TIMOTHY ELSTON

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Dose-to-duration encoding and signaling beyond saturation in intracellular signaling networks
    Marcelo Behar
    Department of Physics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Comput Biol 4:e1000197. 2008
  2. ncbi request reprint Probing pathways periodically
    Timothy C Elston
    Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA
    Sci Signal 1:pe47. 2008
  3. pmc A mathematical model for human nucleotide excision repair: damage recognition by random order assembly and kinetic proofreading
    Kevin J Kesseler
    Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7255, USA
    J Theor Biol 249:361-75. 2007
  4. pmc Kinetic models for the coordinated stepping of cytoplasmic dynein
    Denis Tsygankov
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Chem Phys 130:025101. 2009
  5. ncbi request reprint Causal mapping as a tool to mechanistically interpret phenomena in cell motility: application to cortical oscillations in spreading cells
    Gabriel E Weinreb
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Cell Motil Cytoskeleton 63:523-32. 2006
  6. pmc In silico generation of alternative hypotheses using causal mapping (CMAP)
    Gabriel E Weinreb
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e5378. 2009
  7. pmc Biochemical Network Stochastic Simulator (BioNetS): software for stochastic modeling of biochemical networks
    David Adalsteinsson
    Department of Mathematics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3250, USA
    BMC Bioinformatics 5:24. 2004
  8. pmc Bistability, stochasticity, and oscillations in the mitogen-activated protein kinase cascade
    Xiao Wang
    Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7365, USA
    Biophys J 90:1961-78. 2006
  9. pmc Control of MAPK specificity by feedback phosphorylation of shared adaptor protein Ste50
    Nan Hao
    Department of Biochemistry, University of North Carolina, Chapel Hill, North Carolina 27599 7260, USA
    J Biol Chem 283:33798-802. 2008
  10. ncbi request reprint Regulators of G protein signaling and transient activation of signaling: experimental and computational analysis reveals negative and positive feedback controls on G protein activity
    Nan Hao
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 0812, USA
    J Biol Chem 278:46506-15. 2003

Collaborators

Detail Information

Publications19

  1. pmc Dose-to-duration encoding and signaling beyond saturation in intracellular signaling networks
    Marcelo Behar
    Department of Physics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Comput Biol 4:e1000197. 2008
    ....
  2. ncbi request reprint Probing pathways periodically
    Timothy C Elston
    Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA
    Sci Signal 1:pe47. 2008
    ..These studies shed light on how the network functions as a whole to respond to changing environmental conditions...
  3. pmc A mathematical model for human nucleotide excision repair: damage recognition by random order assembly and kinetic proofreading
    Kevin J Kesseler
    Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7255, USA
    J Theor Biol 249:361-75. 2007
    ..Finally, a comparison between the random order assembly with kinetic proofreading model and a sequential assembly model is made. This investigation reveals the advantages of the random order assembly/kinetic proofreading model...
  4. pmc Kinetic models for the coordinated stepping of cytoplasmic dynein
    Denis Tsygankov
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Chem Phys 130:025101. 2009
    ..Finally, we use the results of these investigations to develop a full model for dimeric dynein's chemomechanical cycle and analyze this model to make experimentally testable predictions...
  5. ncbi request reprint Causal mapping as a tool to mechanistically interpret phenomena in cell motility: application to cortical oscillations in spreading cells
    Gabriel E Weinreb
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Cell Motil Cytoskeleton 63:523-32. 2006
    ....
  6. pmc In silico generation of alternative hypotheses using causal mapping (CMAP)
    Gabriel E Weinreb
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e5378. 2009
    ..The method can be widely applied to other cellular systems to generate and compare alternative hypotheses based on experimentally observed data and using computer simulations...
  7. pmc Biochemical Network Stochastic Simulator (BioNetS): software for stochastic modeling of biochemical networks
    David Adalsteinsson
    Department of Mathematics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3250, USA
    BMC Bioinformatics 5:24. 2004
    ..Therefore, there is a need for computational tools for developing and investigating stochastic models of biochemical networks...
  8. pmc Bistability, stochasticity, and oscillations in the mitogen-activated protein kinase cascade
    Xiao Wang
    Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7365, USA
    Biophys J 90:1961-78. 2006
    ..We demonstrate that the inclusion of protein turnover can lead to sustained oscillations of protein concentrations in the absence of feedback regulation. Thus, protein turnover can profoundly influence the output of a signaling pathway...
  9. pmc Control of MAPK specificity by feedback phosphorylation of shared adaptor protein Ste50
    Nan Hao
    Department of Biochemistry, University of North Carolina, Chapel Hill, North Carolina 27599 7260, USA
    J Biol Chem 283:33798-802. 2008
    ..Thus feedback regulation of a shared component can restrict the activity of a competing MAP kinase to ensure signal fidelity...
  10. ncbi request reprint Regulators of G protein signaling and transient activation of signaling: experimental and computational analysis reveals negative and positive feedback controls on G protein activity
    Nan Hao
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 0812, USA
    J Biol Chem 278:46506-15. 2003
    ..We identified and quantitated these positive and negative feedback loops, which account for the transient response to external signals observed in vivo...
  11. pmc Mechanical and biochemical modeling of cortical oscillations in spreading cells
    Maryna Kapustina
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Biophys J 94:4605-20. 2008
    ....
  12. pmc RhoA regulates calcium-independent periodic contractions of the cell cortex
    Nancy Costigliola
    Department of Cell and Developmental Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Biophys J 99:1053-63. 2010
    ..Not only will these studies guide future experiments, they will also provide a framework for the development of refined mathematical models of the oscillatory process...
  13. ncbi request reprint A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress-response pathway
    Nan Hao
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Curr Biol 17:659-67. 2007
    ..For instance in yeast, the mitogen-activated protein (MAP) kinase Hog1 is activated and inactivated within minutes, even when the osmotic-stress stimulus is sustained...
  14. ncbi request reprint A numerical algorithm for investigating the role of the motor-cargo linkage in molecular motor-driven transport
    John Fricks
    Department of Mathematics, University of North Carolina, Chapel Hill, NC 27599 3250, USA
    J Theor Biol 239:33-48. 2006
    ..The MATLAB code used in this paper is available at: http://www.unc.edu/approximatelytelston/code/...
  15. pmc Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5
    Nan Hao
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Cell 30:649-56. 2008
    ..We propose that scaffold proteins serve to modulate the temporal and dose-response behavior of the MAP kinase...
  16. pmc Mathematical and computational analysis of adaptation via feedback inhibition in signal transduction pathways
    Marcelo Behar
    Department of Physics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Biophys J 93:806-21. 2007
    ..Finally, we present characteristic features for each form of feedback regulation that can aid in their identification...
  17. pmc A structural model reveals energy transduction in dynein
    Adrian W R Serohijos
    Department of Physics and Astronomy, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 103:18540-5. 2006
    ..This study provides insights into the structure and function of dynein that can guide further experimental investigations into energy transduction in dynein...
  18. pmc Modeling capping protein FRAP and CALI experiments reveals in vivo regulation of actin dynamics
    Maryna Kapustina
    Department of Cell and Developmental Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7090, USA
    Cytoskeleton (Hoboken) 67:519-34. 2010
    ....
  19. pmc Kinetic insulation as an effective mechanism for achieving pathway specificity in intracellular signaling networks
    Marcelo Behar
    Department of Physics, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 104:16146-51. 2007
    ..Our results suggest that multilevel signaling cascades may have evolved to modulate the temporal profile of pathway activity so that stimulus information can be efficiently encoded and transmitted while ensuring signal specificity...

Research Grants9

  1. Spatiotemporal modeling of signal transduction in yeast
    Timothy C Elston; Fiscal Year: 2010
    ..Because yeast has long served as a prototype for hormone, neurotransmitter and sensory responses in humans, the results of these investigations may ultimately lead to novel strategies for treating human disease. ..
  2. Cytoskeletal Oscillations: Mathematical Modeling Integrated with Experiments
    TIMOTHY ELSTON; Fiscal Year: 2006
    ..inputs to the cell affect oscillatory behavior? 3) How is the biochemical network connected to the constituents and mechanics of the cytoskeleton and how does spatial heterogeneity of cellular elements affect the oscillations? ..
  3. Cytoskeletal Oscillations: Mathematical Modeling Integrated with Experiments
    TIMOTHY ELSTON; Fiscal Year: 2007
    ..inputs to the cell affect oscillatory behavior? 3) How is the biochemical network connected to the constituents and mechanics of the cytoskeleton and how does spatial heterogeneity of cellular elements affect the oscillations? ..
  4. Spatiotemporal modeling of signal transduction in yeast
    TIMOTHY ELSTON; Fiscal Year: 2007
    ..Finally, the spatiotemporal model is linked to a temporal model of the pheromone-regulated promoter developed in Aim 2 to accurately predict how protein localization affects transcriptional induction over time. ..
  5. Cytoskeletal Oscillations: Mathematical Modeling Integrated with Experiments
    TIMOTHY ELSTON; Fiscal Year: 2009
    ..inputs to the cell affect oscillatory behavior? 3) How is the biochemical network connected to the constituents and mechanics of the cytoskeleton and how does spatial heterogeneity of cellular elements affect the oscillations? ..
  6. Spatiotemporal modeling of signal transduction in yeast
    TIMOTHY ELSTON; Fiscal Year: 2009
    ..Finally, the spatiotemporal model is linked to a temporal model of the pheromone-regulated promoter developed in Aim 2 to accurately predict how protein localization affects transcriptional induction over time. ..