C A Elmets

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Photoimmunology
    Craig A Elmets
    Department of Dermatology, UAB Skin Diseases Research Center, UAB Comprehensive Cancer Center, Birmingham VA Medical Center, University of Alabama at Birmingham, EFH 414, 1720 2nd Avenue South, Birmingham, AL 35294 0009, USA Electronic address
    Dermatol Clin 32:277-90, vii. 2014
  2. pmc Chemoprevention of nonmelanoma skin cancer with celecoxib: a randomized, double-blind, placebo-controlled trial
    Craig A Elmets
    Department of Dermatology, 1530 3rd Ave South, EFH 414, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Natl Cancer Inst 102:1835-44. 2010
  3. ncbi request reprint An animal model of psoriasis in mice deficient in epidermal Jun proteins
    Craig A Elmets
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294 0009, USA
    Arch Dermatol 142:1499-500. 2006
  4. ncbi request reprint Topical application of dimethylbenz[a]anthracene results in the generation of multiple melanocytic nevi in C3H/HeN mice
    Craig A Elmets
    Department of Dermatology, The University of Alabama at Birmingham, Birmingham, AL 35294 0009, USA
    Toxicol Appl Pharmacol 195:355-60. 2004
  5. ncbi request reprint Host defense mechanisms in polyaromatic hydrocarbon carcinogenesis
    C A Elmets
    Departmentof Dermatology, University of Alabama at Birmingham, Ala 35294 0009, USA
    Skin Pharmacol Appl Skin Physiol 14:386-92. 2001
  6. pmc Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans
    Craig A Elmets
    Department of Dermatology, UAB Skin Diseases Research Center and UAB Comprehensive Cancer Center, The University of Alabama at Birmingham, 35294 0019, USA
    Cancer Prev Res (Phila) 3:8-11. 2010
  7. pmc Susceptibility to the biological effects of polyaromatic hydrocarbons is influenced by genes of the major histocompatibility complex
    C A Elmets
    Department of Dermatology and the Skin Diseases Research Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 95:14915-9. 1998
  8. ncbi request reprint Green tea polyphenols: DNA photodamage and photoimmunology
    S K Katiyar
    Department of Dermatology, School of Medicine, University of Alabama at Birmingham, 1670 University Blvd, VH501, Box 202, Birmingham, AL 35294, USA
    J Photochem Photobiol B 65:109-14. 2001
  9. pmc Resveratrol enhances cell-mediated immune response to DMBA through TLR4 and prevents DMBA induced cutaneous carcinogenesis
    Nabiha Yusuf
    Department of Dermatology, Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Mol Carcinog 48:713-23. 2009
  10. ncbi request reprint (-)-Epigallocatechin-3-gallate prevents photocarcinogenesis in mice through interleukin-12-dependent DNA repair
    Syed M Meeran
    Department of Dermatology, University of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, Alabama 35294, USA
    Cancer Res 66:5512-20. 2006

Research Grants

  1. IMMUNODERMATOLOGICAL THERAPY OF SKIN CANCER
    Craig Elmets; Fiscal Year: 1999
  2. Training in Investigative Dermatology
    Craig Elmets; Fiscal Year: 2007
  3. PHTHALOCYANINE PDT--IN VIVO RESPONSES AND MECHANISMS
    Craig Elmets; Fiscal Year: 2004
  4. PHTHALOCYANINE PDT--IN VIVO RESPONSES AND MECHANISMS
    Craig Elmets; Fiscal Year: 2003
  5. IMMUNODERMATOLOGICAL THERAPY OF SKIN CANCER
    Craig Elmets; Fiscal Year: 2003
  6. PHTHALOCYANINE PDT--IN VIVO RESPONSES AND MECHANISMS
    Craig Elmets; Fiscal Year: 2002
  7. IMMUNODERMATOLOGICAL THERAPY OF SKIN CANCER
    Craig Elmets; Fiscal Year: 2002
  8. PHTHALOCYANINE PDT--IN VIVO RESPONSES AND MECHANISMS
    Craig Elmets; Fiscal Year: 2001
  9. IMMUNODERMATOLOGICAL THERAPY OF SKIN CANCER
    Craig Elmets; Fiscal Year: 2001
  10. IMMUNODERMATOLOGICAL THERAPY OF SKIN CANCER
    Craig Elmets; Fiscal Year: 2000

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Photoimmunology
    Craig A Elmets
    Department of Dermatology, UAB Skin Diseases Research Center, UAB Comprehensive Cancer Center, Birmingham VA Medical Center, University of Alabama at Birmingham, EFH 414, 1720 2nd Avenue South, Birmingham, AL 35294 0009, USA Electronic address
    Dermatol Clin 32:277-90, vii. 2014
    ....
  2. pmc Chemoprevention of nonmelanoma skin cancer with celecoxib: a randomized, double-blind, placebo-controlled trial
    Craig A Elmets
    Department of Dermatology, 1530 3rd Ave South, EFH 414, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Natl Cancer Inst 102:1835-44. 2010
    ....
  3. ncbi request reprint An animal model of psoriasis in mice deficient in epidermal Jun proteins
    Craig A Elmets
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294 0009, USA
    Arch Dermatol 142:1499-500. 2006
  4. ncbi request reprint Topical application of dimethylbenz[a]anthracene results in the generation of multiple melanocytic nevi in C3H/HeN mice
    Craig A Elmets
    Department of Dermatology, The University of Alabama at Birmingham, Birmingham, AL 35294 0009, USA
    Toxicol Appl Pharmacol 195:355-60. 2004
    ....
  5. ncbi request reprint Host defense mechanisms in polyaromatic hydrocarbon carcinogenesis
    C A Elmets
    Departmentof Dermatology, University of Alabama at Birmingham, Ala 35294 0009, USA
    Skin Pharmacol Appl Skin Physiol 14:386-92. 2001
    ..This may form the basis for novel immunopreventive strategies for individuals at high risk for development of tumors produced by PAHs...
  6. pmc Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans
    Craig A Elmets
    Department of Dermatology, UAB Skin Diseases Research Center and UAB Comprehensive Cancer Center, The University of Alabama at Birmingham, 35294 0019, USA
    Cancer Prev Res (Phila) 3:8-11. 2010
    ..discusses our knowledge of the contribution of polyamines to BCC pathogenesis, how this knowledge advanced the development of a new method to prevent BCCs, and prospects for future studies of DFMO in BCC prevention...
  7. pmc Susceptibility to the biological effects of polyaromatic hydrocarbons is influenced by genes of the major histocompatibility complex
    C A Elmets
    Department of Dermatology and the Skin Diseases Research Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 95:14915-9. 1998
    ..The observations are consistent with the hypothesis that cell-mediated immunity to chemical carcinogens serves to protect individuals by removing mutant cells before they can evolve into clinically apparent neoplasms...
  8. ncbi request reprint Green tea polyphenols: DNA photodamage and photoimmunology
    S K Katiyar
    Department of Dermatology, School of Medicine, University of Alabama at Birmingham, 1670 University Blvd, VH501, Box 202, Birmingham, AL 35294, USA
    J Photochem Photobiol B 65:109-14. 2001
    ..These in vivo observations suggest that GTPs are photoprotective, and can be used as pharmacological agents for the prevention of solar UVB light-induced skin disorders associated with immune suppression and DNA damage...
  9. pmc Resveratrol enhances cell-mediated immune response to DMBA through TLR4 and prevents DMBA induced cutaneous carcinogenesis
    Nabiha Yusuf
    Department of Dermatology, Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Mol Carcinog 48:713-23. 2009
    ..The results of this study indicate that TLR4 is an important mediator of resveratrol chemoprevention in DMBA skin tumorigenesis...
  10. ncbi request reprint (-)-Epigallocatechin-3-gallate prevents photocarcinogenesis in mice through interleukin-12-dependent DNA repair
    Syed M Meeran
    Department of Dermatology, University of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, Alabama 35294, USA
    Cancer Res 66:5512-20. 2006
    ..Taken together, these results indicate for the first time that EGCG can prevent photocarcinogenesis through an EGCG-induced IL-12-dependent DNA repair mechanism...
  11. pmc Interleukin-12 deficiency is permissive for angiogenesis in UV radiation-induced skin tumors
    Syed M Meeran
    Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294, USA
    Cancer Res 67:3785-93. 2007
    ....
  12. ncbi request reprint Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice
    Syed M Meeran
    Department of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall 557, P O Box 202, Birmingham, AL 35294, USA
    Mol Cancer Ther 5:1660-8. 2006
    ..These data indicate for the first time that silymarin has the ability to protect mice from UVB-induced immunosuppression and that this protective effect is mediated, at least in part, through IL-12...
  13. ncbi request reprint T4 endonuclease V: review and application to dermatology
    Jennifer A Cafardi
    University of Alabama at Birmingham, Department of Dermatology, USA
    Expert Opin Biol Ther 8:829-38. 2008
    ..When packaged in liposomes and applied topically, T4 endonuclease V can traverse the stratum corneum and become incorporated within the cytoplasm and nucleus of epidermal keratinocytes and Langerhans cells...
  14. ncbi request reprint Green tea polyphenolic antioxidants and skin photoprotection (Review)
    S K Katiyar
    Department of Dermatology, School of Medicine, University of Alabama at Birmingham, VH 501B, Birmingham, AL 35294, USA
    Int J Oncol 18:1307-13. 2001
    ..Therefore, the focus of this communication is to review and analyze the photoprotective effects of green tea polyphenols to skin...
  15. ncbi request reprint Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors
    Sudheer K Mantena
    Department of Dermatology, University of Alabama at Birmingham, AL, USA
    J Nutr 135:2871-7. 2005
    ....
  16. ncbi request reprint Mass spectrometric proteomics profiles of in vivo tumor secretomes: capillary ultrafiltration sampling of regressive tumor masses
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA
    Proteomics 6:6107-16. 2006
    ..The technique involving CUF probes linked to mass spectrometric proteomics reinforces systems biology studies of cell-cell interactions and is potentially applicable to the discovery of in vivo biomarkers in human disease...
  17. ncbi request reprint Phthalocyanine photodynamic therapy: disparate effects of pharmacologic inhibitors on cutaneous photosensitivity and on tumor regression
    C Anderson
    Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA
    Photochem Photobiol 65:895-901. 1997
    ..The findings suggest that it should be possible to devise PDT protocols that block cutaneous photosensitivity without impairing the anti-tumor response to the agents...
  18. pmc CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses
    Donggou He
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 177:6852-8. 2006
    ..This indicates that CD8+ IL-17-producing cells are distinct from Tc1 cells and are important in effector functions at the elicitation of CHS. These studies provide insights into a novel mechanism for CHS...
  19. ncbi request reprint Surfactant sodium lauryl sulfate enhances skin vaccination: molecular characterization via a novel technique using ultrafiltration capillaries and mass spectrometric proteomics
    Chun Ming Huang
    Department of Dermatology, Skin Diseases Research Center, University of Alabama, Birmingham, Alabama 35294, USA
    Mol Cell Proteomics 5:523-32. 2006
    ..Two secretory proteins, named as calcium-binding protein S100A9 and thymosin beta4, were identified by this novel technique. These two proteins thus may provide new insight into the enhancing effect of surfactants on skin vaccination...
  20. pmc IL-17 and IFN-gamma mediate the elicitation of contact hypersensitivity responses by different mechanisms and both are required for optimal responses
    Donggou He
    Department of Dermatology, University of Alabama, Birmingham, Alabama 35294, USA
    J Immunol 183:1463-70. 2009
    ..This outcome improves understanding of pathogenesis and provides new insights into therapeutic strategies for CHS...
  21. ncbi request reprint Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair
    Suchitra Katiyar
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Nutr Biochem 18:287-96. 2007
    ..New mechanistic information strongly supports and explains the chemopreventive activity of GTPs against photocarcinogenesis...
  22. pmc Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity
    Nabiha Yusuf
    Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 182:675-83. 2009
    ..The results suggest that HSPs form a link between adaptive and innate immunity during the early stages of contact hypersensitivity...
  23. pmc CD4 T cell-induced, bid-dependent apoptosis of cutaneous dendritic cells regulates T cell expansion and immune responses
    Sanjay Pradhan
    Department of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, VH 509 Birmingham, AL 35294, USA
    J Immunol 177:5956-67. 2006
    ..Thus, enhanced Ag presentation function was intrinsic to Bid KO cDCs. Therefore, Bid is an important regulator of LC viability and Ag presentation function...
  24. pmc Antagonistic roles of CD4+ and CD8+ T-cells in 7,12-dimethylbenz(a)anthracene cutaneous carcinogenesis
    Nabiha Yusuf
    Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, Alabama, USA
    Cancer Res 68:3924-30. 2008
    ..Manipulation of T-cell subpopulations that are induced by carcinogenic chemicals, like DMBA, could be a means of preventing skin cancers caused by these agents...
  25. pmc IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells
    Donggou He
    Department of Dermatology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 184:2281-8. 2010
    ..The study provides novel insights into the role of IL-17 in tumor development and has major implications for targeting IL-17 in treatment of tumors...
  26. ncbi request reprint Photoprotective effects of green tea polyphenols
    Nabiha Yusuf
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Photodermatol Photoimmunol Photomed 23:48-56. 2007
    ..Green tea polyphenols thus have the potential, when used in conjunction with traditional sunscreens, to further protect the skin against the adverse effects of ultraviolet radiation...
  27. pmc Acquired and innate immunity to polyaromatic hydrocarbons
    Nabiha Yusuf
    Department of Dermatology, University of Alabama at Birmingham, 1530 Third Avenue South, Birmingham, AL, USA
    Toxicol Appl Pharmacol 224:308-12. 2007
    ..Efforts to augment immune responses to the chemicals that cause tumors may be a productive approach to the prevention of tumors caused by these agents...
  28. pmc Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis
    Nabiha Yusuf
    Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, 1670 University Boulevard, VH 566A, P O Box 202, Birmingham, AL 35294 0019, USA
    Cancer Res 68:615-22. 2008
    ..Efforts to divert the cell-mediated immune response from one that is IL-17 mediated to one that is IFN-gamma mediated may prove to be beneficial in the prevention of DMBA-induced cutaneous tumors...
  29. pmc DNA damage, apoptosis and langerhans cells--Activators of UV-induced immune tolerance
    Laura Timares
    Department of Dermatology, The UAB Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, AL, USA
    Photochem Photobiol 84:422-36. 2008
    ....
  30. pmc Osteopontin expression in normal skin and non-melanoma skin tumors
    Pi Ling Chang
    Department of Nutrition Sciences, 311 Susan Mott Webb Nutrition Sciences Building, 1675 University Boulevard, University of Alabama at Birmingham, Birmingham, Alabama 35295 3360, USA
    J Histochem Cytochem 56:57-66. 2008
    ..In conclusion, these data suggest that OPN is associated with keratinocyte differentiation and that it is expressed in AK and SCC, which have metastatic potential, but minimally expressed in solid BCC...
  31. ncbi request reprint In vivo detection of secreted proteins from wounded skin using capillary ultrafiltration probes and mass spectrometric proteomics
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA
    Proteomics 6:5805-14. 2006
    ..The technique of using CUF probes linked to mass spectrometric proteomics represents a powerful method to identify in vivo secreted proteins, and may be applicable for identification of proteins relevant in various human diseases...
  32. ncbi request reprint Prospective highlights of functional skin proteomics
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mass Spectrom Rev 24:647-60. 2005
    ..This type of research into functional skin proteomics will provide a critical step toward understanding disease and developing successful therapeutic strategies...
  33. ncbi request reprint Identification of Bacillus anthracis proteins associated with germination and early outgrowth by proteomic profiling of anthrax spores
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, 35294 0019, USA
    Proteomics 4:2653-61. 2004
    ..The 31 new proteins identified in this study also complement an emerging proteomic database of B. anthracis...
  34. ncbi request reprint Comparative proteomic profiling of murine skin
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, USA
    J Invest Dermatol 121:51-64. 2003
    ..These data establish numerous reference markers within the proteome map of murine skin and provide an important framework for future efforts aimed at characterization of the epidermal and subepidermal responses to environmental changes...
  35. pmc A differential proteome in tumors suppressed by an adenovirus-based skin patch vaccine encoding human carcinoembryonic antigen
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, VH 501, 1670 University Blvd, Birmingham, AL 35294 0019, USA
    Proteomics 5:1013-23. 2005
    ..These proteins may provide a vital link between early-stage tumor suppression and immune response of skin patch vaccination...
  36. ncbi request reprint Green tea polyphenols prevent ultraviolet light-induced oxidative damage and matrix metalloproteinases expression in mouse skin
    Praveen K Vayalil
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Invest Dermatol 122:1480-7. 2004
    ..These data suggest that GTP as a dietary supplement could be useful to attenuate solar UVB light-induced premature skin aging...
  37. ncbi request reprint Proteomics reveals that proteins expressed during the early stage of Bacillus anthracis infection are potential targets for the development of vaccines and drugs
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, Alabama, USA
    Genomics Proteomics Bioinformatics 2:143-51. 2004
    ....
  38. ncbi request reprint Proteomic characterization of skin and epidermis in response to environmental agents
    Chun Ming Huang
    Department of Dermatology, Skin Diseases Research Center, University of Alabama, Birmingham, AL 35294 0019, USA
    Expert Rev Proteomics 2:809-20. 2005
    ....
  39. ncbi request reprint In vivo protein sampling using capillary ultrafiltration semi-permeable hollow fiber and protein identification via mass spectrometry-based proteomics
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, VH 566A, 1670 University Blvd, Birmingham, AL 35294 0019, USA
    J Chromatogr A 1109:144-51. 2006
    ..Also, the technique represents a powerful method for the identification of in vivo secreted proteins and has potential application for in the detection of biomarkers for human diseases...
  40. ncbi request reprint Phthalocyanine 4 (Pc 4) photodynamic therapy of human OVCAR-3 tumor xenografts
    V C Colussi
    Department of Dermatology, Case Western Reserve University, Cleveland, OH 44106 5028, USA
    Photochem Photobiol 69:236-41. 1999
    ..Early apoptosis, as revealed by PARP cleavage, DNA fragmentation and p21 overexpression, may be responsible for the excellent Pc 4-PDT response. Clinical trials of Pc 4-PDT are warranted...
  41. ncbi request reprint In situ changes in the relative abundance of human epidermal cytokine messenger RNA levels following exposure to the poison ivy/oak contact allergen urushiol
    K D Boehm
    Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA
    Exp Dermatol 5:150-60. 1996
    ..The data provide evidence for an in vivo role for epidermal IL-1 alpha, IL-1 beta and TNF-alpha transcription in the regulation of IL-1 beta and TNF-alpha polypeptide levels in the epidermis in response to this common contact allergen...
  42. ncbi request reprint Inhibition of the high affinity Fc receptor (Fc gamma RI) on human monocytes by porphyrin photosensitization is highly specific and mediated by the generation of superoxide radicals
    J Krutmann
    Department of Dermatology, Case Western Reserve University, Cleveland, Ohio 44106
    J Biol Chem 264:11407-13. 1989
    ..These studies identify porphyrin photosensitization as a unique mechanism by which to selectively down-regulate Fc gamma RI-mediated functions...
  43. ncbi request reprint Treatment of green tea polyphenols in hydrophilic cream prevents UVB-induced oxidation of lipids and proteins, depletion of antioxidant enzymes and phosphorylation of MAPK proteins in SKH-1 hairless mouse skin
    Praveen K Vayalil
    Department of Dermatology, University of Alabama at Birmingham, 1670 University Blvd, Volker Hall 557, 35294, USA
    Carcinogenesis 24:927-36. 2003
    ....
  44. ncbi request reprint CD11b+ cells are the major source of oxidative stress in UV radiation-irradiated skin: possible role in photoaging and photocarcinogenesis
    Anshu Mittal
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Photochem Photobiol 77:259-64. 2003
    ....
  45. pmc IL-12 deficiency suppresses 12-O-tetradecanoylphorbol-13-acetate-induced skin tumor development in 7,12-dimethylbenz(a)anthracene-initiated mouse skin through inhibition of inflammation
    Som D Sharma
    Department of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall 557, Birmingham, AL 35294, USA
    Carcinogenesis 30:1970-7. 2009
    ..In the case of DMBA/TPA-induced skin tumor development, the endogenous IL-12 modulates the tumor promoter stimulation of inflammatory responses...
  46. pmc A critical role for the proapoptotic protein bid in ultraviolet-induced immune suppression and cutaneous apoptosis
    Sanjay Pradhan
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 181:3077-88. 2008
    ..These studies provide evidence that Bid activation is a critical upstream mediator in UV-induced keratinocyte and LC apoptosis and that its absence abrogates UV-induced immune tolerance...
  47. ncbi request reprint Interleukin-12-deficient mice are at greater risk of UV radiation-induced skin tumors and malignant transformation of papillomas to carcinomas
    Syed M Meeran
    Department of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall 557, P O Box 202, Birmingham, AL 35294, USA
    Mol Cancer Ther 5:825-32. 2006
    ..Taken together, our data show that IL-12 deficiency is associated with the greater risk of photocarcinogenesis in mice, and this may be due to reduction in damaged DNA repair ability...
  48. ncbi request reprint Cutaneous photoprotection from ultraviolet injury by green tea polyphenols
    C A Elmets
    Department of Dermatology, Case Western Reserve, Cleveland, Ohio, USA
    J Am Acad Dermatol 44:425-32. 2001
    ..CONCLUSION: Polyphenolic extracts of green tea are effective chemopreventive agents for many of the adverse effects of sunlight on human health and may thus serve as natural alternatives for photoprotection...
  49. ncbi request reprint The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node
    H Xu
    Department of Dermatology, University of Alabama at Birmingham, Birmingham 35294, USA
    Eur J Immunol 31:3085-93. 2001
    ..This study indicates that ICAM-1 regulates the migration of dendritic cells into regional lymph nodes but not into or out of the skin...
  50. pmc The immunosuppressive effects of phthalocyanine photodynamic therapy in mice are mediated by CD4+ and CD8+ T cells and can be adoptively transferred to naive recipients
    Nabiha Yusuf
    Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, AL, USA
    Photochem Photobiol 84:366-70. 2008
    ..Procedures that limit PDT-induced immunosuppression but do not affect PDT-induced regression of tumors may prove superior to PDT alone in promoting long-term antitumor responses...
  51. pmc The other end of the rainbow: infrared and skin
    Aton M Holzer
    Department of Dermatology, University of Alabama at Birmingham, 1530 3rd Avenue S, Birmingham, AL 35294, USA
    J Invest Dermatol 130:1496-9. 2010
    ..Their work paves the way for new research directions in IRA photobiology and raises important clinical questions regarding photoprotection and IRR-based dermatotherapy...
  52. pmc Slit2 inhibits growth and metastasis of fibrosarcoma and squamous cell carcinoma
    Hee Kyung Kim
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neoplasia 10:1411-20. 2008
    ....
  53. ncbi request reprint Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: relationship to decreased fat and lipid peroxidation
    Anshu Mittal
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Carcinogenesis 24:1379-88. 2003
    ..Together, it can be suggested that inhibition of photocarcinogenesis by GSP treatment may be associated with the reduction in UVB-induced oxidative damage and tissue fat content...
  54. pmc Visualizing CD4 T-cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades using in vivo imaging model
    X Wang
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Br J Dermatol 162:487-96. 2010
    ..Chemokines are critical mediators of T-cell homing into inflamed skin. The complex nature of this multicellular response makes it difficult to analyse mechanisms mediating the early responses in vivo...
  55. ncbi request reprint A phase III, randomized, double-blind, placebo-controlled study of peldesine (BCX-34) cream as topical therapy for cutaneous T-cell lymphoma
    M Duvic
    Department of Dermatology, University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA
    J Am Acad Dermatol 44:940-7. 2001
    ..Whether the vehicle cream has more than a placebo therapeutic effect is unclear. The relatively high (24%) placebo response rate should be kept in mind in assessing other treatments for early-stage CTCL...
  56. ncbi request reprint Utilization of narrow-band ultraviolet light B therapy and etanercept for the treatment of psoriasis (UNITE): efficacy, safety, and patient-reported outcomes
    Leon Kircik
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA
    J Drugs Dermatol 7:245-53. 2008
    ..Etanercept and narrow-band ultraviolet light B (NB-UVB) are widely used to treat this disease...
  57. ncbi request reprint A new method to test the effectiveness of sunscreen ingredients in a novel nano-surface skin cell mimic
    Rajagopal Krishnan
    Department of Physics, University of Alabama at Birmingham, Birmingham, AL, USA
    Photochem Photobiol 82:1549-56. 2006
    ..The new method also allows the simultaneous evaluation of a host of photophysical properties of sunscreening chemicals...
  58. ncbi request reprint Safety and immunogenicity of adenovirus-vectored nasal and epicutaneous influenza vaccines in humans
    Kent R Van Kampen
    Vaxin Inc, VH 501, 1670 University Blvd, Birmingham, AL 35294, USA
    Vaccine 23:1029-36. 2005
    ..These results provide the foundation for further human testing of needleless vectored vaccines as promising alternatives to current vaccines...
  59. pmc Grape seed proanthocyanidins induce apoptosis through p53, Bax, and caspase 3 pathways
    Anshu M Roy
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neoplasia 7:24-36. 2005
    ..These data clearly demonstrate that GSP-induced apoptosis is p53-dependent and mediated through the Bcl-2, Bax, and caspase 3 pathways...
  60. ncbi request reprint The safety and efficacy of high-dose alefacept compared with a loading dose of alefacept in patients with chronic plaque psoriasis
    Jennifer A Cafardi
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA
    Skinmed 7:67-72. 2008
    ..Two separate dosing regimens are evaluated in this study: 30 mg IM for 6 weeks followed by 15 mg IM for 6 weeks (group 1) and alefacept 30 mg IM weekly for 12 weeks (group 2)...
  61. pmc Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis
    Jianmin Xu
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Cancer Res 70:6566-76. 2010
    ..Our findings indicate that the ability of CP-31398 to modulate wild-type and mutant p53 results in the inhibition of RMS growth and invasiveness...
  62. ncbi request reprint Fluorescence of sunscreens adsorbed to dielectric nanospheres: parallels to optical behavior on hacat cells and skin
    Rajagopal Krishnan
    Department of Physics, University of Alabama at Birmingham, USA
    Photochem Photobiol 82:1557-65. 2006
    ..An unexpected result of this comparative study was the observation of an increase in a specific skin component emission caused by addition of padimate O...
  63. ncbi request reprint Quantitative proteomes and in vivo secretomes of progressive and regressive UV-induced fibrosarcoma tumor cells: mimicking tumor microenvironment using a dermis-based cell-trapped system linked to tissue chamber
    Yang Shi
    Burnham Institute for Medical Research, La Jolla, CA, USA
    Proteomics 7:4589-600. 2007
    ..Differential tumor proteomes and in vivo secretome were thus accentuated as potential therapeutic targets to control tumor growth...
  64. doi request reprint Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics
    Alan Menter
    Baylor University Medical Center, Dallas, Texas, USA
    J Am Acad Dermatol 58:826-50. 2008
    ..Finally, we will discuss the safety and efficacy of the biologic treatments used to treat patients with psoriasis...

Research Grants13

  1. IMMUNODERMATOLOGICAL THERAPY OF SKIN CANCER
    Craig Elmets; Fiscal Year: 1999
    ..The ultimate goal of this proposal is to generate new knowledge that can be used to develop new and better strategies for the control of non-melanoma and melanoma skin cancer. ..
  2. Training in Investigative Dermatology
    Craig Elmets; Fiscal Year: 2007
    ..The ultimate goal of this program will be to provide superior training for the next generation of academic researchers in investigative dermatology. ..
  3. PHTHALOCYANINE PDT--IN VIVO RESPONSES AND MECHANISMS
    Craig Elmets; Fiscal Year: 2004
    ..The long-term goal of these studies is to generate new knowledge regarding the in vivo mechanisms by which PDT works so that it can be used more effectively to treat cancer. ..
  4. PHTHALOCYANINE PDT--IN VIVO RESPONSES AND MECHANISMS
    Craig Elmets; Fiscal Year: 2003
    ..The long-term goal of these studies is to generate new knowledge regarding the in vivo mechanisms by which PDT works so that it can be used more effectively to treat cancer. ..
  5. IMMUNODERMATOLOGICAL THERAPY OF SKIN CANCER
    Craig Elmets; Fiscal Year: 2003
    ..The ultimate goal of this proposal is to generate new knowledge that can be used to develop new and better strategies for the control of non-melanoma and melanoma skin cancer. ..
  6. PHTHALOCYANINE PDT--IN VIVO RESPONSES AND MECHANISMS
    Craig Elmets; Fiscal Year: 2002
    ..The long-term goal of these studies is to generate new knowledge regarding the in vivo mechanisms by which PDT works so that it can be used more effectively to treat cancer. ..
  7. IMMUNODERMATOLOGICAL THERAPY OF SKIN CANCER
    Craig Elmets; Fiscal Year: 2002
    ..The ultimate goal of this proposal is to generate new knowledge that can be used to develop new and better strategies for the control of non-melanoma and melanoma skin cancer. ..
  8. PHTHALOCYANINE PDT--IN VIVO RESPONSES AND MECHANISMS
    Craig Elmets; Fiscal Year: 2001
    ..The long-term goal of these studies is to generate new knowledge regarding the in vivo mechanisms by which PDT works so that it can be used more effectively to treat cancer. ..
  9. IMMUNODERMATOLOGICAL THERAPY OF SKIN CANCER
    Craig Elmets; Fiscal Year: 2001
    ..The ultimate goal of this proposal is to generate new knowledge that can be used to develop new and better strategies for the control of non-melanoma and melanoma skin cancer. ..
  10. IMMUNODERMATOLOGICAL THERAPY OF SKIN CANCER
    Craig Elmets; Fiscal Year: 2000
    ..The ultimate goal of this proposal is to generate new knowledge that can be used to develop new and better strategies for the control of non-melanoma and melanoma skin cancer. ..
  11. PHTHALOCYANINE PDT--IN VIVO RESPONSES AND MECHANISMS
    Craig Elmets; Fiscal Year: 2000
    ..The long-term goal of these studies is to generate new knowledge regarding the in vivo mechanisms by which PDT works so that it can be used more effectively to treat cancer. ..