Holger K Eltzschig

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Attenuating myocardial ischemia by targeting A2B adenosine receptors
    Holger K Eltzschig
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA
    Trends Mol Med 19:345-54. 2013
  2. pmc Ischemia and reperfusion--from mechanism to translation
    Holger K Eltzschig
    Department of Anesthesiology, Mucosal Inflammation Program, University of Colorado, Aurora, Colorado, USA
    Nat Med 17:1391-401. 2011
  3. pmc Adenosine: an old drug newly discovered
    Holger K Eltzschig
    Department of Anesthesiology, University of Colorado Denver, 12700 E 19th Avenue, Aurora, CO 80045, USA
    Anesthesiology 111:904-15. 2009
  4. pmc Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation
    Holger K Eltzschig
    University of Colorado, Mucosal Inflammation Program, Department of Medicine, Denver, 12700 E 19th Avenue, Mailstop B112, Research Complex 2, Room 7124, Aurora, CO 80045, USA
    Expert Opin Ther Targets 13:1267-77. 2009
  5. pmc Equilibrative nucleoside transporter (ENT)-1-dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusion
    Michael A Zimmerman
    Division of Transplant Surgery, Department of Surgery, University of Colorado, Aurora, CO
    Hepatology 58:1766-78. 2013
  6. pmc Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    Eric T Clambey
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 109:E2784-93. 2012
  7. pmc Identification of Hypoxia-Inducible Factor HIF-1A as Transcriptional Regulator of the A2B Adenosine Receptor during Acute Lung Injury
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado, Aurora, CO 80045
    J Immunol 192:1249-56. 2014
  8. doi request reprint Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning
    Melanie L Hart
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 135:1739-1750.e3. 2008
  9. pmc HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium
    Tobias Eckle
    Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Denver, Colorado, United States of America
    PLoS Biol 11:e1001665. 2013
  10. pmc Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado School of Medicine, 12700 E 19th Ave, Aurora, CO 80045, USA
    FASEB J 27:3078-89. 2013

Collaborators

Detail Information

Publications59

  1. pmc Attenuating myocardial ischemia by targeting A2B adenosine receptors
    Holger K Eltzschig
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA
    Trends Mol Med 19:345-54. 2013
    ....
  2. pmc Ischemia and reperfusion--from mechanism to translation
    Holger K Eltzschig
    Department of Anesthesiology, Mucosal Inflammation Program, University of Colorado, Aurora, Colorado, USA
    Nat Med 17:1391-401. 2011
    ....
  3. pmc Adenosine: an old drug newly discovered
    Holger K Eltzschig
    Department of Anesthesiology, University of Colorado Denver, 12700 E 19th Avenue, Aurora, CO 80045, USA
    Anesthesiology 111:904-15. 2009
    ..If these laboratory studies can be translated into clinical practice, adenosine receptor-based therapeutics may become an integral pharmacological component of daily anesthesiology practice...
  4. pmc Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation
    Holger K Eltzschig
    University of Colorado, Mucosal Inflammation Program, Department of Medicine, Denver, 12700 E 19th Avenue, Mailstop B112, Research Complex 2, Room 7124, Aurora, CO 80045, USA
    Expert Opin Ther Targets 13:1267-77. 2009
    ..In addition, we discuss the role of this pathway in dampening hypoxia-elicited inflammation, specifically in the setting of intestinal ischemia and inflammation...
  5. pmc Equilibrative nucleoside transporter (ENT)-1-dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusion
    Michael A Zimmerman
    Division of Transplant Surgery, Department of Surgery, University of Colorado, Aurora, CO
    Hepatology 58:1766-78. 2013
    ..Conclusion: These findings implicate ENT1 in liver protection from ischemia and reperfusion injury and suggest ENT inhibitors may be of benefit in the prevention or treatment of ischemic liver injury. (Hepatology 2013;58:1766-1778). ..
  6. pmc Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    Eric T Clambey
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 109:E2784-93. 2012
    ..These studies demonstrate that hypoxia is an intrinsic molecular cue that promotes FoxP3 expression, in turn eliciting potent anti-inflammatory mechanisms to limit tissue damage in conditions of reduced oxygen availability...
  7. pmc Identification of Hypoxia-Inducible Factor HIF-1A as Transcriptional Regulator of the A2B Adenosine Receptor during Acute Lung Injury
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado, Aurora, CO 80045
    J Immunol 192:1249-56. 2014
    ..Together, these studies implicate HIF in the transcriptional control of pulmonary adenosine signaling during ALI. ..
  8. doi request reprint Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning
    Melanie L Hart
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 135:1739-1750.e3. 2008
    ..We investigated whether ecto-5'-nucleotidase (CD73), the "pacemaker" enzyme of extracellular adenosine production, is critical for hepatic protection by IP...
  9. pmc HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium
    Tobias Eckle
    Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Denver, Colorado, United States of America
    PLoS Biol 11:e1001665. 2013
    ..Therefore, we hypothesized that mechanical ventilation and concomitant stretch-exposure of pulmonary epithelia could activate endogenous pathways important in lung protection...
  10. pmc Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado School of Medicine, 12700 E 19th Ave, Aurora, CO 80045, USA
    FASEB J 27:3078-89. 2013
    ..Our newly identified crosstalk pathway between ENT2 and alveolar epithelial Adora2b in lung protection during ALI opens possibilities for combined therapies targeted to this protein set...
  11. pmc CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury
    Heidi Ehrentraut
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    FASEB J 27:2207-19. 2013
    ..Together, these studies implicate CD73-dependent adenosine generation in Tregs in promoting ALI resolution...
  12. pmc Signaling through hepatocellular A2B adenosine receptors dampens ischemia and reperfusion injury of the liver
    Michael A Zimmerman
    Division of Transplant Surgery, Department of Surgery, and Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado, Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 110:12012-7. 2013
    ..These studies provide a unique role for hepatocellular-specific Adora2b signaling in liver protection during ischemia and reperfusion injury...
  13. pmc Protective role for netrin-1 during diabetic nephropathy
    Eunyoung Tak
    Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, 12700 E 19th Avenue, Mailstop B112, Research Complex 2, Room 7121, Aurora, CO 80045, USA
    J Mol Med (Berl) 91:1071-80. 2013
    ..Taken together, these studies demonstrate a functional role for endogenous netrin-1 in attenuating diabetic kidney disease...
  14. pmc Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
    J Clin Invest 122:693-710. 2012
    ..These studies identify ENT1 and adenosine receptors as key to the process of reestablishing renal perfusion following ischemic AKI. If translatable from mice to humans, these data have important therapeutic implications...
  15. pmc Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery
    Sean P Colgan
    Departments of Medicine and Anesthesiology and the Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Annu Rev Physiol 74:153-75. 2012
    ..Such information has provided new insights into disease pathogenesis and, importantly, will provide insights into new therapeutic targets...
  16. pmc A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 118:3301-15. 2008
    ..Taken together, these studies reveal a role for A2BAR signaling in attenuating VILI and implicate this receptor as a potential therapeutic target during acute lung injury...
  17. pmc Adora2b adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNF-α release
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 189:4566-73. 2012
    ..In total, these data demonstrate a critical role of adenosine signaling in constraining neutrophil-dependent production of TNF-α and implicate therapies targeting TNF-α in the treatment of ischemic AKI...
  18. pmc Selective deletion of the A1 adenosine receptor abolishes heart-rate slowing effects of intravascular adenosine in vivo
    Michael Koeppen
    Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Denver, Aurora, Colorado, USA
    PLoS ONE 4:e6784. 2009
    ..Here, we used comparative genetic in vivo studies to address the contribution of individual ARs to the heart-rate slowing effects of intravascular adenosine...
  19. pmc The reno-vascular A2B adenosine receptor protects the kidney from ischemia
    Almut Grenz
    Department of Pharmacology and Toxicology, Tubingen University Hospital, Tubingen, Germany Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    PLoS Med 5:e137. 2008
    ..Here, we identified a novel pathway of renal protection from ischemia using ischemic preconditioning (IP)...
  20. ncbi request reprint Role of extracellular adenosine in acute lung injury
    Tobias Eckle
    Department of Anesthesiology, Mucosal Inflammation Program, University of Colorado Denver, Aurora, Colorado, USA
    Physiology (Bethesda) 24:298-306. 2009
    ..As such, recent evidence indicates extracellular adenosine in orchestrating the resolution of pulmonary edema and inflammation during ALI...
  21. pmc Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis
    Carol M Aherne
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA
    Gut 61:695-705. 2012
    ..We therefore hypothesised that netrin-1 could modulate leucocyte infiltration and disease activity in a model of inflammatory bowel disease...
  22. ncbi request reprint Use of a hanging-weight system for liver ischemic preconditioning in mice
    Melanie L Hart
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1431-40. 2008
    ..Taken together, these studies confirm highly reproducible liver injury and protection by IP when using the hanging-weight system for hepatic ischemia and intermittent reperfusion. Further studies of murine IP may consider this technique...
  23. pmc Intraoperative evaluation of transmitral pressure gradients after edge-to-edge mitral valve repair
    Jan N Hilberath
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e73617. 2013
    ....
  24. pmc Central role of Sp1-regulated CD39 in hypoxia/ischemia protection
    Holger K Eltzschig
    Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Blood 113:224-32. 2009
    ..In summary, these results identify a novel Sp1-dependent regulatory pathway for CD39 and indicate the likelihood that CD39 is central to protective responses to hypoxia/ischemia...
  25. pmc Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease
    Jens M Poth
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado School of Medicine, 12700 East 19th Avenue, Mailstop B112, Aurora, CO 80045, USA
    J Mol Med (Berl) 91:183-93. 2013
    ....
  26. pmc Perioperative organ injury
    Karsten Bartels
    Fellow in Critical Care Medicine and Cardiothoracic Anesthesiology, Assistant Professor of Anesthesiology, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina Assistant Professor of Anesthesiology, Associate Professor of Anesthesiology, Professor of Anesthesiology, Department of Anesthesiology, University of Colorado Denver, Aurora, Colorado
    Anesthesiology 119:1474-89. 2013
    ....
  27. ncbi request reprint Transesophageal echocardiography for detecting extrapulmonary thrombi during pulmonary embolectomy
    Peter Rosenberger
    Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ann Thorac Surg 78:862-6; discussion 866. 2004
    ..However, its utility for detecting concurrent intrathoracic, extrapulmonary thromboemboli has not been thoroughly investigated...
  28. pmc Hypoxia signaling during intestinal ischemia and inflammation
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado, Aurora, Colorado 80045, USA
    Curr Opin Crit Care 18:178-85. 2012
    ..In many instances, HIF-dependent alterations of gene expression represent endogenous adaptive responses that dampen pathologic inflammation and could be targeted to treat intestinal injury...
  29. pmc Extracellular adenosine: a safety signal that dampens hypoxia-induced inflammation during ischemia
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA
    Antioxid Redox Signal 15:2221-34. 2011
    ....
  30. doi request reprint Interplay of hypoxia and A2B adenosine receptors in tissue protection
    Michael Koeppen
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, USA
    Adv Pharmacol 61:145-86. 2011
    ..As such, the ADORA(2B) has emerged as a therapeutic target for dampening hypoxia-induced inflammation and tissue adaptation to limited oxygen availability...
  31. pmc Partial netrin-1 deficiency aggravates acute kidney injury
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
    PLoS ONE 6:e14812. 2011
    ..Finally, treatment of Ntn-1(+/-) mice with exogenous netrin-1 restored a normal phenotype during AKI. Taking together, these studies implicate endogenous netrin-1 in attenuating renal inflammation during AKI...
  32. ncbi request reprint Rescue transoesophageal echocardiography for refractory haemodynamic instability during transvenous lead extraction
    Jan N Hilberath
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Eur Heart J Cardiovasc Imaging 15:926-32. 2014
    ....
  33. pmc Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis
    Joanne C Masterson
    Section of Pediatric Gastroenterology, Hepatology and Nutrition, Digestive Health Institute, Aurora, Colorado, USA
    Gut 63:43-53. 2014
    ..Eosinophilic oesophagitis (EoE) is a chronic inflammatory condition of the oesophagus with limited treatment options. No previous transgenic model has specifically targeted the oesophageal mucosa to induce oesophageal eosinophilia...
  34. ncbi request reprint Critical role of inferior vena caval filter placement after pulmonary embolectomy
    Peter Rosenberger
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospita, Boston, MA, USA
    J Card Surg 20:289-90. 2005
    ..Therefore, concurrent IVCF placement should be considered during or immediately after pulmonary embolectomy to prevent recurrent pulmonary embolism...
  35. doi request reprint A novel view for visualizing a left pulmonary artery thromboembolus with intraoperative transesophageal echocardiography
    Martina Nowak
    Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Clin Anesth 20:136-8. 2008
    ..We present a case in which thromboembolic material within the midleft pulmonary artery was incidentally diagnosed using additional, modified transesophageal echocardiography views, in a patient undergoing mitral valve repair...
  36. pmc The hypoxia-inflammation link and potential drug targets
    Michael Koeppen
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, Colorado 80045, USA
    Curr Opin Anaesthesiol 24:363-9. 2011
    ..Hypoxia represents one of the strongest transcriptional stimuli known to us. In most cases, hypoxia-induced changes in gene expression are directed towards adapting tissues to conditions of limited oxygen availability...
  37. doi request reprint Usefulness of pressure-controlled ventilation at high inspiratory pressures to induce acute lung injury in mice
    Tobias Eckle
    University of Colorado Denver Dept of Anesthesiology and Perioperative Medicine, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 295:L718-24. 2008
    ..Together, these studies demonstrate feasibility of this model to induce murine ALI...
  38. doi request reprint Adenosine generation and signaling during acute kidney injury
    Jessica D Bauerle
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, 12700 E 19 Avenue, Mailstop B112, Research Complex 2, Room 7124, Aurora, CO 80045, USA
    J Am Soc Nephrol 22:14-20. 2011
    ..If these experimental strategies can be translated into a clinical setting, adenosine receptor therapeutics may become an integral part in the prevention or treatment of AKI from renal ischemia...
  39. pmc Adora2b adenosine receptor engagement enhances regulatory T cell abundance during endotoxin-induced pulmonary inflammation
    Heidi Ehrentraut
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 7:e32416. 2012
    ..In total, these data indicate that the Adora2b adenosine receptor serves a potent anti-inflammatory role, functioning at least in part through the enhancement of Tregs, to limit inflammation...
  40. pmc Descending aortic calcification increases renal dysfunction and in-hospital mortality in cardiac surgery patients with intraaortic balloon pump counterpulsation placed perioperatively: a case control study
    Martina Nowak-Machen
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Crit Care 16:R17. 2012
    ..This might be due to dislodgement of atherosclerotic material in the descending thoracic aorta (DTA). Therefore, we retrospectively studied the correlation between DTA atheroma, AKI and in-hospital mortality...
  41. pmc Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, USA
    Nat Med 18:774-82. 2012
    ....
  42. pmc Neutrophil intercellular communication in acute lung injury. Emerging roles of microparticles and gap junctions
    Viola Dengler
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Am J Respir Cell Mol Biol 49:1-5. 2013
    ..By focusing on these cell-cell communications, we aim to demonstrate significant gaps of knowledge and identify areas of considerable need for further investigations of the processes of acute lung inflammation. ..
  43. ncbi request reprint The usefulness of transesophageal echocardiography during intraoperative cardiac arrest in noncardiac surgery
    Stavros G Memtsoudis
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesth Analg 102:1653-7. 2006
    ..Thus, TEE may provide additional diagnostic information in patients with intraoperative cardiac arrest and may directly guide specific, potentially life-saving therapy...
  44. doi request reprint The feasibility of epicardial echocardiography for measuring aortic valve area by the continuity equation
    Jan N Hilberath
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Anesth Analg 108:17-22. 2009
    ....
  45. pmc Neutrophils as sources of extracellular nucleotides: functional consequences at the vascular interface
    Holger K Eltzschig
    Department of Anesthesiology and Intensive Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80220, USA
    Trends Cardiovasc Med 18:103-7. 2008
    ..Here, we review the mechanisms of ATP release and subsequent functional implications of ATP metabolism at the interface between PMN and vascular endothelial cells during inflammation and in hypoxia...
  46. pmc Evaluation of transmitral pressure gradients in the intraoperative echocardiographic diagnosis of mitral stenosis after mitral valve repair
    Ann K Riegel
    Department of Anesthesiology, University of Colorado Denver, Denver, Colorado, United States of America
    PLoS ONE 6:e26559. 2011
    ..Acute mitral stenosis (MS) following mitral valve (MV) repair is a rare but severe complication. We hypothesize that intraoperative echocardiography can be utilized to diagnose iatrogenic MS immediately after MV repair...
  47. doi request reprint Purinergic regulation of airway inflammation
    Michael Koeppen
    Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA
    Subcell Biochem 55:159-93. 2011
    ..By the end of this chapter, the reader will have a new appreciation for this aspect of airway defenses, and several leads in terms of therapeutic applications for the treatment of chronic respiratory diseases...
  48. pmc Sphingosine-1-phosphate receptor signaling during acute kidney injury: the tissue is the issue
    Karsten Bartels
    Organ Protection Program, Department of Anesthesiology, University of Colorado, Aurora, Colorado, USA
    Kidney Int 85:733-5. 2014
    ..Indeed, S1P1R agonists have been used for the treatment of patients suffering from autoimmune encephalitis. Endothelial S1P1R signaling could be targeted for AKI prevention in surgical patients. ..
  49. pmc Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury
    Melanie L Hart
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 22:2784-97. 2008
    ..These data reveal a previously unrecognized role of CD73 in attenuating intestinal IR-mediated injury...
  50. doi request reprint Safety of transesophageal echocardiography
    Jan N Hilberath
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Echocardiogr 23:1115-27; quiz 1220-1. 2010
    ..In addition, alternative echocardiographic modalities (e.g., epicardial echocardiography) that may be considered when TEE probe placement is contraindicated or not feasible are discussed...
  51. ncbi request reprint Role of pulmonary adenosine during hypoxia: extracellular generation, signaling and metabolism by surface adenosine deaminase/CD26
    Annemie Van Linden
    University of Colorado Health Science Center, Mucosal Inflammation Program, Department of Anesthesiology, Perioperative Care and Pain Medicine, Biochemistry Research Building BRB, Room 852, 4200 E 9th Avenue, Campus Box B113, Denver, CO 80262, USA
    Expert Opin Biol Ther 7:1437-47. 2007
    ..This paper reviews metabolic and transcriptional changes of extracellular adenosine generation, signaling and degradation during acute and prolonged pulmonary hypoxia...
  52. ncbi request reprint Acute hemodynamic collapse after induction of general anesthesia for emergent pulmonary embolectomy
    Peter Rosenberger
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Anesth Analg 102:1311-5. 2006
    ....
  53. ncbi request reprint Utility of intraoperative transesophageal echocardiography for diagnosis of pulmonary embolism
    Peter Rosenberger
    Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Anesth Analg 99:12-6. 2004
    ..Therefore, the use of intraoperative TEE to diagnose acute PE via direct visualization is limited. Indirect TEE evidence of PA obstruction may be helpful in supporting a diagnosis of PE...
  54. pmc Purinergic Signaling during Inflammation
    Holger K Eltzschig
    From the Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado School of Medicine, Aurora H K E and the New England Inflammation and Tissue Protection Institute, Northeastern University M V S, and the Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School S C R both in Boston
    N Engl J Med 367:2322-33. 2012
    ..ATP and ADP signaling is mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for these nucleosides are emerging as therapeutic targets in a number of inflammatory and autoimmune diseases...
  55. pmc The resurgence of A2B adenosine receptor signaling
    Carol M Aherne
    Department of Anesthesiology, University of Colorado, Aurora, CO, USA
    Biochim Biophys Acta 1808:1329-39. 2011
    ..This is an important consideration for future studies where tissue or cell type specific targeting of the A2BAR may be used as therapeutic approach...
  56. ncbi request reprint The use of readily available equipment in a simple method for intraoperative monitoring of recurrent laryngeal nerve function during thyroid surgery: initial experience with more than 300 cases
    Holger K Eltzschig
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Arch Surg 137:452-6; discussion 456-7. 2002
    ..An inexpensive and widely applicable technique to monitor recurrent laryngeal nerve (RLN) function during thyroid surgery can be safely implemented...
  57. ncbi request reprint Epicardial echocardiography: diagnostic utility for evaluating aortic valve disease during coronary surgery
    Vlad E Frenk
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Clin Anesth 15:271-4. 2003
    ..However, attempts to place a TEE probe were abandoned due to high resistance on probe insertion. Epicardial echocardiography revealed previously undiagnosed aortic valve disease resulting in replacement of this valve...