M A Elovitz

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc A functional genomics screen for microRNA regulators of NF-kappaB signaling
    Anthony O Olarerin-George
    Genomics and Computational Biology Graduate Group, 1420 Blockley Hall, 423 Guardian Drive, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Biol 11:19. 2013
  2. pmc Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study
    Lori D Hill
    Department of Obstetrics and Gynecology and Center on Health Disparities, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    BMC Med Genet 12:64. 2011
  3. ncbi request reprint The role of thrombin in preterm parturition
    M A Elovitz
    Department of Obstetrics and Gynecology, University of Chicago, Ill, USA
    Am J Obstet Gynecol 185:1059-63. 2001
  4. pmc Intrauterine inflammation, insufficient to induce parturition, still evokes fetal and neonatal brain injury
    Michal A Elovitz
    Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Center for Research in Reproduction and Women s Health, University of Pennsylvania School of Medicine, 421 Curie Blvd, 1354 BRB 2 3, Philadelphia, PA 19104 6142, United States
    Int J Dev Neurosci 29:663-71. 2011
  5. ncbi request reprint Anti-inflammatory interventions in pregnancy: now and the future
    Michal A Elovitz
    Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, 421 Curie Boulevard, 1353 BRB 2 3, Philadelphia, PA 19104 6142, USA
    Semin Fetal Neonatal Med 11:327-32. 2006
  6. ncbi request reprint Elucidating the early signal transduction pathways leading to fetal brain injury in preterm birth
    Michal A Elovitz
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia 19104 6142, USA
    Pediatr Res 59:50-5. 2006
  7. ncbi request reprint Can medroxyprogesterone acetate alter Toll-like receptor expression in a mouse model of intrauterine inflammation?
    Michal A Elovitz
    Department of Obstetrics and Gynecology, Center for Research in Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA, USA
    Am J Obstet Gynecol 193:1149-55. 2005
  8. ncbi request reprint Animal models of preterm birth
    Michal A Elovitz
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104 6142, USA
    Trends Endocrinol Metab 15:479-87. 2004
  9. ncbi request reprint Medroxyprogesterone acetate, but not progesterone, protects against inflammation-induced parturition and intrauterine fetal demise
    Michal Elovitz
    University of Pennsylvania, Center for Research in Reproduction and Women s Health, Department of Obstetrics and Gynecology, Philadelphia, PA, USA
    Am J Obstet Gynecol 190:693-701. 2004
  10. pmc A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4
    Michal A Elovitz
    Center for Research and Reproduction in Women s Health, Department of Obstetrics and Gynecology, Biomedical Research Building II III, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104 6142, USA
    Am J Pathol 163:2103-11. 2003

Research Grants

Collaborators

Detail Information

Publications41

  1. pmc A functional genomics screen for microRNA regulators of NF-kappaB signaling
    Anthony O Olarerin-George
    Genomics and Computational Biology Graduate Group, 1420 Blockley Hall, 423 Guardian Drive, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Biol 11:19. 2013
    ..miRNAs are small non-coding RNAs and are common components of signal transduction pathways. Here we present a cell-based functional genomics screen to systematically identify miRNAs that regulate NF-κB signaling...
  2. pmc Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study
    Lori D Hill
    Department of Obstetrics and Gynecology and Center on Health Disparities, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    BMC Med Genet 12:64. 2011
    ..Furthermore, ERAP2 expression is altered in first trimester placentas of women destined to develop preeclampsia...
  3. ncbi request reprint The role of thrombin in preterm parturition
    M A Elovitz
    Department of Obstetrics and Gynecology, University of Chicago, Ill, USA
    Am J Obstet Gynecol 185:1059-63. 2001
    ..This study sought to determine whether thrombin activation, as measured by thrombin-antithrombin III levels, is associated with premature labor...
  4. pmc Intrauterine inflammation, insufficient to induce parturition, still evokes fetal and neonatal brain injury
    Michal A Elovitz
    Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Center for Research in Reproduction and Women s Health, University of Pennsylvania School of Medicine, 421 Curie Blvd, 1354 BRB 2 3, Philadelphia, PA 19104 6142, United States
    Int J Dev Neurosci 29:663-71. 2011
    ..Subclinical intrauterine inflammation can lead to fetal brain injury and is likely to be mechanistically associated with long term adverse outcomes for exposed offspring...
  5. ncbi request reprint Anti-inflammatory interventions in pregnancy: now and the future
    Michal A Elovitz
    Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, 421 Curie Boulevard, 1353 BRB 2 3, Philadelphia, PA 19104 6142, USA
    Semin Fetal Neonatal Med 11:327-32. 2006
    ..Only when the pathogenesis of obstetrical complications is more fully understood can meaningful therapeutic interventions become a realistic goal...
  6. ncbi request reprint Elucidating the early signal transduction pathways leading to fetal brain injury in preterm birth
    Michal A Elovitz
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia 19104 6142, USA
    Pediatr Res 59:50-5. 2006
    ..With increased understanding of the mechanisms by which inflammation promotes brain injury in the preterm neonate, identification of potential targets to limit adverse neonatal outcomes becomes possible...
  7. ncbi request reprint Can medroxyprogesterone acetate alter Toll-like receptor expression in a mouse model of intrauterine inflammation?
    Michal A Elovitz
    Department of Obstetrics and Gynecology, Center for Research in Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA, USA
    Am J Obstet Gynecol 193:1149-55. 2005
    ..These studies were performed to elucidate the effect of intrauterine inflammation and medroxyprogesterone acetate on Toll-like receptor expression in the uterus, cervix, and placenta in a mouse model of intrauterine inflammation...
  8. ncbi request reprint Animal models of preterm birth
    Michal A Elovitz
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104 6142, USA
    Trends Endocrinol Metab 15:479-87. 2004
    ..An understanding of such models will hopefully promote continued research that will ultimately lead to a decrease in preterm birth and an improvement in neonatal outcome...
  9. ncbi request reprint Medroxyprogesterone acetate, but not progesterone, protects against inflammation-induced parturition and intrauterine fetal demise
    Michal Elovitz
    University of Pennsylvania, Center for Research in Reproduction and Women s Health, Department of Obstetrics and Gynecology, Philadelphia, PA, USA
    Am J Obstet Gynecol 190:693-701. 2004
    ..This study was undertaken to determine whether progestational agents can prevent inflammation-induced preterm parturition and fetal demise...
  10. pmc A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4
    Michal A Elovitz
    Center for Research and Reproduction in Women s Health, Department of Obstetrics and Gynecology, Biomedical Research Building II III, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104 6142, USA
    Am J Pathol 163:2103-11. 2003
    ..The use of this model will increase our understanding of the significant clinical problem of inflammation-induced preterm birth and will elucidate signal transduction pathways involved in an inflammatory state...
  11. doi request reprint Medroxyprogesterone acetate modulates the immune response in the uterus, cervix and placenta in a mouse model of preterm birth
    Michal A Elovitz
    Center for Research in Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Matern Fetal Neonatal Med 21:223-30. 2008
    ..These studies sought to determine whether a progestational agent, specifically medroxyprogesterone acetate (MPA) prevents inflammation-induced preterm birth, in a mouse model, through modulation of the host immune response...
  12. doi request reprint Preterm and term cervical ripening in CD1 Mice (Mus musculus): similar or divergent molecular mechanisms?
    Juan M Gonzalez
    Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 81:1226-32. 2009
    ..Our results indicate that the molecular mechanisms governing preterm and term cervical ripening are distinctly different...
  13. doi request reprint Can placental pathology explain second-trimester pregnancy loss and subsequent pregnancy outcomes?
    Sindhu K Srinivas
    Department of Obstetrics and Gynecology, University of Pennsylvania Health System, Philadelphia, PA, USA
    Am J Obstet Gynecol 199:402.e1-5. 2008
    ..This study sought to determine whether specific placental pathology may provide further insight into the mechanisms of second-trimester pregnancy loss, particularly in cases without inflammation...
  14. doi request reprint N-terminal pro-brain natriuretic Peptide as a biomarker for hypertensive disorders of pregnancy
    Nazanin Moghbeli
    Penn Cardiovascular Institute, Philadelphia, Pennsylvania, USA
    Am J Perinatol 27:313-9. 2010
    ..10 P < 0.001). N-terminal pro-brain natriuretic peptide levels were increased in hypertensive disorders of pregnancy and discriminate between subcategories of disease...
  15. ncbi request reprint The use of progestational agents for preterm birth: lessons from a mouse model
    Michal A Elovitz
    Department of Obstetrics and Gynecology, Center for Research in Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA, USA
    Am J Obstet Gynecol 195:1004-10. 2006
    ..Because inflammation/infection is believed to be a contributing factor in many cases of preterm birth, it is imperative to understand the effect of 17-alpha hydroxyprogesterone caproate treatment in this clinical situation...
  16. doi request reprint Adverse neonatal outcomes: examining the risks between preterm, late preterm, and term infants
    Jamie A Bastek
    Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Obstet Gynecol 199:367.e1-8. 2008
    ..This study sought to assess differences in adverse outcomes between infants delivering 32 to 33 6/7, 34 to 36 6/7 weeks, and 37 weeks or later...
  17. pmc Rethinking IUGR in preeclampsia: dependent or independent of maternal hypertension?
    S K Srinivas
    Department of Obstetrics and Gynecology, University of Pennsylvania Health System, Philadelphia, PA, USA
    J Perinatol 29:680-4. 2009
    ....
  18. pmc Beyond white matter damage: fetal neuronal injury in a mouse model of preterm birth
    Irina Burd
    Department of Obstetrics and Gynecology, Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6142, USA
    Am J Obstet Gynecol 201:279.e1-8. 2009
    ..The purpose of this study was to elucidate possible mechanisms of fetal neuronal injury in inflammation-induced preterm birth...
  19. ncbi request reprint Placental inflammation and viral infection are implicated in second trimester pregnancy loss
    Sindhu K Srinivas
    Department of Obstetrics and Gynecology, University of Pennsylvania Health System, Philadelphia, PA, USA
    Am J Obstet Gynecol 195:797-802. 2006
    ....
  20. doi request reprint Limitations of ultrasound in diagnosing intrauterine growth restriction in severe preeclampsia
    Jamie A Bastek
    Department of Obstetrics and Gynecology, Maternal and Child Health Research Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Matern Fetal Neonatal Med 22:1039-44. 2009
    ..The objective of this study was to determine test characteristics of ultrasound in detecting intrauterine growth restriction (IUGR) in severe preeclampsia (S-PEC)...
  21. pmc Inflammation-induced preterm birth alters neuronal morphology in the mouse fetal brain
    Irina Burd
    Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104 6142, USA
    J Neurosci Res 88:1872-81. 2010
    ..001, ANOVA between groups). These results suggest that inflammation-induced preterm birth and not the process of preterm birth may result in neuroinflammation and alter fetal neuronal morphology...
  22. pmc Magnesium sulfate reduces inflammation-associated brain injury in fetal mice
    Irina Burd
    Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Center for Research on Reproduction and Women s Health, University of Pennsylvania, 1353 Biomedical Research Bldg II III, 421 Curie Blvd, Philadelphia, PA 19104 6142, USA
    Am J Obstet Gynecol 202:292.e1-9. 2010
    ..The purpose of this study was to investigate whether magnesium sulfate (MgSO(4)) prevents fetal brain injury in inflammation-associated preterm birth (PTB)...
  23. doi request reprint The use of angiogenic factors in discriminating preeclampsia: are they ready for prime time?
    Sindhu K Srinivas
    Department of Obstetrics and Gynecology, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    J Matern Fetal Neonatal Med 23:1294-300. 2010
    ....
  24. doi request reprint The effects of a preterm labor episode prior to 34 weeks are evident in late preterm outcomes, despite the administration of betamethasone
    Jamie A Bastek
    Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Obstet Gynecol 203:140.e1-7. 2010
    ..We sought to assess whether betamethasone (BETA) <34 weeks reduces adverse outcomes in late preterm infants...
  25. ncbi request reprint Transcytosis of Human immunodeficiency virus 1 across the placenta is enhanced by treatment with tumour necrosis factor alpha
    Samuel Parry
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6142, USA
    J Gen Virol 87:2269-78. 2006
    ....
  26. ncbi request reprint Second-trimester loss and subsequent pregnancy outcomes: What is the real risk?
    Andrea G Edlow
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Obstet Gynecol 197:581.e1-6. 2007
    ..This study was performed to determine whether second-trimester pregnancy loss was associated with an increased risk for spontaneous preterm birth or recurrent second-trimester loss in a subsequent pregnancy...
  27. doi request reprint Progesterone suppresses the fetal inflammatory response ex vivo
    Nadav Schwartz
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY, USA
    Am J Obstet Gynecol 201:211.e1-9. 2009
    ..Progesterone supplementation has been shown to be efficacious in preventing preterm birth. We sought to investigate the effects of progesterone on fetal inflammatory responses...
  28. doi request reprint Do neonatal outcomes differ depending on the cause of preterm birth? A comparison between spontaneous birth and iatrogenic delivery for preeclampsia
    Jamie A Bastek
    Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Perinatol 27:163-9. 2010
    ..Future studies should address mechanisms by which the etiology of PTB leads to specific adverse outcomes, thus allowing for more direct interventional strategies...
  29. doi request reprint Evaluating the association between all components of the metabolic syndrome and pre-eclampsia
    Sindhu K Srinivas
    Department of Obstetrics and Gynecology, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    J Matern Fetal Neonatal Med 22:501-9. 2009
    ....
  30. ncbi request reprint Nausea, emesis, and muscle weakness in a pregnant adolescent
    Sindhu K Srinivas
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Obstet Gynecol 107:481-4. 2006
    ..Gitelman syndrome is a rare autosomal recessive disorder that presents in early adulthood with fatigue, muscle cramps and electrolyte abnormalities...
  31. doi request reprint Periodontal disease and adverse pregnancy outcomes: is there an association?
    Sindhu K Srinivas
    Department of Obstetrics and Gynecology, University of Pennsylvania Health System, Philadelphia, PA, USA
    Am J Obstet Gynecol 200:497.e1-8. 2009
    ..We assessed the risk of adverse pregnancy outcomes (preterm birth [PTB], preeclampsia [PRE], fetal growth restriction [FGR], or perinatal death) in women with periodontal disease (PD) compared to those without...
  32. ncbi request reprint Toll-like receptors in the uterus, cervix, and placenta: is pregnancy an immunosuppressed state?
    Juan M Gonzalez
    Department of Obstetrics and Gynecology, Center for Research in Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA, USA
    Am J Obstet Gynecol 197:296.e1-6. 2007
    ..These studies were performed to elucidate the expression of Toll-like receptors (TLRs) in the uterus, cervix, and placenta in pregnancy and across gestation...
  33. doi request reprint Is routine infectious and toxicologic screening in preterm labor effective in predicting preterm birth?
    Jamie A Bastek
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA
    Am J Obstet Gynecol 198:e38-42. 2008
    ..Our objective was to evaluate whether a significant association exists between cocaine use, cervical, urine, and/or Group B streptococcus (GBS) infections and preterm birth (PTB) in patients admitted with active preterm labor (PTL)...
  34. doi request reprint Preventing cervical ripening: the primary mechanism by which progestational agents prevent preterm birth?
    Hua Xu
    Center for Research in Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104 6142, USA
    Am J Obstet Gynecol 198:314.e1-8. 2008
    ..These studies sought to assess novel pathways by which progestational agents (PAs) may modify signal transduction pathways that are involved in cervical ripening...
  35. doi request reprint Investigating the risk of hypertension shortly after pregnancies complicated by preeclampsia
    Andrea G Edlow
    Department of Obstetrics Gynecology, University of Pennsylvania Health System, Philadelphia, PA, USA
    Am J Obstet Gynecol 200:e60-2. 2009
    ..This study assessed whether a pregnancy complicated by preeclampsia is associated with an increased prevalence of maternal hypertension and other cardiovascular risk factors shortly after delivery...
  36. doi request reprint Allelic variations in angiogenic pathway genes are associated with preeclampsia
    Sindhu K Srinivas
    Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Obstet Gynecol 202:445.e1-11. 2010
    ..This study investigates the association of allelic variation in angiogenic pathway genes and preeclampsia...
  37. ncbi request reprint Metabolic score as a novel approach to assessing preeclampsia risk
    Rebecca M Mazar
    Department of Obstetrics and Gynecology, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Am J Obstet Gynecol 197:411.e1-5. 2007
    ..Because recent evidence suggests that preeclampsia is a risk factor for future CVD, we sought to determine whether metabolic syndrome was associated with preeclampsia...
  38. pmc The negative regulators of the host immune response: an unexplored pathway in preterm birth
    Brianna Lyttle
    Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Am J Obstet Gynecol 201:284.e1-7. 2009
    ..These studies assessed the expression of negative regulators (interleukin receptor-associated kinase [IRAK]-3, IRAK-1, Fas-associated protein with death domain) during pregnancy and in preterm birth (PTB)...
  39. ncbi request reprint Hyperosmolar hyperglycemic state of pregnancy with intrauterine fetal demise and preeclampsia
    Juan M Gonzalez
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Perinatol 24:541-3. 2007
    ..The practitioner should have a high index of suspicion for HHS in obese patients presenting with hyperglycemia...
  40. doi request reprint Evidence of a gene-environment interaction that predisposes to spontaneous preterm birth: a role for asymptomatic bacterial vaginosis and DNA variants in genes that control the inflammatory response
    Luis M Gomez
    Division of Maternal Fetal Medicine, Maternal and Child Research Program, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Obstet Gynecol 202:386.e1-6. 2010
    ..We determined whether an environmental exposure to bacterial vaginosis (BV) modified genetic susceptibilities for spontaneous preterm delivery within genes that regulate the inflammatory response...
  41. doi request reprint Maternal mortality from systemic illness: unraveling the contribution of the immune response
    Juan M Gonzalez
    Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Obstet Gynecol 200:430.e1-8. 2009
    ..Alterations in the immune response could account for the increase MM. We sought to determine whether the immune response is functionally different during pregnant and nonpregnant (NP) states...

Research Grants5

  1. Intrauterine Inflammation & Adverse Neurological Outcome
    Michal Elovitz; Fiscal Year: 2009
    ..abstract_text> ..
  2. Intrauterine Inflammation & Adverse Neurological Outcome
    Michal A Elovitz; Fiscal Year: 2010
    ..abstract_text> ..