodriguez
Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, NPI C8 846, 740 Westwood Plaza, Los Angeles, CA 90095, USA
Neuroscience 121:523-30. 2003..These results are consistent with a role of 5-HT in the antidepressant effects of sleep deprivation... - Three-dimensional preoperative maps of hippocampal atrophy predict surgical outcomes in temporal lobe epilepsyJ J Lin
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Neurology 65:1094-7. 2005..These atrophic regions may indicate areas of increased epileptogenicity, contributing to poorer surgical outcomes... - FDG-PET/MRI coregistration improves detection of cortical dysplasia in patients with epilepsyN Salamon
Reed Neurological Research Center, 710 Westwood Plaza, Room 2123, Los Angeles, CA 90095 1769, USA
Neurology 71:1594-601. 2008..This study determined whether fluorodeoxyglucose (FDG)-PET/MRI coregistration enhanced the recognition of CD in epilepsy surgery patients... - In vivo measurements of glutamine + glutamate (Glx) and N-acetyl aspartate (NAA) levels in human partial epilepsyI Savic
Dept of Neurology, UCLA, Los Angeles, USA
Acta Neurol Scand 102:179-88. 2000..To investigate whether cerebral levels of N-acetyl aspartate (NAA), and glutamine + glutamate (Glx), are interictally altered in the epileptogenic regions of patients with partial seizures... - Ictal magnetic source imaging as a localizing tool in partial epilepsyD S Eliashiv
Departments of Neurology, University of California Los Angeles, CA 90048, USA
Neurology 59:1600-10. 2002..To determine the feasibility and usefulness of ictal magnetoencephalography (MEG) recordings in the presurgical evaluation of patients with epilepsy... - Ultradian sleep-cycle variation of serotonin in the human lateral ventricleJ M Zeitzer
Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Neurology 59:1272-4. 2002..They hypothesize that CSF serotonin may be acting in an endocrine-like manner through activation of known leptomeningeal serotonin receptors and possibly participating in modulation of choroidal production of CSF...
Research Grants
- Early Randomized Surgical Epilepsy TrialJerome Engel; Fiscal Year: 2007..abstract_text> ..
- IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUSJerome Engel; Fiscal Year: 2007..abstract_text> ..
- IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUSJerome Engel; Fiscal Year: 2002..Results of these studies at the systems level will provide critical data to complement investigations at the intrinsic cellular and synaptic level to be proposed as part of our NIH program project (NS02808) renewal. ..