Affiliation: University of California
- HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus controlBrinda Emu
Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
J Virol 82:5398-407. 2008..Defining mechanisms for virus control in "non-T-cell controllers" might lead to insights into preventing HIV transmission or preventing virus replication...
- Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapyPeter W Hunt
Positive Health Program, San Francisco General Hospital, Bldg 80, Ward 84, 995 Potrero Ave, San Francisco, CA 94110, USA
J Infect Dis 197:126-33. 2008....
- A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllersPeter W Hunt
Departments of Medicine and Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 6:e15924. 2011..These data support a model in which low frequencies of Tregs in HIV controllers may contribute to an effective adaptive immune response, but may also contribute to generalized immune activation, potentially contributing to CD4 depletion...
- Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatmentBrinda Emu
Department of Medicine, San Francisco General Hospital, University of California, 94110, USA
J Virol 79:14169-78. 2005....
- HIV disease progression correlates with the generation of dysfunctional naive CD8(low) T cellsDavid Favre
Division of Experimental Medicine, University of California at San Francisco, San Francisco, CA, USA
Blood 117:2189-99. 2011..This study is registered at www.clinicaltrials.gov as NCT00187512...
- Loss of T cell responses following long-term cryopreservationRachel E Owen
Blood Systems Research Institute, 270 Masonic Avenue, San Francisco, CA 94118, USA
J Immunol Methods 326:93-115. 2007..Long-term cryopreservation, however, may lead to the loss of CD4(+) T cell responses and mild skewing of T cell phenotypic marker expression...
- Immune Correlates of Protection in Drug-Resistant HIVBrinda Emu; Fiscal Year: 2007..For Aims 1 and 2, I will use samples collected in an established cohort study. For Aim 3, I will conduct a prospective interventional study, where I will design and implement an independent clinical research project. ..