Research Topics
Genomes and Genes | Holger K EltzschigSummaryAffiliation: University of Colorado Denver Country: USA Publications
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Publications
Ischemia and reperfusion--from mechanism to translationHolger K Eltzschig
Department of Anesthesiology, Mucosal Inflammation Program, University of Colorado, Aurora, Colorado, USA
Nat Med 17:1391-401. 2011....
Adenosine: an old drug newly discoveredHolger K Eltzschig
Department of Anesthesiology, University of Colorado Denver, 12700 E 19th Avenue, Aurora, CO 80045, USA
Anesthesiology 111:904-15. 2009..If these laboratory studies can be translated into clinical practice, adenosine receptor-based therapeutics may become an integral pharmacological component of daily anesthesiology practice...- Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammationHolger K Eltzschig
University of Colorado, Mucosal Inflammation Program, Department of Medicine, Denver, 12700 E 19th Avenue, Mailstop B112, Research Complex 2, Room 7124, Aurora, CO 80045, USA
Expert Opin Ther Targets 13:1267-77. 2009..In addition, we discuss the role of this pathway in dampening hypoxia-elicited inflammation, specifically in the setting of intestinal ischemia and inflammation... - Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioningMelanie L Hart
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Gastroenterology 135:1739-1750.e3. 2008..We investigated whether ecto-5'-nucleotidase (CD73), the "pacemaker" enzyme of extracellular adenosine production, is critical for hepatic protection by IP... - Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosaEric T Clambey
Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 109:E2784-93. 2012..These studies demonstrate that hypoxia is an intrinsic molecular cue that promotes FoxP3 expression, in turn eliciting potent anti-inflammatory mechanisms to limit tissue damage in conditions of reduced oxygen availability... - Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in miceAlmut Grenz
Mucosal Inflammation Program, Department of Anesthesiology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
J Clin Invest 122:693-710. 2012..These studies identify ENT1 and adenosine receptors as key to the process of reestablishing renal perfusion following ischemic AKI. If translatable from mice to humans, these data have important therapeutic implications... - Adenosine and hypoxia-inducible factor signaling in intestinal injury and recoverySean P Colgan
Departments of Medicine and Anesthesiology and the Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
Annu Rev Physiol 74:153-75. 2012..Such information has provided new insights into disease pathogenesis and, importantly, will provide insights into new therapeutic targets... - A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in miceTobias Eckle
Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
J Clin Invest 118:3301-15. 2008..Taken together, these studies reveal a role for A2BAR signaling in attenuating VILI and implicate this receptor as a potential therapeutic target during acute lung injury... - Selective deletion of the A1 adenosine receptor abolishes heart-rate slowing effects of intravascular adenosine in vivoMichael Koeppen
Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Denver, Aurora, Colorado, USA
PLoS ONE 4:e6784. 2009..Here, we used comparative genetic in vivo studies to address the contribution of individual ARs to the heart-rate slowing effects of intravascular adenosine... - Adora2b Adenosine Receptor Signaling Protects during Acute Kidney Injury via Inhibition of Neutrophil-Dependent TNF-α ReleaseAlmut Grenz
Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045
J Immunol 189:4566-73. 2012..In total, these data demonstrate a critical role of adenosine signaling in constraining neutrophil-dependent production of TNF-α and implicate therapies targeting TNF-α in the treatment of ischemic AKI... - The reno-vascular A2B adenosine receptor protects the kidney from ischemiaAlmut Grenz
Department of Pharmacology and Toxicology, Tubingen University Hospital, Tubingen, Germany Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
PLoS Med 5:e137. 2008..Here, we identified a novel pathway of renal protection from ischemia using ischemic preconditioning (IP)... - Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitisCarol M Aherne
Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA
Gut 61:695-705. 2012..We therefore hypothesised that netrin-1 could modulate leucocyte infiltration and disease activity in a model of inflammatory bowel disease... - Role of extracellular adenosine in acute lung injuryTobias Eckle
Department of Anesthesiology, Mucosal Inflammation Program, University of Colorado Denver, Aurora, Colorado, USA
Physiology (Bethesda) 24:298-306. 2009..As such, recent evidence indicates extracellular adenosine in orchestrating the resolution of pulmonary edema and inflammation during ALI... - Central role of Sp1-regulated CD39 in hypoxia/ischemia protectionHolger K Eltzschig
Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
Blood 113:224-32. 2009..In summary, these results identify a novel Sp1-dependent regulatory pathway for CD39 and indicate the likelihood that CD39 is central to protective responses to hypoxia/ischemia... - Use of a hanging-weight system for liver ischemic preconditioning in miceMelanie L Hart
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Physiol Gastrointest Liver Physiol 294:G1431-40. 2008..Taken together, these studies confirm highly reproducible liver injury and protection by IP when using the hanging-weight system for hepatic ischemia and intermittent reperfusion. Further studies of murine IP may consider this technique... - Hypoxia signaling during intestinal ischemia and inflammationAlmut Grenz
Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado, Aurora, Colorado 80045, USA
Curr Opin Crit Care 18:178-85. 2012..In many instances, HIF-dependent alterations of gene expression represent endogenous adaptive responses that dampen pathologic inflammation and could be targeted to treat intestinal injury... - Extracellular adenosine: a safety signal that dampens hypoxia-induced inflammation during ischemiaAlmut Grenz
Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA
Antioxid Redox Signal 15:2221-34. 2011.... - Interplay of hypoxia and A2B adenosine receptors in tissue protectionMichael Koeppen
Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, USA
Adv Pharmacol 61:145-86. 2011..As such, the ADORA(2B) has emerged as a therapeutic target for dampening hypoxia-induced inflammation and tissue adaptation to limited oxygen availability... - Partial netrin-1 deficiency aggravates acute kidney injuryAlmut Grenz
Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
PLoS ONE 6:e14812. 2011..Finally, treatment of Ntn-1(+/-) mice with exogenous netrin-1 restored a normal phenotype during AKI. Taking together, these studies implicate endogenous netrin-1 in attenuating renal inflammation during AKI... - The hypoxia-inflammation link and potential drug targetsMichael Koeppen
Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, Colorado 80045, USA
Curr Opin Anaesthesiol 24:363-9. 2011..Hypoxia represents one of the strongest transcriptional stimuli known to us. In most cases, hypoxia-induced changes in gene expression are directed towards adapting tissues to conditions of limited oxygen availability... - Adenosine generation and signaling during acute kidney injuryJessica D Bauerle
Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, 12700 E 19 Avenue, Mailstop B112, Research Complex 2, Room 7124, Aurora, CO 80045, USA
J Am Soc Nephrol 22:14-20. 2011..If these experimental strategies can be translated into a clinical setting, adenosine receptor therapeutics may become an integral part in the prevention or treatment of AKI from renal ischemia... - Usefulness of pressure-controlled ventilation at high inspiratory pressures to induce acute lung injury in miceTobias Eckle
University of Colorado Denver Dept of Anesthesiology and Perioperative Medicine, Aurora, CO 80045, USA
Am J Physiol Lung Cell Mol Physiol 295:L718-24. 2008..Together, these studies demonstrate feasibility of this model to induce murine ALI... - Adora2b adenosine receptor engagement enhances regulatory T cell abundance during endotoxin-induced pulmonary inflammationHeidi Ehrentraut
Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, Colorado, United States of America
PLoS ONE 7:e32416. 2012..In total, these data indicate that the Adora2b adenosine receptor serves a potent anti-inflammatory role, functioning at least in part through the enhancement of Tregs, to limit inflammation... - Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory diseaseJens M Poth
Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado School of Medicine, 12700 East 19th Avenue, Mailstop B112, Aurora, CO 80045, USA
J Mol Med (Berl) 91:183-93. 2013.... - Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemiaTobias Eckle
Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, USA
Nat Med 18:774-82. 2012.... - Evaluation of transmitral pressure gradients in the intraoperative echocardiographic diagnosis of mitral stenosis after mitral valve repairAnn K Riegel
Department of Anesthesiology, University of Colorado Denver, Denver, Colorado, United States of America
PLoS ONE 6:e26559. 2011..Acute mitral stenosis (MS) following mitral valve (MV) repair is a rare but severe complication. We hypothesize that intraoperative echocardiography can be utilized to diagnose iatrogenic MS immediately after MV repair... - Neutrophils as sources of extracellular nucleotides: functional consequences at the vascular interfaceHolger K Eltzschig
Department of Anesthesiology and Intensive Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80220, USA
Trends Cardiovasc Med 18:103-7. 2008..Here, we review the mechanisms of ATP release and subsequent functional implications of ATP metabolism at the interface between PMN and vascular endothelial cells during inflammation and in hypoxia... - Descending aortic calcification increases renal dysfunction and in-hospital mortality in cardiac surgery patients with intraaortic balloon pump counterpulsation placed perioperatively: a case control studyMartina Nowak-Machen
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Crit Care 16:R17. 2012..This might be due to dislodgement of atherosclerotic material in the descending thoracic aorta (DTA). Therefore, we retrospectively studied the correlation between DTA atheroma, AKI and in-hospital mortality... - The resurgence of A2B adenosine receptor signalingCarol M Aherne
Department of Anesthesiology, University of Colorado, Aurora, CO, USA
Biochim Biophys Acta 1808:1329-39. 2011..This is an important consideration for future studies where tissue or cell type specific targeting of the A2BAR may be used as therapeutic approach... - Purinergic regulation of airway inflammationMichael Koeppen
Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA
Subcell Biochem 55:159-93. 2011..By the end of this chapter, the reader will have a new appreciation for this aspect of airway defenses, and several leads in terms of therapeutic applications for the treatment of chronic respiratory diseases... - Safety of transesophageal echocardiographyJan N Hilberath
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Am Soc Echocardiogr 23:1115-27; quiz 1220-1. 2010..In addition, alternative echocardiographic modalities (e.g., epicardial echocardiography) that may be considered when TEE probe placement is contraindicated or not feasible are discussed... - Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injuryMelanie L Hart
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
FASEB J 22:2784-97. 2008..These data reveal a previously unrecognized role of CD73 in attenuating intestinal IR-mediated injury... 
Epicardial echocardiography: diagnostic utility for evaluating aortic valve disease during coronary surgeryVlad E Frenk
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
J Clin Anesth 15:271-4. 2003..However, attempts to place a TEE probe were abandoned due to high resistance on probe insertion. Epicardial echocardiography revealed previously undiagnosed aortic valve disease resulting in replacement of this valve...- Utility of intraoperative transesophageal echocardiography for diagnosis of pulmonary embolismPeter Rosenberger
Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA
Anesth Analg 99:12-6. 2004..Therefore, the use of intraoperative TEE to diagnose acute PE via direct visualization is limited. Indirect TEE evidence of PA obstruction may be helpful in supporting a diagnosis of PE... - Transesophageal echocardiography for detecting extrapulmonary thrombi during pulmonary embolectomyPeter Rosenberger
Department of Anesthesiology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA
Ann Thorac Surg 78:862-6; discussion 866. 2004..These findings support the critical role of intraoperative echocardiography during pulmonary embolectomy... - Acute hemodynamic collapse after induction of general anesthesia for emergent pulmonary embolectomyPeter Rosenberger
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Anesth Analg 102:1311-5. 2006.... - The usefulness of transesophageal echocardiography during intraoperative cardiac arrest in noncardiac surgeryStavros G Memtsoudis
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Anesth Analg 102:1653-7. 2006..Thus, TEE may provide additional diagnostic information in patients with intraoperative cardiac arrest and may directly guide specific, potentially life-saving therapy... - Role of pulmonary adenosine during hypoxia: extracellular generation, signaling and metabolism by surface adenosine deaminase/CD26Annemie Van Linden
University of Colorado Health Science Center, Mucosal Inflammation Program, Department of Anesthesiology, Perioperative Care and Pain Medicine, Biochemistry Research Building BRB, Room 852, 4200 E 9th Avenue, Campus Box B113, Denver, CO 80262, USA
Expert Opin Biol Ther 7:1437-47. 2007..This paper reviews metabolic and transcriptional changes of extracellular adenosine generation, signaling and degradation during acute and prolonged pulmonary hypoxia... - The use of readily available equipment in a simple method for intraoperative monitoring of recurrent laryngeal nerve function during thyroid surgery: initial experience with more than 300 casesHolger K Eltzschig
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Arch Surg 137:452-6; discussion 456-7. 2002..CONCLUSIONS: This technique can be applied to thyroid surgery as a safe means of managing the airway. It is associated with an ability to test RLN function at will in more than 95% of cases using readily available equipment...