Mahmoud A ElSohly

Summary

Affiliation: University of Mississippi
Country: USA

Publications

  1. ncbi request reprint Chemical constituents of marijuana: the complex mixture of natural cannabinoids
    Mahmoud A ElSohly
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Life Sci 78:539-48. 2005
  2. doi request reprint Synthetic cannabinoids: analysis and metabolites
    Mahmoud A ElSohly
    ElSohly Laboratories, Inc, 5 Industrial Park Drive, Oxford, MS 38655, USA National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677, USA Electronic address
    Life Sci 97:78-90. 2014
  3. doi request reprint Biologically active cannabinoids from high-potency Cannabis sativa
    Mohamed M Radwan
    Department of Pharmaceutics, National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Mississippi 38677, USA
    J Nat Prod 72:906-11. 2009
  4. pmc Chemical stability and bioadhesive properties of an ester prodrug of Delta 9-tetrahydrocannabinol in poly(ethylene oxide) matrices: effect of formulation additives
    Sridhar Thumma
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Int J Pharm 362:126-32. 2008
  5. doi request reprint Non-cannabinoid constituents from a high potency Cannabis sativa variety
    Mohamed M Radwan
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Phytochemistry 69:2627-33. 2008
  6. pmc Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers
    Desmond Slade
    National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Bioorg Med Chem 17:7949-57. 2009
  7. ncbi request reprint LC-(TOF) MS analysis of benzodiazepines in urine from alleged victims of drug-facilitated sexual assault
    Mahmoud A ElSohly
    ElSohly Laboratories, Incorporated, 5 Industrial Park Drive, Oxford, Mississippi 38655, USA
    J Anal Toxicol 31:505-14. 2007
  8. pmc Chemical stabilization of a Delta9-tetrahydrocannabinol prodrug in polymeric matrix systems produced by a hot-melt method: role of microenvironment pH
    Manish Munjal
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS, USA
    AAPS PharmSciTech 7:71. 2006
  9. pmc Preformulation studies of a prodrug of Delta9-tetrahydrocannabinol
    Sridhar Thumma
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA
    AAPS PharmSciTech 9:982-90. 2008
  10. doi request reprint Synthesis and evaluation of dihydroartemisinin and dihydroartemisitene acetal dimers showing anticancer and antiprotozoal activity
    Ahmed M Galal
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Bioorg Med Chem 17:741-51. 2009

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Chemical constituents of marijuana: the complex mixture of natural cannabinoids
    Mahmoud A ElSohly
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Life Sci 78:539-48. 2005
    ..This manuscript discusses the chemical constituents of the plant with particular emphasis on the cannabinoids as the class of compounds responsible for the drug's psychological properties...
  2. doi request reprint Synthetic cannabinoids: analysis and metabolites
    Mahmoud A ElSohly
    ElSohly Laboratories, Inc, 5 Industrial Park Drive, Oxford, MS 38655, USA National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677, USA Electronic address
    Life Sci 97:78-90. 2014
    ....
  3. doi request reprint Biologically active cannabinoids from high-potency Cannabis sativa
    Mohamed M Radwan
    Department of Pharmaceutics, National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Mississippi 38677, USA
    J Nat Prod 72:906-11. 2009
    ..Compounds 6 and 7 displayed significant antibacterial and antifungal activities, respectively, while 5 displayed strong antileishmanial activity...
  4. pmc Chemical stability and bioadhesive properties of an ester prodrug of Delta 9-tetrahydrocannabinol in poly(ethylene oxide) matrices: effect of formulation additives
    Sridhar Thumma
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Int J Pharm 362:126-32. 2008
    ..4%) at the end of 3 months at 25 degrees C/60% RH. The prodrug was very stable in both of the final formulations at the end of the 3 months at 40 degrees C/75% RH...
  5. doi request reprint Non-cannabinoid constituents from a high potency Cannabis sativa variety
    Mohamed M Radwan
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Phytochemistry 69:2627-33. 2008
    ..Some isolates displayed weak to strong antimicrobial, antileishmanial, antimalarial and anti-oxidant activities. Compounds 2-4 were inactive as analgesics...
  6. pmc Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers
    Desmond Slade
    National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Bioorg Med Chem 17:7949-57. 2009
    ..The antileishmanial and antibacterial activities were marginal. A number of dihydroartemisinin acetal monomers (15-17) and a trimer (18) were isolated as byproducts from the dimer synthesis and were also tested for biological activity...
  7. ncbi request reprint LC-(TOF) MS analysis of benzodiazepines in urine from alleged victims of drug-facilitated sexual assault
    Mahmoud A ElSohly
    ElSohly Laboratories, Incorporated, 5 Industrial Park Drive, Oxford, Mississippi 38655, USA
    J Anal Toxicol 31:505-14. 2007
    ..Additionally, the distribution of the individual benzodiazepines of interest among the 156 specimens as well as their prevalence in specimens originating in different U.S. states is presented...
  8. pmc Chemical stabilization of a Delta9-tetrahydrocannabinol prodrug in polymeric matrix systems produced by a hot-melt method: role of microenvironment pH
    Manish Munjal
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS, USA
    AAPS PharmSciTech 7:71. 2006
    ..Investigation of the pH effect revealed that the pH of the microenvironment in these polymeric systems could be modulated to significantly improve the stability of THC-HS, degradation being the least in a relatively acidic medium...
  9. pmc Preformulation studies of a prodrug of Delta9-tetrahydrocannabinol
    Sridhar Thumma
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA
    AAPS PharmSciTech 9:982-90. 2008
    ..THC-HG was found to be sensitive to the presence of oxygen. The release of the active from the polymeric matrices decreased, while bioadhesion increased, with an increase in molecular weight of PEO...
  10. doi request reprint Synthesis and evaluation of dihydroartemisinin and dihydroartemisitene acetal dimers showing anticancer and antiprotozoal activity
    Ahmed M Galal
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Bioorg Med Chem 17:741-51. 2009
    ..The dimers were also evaluated for their antimalarial and antileishmanial activities. The antimalarial activity ranged from 0.3 to 32 nM (IC(50)), compared to 9.9 nM for artemisinin...
  11. pmc Influence of plasticizers on the stability and release of a prodrug of Delta(9)-tetrahydrocannabinol incorporated in poly (ethylene oxide) matrices
    Sridhar Thumma
    Department of Pharmaceutics, The University of Mississippi, MS 38677, USA
    Eur J Pharm Biopharm 70:605-14. 2008
    ..A faster release resulted from water-soluble plasticizers, PEG 8000 and triacetin, and with increasing concentration. However, a slower release was observed with an increase in concentration of water-insoluble plasticizers, VES and ATBC...
  12. doi request reprint Potency trends of Δ9-THC and other cannabinoids in confiscated cannabis preparations from 1993 to 2008
    Zlatko Mehmedic
    National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    J Forensic Sci 55:1209-17. 2010
    ..0-29.3% (2004-2008). Hash oil potencies also varied considerably during this period (16.8 ± 16.3%). The increase in cannabis preparation potency is mainly due to the increase in the potency of nondomestic versus domestic samples...
  13. pmc Enhanced solubility, stability, and transcorneal permeability of δ-8-tetrahydrocannabinol in the presence of cyclodextrins
    Ketan Hippalgaonkar
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, Oxford, 38677, USA
    AAPS PharmSciTech 12:723-31. 2011
    ..Thus, topical ophthalmic formulations containing Δ(8)-THC and modified beta CDs may show markedly improved ocular bioavailability...
  14. doi request reprint Cannabinoid ester constituents from high-potency Cannabis sativa
    Safwat A Ahmed
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA
    J Nat Prod 71:536-42. 2008
    ..Compound 8 showed moderate antimicrobial activity against Candida albicans ATCC 90028 with an IC 50 value of 8.5 microg/mL. The isolated acids and the ester-containing fractions showed low affinity to the CB-1 receptor. [corrected]..
  15. ncbi request reprint Simultaneous analysis of thirty-five benzodiazepines in urine using liquid chromatography-mass spectrometry-time of flight
    Mahmoud A ElSohly
    ElSohly Laboratories, Incorporated, 5 Industrial Park Drive, Oxford, Mississippi 38655, USA
    J Anal Toxicol 32:547-61. 2008
    ..All immunoassay positive specimens were confirmed by this procedure for one or more analytes. However, only 12 out of the 35 benzodiazepines analyzed were detected in these specimens...
  16. pmc Ocular disposition of the hemiglutarate ester prodrug of ∆⁹-Tetrahydrocannabinol from various ophthalmic formulations
    Tushar Hingorani
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA
    Pharm Res 30:2146-56. 2013
    ..The overall goal of this project is to enhance ocular delivery of ∆(9)-Tetrahydrocannabinol (THC) through the topical route...
  17. doi request reprint Pelargonium oil and methyl hexaneamine (MHA): analytical approaches supporting the absence of MHA in authenticated Pelargonium graveolens plant material and oil
    Mahmoud A ElSohly
    ElSohly Laboratories, Inc, 5 Industrial Park Drive, Oxford, MS 38655, USA
    J Anal Toxicol 36:457-71. 2012
    ..The amounts of MHA measured are incompatible with the use of reasonable amounts of P. graveolens extract or concentrate, suggesting that MHA was of synthetic origin...
  18. doi request reprint Molecular analysis of genetic fidelity in Cannabis sativa L. plants grown from synthetic (encapsulated) seeds following in vitro storage
    Hemant Lata
    National Center for Natural Product Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA
    Biotechnol Lett 33:2503-8. 2011
    ....
  19. pmc Polymeric systems for amorphous Delta9-tetrahydrocannabinol produced by a hot-melt method. Part II: Effect of oxidation mechanisms and chemical interactions on stability
    Manish Munjal
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, Mississippi 38677 1848, USA
    J Pharm Sci 95:2473-85. 2006
    ..These studies are relevant to the development of a stable transmucosal matrix system for the therapeutic delivery of amorphous THC...
  20. doi request reprint Genetic identification of female Cannabis sativa plants at early developmental stage
    Natascha Techen
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Planta Med 76:1938-9. 2010
    ..The results of this study represent a quick and reliable technique for the identification of sex in Cannabis plants using SCAR markers at a very early developmental stage...
  21. doi request reprint Assessment of cannabinoids content in micropropagated plants of Cannabis sativa and their comparison with conventionally propagated plants and mother plant during developmental stages of growth
    Suman Chandra
    National Center for Natural Product Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Planta Med 76:743-50. 2010
    ....
  22. doi request reprint Assessment of the genetic stability of micropropagated plants of Cannabis sativa by ISSR markers
    Hemant Lata
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Planta Med 76:97-100. 2010
    ..These results suggest that the micropropagation protocol developed by us for rapid IN VITRO multiplication is appropriate and applicable for clonal mass propagation of C. SATIVA...
  23. ncbi request reprint Deoxyartemisinin derivatives from photooxygenation of anhydrodeoxydihydroartemisinin and their cytotoxic evaluation
    Ahmed M Galal
    National Center for Natural Products Research, University of Mississippi, 38677, USA
    J Nat Prod 65:184-8. 2002
    ..Of the compounds tested, deoxyartemisitene (14) demonstrated significant cytotoxicity against a number of human cancer cell lines...
  24. doi request reprint Isolation and characterization of new Cannabis constituents from a high potency variety
    Mohamed M Radwan
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Planta Med 74:267-72. 2008
    ..The antimicrobial as well as the antileishmanial activities were investigated...
  25. ncbi request reprint Liquid chromatography-tandem mass spectrometry analysis of urine specimens for K2 (JWH-018) metabolites
    Mahmoud A ElSohly
    ElSohly Laboratories, Inc, 5 Industrial Park Drive, Oxford, Mississippi 38655, USA
    J Anal Toxicol 35:487-95. 2011
    ..The concentrations of these metabolites are determined in several forensic urine specimens...
  26. pmc Towards a better understanding of the psychopharmacology of nutmeg: Activities in the mouse tetrad assay
    Abir T El-Alfy
    Pharmacology Department, School of Pharmacy, The University of Mississippi, MS 38677, United States
    J Ethnopharmacol 126:280-6. 2009
    ..Nutmeg at high doses is considered a cheap substitute to several drugs of abuse. Earlier reports have attributed amphetamine-like activities to nutmeg...
  27. doi request reprint High frequency plant regeneration from leaf derived callus of high Δ9-tetrahydrocannabinol yielding Cannabis sativa L
    Hemant Lata
    School of Pharmacy, University of Mississippi, University, MS, USA
    Planta Med 76:1629-33. 2010
    ..5 µM IBA. The rooted plantlets were successfully established in soil and grown to maturity with no gross variations in morphology and cannabinoids content at a survival rate of 95 % in the indoor growroom...
  28. pmc Preparation and characterization of inclusion complexes of a hemisuccinate ester prodrug of delta9-tetrahydrocannabinol with modified beta-cyclodextrins
    Sampada B Upadhye
    Department of Pharmaceutics, The University of Mississippi, P O Box 1848, University, Mississippi 38677, USA
    AAPS PharmSciTech 11:509-17. 2010
    ..The solubility of THC-HS was significantly higher in RAMEB compared to HPBCD. Solid dispersions of THC-HS with CDs will be further utilized to develop oral formulations of THC-HS with enhanced bioavailability...
  29. ncbi request reprint Polymeric systems for amorphous Delta 9-tetrahydrocannabinol produced by a hot-melt method. Part I: chemical and thermal stability during processing
    Manish Munjal
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, 38677 1848, USA
    J Pharm Sci 95:1841-53. 2006
    ..Due to this, matrix fabrication was found to be favorable at relatively lower temperatures, such as 120 degrees C...
  30. doi request reprint Profiling primaquine metabolites in primary human hepatocytes using UHPLC-QTOF-MS with 13C stable isotope labeling
    Bharathi Avula
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    J Mass Spectrom 48:276-85. 2013
    ..These findings shed additional light on the human hepatic metabolism of PQ, and the method can be applied for identification of reactive PQ metabolites generated in vivo in preclinical and clinical studies...
  31. ncbi request reprint Syncarpamide, a new antiplasmodial (+)-norepinephrine derivative from Zanthoxylum syncarpum
    Samir A Ross
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS 38677 1848, USA
    J Nat Prod 67:88-90. 2004
    ..42 microM, whereas compound 1 was not cytotoxic at 10.42 microM. Compound 1 was tested for hypotensive activity, but no activity was observed. Compound 2 showed no antiplasmodial or antimicrobial activities...
  32. ncbi request reprint Antioxidant effect of flavonoids on DCF production in HL-60 cells
    Satoshi Takamatsu
    National Center for Natural Products Research and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA
    Phytother Res 17:963-6. 2003
    ..In the present study, the antioxidant activity of a number of structurally related flavonoids of plant origin and some of their microbial transformation products (1-18) were evaluated...
  33. pmc Photosynthetic response of Cannabis sativa L. to variations in photosynthetic photon flux densities, temperature and CO2 conditions
    Suman Chandra
    National Center for Natural Product Research, School of Pharmacy, University of Mississippi, Oxford, MS 38677 USA
    Physiol Mol Biol Plants 14:299-306. 2008
    ..Furthermore, higher PN, WUE and nearly constant Ci/Ca ratio under elevated CO2 concentrations in C. sativa, reflects its potential for better survival, growth and productivity in drier and CO2 rich environment...
  34. ncbi request reprint Determination of the anthraquinones aloe-emodin and aloin-A by liquid chromatography with mass spectrometric and diode array detection
    Mahmoud A ElSohly
    ElSohly Laboratories Inc, 5 Industrial Park Dr, Oxford, MS 38655, USA
    J AOAC Int 90:28-42. 2007
    ..025 ng by LC/MS for aloin-A and aloe-emodin, respectively. The methods are simple and sensitive and provide reproducible results; therefore, they are suitable for the determination of these anthraquinones in various aloe-based products...
  35. ncbi request reprint Naturally occurring and related synthetic cannabinoids and their potential therapeutic applications
    Ahmed M Galal
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Recent Pat CNS Drug Discov 4:112-36. 2009
    ....
  36. pmc Temperature response of photosynthesis in different drug and fiber varieties of Cannabis sativa L
    Suman Chandra
    National Center for Natural Product Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677 USA
    Physiol Mol Biol Plants 17:297-303. 2011
    ..The results provide a valuable indication regarding variations in temperature dependence of PN in different varieties of Cannabis sativa L...
  37. pmc Photosynthetic response of Cannabis sativa L., an important medicinal plant, to elevated levels of CO2
    Suman Chandra
    National Center for Natural Product Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677 USA
    Physiol Mol Biol Plants 17:291-5. 2011
    ..The higher P N, WUE and nearly constant C i/C a ratio under elevated CO2 concentrations in this species reflect a close coordination between its stomatal and mesophyll functions...
  38. pmc Propagation through alginate encapsulation of axillary buds of Cannabis sativa L. - an important medicinal plant
    Hemant Lata
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677 USA
    Physiol Mol Biol Plants 15:79-86. 2009
    ..These plants are selected to be used in mass cultivation for the production of biomass as a starting material for the isolation of THC as a bulk active pharmaceutical...
  39. ncbi request reprint LC-MS-(TOF) analysis method for benzodiazepines in urine samples from alleged drug-facilitated sexual assault victims
    Mahmoud A ElSohly
    ElSohly Laboratories, Inc, 5 Industrial Park Drive, Oxford, Mississippi 38655, USA
    J Anal Toxicol 30:524-38. 2006
    ..The results of reanalysis of these samples using this LC-MS method are reported...
  40. ncbi request reprint Hydrolysis of conjugated metabolites of buprenorphine II. The quantitative enzymatic hydrolysis of norbuprenorphine-3-beta-D-glucuronide in human urine
    Mahmoud A ElSohly
    ElSohly Laboratories, Incorporated, Oxford, Mississippi 38655, USA
    J Anal Toxicol 29:570-3. 2005
    ..At 60 degrees C, complete hydrolysis was achieved with 1000 units of H. pomatia in 4 h and after only 1 h with glusulase. On the other hand, incubation at 60 degrees C for 4 h with Patella vulgata resulted in only 14.7% hydrolysis...
  41. ncbi request reprint Recent patent reviews on small molecule-based antimalarial drugs
    Mahmoud A ElSohly
    ElSohly Laboratories, Incorporated, 5 Industrial Park Drive, Oxford, Mississippi 38655, USA
    Recent Pat Antiinfect Drug Discov 2:222-32. 2007
    ..This review presents the recent patents that reveal development of novel antimalarial drugs...
  42. doi request reprint LC-MS-MS analysis of dietary supplements for N-ethyl-α-ethyl-phenethylamine (ETH), N, N-diethylphenethylamine and phenethylamine
    Mahmoud A ElSohly
    1 ElSohly Laboratories, Inc ELI and Phytochemical Services, Incorporated PSI, 5 Industrial Park Drive, Oxford, MS 38655, USA
    J Anal Toxicol 38:63-72. 2014
    ..The day-to-day variability was 9.8% for the low control and 3.1% for the high control. The method was used to analyze a variety of dietary supplements for ETH as well as PEA and its N, N-diethyl derivative (NDP). ..
  43. pmc Temperature stability and bioadhesive properties of delta9-tetrahydrocannabinol incorporated hydroxypropylcellulose polymer matrix systems
    Michael A Repka
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677 1848, USA
    Drug Dev Ind Pharm 32:21-32. 2006
    ....
  44. ncbi request reprint Flavonoid glycosides and cannabinoids from the pollen of Cannabis sativa L
    Samir A Ross
    National Center for Natural Products Research, University of Mississippi, University, Mississippi 38677 1848, USA
    Phytochem Anal 16:45-8. 2005
    ....
  45. ncbi request reprint Practical challenges to positive drug tests for marijuana
    Mahmoud A ElSohly
    Clin Chem 49:1037-8. 2003
  46. ncbi request reprint Antifungal activity of artemisinin derivatives
    Ahmed M Galal
    College of Pharmacy, Cairo University, Kasr El Eini Street, 11562, Cairo, Egypt
    J Nat Prod 68:1274-6. 2005
    ..neoformans. Against C. albicans, the overall antifungal effect of these compounds was weak or negligible. Derivatives 2-30 were prepared according to literature procedures...