Mahmoud A ElSohly

Summary

Affiliation: University of Mississippi
Country: USA

Publications

  1. ncbi Chemical constituents of marijuana: the complex mixture of natural cannabinoids
    Mahmoud A ElSohly
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Life Sci 78:539-48. 2005
  2. ncbi Biologically active cannabinoids from high-potency Cannabis sativa
    Mohamed M Radwan
    Department of Pharmaceutics, National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Mississippi 38677, USA
    J Nat Prod 72:906-11. 2009
  3. ncbi Chemical stability and bioadhesive properties of an ester prodrug of Delta 9-tetrahydrocannabinol in poly(ethylene oxide) matrices: effect of formulation additives
    Sridhar Thumma
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Int J Pharm 362:126-32. 2008
  4. ncbi Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers
    Desmond Slade
    National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Bioorg Med Chem 17:7949-57. 2009
  5. ncbi Non-cannabinoid constituents from a high potency Cannabis sativa variety
    Mohamed M Radwan
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Phytochemistry 69:2627-33. 2008
  6. ncbi Preformulation studies of a prodrug of Delta9-tetrahydrocannabinol
    Sridhar Thumma
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA
    AAPS PharmSciTech 9:982-90. 2008
  7. ncbi Chemical stabilization of a Delta9-tetrahydrocannabinol prodrug in polymeric matrix systems produced by a hot-melt method: role of microenvironment pH
    Manish Munjal
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS, USA
    AAPS PharmSciTech 7:71. 2006
  8. ncbi Potency trends of Δ9-THC and other cannabinoids in confiscated cannabis preparations from 1993 to 2008
    Zlatko Mehmedic
    National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    J Forensic Sci 55:1209-17. 2010
  9. ncbi Influence of plasticizers on the stability and release of a prodrug of Delta(9)-tetrahydrocannabinol incorporated in poly (ethylene oxide) matrices
    Sridhar Thumma
    Department of Pharmaceutics, The University of Mississippi, MS 38677, USA
    Eur J Pharm Biopharm 70:605-14. 2008
  10. ncbi Enhanced solubility, stability, and transcorneal permeability of δ-8-tetrahydrocannabinol in the presence of cyclodextrins
    Ketan Hippalgaonkar
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, Oxford, 38677, USA
    AAPS PharmSciTech 12:723-31. 2011

Collaborators

Detail Information

Publications32

  1. ncbi Chemical constituents of marijuana: the complex mixture of natural cannabinoids
    Mahmoud A ElSohly
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Life Sci 78:539-48. 2005
    ..This manuscript discusses the chemical constituents of the plant with particular emphasis on the cannabinoids as the class of compounds responsible for the drug's psychological properties...
  2. ncbi Biologically active cannabinoids from high-potency Cannabis sativa
    Mohamed M Radwan
    Department of Pharmaceutics, National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Mississippi 38677, USA
    J Nat Prod 72:906-11. 2009
    ..Compounds 6 and 7 displayed significant antibacterial and antifungal activities, respectively, while 5 displayed strong antileishmanial activity...
  3. ncbi Chemical stability and bioadhesive properties of an ester prodrug of Delta 9-tetrahydrocannabinol in poly(ethylene oxide) matrices: effect of formulation additives
    Sridhar Thumma
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Int J Pharm 362:126-32. 2008
    ..4%) at the end of 3 months at 25 degrees C/60% RH. The prodrug was very stable in both of the final formulations at the end of the 3 months at 40 degrees C/75% RH...
  4. ncbi Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers
    Desmond Slade
    National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Bioorg Med Chem 17:7949-57. 2009
    ..The antileishmanial and antibacterial activities were marginal. A number of dihydroartemisinin acetal monomers (15-17) and a trimer (18) were isolated as byproducts from the dimer synthesis and were also tested for biological activity...
  5. ncbi Non-cannabinoid constituents from a high potency Cannabis sativa variety
    Mohamed M Radwan
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Phytochemistry 69:2627-33. 2008
    ..Some isolates displayed weak to strong antimicrobial, antileishmanial, antimalarial and anti-oxidant activities. Compounds 2-4 were inactive as analgesics...
  6. ncbi Preformulation studies of a prodrug of Delta9-tetrahydrocannabinol
    Sridhar Thumma
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA
    AAPS PharmSciTech 9:982-90. 2008
    ..THC-HG was found to be sensitive to the presence of oxygen. The release of the active from the polymeric matrices decreased, while bioadhesion increased, with an increase in molecular weight of PEO...
  7. ncbi Chemical stabilization of a Delta9-tetrahydrocannabinol prodrug in polymeric matrix systems produced by a hot-melt method: role of microenvironment pH
    Manish Munjal
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS, USA
    AAPS PharmSciTech 7:71. 2006
    ..Investigation of the pH effect revealed that the pH of the microenvironment in these polymeric systems could be modulated to significantly improve the stability of THC-HS, degradation being the least in a relatively acidic medium...
  8. ncbi Potency trends of Δ9-THC and other cannabinoids in confiscated cannabis preparations from 1993 to 2008
    Zlatko Mehmedic
    National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    J Forensic Sci 55:1209-17. 2010
    ..0-29.3% (2004-2008). Hash oil potencies also varied considerably during this period (16.8 ± 16.3%). The increase in cannabis preparation potency is mainly due to the increase in the potency of nondomestic versus domestic samples...
  9. ncbi Influence of plasticizers on the stability and release of a prodrug of Delta(9)-tetrahydrocannabinol incorporated in poly (ethylene oxide) matrices
    Sridhar Thumma
    Department of Pharmaceutics, The University of Mississippi, MS 38677, USA
    Eur J Pharm Biopharm 70:605-14. 2008
    ..A faster release resulted from water-soluble plasticizers, PEG 8000 and triacetin, and with increasing concentration. However, a slower release was observed with an increase in concentration of water-insoluble plasticizers, VES and ATBC...
  10. ncbi Enhanced solubility, stability, and transcorneal permeability of δ-8-tetrahydrocannabinol in the presence of cyclodextrins
    Ketan Hippalgaonkar
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, Oxford, 38677, USA
    AAPS PharmSciTech 12:723-31. 2011
    ..Thus, topical ophthalmic formulations containing Δ(8)-THC and modified beta CDs may show markedly improved ocular bioavailability...
  11. ncbi Cannabinoid ester constituents from high-potency Cannabis sativa
    Safwat A Ahmed
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA
    J Nat Prod 71:536-42. 2008
    ..Compound 8 showed moderate antimicrobial activity against Candida albicans ATCC 90028 with an IC 50 value of 8.5 microg/mL. The isolated acids and the ester-containing fractions showed low affinity to the CB-1 receptor. [corrected]..
  12. ncbi Molecular analysis of genetic fidelity in Cannabis sativa L. plants grown from synthetic (encapsulated) seeds following in vitro storage
    Hemant Lata
    National Center for Natural Product Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA
    Biotechnol Lett 33:2503-8. 2011
    ....
  13. ncbi Assessment of the genetic stability of micropropagated plants of Cannabis sativa by ISSR markers
    Hemant Lata
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Planta Med 76:97-100. 2010
    ..These results suggest that the micropropagation protocol developed by us for rapid IN VITRO multiplication is appropriate and applicable for clonal mass propagation of C. SATIVA...
  14. ncbi Genetic identification of female Cannabis sativa plants at early developmental stage
    Natascha Techen
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Planta Med 76:1938-9. 2010
    ..The results of this study represent a quick and reliable technique for the identification of sex in Cannabis plants using SCAR markers at a very early developmental stage...
  15. ncbi Assessment of cannabinoids content in micropropagated plants of Cannabis sativa and their comparison with conventionally propagated plants and mother plant during developmental stages of growth
    Suman Chandra
    National Center for Natural Product Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Planta Med 76:743-50. 2010
    ....
  16. ncbi Polymeric systems for amorphous Delta9-tetrahydrocannabinol produced by a hot-melt method. Part II: Effect of oxidation mechanisms and chemical interactions on stability
    Manish Munjal
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, Mississippi 38677-1848, USA
    J Pharm Sci 95:2473-85. 2006
    ..These studies are relevant to the development of a stable transmucosal matrix system for the therapeutic delivery of amorphous THC...
  17. ncbi Deoxyartemisinin derivatives from photooxygenation of anhydrodeoxydihydroartemisinin and their cytotoxic evaluation
    Ahmed M Galal
    National Center for Natural Products Research, University of Mississippi, 38677, USA
    J Nat Prod 65:184-8. 2002
    ..Of the compounds tested, deoxyartemisitene (14) demonstrated significant cytotoxicity against a number of human cancer cell lines...
  18. ncbi Synthesis and evaluation of dihydroartemisinin and dihydroartemisitene acetal dimers showing anticancer and antiprotozoal activity
    Ahmed M Galal
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Bioorg Med Chem 17:741-51. 2009
    ..The dimers were also evaluated for their antimalarial and antileishmanial activities. The antimalarial activity ranged from 0.3 to 32 nM (IC(50)), compared to 9.9 nM for artemisinin...
  19. ncbi Polymeric systems for amorphous Delta 9-tetrahydrocannabinol produced by a hot-melt method. Part I: chemical and thermal stability during processing
    Manish Munjal
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, 38677-1848, USA
    J Pharm Sci 95:1841-53. 2006
    ..Due to this, matrix fabrication was found to be favorable at relatively lower temperatures, such as 120 degrees C...
  20. ncbi Towards a better understanding of the psychopharmacology of nutmeg: Activities in the mouse tetrad assay
    Abir T El-Alfy
    Pharmacology Department, School of Pharmacy, The University of Mississippi, MS 38677, United States
    J Ethnopharmacol 126:280-6. 2009
    ..Nutmeg at high doses is considered a cheap substitute to several drugs of abuse. Earlier reports have attributed amphetamine-like activities to nutmeg...
  21. ncbi High frequency plant regeneration from leaf derived callus of high Δ9-tetrahydrocannabinol yielding Cannabis sativa L
    Hemant Lata
    School of Pharmacy, University of Mississippi, University, MS, USA
    Planta Med 76:1629-33. 2010
    ..5 µM IBA. The rooted plantlets were successfully established in soil and grown to maturity with no gross variations in morphology and cannabinoids content at a survival rate of 95 % in the indoor growroom...
  22. ncbi Preparation and characterization of inclusion complexes of a hemisuccinate ester prodrug of delta9-tetrahydrocannabinol with modified beta-cyclodextrins
    Sampada B Upadhye
    Department of Pharmaceutics, The University of Mississippi, P O Box 1848, University, Mississippi 38677, USA
    AAPS PharmSciTech 11:509-17. 2010
    ..The solubility of THC-HS was significantly higher in RAMEB compared to HPBCD. Solid dispersions of THC-HS with CDs will be further utilized to develop oral formulations of THC-HS with enhanced bioavailability...
  23. ncbi Syncarpamide, a new antiplasmodial (+)-norepinephrine derivative from Zanthoxylum syncarpum
    Samir A Ross
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS 38677 1848, USA
    J Nat Prod 67:88-90. 2004
    ..42 microM, whereas compound 1 was not cytotoxic at 10.42 microM. Compound 1 was tested for hypotensive activity, but no activity was observed. Compound 2 showed no antiplasmodial or antimicrobial activities...
  24. ncbi Antioxidant effect of flavonoids on DCF production in HL-60 cells
    Satoshi Takamatsu
    National Center for Natural Products Research and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA
    Phytother Res 17:963-6. 2003
    ..In the present study, the antioxidant activity of a number of structurally related flavonoids of plant origin and some of their microbial transformation products (1-18) were evaluated...
  25. ncbi Isolation and characterization of new Cannabis constituents from a high potency variety
    Mohamed M Radwan
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Planta Med 74:267-72. 2008
    ..The antimicrobial as well as the antileishmanial activities were investigated...
  26. ncbi Naturally occurring and related synthetic cannabinoids and their potential therapeutic applications
    Ahmed M Galal
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Recent Pat CNS Drug Discov 4:112-36. 2009
    ....
  27. ncbi Temperature stability and bioadhesive properties of delta9-tetrahydrocannabinol incorporated hydroxypropylcellulose polymer matrix systems
    Michael A Repka
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677 1848, USA
    Drug Dev Ind Pharm 32:21-32. 2006
    ....
  28. ncbi Flavonoid glycosides and cannabinoids from the pollen of Cannabis sativa L
    Samir A Ross
    National Center for Natural Products Research, University of Mississippi, University, Mississippi 38677 1848, USA
    Phytochem Anal 16:45-8. 2005
    ....
  29. ncbi Determination of the anthraquinones aloe-emodin and aloin-A by liquid chromatography with mass spectrometric and diode array detection
    Mahmoud A ElSohly
    ElSohly Laboratories Inc, 5 Industrial Park Dr, Oxford, MS 38655, USA
    J AOAC Int 90:28-42. 2007
    ..025 ng by LC/MS for aloin-A and aloe-emodin, respectively. The methods are simple and sensitive and provide reproducible results; therefore, they are suitable for the determination of these anthraquinones in various aloe-based products...
  30. ncbi Antifungal activity of artemisinin derivatives
    Ahmed M Galal
    College of Pharmacy, Cairo University, Kasr El Eini Street, 11562, Cairo, Egypt
    J Nat Prod 68:1274-6. 2005
    ..neoformans. Against C. albicans, the overall antifungal effect of these compounds was weak or negligible. Derivatives 2-30 were prepared according to literature procedures...
  31. ncbi Practical challenges to positive drug tests for marijuana
    Mahmoud A ElSohly
    Clin Chem 49:1037-8. 2003
  32. ncbi Recent patent reviews on small molecule-based antimalarial drugs
    Mahmoud A ElSohly
    ElSohly Laboratories, Incorporated, 5 Industrial Park Drive, Oxford, Mississippi 38655, USA
    Recent Pat Antiinfect Drug Discov 2:222-32. 2007
    ..This review presents the recent patents that reveal development of novel antimalarial drugs...