Research Topics
| Graham J EmslieSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Publications
Insomnia moderates outcome of serotonin-selective reuptake inhibitor treatment in depressed youthGraham J Emslie
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8589, USA
J Child Adolesc Psychopharmacol 22:21-8. 2012..There are limited data on the impact of insomnia in response to acute treatment, which is particularly relevant with serotonin-selective reuptake inhibitors, given their tendency to worsen sleep architecture...
Sleep polysomnography as a predictor of recurrence in children and adolescents with major depressive disorderG J Emslie
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 75390 8589, USA
Int J Neuropsychopharmacol 4:159-68. 2001..Depression in children and adolescents is frequently a chronic, recurrent illness. Factors that can predict clinical course are important in increasing our understanding of depression in this age group...
Escitalopram in the treatment of adolescent depression: a randomized placebo-controlled multisite trialGraham J Emslie
University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8589, USA
J Am Acad Child Adolesc Psychiatry 48:721-9. 2009..This article presents the results from a prospective, randomized, double-blind, placebo-controlled trial of escitalopram in adolescent patients with major depressive disorder...- Continuation and maintenance therapy of early-onset major depressive disorderGraham J Emslie
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas and Children s Medical Center of Dallas, Dallas, Texas, USA
Paediatr Drugs 7:203-17. 2005.... - A feasibility study of the childhood depression medication algorithm: the Texas Children's Medication Algorithm Project (CMAP)Graham J Emslie
University of Texas Southwestern Medical Center Dallas, TX 75390 8589, USA
J Am Acad Child Adolesc Psychiatry 43:519-27. 2004.... - Predictors of response to treatment in children and adolescents with mood disordersGraham J Emslie
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 8589, USA
Psychiatr Clin North Am 26:435-56. 2003..Such a biopsychosocial approach to treatment of these disorders will likely improve overall outcome... - Fluoxetine versus placebo in preventing relapse of major depression in children and adolescentsGraham J Emslie
University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8589, USA
Am J Psychiatry 165:459-67. 2008..The authors compared fluoxetine and placebo in continuation treatment to prevent relapse of major depressive disorder in children and adolescents... - Treatment of Resistant Depression in Adolescents (TORDIA): week 24 outcomesGraham J Emslie
University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8589, USA
Am J Psychiatry 167:782-91. 2010.... - Paroxetine treatment in children and adolescents with major depressive disorder: a randomized, multicenter, double-blind, placebo-controlled trialGraham J Emslie
University of Texas Southwestern Medical Center at Dallas, 75390 8589, USA
J Am Acad Child Adolesc Psychiatry 45:709-19. 2006..To assess the efficacy and tolerability of paroxetine in pediatric major depressive disorder... - Venlafaxine ER for the treatment of pediatric subjects with depression: results of two placebo-controlled trialsGraham J Emslie
University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
J Am Acad Child Adolesc Psychiatry 46:479-88. 2007.... - Cognitive-behavioral therapy to prevent relapse in pediatric responders to pharmacotherapy for major depressive disorderBetsy D Kennard
University of Texas Southwestern Medical Center, Dallas, TX 75390 8589, USA
J Am Acad Child Adolesc Psychiatry 47:1395-404. 2008.... - Texas Children's Medication Algorithm Project: update from Texas Consensus Conference Panel on Medication Treatment of Childhood Major Depressive DisorderCarroll W Hughes
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8589, USA
J Am Acad Child Adolesc Psychiatry 46:667-86. 2007..To revise and update consensus guidelines for medication treatment algorithms for childhood major depressive disorder based on new scientific evidence and expert clinical consensus when evidence is lacking... - Do children and adolescents have differential response rates in placebo-controlled trials of fluoxetine?Taryn L Mayes
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8589, USA
CNS Spectr 12:147-54. 2007.... - Remission and recovery in the Treatment for Adolescents with Depression Study (TADS): acute and long-term outcomesBetsy D Kennard
5323 Harry Hines Blvd, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8589, USA
J Am Acad Child Adolesc Psychiatry 48:186-95. 2009..We examine remission rate probabilities, recovery rates, and residual symptoms across 36 weeks in the Treatment for Adolescents with Depression Study (TADS)... - Psychometric properties of the Quick Inventory of Depressive Symptomatology in adolescentsIra H Bernstein
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9066, USA
Int J Methods Psychiatr Res 19:185-94. 2010..This study evaluated both versions of the QIDS and the 17-item Children's Depressive Rating Scale - Revised (CDRS-R) in an adolescent outpatient sample... - Maternal depressive symptoms in pediatric major depressive disorder: relationship to acute treatment outcomeBetsy D Kennard
University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8589, USA
J Am Acad Child Adolesc Psychiatry 47:694-9. 2008..In the present study, we assess maternal depressive symptoms at the beginning and end of treatment to investigate the possible reciprocal relationship of maternal illness with the child's depressive illness and treatment... - Fluoxetine treatment for prevention of relapse of depression in children and adolescents: a double-blind, placebo-controlled studyGraham J Emslie
University of Texas Southwestern Medical Center at Dallas, Texas, USA
J Am Acad Child Adolesc Psychiatry 43:1397-405. 2004..CONCLUSIONS: Fluoxetine 20 to 60 mg/day was well tolerated and can significantly delay relapse of major depressive disorder symptoms in children and adolescents... - Assessment of safety and long-term outcomes of initial treatment with placebo in TADSBetsy D Kennard
University of Texas Southwestern Medical Center at Dallas, 75390 8589, USA
Am J Psychiatry 166:337-44. 2009.... - Effective components of TORDIA cognitive-behavioral therapy for adolescent depression: preliminary findingsBetsy D Kennard
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8589, USA
J Consult Clin Psychol 77:1033-41. 2009..Finally, social skills and problem solving may be active elements in CBT for adolescent depression and should be considered in treatment by those working with seriously depressed youths... - Psychometric properties of the Children's Depression Rating Scale-Revised in adolescentsTaryn L Mayes
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8589, USA
J Child Adolesc Psychopharmacol 20:513-6. 2010..The aim of this study was to present the reliability and validity of the Children's Depression Rating Scale-Revised (CDRS-R) in the adolescent age group... - A psychometric evaluation of the CDRS and MADRS in assessing depressive symptoms in childrenShailesh Jain
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Am Acad Child Adolesc Psychiatry 46:1204-12. 2007..This study compared the psychometric properties of the Children's Depression Rating Scale-Revised (CDRS-R) and the Montgomery-Asberg Depression Rating Scale (MADRS) in children with major depressive disorder... - The Texas Children's Medication Algorithm Project: revision of the algorithm for pharmacotherapy of attention-deficit/hyperactivity disorderSteven R Pliszka
Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78229 3900, USA
J Am Acad Child Adolesc Psychiatry 45:642-57. 2006..Advances in the psychopharmacology of ADHD and results of a feasibility study of algorithm use in community mental health centers caused the algorithm to be modified and updated... - DepressionChristine J Choe
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8589, USA
Child Adolesc Psychiatr Clin N Am 21:807-29. 2012..Further research is needed in the pharmacologic treatment of depressed youth, including expanding the study of non-SSRI antidepressants, augmentation and adjunctive strategies, and treatment in patients with comorbid conditions... - Sex and age differences in sleep macroarchitecture in childhood and adolescent depressionJennifer J T Robert
Department of Psychiatry, University of Michigan, Ann Arbor 48105, USA
Sleep 29:351-8. 2006..Sex differences are substantially smaller in healthy individuals compared with those with depression, in agreement with previous studies in depressed adults... - Symptom improvement and residual symptoms during acute antidepressant treatment in pediatric major depressive disorderRongrong Tao
University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8589, USA
J Child Adolesc Psychopharmacol 20:423-30. 2010.... - Long-term, open-label venlafaxine extended-release treatment in children and adolescents with major depressive disorderGraham J Emslie
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
CNS Spectr 12:223-33. 2007..Yet, data on long-term treatment with antidepressants in pediatric MDD are limited... - Relapse and recurrence in pediatric depressionBetsy D Kennard
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 8589, USA
Child Adolesc Psychiatr Clin N Am 15:1057-79, xi. 2006..Lack of consistent efficacy in acute treatment studies has limited long-term prevention treatment research in pediatric depression. The impact of long-term treatments, both psychosocial and pharmacologic, is currently unknown... - Sleep microarchitecture as a predictor of recurrence in children and adolescents with depressionRoseanne Armitage
Psychiatry Department, University of Texas Southwestern Medical Center at Dallas, TX 75390 9070, USA
Int J Neuropsychopharmacol 5:217-28. 2002..Significant sex differences were found with a stronger relationship between temporal coherence and clinical course in boys. This study supports the use of quantitative sleep EEG measures as a predictor of clinical course in depression... - Atomoxetine alone or combined with fluoxetine for treating ADHD with comorbid depressive or anxiety symptomsChristopher J Kratochvil
Department of Psychiatry, Nebraska Medical Center, Omaha 68198 5581, USA
J Am Acad Child Adolesc Psychiatry 44:915-24. 2005..The authors assessed the safety and effectiveness of atomoxetine monotherapy compared with combined atomoxetine/fluoxetine therapy in a population of children and adolescents with ADHD and concurrent symptoms of depression or anxiety... - Major depressive disorder in children and adolescents: clinical trial design and antidepressant efficacyGraham J Emslie
Child and Adolescent Psychiatry Division, University of Texas Southwestern Medical Center at Dallas, Dallas, USA
J Clin Psychiatry 66:14-20. 2005.... - A comparison of various methods of measuring antidepressant medication adherence among children and adolescents with major depressive disorder in a 12-week open trial of fluoxetinePaul A Nakonezny
Division of Biostatistics, Department of Clinical Sciences, UT Southwestern Medical Center, Dallas, Texas 75390 8828, USA
J Child Adolesc Psychopharmacol 20:431-9. 2010..We then suggested recommendations for clinical researchers and practicing clinicians regarding medication adherence assessment... - Brain activity in adolescent major depressive disorder before and after fluoxetine treatmentRongrong Tao
Department of Psychiatry, The Department of Neurology, the Division of Biostatistics of the Department of Clinical Sciences, and the Advanced Imaging Center, University of Texas Southwestern Medical Center at Dallas, USA
Am J Psychiatry 169:381-8. 2012.... - Antidepressant management in the context of suicidal ideationGraham J Emslie
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, TX, USA
J Am Acad Child Adolesc Psychiatry 46:1222-5. 2007 - Fluoxetine for acute treatment of depression in children and adolescents: a placebo-controlled, randomized clinical trialGraham J Emslie
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, USA
J Am Acad Child Adolesc Psychiatry 41:1205-15. 2002..Fluoxetine is the only antidepressant that has demonstrated efficacy in two placebo-controlled, randomized clinical trials of pediatric depression... - Cognitions and depressive symptoms among ethnic minority adolescentsBetsy D Kennard
Psychiatry Department, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Cultur Divers Ethnic Minor Psychol 12:578-91. 2006..Our findings demonstrate support for the cognitive model of depression across ethnic groups. The importance of controlling for social class when examining ethnic differences in psychological variables is highlighted by our findings... - Effect of structured interviews on evaluation time in pediatric community mental health settingsCarroll W Hughes
Department of Psychiatry, University of Texas Southwestern Medical Center, 5232 Harry Hines Boulevard, Dallas, Texas 75390, USA
Psychiatr Serv 56:1098-103. 2005.... - Adolescent suicide attempters in Hong Kong and the United StatesSunita M Stewart
UT Southwestern Medical Center at Dallas, TX, USA
Soc Sci Med 63:296-306. 2006..These findings do not support the proposition that depression is a less relevant variable in suicide attempts in Chinese versus western groups... - The Quick Inventory of Depressive Symptomatology-Self-report: a psychometric evaluation in patients with asthma and major depressive disorderE Sherwood Brown
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8849, USA
Ann Allergy Asthma Immunol 100:433-8. 2008..Despite the high co-occurrence between depression and asthma, few studies have addressed methods assessing the severity of depressive symptoms among patients with asthma... - Increased cortical excitability with prefrontal high-frequency repetitive transcranial magnetic stimulation in adolescents with treatment-resistant major depressive disorderPaul E Croarkin
Division of Child and Adolescent Psychiatry, Department of Psychiatry, UT Southwestern Medical Center Dallas, Dallas, Texas 75390 8589, USA
J Child Adolesc Psychopharmacol 22:56-64. 2012..To examine changes in motor cortical excitability in adolescent subjects receiving 30 sessions of high-frequency prefrontal repetitive transcranial magnetic stimulation (rTMS)... - A cross-cultural investigation of cognitions and depressive symptoms in adolescentsSunita Mahtani Stewart
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 75390 8589, USA
J Abnorm Psychol 113:248-57. 2004..There was some support for the hypothesis that self-efficacy is less salient in collective compared with individualistic cultures. These findings extend cognitive theories of depression to a non-Western culture... - A preliminary investigation of corpus callosum and anterior commissure aberrations in aggressive youth with bipolar disordersKirti Saxena
Department of Psychiatry, University of Texas Health Science Center at Houston, Houston, Texas 77054, USA
J Child Adolesc Psychopharmacol 22:112-9. 2012.... - Neuroleptic malignant syndrome associated with atypical antipsychotics in pediatric patients: a review of published casesPaul E Croarkin
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
J Clin Psychiatry 69:1157-65. 2008.... - Depressive symptoms predict hospitalization for adolescents with type 1 diabetes mellitusSunita M Stewart
Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8589, USA
Pediatrics 115:1315-9. 2005..To examine the role of self-reported depressive symptoms in predicting hospitalization for complications of diabetes mellitus over a period of up to 2 years... - A feasibility study of the children's medication algorithm project (CMAP) algorithm for the treatment of ADHDSteven R Pliszka
University of Texas Health Science Center at San Antonio, Texas 8229 3900, USA
J Am Acad Child Adolesc Psychiatry 42:279-87. 2003..To determine whether an algorithm for the treatment of attention-deficit/hyperactivity disorder (ADHD) can be implemented in a community mental health center... - The use of antidepressants to treat depression in children and adolescentsAmy H Cheung
Department of Psychiatry, University of Toronto, Toronto, Ont
CMAJ 174:193-200. 2006..In addition, we discuss methodologic issues and clinical implications specific to the pediatric population... - Efficacy and safety of atomoxetine in adolescents with attention-deficit/hyperactivity disorder and major depressionMark E Bangs
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
J Child Adolesc Psychopharmacol 17:407-20. 2007..ATX was an effective and safe treatment for ADHD in adolescents with ADHD and MDD. However, this trial showed no evidence for ATX of efficacy in treating MDD... - Psychopharmacological treatment for very young children: contexts and guidelinesMary Margaret Gleason
Bradley Hasbro Research Center, Providence, RI 02903, USA
J Am Acad Child Adolesc Psychiatry 46:1532-72. 2007..The purpose of this effort is to promote responsible treatment of young children, recognizing that this will sometimes involve the use of medications... - Citalopram in children and adolescents with depression or anxietyJennifer L Baumgartner
College of Pharmacy, University of Texas, Texas Department of Mental Health and Mental Retardation, Austin, USA
Ann Pharmacother 36:1692-7. 2002..Controlled studies in this patient population are indicated... - Efficacy of atomoxetine versus placebo in school-age girls with attention-deficit/hyperactivity disorderJoseph Biederman
Massachusetts General Hospital, Boston, Massachusetts, USA
Pediatrics 110:e75. 2002..One patient from each of the atomoxetine and placebo groups discontinued the study as a result of an adverse event. CONCLUSION: Atomoxetine was found to be effective and well tolerated for the treatment of ADHD in school-age girls... - Validation of the Mood Disorder Questionnaire for bipolar disorders in adolescentsKaren Dineen Wagner
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0188, USA
J Clin Psychiatry 67:827-30. 2006.... - A double-blind, randomized, placebo-controlled trial of oxcarbazepine in the treatment of bipolar disorder in children and adolescentsKaren Dineen Wagner
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77755 0188, USA
Am J Psychiatry 163:1179-86. 2006..This multicenter trial examined the efficacy and safety of oxcarbazepine in the treatment of bipolar disorder in children and adolescents... - Review of the efficacy and safety of antidepressants in youth depressionAmy H Cheung
Department of Psychiatry, University of Toronto, Ontario, Canada
J Child Psychol Psychiatry 46:735-54. 2005..This review examined the available evidence from clinical trials of antidepressants in adolescents and children with depression... - A pilot study of an electronic, adolescent version of the quick inventory of depressive symptomatologyHeidi K Moore
Healthcare Technology Systems, Inc, Madison, WI 53717, USA
J Clin Psychiatry 68:1436-40. 2007..An adolescent version of the QIDS (QIDS-A-IVR) was created using speaker-independent voice recognition technology. An informant version, QIDS-P-IVR, collects ratings from parents or other knowledgeable adults... - Improving outcome in pediatric depressionGraham J Emslie
Am J Psychiatry 165:1-3. 2008 - National Depressive and Manic-Depressive Association consensus statement on the use of placebo in clinical trials of mood disordersDennis S Charney
Division of Intramural Research Programs, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Arch Gen Psychiatry 59:262-70. 2002..Research is needed on the ethical conduct of studies to limit risks of medication-free intervals and facilitate poststudy treatment. Patients must fully understand the risks and lack of individualized treatment involved in research...
Research Grants
- Pediatric MDD: Sequential Treatment with Fluoxetine and Relapse Prevention CBTGraham Emslie; Fiscal Year: 2009....
- Child Psychiatry Research Education Program (C-PREP)Graham Emslie; Fiscal Year: 2007....
- TREATMENT OF SSRI-RESISTANT DEPRESSION IN ADOLESCENTSGraham Emslie; Fiscal Year: 2006..This site is based in Pittsburgh, which also serves as the Data Coordinating Center for the study ..
- Treatment of Adolescent Suicide Attempters in DallasGraham Emslie; Fiscal Year: 2006..This exemplary protocol stimulated the formation of a collaborative group of 8 RUPP-PI applicants. By creating the protocol, the group forged an ability to work together. ..
- CHILDHOOD DEPRESSION: REMISSION AND RELAPSEGraham Emslie; Fiscal Year: 2004..The primary outcome variable will be response to acute treatment and relapse during continuation phase treatment. There have been no studies of need for continuation treatment in depression in the pediatric age group. ..
- Treatment of Early Age Mania (TEAM)Graham Emslie; Fiscal Year: 2003..D. (4) University of Texas, Dallas, PI: Graham Emslie, M.D. (5) University of Texas, Galveston, PI: Karen Dineen Wagner, M.D. and (6) Washington University, St. Louis, PI; Joan Luby, M.D. ..
- CHILDHOOD DEPRESSION-BIOLOGICAL CORRELATESGraham Emslie; Fiscal Year: 1993..Clinically antidepressants are widely used in treatment of depression in this age group and yet controlled studies are limited. If medication is effective in some then it would be important to determine in whom...
- Pediatric MDD: Sequential Treatment with Fluoxetine and Relapse Prevention CBTBeth D Kennard; Fiscal Year: 2010....