CHARLES ELSON

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Host-microbiota interactions in inflammatory bowel disease
    Charles O Elson
    Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Gut Microbes 3:332-44. 2012
  2. ncbi request reprint Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota
    Charles O Elson
    Division of Gastroenterology and Hepatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Immunol Rev 206:260-76. 2005
  3. ncbi request reprint Gene disruption and immunity in experimental colitis
    Charles O Elson
    Division of Gastroenterology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Inflamm Bowel Dis 10:S25-8. 2004
  4. ncbi request reprint Molecular approaches to the role of the microbiota in inflammatory bowel disease
    Charles O Elson
    Division of Gastroenterology and Hepatology, The University of Alabama Birmingham, 633 Zeigler Research Building, 703 S 19th Street, Birmingham, AL 35294 0007, USA
    Ann N Y Acad Sci 1072:39-51. 2006
  5. ncbi request reprint Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice
    Charles O Elson
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Gastroenterology 132:2359-70. 2007
  6. ncbi request reprint Understanding immune-microbial homeostasis in intestine
    Charles O Elson
    Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, 35294 0007, USA
    Immunol Res 26:87-94. 2002
  7. ncbi request reprint Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora
    Yingzi Cong
    Division of Gastroenterology and Hepatology, University of Alabama, Birmingham 35294, USA
    J Immunol 169:6112-9. 2002
  8. pmc Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis
    Ting Feng
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 207:1321-32. 2010
  9. ncbi request reprint Isolation of flagellated bacteria implicated in Crohn's disease
    L Wayne Duck
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Inflamm Bowel Dis 13:1191-201. 2007
  10. ncbi request reprint Tight mucosal compartmentation of the murine immune response to antigens of the enteric microbiota
    Astrid Konrad
    Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Gastroenterology 130:2050-9. 2006

Research Grants

  1. 11th International Congress of Mucosal Immunology
    CHARLES ELSON; Fiscal Year: 2002
  2. CORE--ANIMAL MODEL
    CHARLES ELSON; Fiscal Year: 2007
  3. INTESTINAL T-REGULATORY-1 CELLS IN MUCOSAL HOMEOSTASIS
    CHARLES ELSON; Fiscal Year: 2006

Collaborators

Detail Information

Publications39

  1. pmc Host-microbiota interactions in inflammatory bowel disease
    Charles O Elson
    Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Gut Microbes 3:332-44. 2012
    ..However, host genotype and the environment have a major impact on the shape of such dysbiosis, as well as upon which members of the microbiota stimulate pathogenic immune responses...
  2. ncbi request reprint Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota
    Charles O Elson
    Division of Gastroenterology and Hepatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Immunol Rev 206:260-76. 2005
    ..The same is true for both spontaneous models of IBD, C3H/HeJBir and SAMPI/Yit mice. The thesis is advanced that 'multiple hits' or defects in these interacting components is required for IBD to occur in both mouse and human...
  3. ncbi request reprint Gene disruption and immunity in experimental colitis
    Charles O Elson
    Division of Gastroenterology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Inflamm Bowel Dis 10:S25-8. 2004
  4. ncbi request reprint Molecular approaches to the role of the microbiota in inflammatory bowel disease
    Charles O Elson
    Division of Gastroenterology and Hepatology, The University of Alabama Birmingham, 633 Zeigler Research Building, 703 S 19th Street, Birmingham, AL 35294 0007, USA
    Ann N Y Acad Sci 1072:39-51. 2006
    ..Previously unknown microbial flagellins were the dominant cluster of antigens identified. About half of the sera from patients with Crohn's disease have IgG antibodies to these flagellins...
  5. ncbi request reprint Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice
    Charles O Elson
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Gastroenterology 132:2359-70. 2007
    ..Interleukin (IL)-23 supports a distinct lineage of T cells producing IL-17 (Th17) that can mediate chronic inflammation. This study was performed to define the role of IL-23 and Th17 cells in chronic colitis in mice...
  6. ncbi request reprint Understanding immune-microbial homeostasis in intestine
    Charles O Elson
    Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, 35294 0007, USA
    Immunol Res 26:87-94. 2002
    ..Manyquestions remain to be answered, including, How do the enteric bacterial-host interactions shape the immune system for abnormal responses such as inflammatory bowel disease, autoimmunity, and allergy?..
  7. ncbi request reprint Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora
    Yingzi Cong
    Division of Gastroenterology and Hepatology, University of Alabama, Birmingham 35294, USA
    J Immunol 169:6112-9. 2002
    ..We conclude that CD4(+) T cells with the properties of Tr1 cells are present in the intestinal lamina propria and hypothesize that these cells maintain intestinal immune homeostasis to the enteric flora...
  8. pmc Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis
    Ting Feng
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 207:1321-32. 2010
    ..Collectively, our data demonstrate that induction of colitis requires both spontaneous proliferation of T cells driven by microbiota-derived innate signals and antigen-specific T cell proliferation...
  9. ncbi request reprint Isolation of flagellated bacteria implicated in Crohn's disease
    L Wayne Duck
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Inflamm Bowel Dis 13:1191-201. 2007
    ..The present study was done to identify the microbial source of such flagellins...
  10. ncbi request reprint Tight mucosal compartmentation of the murine immune response to antigens of the enteric microbiota
    Astrid Konrad
    Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Gastroenterology 130:2050-9. 2006
    ..The normal host immune response to antigens of the enteric microbiota is poorly defined. In this study, we isolated recombinant microbial antigens from commensal bacteria and used them to probe the normal murine immune response...
  11. doi request reprint Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid
    Ting Feng
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 185:5915-25. 2010
    ..These data indicate that RA plays a critical role in the generation of mucosal DCs from bone marrow and in their functional activity...
  12. pmc T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis
    Nuzhat Iqbal
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    J Exp Med 195:71-84. 2002
    ....
  13. ncbi request reprint Animal models of intestinal inflammation: ineffective communication between coalition members
    Robin G Lorenz
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Springer Semin Immunopathol 27:233-47. 2005
    ..These animal models of colitis have shown that alterations in communication between members of this coalition ultimately lead to gastrointestinal disease...
  14. ncbi request reprint Transforming growth factor-beta induces development of the T(H)17 lineage
    Paul R Mangan
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    Nature 441:231-4. 2006
    ..The action of TGF-beta on naive T cells is antagonized by interferon-gamma and IL-4, thus providing a mechanism for divergence of the T(H)1, T(H)2 and T(H)17 lineages...
  15. ncbi request reprint Immune response versus mucosal tolerance to mucosally administered antigens
    Jiri Mestecky
    Department of Microbiology BBRB 757, University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294 2170, USA
    Vaccine 23:1800-3. 2005
    ..Thus, ongoing systemic responses are refractory to the induction of mucosal tolerance in humans. This finding is of considerable importance for the development of and sequence of immunization with mucosally administered vaccines...
  16. pmc A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota
    Yingzi Cong
    Departments of Medicine and Microbiology, Pediatric Dentistry, and Genetics, University of Alabama at Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 106:19256-61. 2009
    ..We propose that the major role of this coordinated Treg-IgA response is to maintain commensalism with the microbiota...
  17. doi request reprint Curcumin induces the tolerogenic dendritic cell that promotes differentiation of intestine-protective regulatory T cells
    Yingzi Cong
    Division of Gastroenterology and Hepatology, Department of Medicine, Birmingham, AL 35294 0007, USA
    Eur J Immunol 39:3134-46. 2009
    ..More importantly, these Treg inhibited antigen-specific T-cell activation in vitro and inhibited colitis due to antigen-specific pathogenic T cells in vivo...
  18. pmc TGF-beta promotes Th17 cell development through inhibition of SOCS3
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    J Immunol 183:97-105. 2009
    ..Our data indicate that inhibition of SOCS3 and, thus, enhancement of STAT3 activation is at least one of the mechanisms of TGF-beta promotion of Th17 cell development...
  19. pmc Late developmental plasticity in the T helper 17 lineage
    Yun Kyung Lee
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Immunity 30:92-107. 2009
    ..These results support a model of late Th17 developmental plasticity with implications for autoimmunity and host defense...
  20. ncbi request reprint Perspectives on mucosal vaccines: is mucosal tolerance a barrier?
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 179:5633-8. 2007
    ..Optimization of mucosal vaccination strategies has the potential for enhancing protective immune responses and suppressing systemic responses to autoantigens desirable for the treatment of autoimmune diseases...
  21. ncbi request reprint Probiotics and immune regulation of inflammatory bowel diseases
    Yingzi Cong
    Division of Gastroenterology and Hepatology, The University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Curr Drug Targets Inflamm Allergy 2:145-54. 2003
    ....
  22. ncbi request reprint Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function
    Yingzi Cong
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 174:2787-95. 2005
    ..We conclude that NF-kappaB-blocked, immature APC are able to induce the differentiation of Treg cells that can function in vitro and in vivo in an Ag-specific manner...
  23. ncbi request reprint Oral tolerance in humans: failure to suppress an existing immune response by oral antigen administration
    Zina Moldoveanu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Ann N Y Acad Sci 1029:299-309. 2004
    ..Therefore, some form of immunomodulation greater than that provided by oral administration of antigen alone is required in humans for suppression of an existing immune response...
  24. ncbi request reprint Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells
    Takekazu Kubo
    Department of Pathology, University of Alabama, Birmingham, AL 35294 2170, USA
    J Immunol 173:7249-58. 2004
    ..Thus, proinflammatory cytokines produced by TLR-activated, mature DCs are required for reversal of Treg anergy, but are not required to overcome Treg suppression...
  25. ncbi request reprint Regulation of gene expression in inflammatory bowel disease and correlation with IBD drugs: screening by DNA microarrays
    Thomas P Dooley
    IntegriDerm Inc, Birmingham, Alabama 35211, USA
    Inflamm Bowel Dis 10:1-14. 2004
    ..This affordable in vitro methodology is promising for expanded studies of IBD and other diseases...
  26. ncbi request reprint Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 179:5966-76. 2007
    ....
  27. ncbi request reprint Genes, microbes, and T cells--new therapeutic targets in Crohn's disease
    Charles O Elson
    University of Alabama at Birmingham, 35294 0007, USA
    N Engl J Med 346:614-6. 2002
  28. ncbi request reprint Challenges in IBD Research: updating the scientific agendas
    Charles O Elson
    Division of Gastroenterology, Inflammatory Bowel Disease Center, University of Alabama at Birmingham, USA
    Inflamm Bowel Dis 9:137-53. 2003
  29. ncbi request reprint Peyer's patches as the inductive site for IgA responses
    Jiri Mestecky
    Division of Gastroenterology, University of Alabama at Birmingham, 703 South 19th Street, Birmingham, AL 35294, USA
    J Immunol 180:1293-4. 2008
  30. ncbi request reprint Refined histopathologic scoring system improves power to detect colitis QTL in mice
    Andre Bleich
    Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, 30625 Hannover, Germany
    Mamm Genome 15:865-71. 2004
    ....
  31. ncbi request reprint Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens
    Jason Beckwith
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Gastroenterology 129:1473-84. 2005
    ..We developed reciprocal Cdcs1 congenic stocks on both interleukin 10-deficient backgrounds to identify the susceptibility gene and its function...
  32. pmc Bacterial flagellin is a dominant antigen in Crohn disease
    Michael J Lodes
    Corixa Corp, Seattle, Washington, USA
    J Clin Invest 113:1296-306. 2004
    ....
  33. ncbi request reprint Fenofibrate represses interleukin-17 and interferon-gamma expression and improves colitis in interleukin-10-deficient mice
    Jimmy W Lee
    Biomedical Sciences Division, University of California, Riverside, California 92521 0121, USA
    Gastroenterology 133:108-23. 2007
    ....
  34. ncbi request reprint A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion
    Jishu Shi
    Department of Anatomy, Physiology, and Pharmacology, Auburn University, Auburn, AL 36849, USA
    J Immunol 179:1245-53. 2007
    ..Thus, alpha-defensins may play an important role in intestinal homeostasis by controlling the production of IL-1beta...
  35. ncbi request reprint Anti-interleukin-12 antibody for active Crohn's disease
    Peter J Mannon
    Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 351:2069-79. 2004
    ..Crohn's disease is associated with excess cytokine activity mediated by type 1 helper T (Th1) cells. Interleukin-12 is a key cytokine that initiates Th1-mediated inflammatory responses...
  36. pmc From cheese to pharma: a designer probiotic for IBD
    Charles O Elson
    Clin Gastroenterol Hepatol 4:836-7. 2006
  37. ncbi request reprint Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease
    Stephan R Targan
    Cedars Sinai Inflammatory Bowel Disease Center, Los Angeles, California 90048, USA
    Gastroenterology 128:2020-8. 2005
    ....
  38. ncbi request reprint CCFA microbial-host interactions workshop: highlights and key observations
    R Balfour Sartor
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Inflamm Bowel Dis 13:600-19. 2007
    ....
  39. ncbi request reprint Anti-flagellin (CBir1) phenotypic and genetic Crohn's disease associations
    Konstantinos A Papadakis
    Cedars Sinai Inflammatory Bowel Disease Center, Los Angeles, California, USA
    Inflamm Bowel Dis 13:524-30. 2007
    ..We examined the association between anti-CBir1 and clinical phenotypes and NOD2 variants in a large cohort of adult CD patients...

Research Grants11

  1. 11th International Congress of Mucosal Immunology
    CHARLES ELSON; Fiscal Year: 2002
    ..b>Charles Elson (University of Alabama)...
  2. CORE--ANIMAL MODEL
    CHARLES ELSON; Fiscal Year: 2007
    ..Dr. Charles Elson will serve as Director and Dr. Casey Weaver will serve as Co-Director...
  3. INTESTINAL T-REGULATORY-1 CELLS IN MUCOSAL HOMEOSTASIS
    CHARLES ELSON; Fiscal Year: 2006
    ..Our long-term goal is an understanding of Tr1 cells sufficient to manipulate this subset as a novel therapy for human intestinal inflammatory diseases. ..