Holger K Eltzschig

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Usefulness of intraoperative epiaortic echocardiography to resolve discrepancy between transthoracic and transesophageal measurements of aortic valve gradient - a case report
    Thomas Edrich
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Can J Anaesth 50:293-6. 2003
  2. ncbi request reprint Impact of intraoperative transesophageal echocardiography on surgical decisions in 12,566 patients undergoing cardiac surgery
    Holger K Eltzschig
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen, Germany
    Ann Thorac Surg 85:845-52. 2008
  3. pmc Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection
    Helene A Haeberle
    Department of Anesthesiology and Intensive Care Medicine, University of Tubingen, Tubingen, Germany
    PLoS ONE 3:e3352. 2008
  4. pmc Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia
    Johannes Kuhlicke
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen, Germany
    PLoS ONE 2:e1364. 2007
  5. pmc Central role of Sp1-regulated CD39 in hypoxia/ischemia protection
    Holger K Eltzschig
    Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Blood 113:224-32. 2009
  6. pmc A2B adenosine receptor dampens hypoxia-induced vascular leak
    Tobias Eckle
    Departments of Anesthesiology and Intensive Care, Tubingen University Hospital, Tubingen, Germany
    Blood 111:2024-35. 2008
  7. ncbi request reprint CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury
    David Kohler
    Department of Anesthesiology and Intensive Care Medicine, University Hospital, Tubingen, Germany
    Circulation 116:1784-94. 2007
  8. pmc The reno-vascular A2B adenosine receptor protects the kidney from ischemia
    Almut Grenz
    Department of Pharmacology and Toxicology, Tubingen University Hospital, Tubingen, Germany Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    PLoS Med 5:e137. 2008
  9. pmc Equilibrative nucleoside transporter (ENT)-1-dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusion
    Michael A Zimmerman
    Division of Transplant Surgery, Department of Surgery, University of Colorado, Aurora, CO
    Hepatology 58:1766-78. 2013
  10. pmc Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    Eric T Clambey
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 109:E2784-93. 2012

Detail Information

Publications86

  1. ncbi request reprint Usefulness of intraoperative epiaortic echocardiography to resolve discrepancy between transthoracic and transesophageal measurements of aortic valve gradient - a case report
    Thomas Edrich
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Can J Anaesth 50:293-6. 2003
    ..We describe here the use of epiaortic echocardiography as an alternative to TEE for the intraoperative evaluation of AS...
  2. ncbi request reprint Impact of intraoperative transesophageal echocardiography on surgical decisions in 12,566 patients undergoing cardiac surgery
    Holger K Eltzschig
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen, Germany
    Ann Thorac Surg 85:845-52. 2008
    ..Therefore, we retrospectively evaluated the impact of before and after cardiopulmonary bypass (CPB) TEE on surgical decisions in 12,566 consecutive patients undergoing cardiac surgery at a single institution...
  3. pmc Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection
    Helene A Haeberle
    Department of Anesthesiology and Intensive Care Medicine, University of Tubingen, Tubingen, Germany
    PLoS ONE 3:e3352. 2008
    ..Based on studies showing that respiratory syncytial virus (RSV) is among the most potent biological stimuli to induce an inflammatory milieu, we hypothesized a role of HIF-1alpha as transcriptional regulator during infections with RSV...
  4. pmc Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia
    Johannes Kuhlicke
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen, Germany
    PLoS ONE 2:e1364. 2007
    ..Therefore, we pursued the hypothesis, that tissue hypoxia may influence innate immune responses by transcriptional modulation of Toll-like receptor (TLRs) expression and function...
  5. pmc Central role of Sp1-regulated CD39 in hypoxia/ischemia protection
    Holger K Eltzschig
    Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Blood 113:224-32. 2009
    ..In summary, these results identify a novel Sp1-dependent regulatory pathway for CD39 and indicate the likelihood that CD39 is central to protective responses to hypoxia/ischemia...
  6. pmc A2B adenosine receptor dampens hypoxia-induced vascular leak
    Tobias Eckle
    Departments of Anesthesiology and Intensive Care, Tubingen University Hospital, Tubingen, Germany
    Blood 111:2024-35. 2008
    ..Taken together, these studies provide pharmacologic and genetic evidence for vascular A2BAR signaling as central control point of hypoxia-associated vascular leak...
  7. ncbi request reprint CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury
    David Kohler
    Department of Anesthesiology and Intensive Care Medicine, University Hospital, Tubingen, Germany
    Circulation 116:1784-94. 2007
    ..In the present study, we studied ecto-enzymatic ATP/ADP-phosphohydrolysis by select members of the ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) family during myocardial ischemia...
  8. pmc The reno-vascular A2B adenosine receptor protects the kidney from ischemia
    Almut Grenz
    Department of Pharmacology and Toxicology, Tubingen University Hospital, Tubingen, Germany Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    PLoS Med 5:e137. 2008
    ..Here, we identified a novel pathway of renal protection from ischemia using ischemic preconditioning (IP)...
  9. pmc Equilibrative nucleoside transporter (ENT)-1-dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusion
    Michael A Zimmerman
    Division of Transplant Surgery, Department of Surgery, University of Colorado, Aurora, CO
    Hepatology 58:1766-78. 2013
    ..Treatment with selective adenosine receptor antagonists indicated a contribution of Adora2b receptor signaling in ENT-dependent liver protection...
  10. pmc Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    Eric T Clambey
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 109:E2784-93. 2012
    ..These studies demonstrate that hypoxia is an intrinsic molecular cue that promotes FoxP3 expression, in turn eliciting potent anti-inflammatory mechanisms to limit tissue damage in conditions of reduced oxygen availability...
  11. pmc Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado School of Medicine, 12700 E 19th Ave, Aurora, CO 80045, USA
    FASEB J 27:3078-89. 2013
    ..Our newly identified crosstalk pathway between ENT2 and alveolar epithelial Adora2b in lung protection during ALI opens possibilities for combined therapies targeted to this protein set...
  12. ncbi request reprint HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak
    Julio C Morote-Garcia
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen, Germany
    Blood 111:5571-80. 2008
    ....
  13. pmc A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 118:3301-15. 2008
    ..Taken together, these studies reveal a role for A2BAR signaling in attenuating VILI and implicate this receptor as a potential therapeutic target during acute lung injury...
  14. ncbi request reprint Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores
    Hanna Hartmann
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Tubingen, Eberhard Karls Universitat, Tubingen, Germany
    Gastroenterology 134:756-67. 2008
    ..However, molecular details of how bacteria activate HIF-1 remain unclear. Here, we pursued the role of bacterial siderophores in HIF-1 activation during infection with Enterobacteriaceae...
  15. doi request reprint Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia
    Peter Rosenberger
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen 72076, Germany
    Nat Immunol 10:195-202. 2009
    ..Our studies demonstrate that HIF-1alpha-dependent induction of netrin-1 attenuates hypoxia-elicited inflammation at mucosal surfaces...
  16. doi request reprint Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia
    Julio C Morote-Garcia
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen, Germany
    Gastroenterology 136:607-18. 2009
    ..Previous studies implicated signaling via extracellular adenosine in endogenous attenuation of intestinal inflammation; we investigated whether epithelial adenosine transport could reduce hypoxia-induced inflammation of the mucosa...
  17. ncbi request reprint Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury
    Almut Grenz
    Department of Pharmacology and Toxicology, Tubingen University Hospital, Tubingen, Germany
    FASEB J 21:2863-73. 2007
    ..Moreover, the present studies suggest apyrase treatment as a novel pharmacological approach to renal diseases precipitated by limited oxygen availability...
  18. ncbi request reprint Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors
    Tobias Eckle
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Circulation 115:1581-90. 2007
    ..Once generated, adenosine can activate cell-surface adenosine receptors (A1 AR, A2A AR, A2B AR, A3 AR). In the present study, we define the contribution of adenosine to cardioprotection by ischemic preconditioning...
  19. pmc Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
    J Clin Invest 122:693-710. 2012
    ..These studies identify ENT1 and adenosine receptors as key to the process of reestablishing renal perfusion following ischemic AKI. If translatable from mice to humans, these data have important therapeutic implications...
  20. pmc CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury
    Heidi Ehrentraut
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    FASEB J 27:2207-19. 2013
    ..Together, these studies implicate CD73-dependent adenosine generation in Tregs in promoting ALI resolution...
  21. pmc Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado, Aurora, CO 80045
    J Immunol 192:1249-56. 2014
    ..Together, these studies implicate HIF in the transcriptional control of pulmonary adenosine signaling during ALI. ..
  22. doi request reprint Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs
    Jörg Reutershan
    Department of Anesthesiology and Intensive Care Medicine, University of Tubingen, Tubingen, Germany
    FASEB J 23:473-82. 2009
    ..Taken together, these data reveal a previously unrecognized role for CD39 and CD73 in attenuating PMN trafficking into the lungs during LPS-induced lung injury and suggest treatment with their soluble compounds as a therapeutic strategy...
  23. pmc Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury
    Ulrich Schingnitz
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen, Germany
    J Immunol 184:5271-9. 2010
    ..These studies suggest the A2BAR as potential therapeutic target in the treatment of endotoxin-induced forms of acute lung injury...
  24. pmc HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium
    Tobias Eckle
    Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Denver, Colorado, United States of America
    PLoS Biol 11:e1001665. 2013
    ..Therefore, we hypothesized that mechanical ventilation and concomitant stretch-exposure of pulmonary epithelia could activate endogenous pathways important in lung protection...
  25. pmc SP1-dependent induction of CD39 facilitates hepatic ischemic preconditioning
    Melanie L Hart
    Department of Anesthesiology and Intensive Care Medicine, University of Tubingen, Tubingen, Germany
    J Immunol 184:4017-24. 2010
    ..Our data suggest a Sp1-dependent regulatory pathway for CD39 during hepatic IP. These studies reveal a novel role of CD39 in hepatic protection and suggest soluble apyrase for the treatment of liver ischemia...
  26. ncbi request reprint ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function
    Holger K Eltzschig
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Germany
    Circ Res 99:1100-8. 2006
    ..01). Taken together, our results identify a previously unappreciated role for Cx43 in activated PMN ATP release, therein contributing to the innate metabolic control of the inflammatory milieu...
  27. pmc Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis
    Carol M Aherne
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA
    Gut 61:695-705. 2012
    ..We therefore hypothesised that netrin-1 could modulate leucocyte infiltration and disease activity in a model of inflammatory bowel disease...
  28. pmc Protective role for netrin-1 during diabetic nephropathy
    Eunyoung Tak
    Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, 12700 E 19th Avenue, Mailstop B112, Research Complex 2, Room 7121, Aurora, CO 80045, USA
    J Mol Med (Berl) 91:1071-80. 2013
    ..Taken together, these studies demonstrate a functional role for endogenous netrin-1 in attenuating diabetic kidney disease...
  29. pmc ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia
    Marion Faigle
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen, Germany
    PLoS ONE 3:e2801. 2008
    ..Extracellular ATP is an important signaling molecule for vascular adaptation to limited oxygen availability (hypoxia). Here, we pursued the contribution of vascular endothelia to extracellular ATP release under hypoxic conditions...
  30. pmc Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery
    Sean P Colgan
    Departments of Medicine and Anesthesiology and the Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Annu Rev Physiol 74:153-75. 2012
    ..Such information has provided new insights into disease pathogenesis and, importantly, will provide insights into new therapeutic targets...
  31. doi request reprint Cutting Edge: A2B Adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury
    Melanie L Hart
    Department of Anesthesiology and Intensive Care Medicine, Center for Inflammation and Hypoxia, University of Tubingen, Germany
    J Immunol 182:3965-8. 2009
    ..Taken together, these studies demonstrate the A2BAR as a novel therapeutic target for protection during gastrointestinal IR injury...
  32. doi request reprint Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning
    Tobias Eckle
    Department of Anesthesiology and Intensive Care Medicine, University Hospital, Tubingen, Germany
    Circulation 118:166-75. 2008
    ..Convincing evidence confirms a central role of hypoxia-inducible factor (HIF)-1 in mammalian oxygen homeostasis. Thus, we pursued HIF-1 as a central component of cardioprotection by ischemic preconditioning...
  33. pmc Hypoxia-inducible factor-1α-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5'-nucleotidase (CD73) and the A2B adenosine receptor
    Melanie L Hart
    Department of Anesthesiology and Critical Care Medicine, Tubingen University Hospital, D 72074 Tubingen, Germany
    J Immunol 186:4367-74. 2011
    ..These studies indicated a tissue-protective role of HIF-dependent enhancement of intestinal adenosine generation and signaling during intestinal IR...
  34. ncbi request reprint Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury
    Tobias Eckle
    Department of Anesthesiology and Intensive Care Medicine, Center for Biomedical Research, Tubingen University Hospital, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    J Immunol 178:8127-37. 2007
    ..Taken together, these data reveal a previously unrecognized role for CD39 and CD73 in lung protection and suggest treatment with their soluble compounds as a therapeutic strategy for noninfectious ALI...
  35. doi request reprint Repression of the equilibrative nucleoside transporters dampens inflammatory lung injury
    Julio C Morote-Garcia
    Department of Anesthesiology and Intensive Care Medicine, Eberhard Karls University and Tübingen University Hospital, Tubingen, Germany
    Am J Respir Cell Mol Biol 49:296-305. 2013
    ..The inhibition of ENTs could be pursued as a therapeutic option to ameliorate inflammatory lung injury. ..
  36. pmc Selective deletion of the A1 adenosine receptor abolishes heart-rate slowing effects of intravascular adenosine in vivo
    Michael Koeppen
    Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Denver, Aurora, Colorado, USA
    PLoS ONE 4:e6784. 2009
    ..Here, we used comparative genetic in vivo studies to address the contribution of individual ARs to the heart-rate slowing effects of intravascular adenosine...
  37. pmc Signaling through hepatocellular A2B adenosine receptors dampens ischemia and reperfusion injury of the liver
    Michael A Zimmerman
    Division of Transplant Surgery, Department of Surgery, and Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado, Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 110:12012-7. 2013
    ..These studies provide a unique role for hepatocellular-specific Adora2b signaling in liver protection during ischemia and reperfusion injury...
  38. pmc Adora2b adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNF-α release
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 189:4566-73. 2012
    ..In total, these data demonstrate a critical role of adenosine signaling in constraining neutrophil-dependent production of TNF-α and implicate therapies targeting TNF-α in the treatment of ischemic AKI...
  39. pmc Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis
    Julia Stefanie Frick
    Institute for Medical Microbiology and Hygiene, University Hospital, Tubingen, Germany
    J Immunol 182:4957-64. 2009
    ....
  40. pmc Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, USA
    Nat Med 18:774-82. 2012
    ....
  41. pmc Partial netrin-1 deficiency aggravates acute kidney injury
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
    PLoS ONE 6:e14812. 2011
    ..Finally, treatment of Ntn-1(+/-) mice with exogenous netrin-1 restored a normal phenotype during AKI. Taking together, these studies implicate endogenous netrin-1 in attenuating renal inflammation during AKI...
  42. ncbi request reprint Role of extracellular adenosine in acute lung injury
    Tobias Eckle
    Department of Anesthesiology, Mucosal Inflammation Program, University of Colorado Denver, Aurora, Colorado, USA
    Physiology (Bethesda) 24:298-306. 2009
    ..As such, recent evidence indicates extracellular adenosine in orchestrating the resolution of pulmonary edema and inflammation during ALI...
  43. ncbi request reprint Nucleotide metabolism and cell-cell interactions
    Holger K Eltzschig
    Department of Anesthesiology and Intensive Care Medicine, Tubingen, Germany
    Methods Mol Biol 341:73-87. 2006
    ..This crosstalk pathway provides an endogenous mechanism to dampen vascular leak syndrome during neutrophil-endothelial interaction. In other words, during TEM, neutrophils close the door behind them...
  44. ncbi request reprint Upregulation of the water channel aquaporin-4 as a potential cause of postischemic cell swelling in a murine model of myocardial infarction
    Arne Warth
    Institute of Pathology, University Hospital Tubingen, Tubingen, Germany
    Cardiology 107:402-10. 2007
    ....
  45. ncbi request reprint Effect of hydroxyethyl starch on vascular leak syndrome and neutrophil accumulation during hypoxia
    Hans Jürgen Dieterich
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen, Germany
    Crit Care Med 34:1775-82. 2006
    ..Therefore, we compared functional influences of hydroxyethyl starch on normoxic or posthypoxic endothelia...
  46. pmc Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26
    Holger K Eltzschig
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Blood 108:1602-10. 2006
    ..In contrast, during acute hypoxia associated with vascular leakage and excessive inflammation, ADA inhibition may serve as therapeutic strategy...
  47. doi request reprint Usefulness of pressure-controlled ventilation at high inspiratory pressures to induce acute lung injury in mice
    Tobias Eckle
    University of Colorado Denver Dept of Anesthesiology and Perioperative Medicine, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 295:L718-24. 2008
    ..Together, these studies demonstrate feasibility of this model to induce murine ALI...
  48. pmc Perioperative organ injury
    Karsten Bartels
    Fellow in Critical Care Medicine and Cardiothoracic Anesthesiology, Assistant Professor of Anesthesiology, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina Assistant Professor of Anesthesiology, Associate Professor of Anesthesiology, Professor of Anesthesiology, Department of Anesthesiology, University of Colorado Denver, Aurora, Colorado
    Anesthesiology 119:1474-89. 2013
    ....
  49. pmc Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation
    Ann Kathrin Riegel
    Department of Anesthesiology and Intensive Care Medicine, University of Tubingen, Tubingen, Germany
    Blood 117:2548-55. 2011
    ..These studies show an important contribution of P2Y(6) signaling in enhancing vascular inflammation during systemic LPS challenge and implicate the P2Y(6) receptor as a therapeutic target during systemic inflammatory responses...
  50. pmc Hypoxia signaling during intestinal ischemia and inflammation
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado, Aurora, Colorado 80045, USA
    Curr Opin Crit Care 18:178-85. 2012
    ..In many instances, HIF-dependent alterations of gene expression represent endogenous adaptive responses that dampen pathologic inflammation and could be targeted to treat intestinal injury...
  51. pmc Neutrophil intercellular communication in acute lung injury. Emerging roles of microparticles and gap junctions
    Viola Dengler
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Am J Respir Cell Mol Biol 49:1-5. 2013
    ..By focusing on these cell-cell communications, we aim to demonstrate significant gaps of knowledge and identify areas of considerable need for further investigations of the processes of acute lung inflammation. ..
  52. pmc Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease
    Jens M Poth
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado School of Medicine, 12700 East 19th Avenue, Mailstop B112, Aurora, CO 80045, USA
    J Mol Med (Berl) 91:183-93. 2013
    ....
  53. pmc Neutrophils as sources of extracellular nucleotides: functional consequences at the vascular interface
    Holger K Eltzschig
    Department of Anesthesiology and Intensive Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80220, USA
    Trends Cardiovasc Med 18:103-7. 2008
    ..Here, we review the mechanisms of ATP release and subsequent functional implications of ATP metabolism at the interface between PMN and vascular endothelial cells during inflammation and in hypoxia...
  54. doi request reprint The influence of epiaortic ultrasonography on intraoperative surgical management in 6051 cardiac surgical patients
    Peter Rosenberger
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen, Germany
    Ann Thorac Surg 85:548-53. 2008
    ..Its impact on surgical decision making has not been thoroughly investigated, however...
  55. ncbi request reprint Protective role of ecto-5'-nucleotidase (CD73) in renal ischemia
    Almut Grenz
    Department of Pharmacology and Toxicology, Tubingen University Hospital, Tubingen, Germany
    J Am Soc Nephrol 18:833-45. 2007
    ....
  56. doi request reprint Purinergic regulation of airway inflammation
    Michael Koeppen
    Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA
    Subcell Biochem 55:159-93. 2011
    ..By the end of this chapter, the reader will have a new appreciation for this aspect of airway defenses, and several leads in terms of therapeutic applications for the treatment of chronic respiratory diseases...
  57. doi request reprint Interplay of hypoxia and A2B adenosine receptors in tissue protection
    Michael Koeppen
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, USA
    Adv Pharmacol 61:145-86. 2011
    ..As such, the ADORA(2B) has emerged as a therapeutic target for dampening hypoxia-induced inflammation and tissue adaptation to limited oxygen availability...
  58. pmc Ischemia and reperfusion--from mechanism to translation
    Holger K Eltzschig
    Department of Anesthesiology, Mucosal Inflammation Program, University of Colorado, Aurora, Colorado, USA
    Nat Med 17:1391-401. 2011
    ....
  59. pmc Extracellular adenosine: a safety signal that dampens hypoxia-induced inflammation during ischemia
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA
    Antioxid Redox Signal 15:2221-34. 2011
    ....
  60. pmc Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis
    Joanne C Masterson
    Section of Pediatric Gastroenterology, Hepatology and Nutrition, Digestive Health Institute, Aurora, Colorado, USA
    Gut 63:43-53. 2014
    ..Eosinophilic oesophagitis (EoE) is a chronic inflammatory condition of the oesophagus with limited treatment options. No previous transgenic model has specifically targeted the oesophageal mucosa to induce oesophageal eosinophilia...
  61. pmc Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation
    Holger K Eltzschig
    University of Colorado, Mucosal Inflammation Program, Department of Medicine, Denver, 12700 E 19th Avenue, Mailstop B112, Research Complex 2, Room 7124, Aurora, CO 80045, USA
    Expert Opin Ther Targets 13:1267-77. 2009
    ..In addition, we discuss the role of this pathway in dampening hypoxia-elicited inflammation, specifically in the setting of intestinal ischemia and inflammation...
  62. doi request reprint Direct treatment of mouse or human blood with soluble 5'-nucleotidase inhibits platelet aggregation
    Melanie L Hart
    Department of Anesthesiology and Intensive Care Medicine, University of Tubingen, Germany
    Arterioscler Thromb Vasc Biol 28:1477-83. 2008
    ..However, the effects of 5'-NT treatment on platelet aggregation remain unknown. We examined the direct effects of 5'-NT treatment on platelet aggregation in vivo and ex vivo using a whole blood aggregation method...
  63. ncbi request reprint Role of pulmonary adenosine during hypoxia: extracellular generation, signaling and metabolism by surface adenosine deaminase/CD26
    Annemie Van Linden
    University of Colorado Health Science Center, Mucosal Inflammation Program, Department of Anesthesiology, Perioperative Care and Pain Medicine, Biochemistry Research Building BRB, Room 852, 4200 E 9th Avenue, Campus Box B113, Denver, CO 80262, USA
    Expert Opin Biol Ther 7:1437-47. 2007
    ..This paper reviews metabolic and transcriptional changes of extracellular adenosine generation, signaling and degradation during acute and prolonged pulmonary hypoxia...
  64. ncbi request reprint Physiological roles of vascular nucleoside transporters
    Michaela Loffler
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Waldhörnle Str 22, 72072, Tubingen, Germany
    Arterioscler Thromb Vasc Biol 27:1004-13. 2007
    ..Taken together, vascular NTs are critical in modulating adenosine-mediated responses during conditions such as inflammation or hypoxia...
  65. pmc Attenuating myocardial ischemia by targeting A2B adenosine receptors
    Holger K Eltzschig
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA
    Trends Mol Med 19:345-54. 2013
    ....
  66. ncbi request reprint Role of transesophageal echocardiography in patients with suspected aortic dissection
    Holger K Eltzschig
    Department of Anesthesiology and Intensive Care Medicine, Tuebingen University Hospital, Tuebingen, Germany
    J Am Soc Echocardiogr 18:1221. 2005
    ..This case demonstrates that intraoperative TEE can be used as a primary diagnostic modality to rule out aortic dissection, and can provide a definitive etiology for cardiogenic shock before a planned surgical intervention...
  67. ncbi request reprint Effect of synthetic colloids on major histocompatibility complex class II expression
    Helene A Haeberle
    Department of Anesthesiology and Intensive Care Medicine, Tuebingen University Hospital, 72076 Tuebingen, Germany
    J Clin Anesth 18:96-101. 2006
    ..We hypothesized that their use may be associated with changes in major histocompatibility complex (MHC) class II expression. This could affect patients' morbidity and mortality during clinical intervention...
  68. pmc HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia
    Holger K Eltzschig
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen, Germany
    J Exp Med 202:1493-505. 2005
    ..Moreover, epithelial Hif1alpha mutant animals displayed increased epithelial ENT1 expression. Together, these results identify transcriptional repression of ENT as an innate mechanism to elevate extracellular Ado during hypoxia...
  69. ncbi request reprint Correlation between ST-T-segment changes with markers of hemostasis in patients with acute coronary syndromes
    Raila Ehlers
    Medizinische Klinik, Abteilung III, Eberhard Karls Universitat, Tubingen, Germany
    Cardiology 98:40-5. 2002
    ..We investigated the correlation between serum markers of the hemostatic/inflammatory system and ECG changes in ACS...
  70. ncbi request reprint Utility of intraoperative transesophageal echocardiography for diagnosis of pulmonary embolism
    Peter Rosenberger
    Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Anesth Analg 99:12-6. 2004
    ..Therefore, the use of intraoperative TEE to diagnose acute PE via direct visualization is limited. Indirect TEE evidence of PA obstruction may be helpful in supporting a diagnosis of PE...
  71. ncbi request reprint Transesophageal echocardiography for detecting extrapulmonary thrombi during pulmonary embolectomy
    Peter Rosenberger
    Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ann Thorac Surg 78:862-6; discussion 866. 2004
    ..However, its utility for detecting concurrent intrathoracic, extrapulmonary thromboemboli has not been thoroughly investigated...
  72. doi request reprint A novel view for visualizing a left pulmonary artery thromboembolus with intraoperative transesophageal echocardiography
    Martina Nowak
    Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Clin Anesth 20:136-8. 2008
    ..We present a case in which thromboembolic material within the midleft pulmonary artery was incidentally diagnosed using additional, modified transesophageal echocardiography views, in a patient undergoing mitral valve repair...
  73. ncbi request reprint Echocardiographic evidence of right ventricular remodeling after transplantation
    Holger K Eltzschig
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Thorac Surg 74:584-6. 2002
    ..Transesophageal echocardiography documents RV hypertrophy and remodeling between RVAD implantation and removal, suggesting a rapid adaptive response of the right ventricle in the presence of pulmonary hypertension...
  74. ncbi request reprint Critical role of intraoperative transesophageal echocardiography for detection of extrapulmonary thromboemboli during surgical pulmonary embolectomy
    Martina Nowak
    Anesthesiology 104:1346; author reply 1346-7. 2006
  75. ncbi request reprint The usefulness of transesophageal echocardiography during intraoperative cardiac arrest in noncardiac surgery
    Stavros G Memtsoudis
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesth Analg 102:1653-7. 2006
    ..Thus, TEE may provide additional diagnostic information in patients with intraoperative cardiac arrest and may directly guide specific, potentially life-saving therapy...
  76. ncbi request reprint Role of intraoperative transesophageal echocardiography for diagnosing and managing pulmonary embolism in the perioperative period
    Peter Rosenberger
    Anesth Analg 100:292-3; author reply 293. 2005
  77. ncbi request reprint Ischemic mitral regurgitation during temporary coronary-artery ligation
    Holger K Eltzschig
    N Engl J Med 350:2424-5. 2004
  78. ncbi request reprint Transesophageal echocardiography for pulmonary embolectomy
    Peter Rosenberger
    Ann Thorac Surg 79:1092-3; author reply 1093. 2005
  79. ncbi request reprint Usefulness of transesophageal echocardiography to diagnose perioperative pulmonary embolism
    Peter Rosenberger
    J Clin Anesth 17:146-7; author reply 147. 2005
  80. ncbi request reprint Cardiac index measurements during rapid preload changes: a comparison of pulmonary artery thermodilution with arterial pulse contour analysis
    Thomas W Felbinger
    Department of Anesthesiology, Grosshadern Medical Center, University of Munich, 81377 Munich, Germany
    J Clin Anesth 17:241-8. 2005
    ....
  81. ncbi request reprint Perioperative pulmonary embolism
    Peter Rosenberger
    Anesth Analg 97:1855. 2003
  82. ncbi request reprint A practical approach to a comprehensive epicardial and epiaortic echocardiographic examination
    Holger K Eltzschig
    Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cardiothorac Vasc Anesth 17:422-9. 2003
    ..The authors developed a comprehensive examination protocol for the intraoperative interrogation of cardiac structures using an epicardial/epiaortic echocardiographic approach...
  83. ncbi request reprint Epicardial echocardiography: diagnostic utility for evaluating aortic valve disease during coronary surgery
    Vlad E Frenk
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Clin Anesth 15:271-4. 2003
    ..However, attempts to place a TEE probe were abandoned due to high resistance on probe insertion. Epicardial echocardiography revealed previously undiagnosed aortic valve disease resulting in replacement of this valve...
  84. ncbi request reprint Images in anesthesia: Detection of a defect pulmonary artery catheter balloon by transesophageal echocardiography
    Thomas W Felbinger
    Boston, Massachusetts, USA
    Can J Anaesth 50:480. 2003
  85. ncbi request reprint Comparison of pulmonary arterial thermodilution and arterial pulse contour analysis: evaluation of a new algorithm
    Thomas W Felbinger
    Department of Anesthesiology, Grosshadern Medical Center, University of Munich, Munich, Germany
    J Clin Anesth 14:296-301. 2002
    ....
  86. ncbi request reprint Intraoperative transesophageal echocardiography to assess septic coronary embolism
    Holger K Eltzschig
    Department of Anesthesiology, Perioperative and Pain Medicine, Division of Cardiac Surgery, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Anesthesiology 97:1627-9. 2002