Research Topics
Species | G I ElmerSummaryAffiliation: University of Maryland Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Drug discovery in psychiatric illness: mining for goldGreg I Elmer
Schizophr Bull 35:287-92. 2009..It will take the collective effort of many disciplines and numerous strategies in close association with clinical colleagues to address quality of life issues and breakthrough treatment barriers in psychiatric illness...
Brain stimulation and morphine reward deficits in dopamine D2 receptor-deficient miceG I Elmer
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland, Maple and Locust Streets, Baltimore, MD 21228, USA
Psychopharmacology (Berl) 182:33-44. 2005..Genetically engineered animal models provide a complementary approach to pharmacological investigations...- Qualitative differences between C57BL/6J and DBA/2J mice in morphine potentiation of brain stimulation reward and intravenous self-administrationGreg I Elmer
Maryland Psychiatric Research Center, Department of Psychiatry, School of Medicine, University Maryland, Maple and Locust Sts, Baltimore, MD 21228, USA
Psychopharmacology (Berl) 208:309-21. 2010..Unfortunately, outside of the oral two-bottle choice procedure, limited and sometimes controversial evidence is available for determining their relative sensitivity to the rewarding effects of morphine... - Failure of intravenous morphine to serve as an effective instrumental reinforcer in dopamine D2 receptor knock-out miceGreg I Elmer
Neuroscience Program, Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
J Neurosci 22:RC224. 2002..Under this range of doses and response requirements, the rewarding effects of morphine appear to depend critically on an intact D2 receptor system... - Texture of locomotor path: a replicable characterization of a complex behavioral phenotypeN Kafkafi
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Maple and Locust Streets, Baltimore, MD 21228, USA
Genes Brain Behav 4:431-43. 2005..Path texture thus has high potential for behavioral phenotyping and the study of drug effects in the mouse... - Opioid operant self-administration, analgesia, stimulation and respiratory depression in mu-deficient miceG I Elmer
Behavioral Pharmacology and Genetics Section, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
Psychopharmacology (Berl) 117:23-31. 1995..abstract truncated at 250 words).. - Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical testsG I Elmer
Behavioral Pharmacology and Genetics Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Pain 75:129-40. 1998.... 
A data mining approach to in vivo classification of psychopharmacological drugsNeri Kafkafi
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Neuropsychopharmacology 34:607-23. 2009....- Identification of candidate genes and gene networks specifically associated with analgesic tolerance to morphineJenica D Tapocik
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, Baltimore, Maryland 21228, USA
J Neurosci 29:5295-307. 2009..A potentially significant role for the micro-RNA and epigenetic mechanisms in response to chronic administration of pharmacologically relevant doses of morphine was highlighted by candidate genes Dicer and H19... - Genotype-environment interactions in mouse behavior: a way out of the problemNeri Kafkafi
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Proc Natl Acad Sci U S A 102:4619-24. 2005..Even though we address the replicability problem in behavioral genetics, our strategy is also applicable in other areas where concern about replicability has been raised... - Altered prepulse inhibition in rats treated prenatally with the antimitotic Ara-C: an animal model for sensorimotor gating deficits in schizophreniaG I Elmer
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
Psychopharmacology (Berl) 174:177-89. 2004..These data provide evidence to support the contention that modest neurodevelopmental insults can significantly affect sensorimotor gating processes in an adult onset dependent manner... - Phentermine and fenfluramine. Preclinical studies in animal models of cocaine addictionR B Rothman
Clinical Psychopharmacology Section, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Baltimore, Maryland 21224, USA
Ann N Y Acad Sci 844:59-74. 1998..The preclinical data obtained with PHEN/FEN in various models of drug provide a strong rationale for pursuing controlled clinical trials in humans with agents that act via a similar mechanism of action... - Disruption of conditioned reward association by typical and atypical antipsychoticsC L Danna
University of Maryland School of Medicine, Department of Psychiatry, Maryland Psychiatric Research Center, Maple and Locust Street, Baltimore, MD 21228, United States
Pharmacol Biochem Behav 96:40-7. 2010..Drug effects on this dimension of reward processing are an important consideration in the development of future pharmacological treatments for schizophrenia... - Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behaviorMichelle C Potter
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Neuropsychopharmacology 35:1734-42. 2010..Our studies raise the prospect that interventions aimed specifically at reducing KYNA formation in the brain may constitute a promising molecular strategy for cognitive improvement in health and disease... - Hyperoxic reperfusion after global cerebral ischemia promotes inflammation and long-term hippocampal neuronal deathJulie L Hazelton
Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Neurotrauma 27:753-62. 2010.... - Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant miceAllison L Chausmer
Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institute of Health, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 163:54-61. 2002..Because these compounds generally lack selectivity among the D2-like DA receptors, the specific roles of the subtypes remain unclear... - Cocaine-induced locomotor activity and cocaine discrimination in dopamine D4 receptor mutant miceJonathan L Katz
Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA
Psychopharmacology (Berl) 170:108-14. 2003..However, given the lack of selectivity of most of the available pharmacological tools among D(2), D(3) and D(4) dopamine receptors, the roles of these specific receptors remain unclear... - Data mining in a behavioral test detects early symptoms in a model of amyotrophic lateral sclerosisNeri Kafkafi
Department of Psychiatry, Maryland Psychiatric Research Center, School of Medicine, University of Maryland, Baltimore, Maryland 21228, USA
Behav Neurosci 122:777-87. 2008..Our results demonstrate the feasibility and potential of detecting subtle behavioral effects using data mining strategies... - Darting behavior: a quantitative movement pattern designed for discrimination and replicability in mouse locomotor behaviorNeri Kafkafi
National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, The Johns Hopkins Bayview Medical Center, Bldg C, Baltimore, MD 21224, USA
Behav Brain Res 142:193-205. 2003..The strategy leading to the darting measure may be used to develop additional discriminative and replicable endpoints of open-field behavior... - SEE locomotor behavior test discriminates C57BL/6J and DBA/2J mouse inbred strains across laboratories and protocol conditionsNeri Kafkafi
Behavioral Neuroscience Branch, National Institute on Drug Abuse Intramural Research Program, Department of Psychiatry, Maryland Psychiatric Research Center, School of Medicine, University of Maryland, Baltimore, Maryland, USA
Behav Neurosci 117:464-77. 2003..Results suggest that well-designed tests may considerably enhance replicability across laboratories... - New replicable anxiety-related measures of wall vs center behavior of mice in the open fieldDina Lipkind
Department of Zoology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel 69978
J Appl Physiol 97:347-59. 2004..The entire set of end points can be used on various genetic and pharmacological models of anxiety with good prospects of providing fine discrimination in a replicable manner... - Activity density in the open field: a measure for differentiating the effect of psychostimulantsNeri Kafkafi
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Maple and Locust Sts, P O Box 21247, Baltimore, MD 21228, USA
Pharmacol Biochem Behav 80:239-49. 2005..The newly developed activity density measure thus provides a more general measure than stereotypy of the path, and can differentiate the effects of AMPH and COC both within and across genotypes... - Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophreniaJames I Koenig
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
Behav Brain Res 156:251-61. 2005..Interestingly, the behaviors that are altered have been used to validate animal models of schizophrenia and therefore, suggest that this preparation may be useful to learn more about some aspects of the pathophysiology of schizophrenia... - Associating quantitative behavioral traits with gene expression in the brain: searching for diamonds in the hayAnat Reiner Benaim
Department of Statistics and Operation Research, Tel Aviv University
Bioinformatics 23:2239-46. 2007..The hierarchical FDR testing strategies presented here can serve beyond the structure of our motivating example study to any complex microarray study. Supplementary information: Supplementary data are available at Bioinformatics online...
Research Grants
- Microarray analysis of morphine's behavioral effectsGREGORY ELMER; Fiscal Year: 2007..abstract_text> ..
- Algorithm for drug discoveryGREGORY ELMER; Fiscal Year: 2007..Second, it will establish a core database for data mining and provide a template for use in screening novel compounds with potential clinical efficacy. ..
- Pattern array: in vivo mining for novel psychoactive drug discoveryGREGORY ELMER; Fiscal Year: 2009..The strategy outlined in this application could be used to screen novel compounds for their similarity to proven therapeutics, thus providing a relatively rapid means to identify new molecular entities with unique therapeutic utility. ..
- Pattern array: in vivo mining for novel psychoactive drug discoveryNeri Kafkafi; Fiscal Year: 2010..The strategy outlined in this application could be used to screen novel compounds for their similarity to proven therapeutics, thus providing a relatively rapid means to identify new molecular entities with unique therapeutic utility. ..