G I Elmer

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Drug discovery in psychiatric illness: mining for gold
    Greg I Elmer
    Schizophr Bull 35:287-92. 2009
  2. ncbi request reprint Brain stimulation and morphine reward deficits in dopamine D2 receptor-deficient mice
    G I Elmer
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland, Maple and Locust Streets, Baltimore, MD 21228, USA
    Psychopharmacology (Berl) 182:33-44. 2005
  3. pmc Qualitative differences between C57BL/6J and DBA/2J mice in morphine potentiation of brain stimulation reward and intravenous self-administration
    Greg I Elmer
    Maryland Psychiatric Research Center, Department of Psychiatry, School of Medicine, University Maryland, Maple and Locust Sts, Baltimore, MD 21228, USA
    Psychopharmacology (Berl) 208:309-21. 2010
  4. ncbi request reprint Failure of intravenous morphine to serve as an effective instrumental reinforcer in dopamine D2 receptor knock-out mice
    Greg I Elmer
    Neuroscience Program, Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    J Neurosci 22:RC224. 2002
  5. ncbi request reprint Texture of locomotor path: a replicable characterization of a complex behavioral phenotype
    N Kafkafi
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Maple and Locust Streets, Baltimore, MD 21228, USA
    Genes Brain Behav 4:431-43. 2005
  6. ncbi request reprint Opioid operant self-administration, analgesia, stimulation and respiratory depression in mu-deficient mice
    G I Elmer
    Behavioral Pharmacology and Genetics Section, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    Psychopharmacology (Berl) 117:23-31. 1995
  7. ncbi request reprint Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests
    G I Elmer
    Behavioral Pharmacology and Genetics Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Pain 75:129-40. 1998
  8. doi request reprint A data mining approach to in vivo classification of psychopharmacological drugs
    Neri Kafkafi
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 34:607-23. 2009
  9. pmc Identification of candidate genes and gene networks specifically associated with analgesic tolerance to morphine
    Jenica D Tapocik
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, Baltimore, Maryland 21228, USA
    J Neurosci 29:5295-307. 2009
  10. pmc Genotype-environment interactions in mouse behavior: a way out of the problem
    Neri Kafkafi
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Proc Natl Acad Sci U S A 102:4619-24. 2005

Collaborators

Detail Information

Publications24

  1. pmc Drug discovery in psychiatric illness: mining for gold
    Greg I Elmer
    Schizophr Bull 35:287-92. 2009
    ..It will take the collective effort of many disciplines and numerous strategies in close association with clinical colleagues to address quality of life issues and breakthrough treatment barriers in psychiatric illness...
  2. ncbi request reprint Brain stimulation and morphine reward deficits in dopamine D2 receptor-deficient mice
    G I Elmer
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland, Maple and Locust Streets, Baltimore, MD 21228, USA
    Psychopharmacology (Berl) 182:33-44. 2005
    ..Genetically engineered animal models provide a complementary approach to pharmacological investigations...
  3. pmc Qualitative differences between C57BL/6J and DBA/2J mice in morphine potentiation of brain stimulation reward and intravenous self-administration
    Greg I Elmer
    Maryland Psychiatric Research Center, Department of Psychiatry, School of Medicine, University Maryland, Maple and Locust Sts, Baltimore, MD 21228, USA
    Psychopharmacology (Berl) 208:309-21. 2010
    ..Unfortunately, outside of the oral two-bottle choice procedure, limited and sometimes controversial evidence is available for determining their relative sensitivity to the rewarding effects of morphine...
  4. ncbi request reprint Failure of intravenous morphine to serve as an effective instrumental reinforcer in dopamine D2 receptor knock-out mice
    Greg I Elmer
    Neuroscience Program, Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    J Neurosci 22:RC224. 2002
    ..Under this range of doses and response requirements, the rewarding effects of morphine appear to depend critically on an intact D2 receptor system...
  5. ncbi request reprint Texture of locomotor path: a replicable characterization of a complex behavioral phenotype
    N Kafkafi
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Maple and Locust Streets, Baltimore, MD 21228, USA
    Genes Brain Behav 4:431-43. 2005
    ..Path texture thus has high potential for behavioral phenotyping and the study of drug effects in the mouse...
  6. ncbi request reprint Opioid operant self-administration, analgesia, stimulation and respiratory depression in mu-deficient mice
    G I Elmer
    Behavioral Pharmacology and Genetics Section, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    Psychopharmacology (Berl) 117:23-31. 1995
    ..abstract truncated at 250 words)..
  7. ncbi request reprint Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests
    G I Elmer
    Behavioral Pharmacology and Genetics Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Pain 75:129-40. 1998
    ....
  8. doi request reprint A data mining approach to in vivo classification of psychopharmacological drugs
    Neri Kafkafi
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 34:607-23. 2009
    ....
  9. pmc Identification of candidate genes and gene networks specifically associated with analgesic tolerance to morphine
    Jenica D Tapocik
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, Baltimore, Maryland 21228, USA
    J Neurosci 29:5295-307. 2009
    ..A potentially significant role for the micro-RNA and epigenetic mechanisms in response to chronic administration of pharmacologically relevant doses of morphine was highlighted by candidate genes Dicer and H19...
  10. pmc Genotype-environment interactions in mouse behavior: a way out of the problem
    Neri Kafkafi
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Proc Natl Acad Sci U S A 102:4619-24. 2005
    ..Even though we address the replicability problem in behavioral genetics, our strategy is also applicable in other areas where concern about replicability has been raised...
  11. ncbi request reprint Altered prepulse inhibition in rats treated prenatally with the antimitotic Ara-C: an animal model for sensorimotor gating deficits in schizophrenia
    G I Elmer
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Psychopharmacology (Berl) 174:177-89. 2004
    ....
  12. ncbi request reprint Phentermine and fenfluramine. Preclinical studies in animal models of cocaine addiction
    R B Rothman
    Clinical Psychopharmacology Section, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 844:59-74. 1998
    ..The preclinical data obtained with PHEN/FEN in various models of drug provide a strong rationale for pursuing controlled clinical trials in humans with agents that act via a similar mechanism of action...
  13. pmc Disruption of conditioned reward association by typical and atypical antipsychotics
    C L Danna
    University of Maryland School of Medicine, Department of Psychiatry, Maryland Psychiatric Research Center, Maple and Locust Street, Baltimore, MD 21228, United States
    Pharmacol Biochem Behav 96:40-7. 2010
    ..Drug effects on this dimension of reward processing are an important consideration in the development of future pharmacological treatments for schizophrenia...
  14. pmc Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior
    Michelle C Potter
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 35:1734-42. 2010
    ..Our studies raise the prospect that interventions aimed specifically at reducing KYNA formation in the brain may constitute a promising molecular strategy for cognitive improvement in health and disease...
  15. pmc Hyperoxic reperfusion after global cerebral ischemia promotes inflammation and long-term hippocampal neuronal death
    Julie L Hazelton
    Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurotrauma 27:753-62. 2010
    ....
  16. ncbi request reprint Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice
    Allison L Chausmer
    Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institute of Health, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 163:54-61. 2002
    ..Because these compounds generally lack selectivity among the D2-like DA receptors, the specific roles of the subtypes remain unclear...
  17. ncbi request reprint Cocaine-induced locomotor activity and cocaine discrimination in dopamine D4 receptor mutant mice
    Jonathan L Katz
    Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA
    Psychopharmacology (Berl) 170:108-14. 2003
    ..However, given the lack of selectivity of most of the available pharmacological tools among D(2), D(3) and D(4) dopamine receptors, the roles of these specific receptors remain unclear...
  18. doi request reprint Data mining in a behavioral test detects early symptoms in a model of amyotrophic lateral sclerosis
    Neri Kafkafi
    Department of Psychiatry, Maryland Psychiatric Research Center, School of Medicine, University of Maryland, Baltimore, Maryland 21228, USA
    Behav Neurosci 122:777-87. 2008
    ..Our results demonstrate the feasibility and potential of detecting subtle behavioral effects using data mining strategies...
  19. ncbi request reprint Darting behavior: a quantitative movement pattern designed for discrimination and replicability in mouse locomotor behavior
    Neri Kafkafi
    National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, The Johns Hopkins Bayview Medical Center, Bldg C, Baltimore, MD 21224, USA
    Behav Brain Res 142:193-205. 2003
    ..The strategy leading to the darting measure may be used to develop additional discriminative and replicable endpoints of open-field behavior...
  20. ncbi request reprint SEE locomotor behavior test discriminates C57BL/6J and DBA/2J mouse inbred strains across laboratories and protocol conditions
    Neri Kafkafi
    Behavioral Neuroscience Branch, National Institute on Drug Abuse Intramural Research Program, Department of Psychiatry, Maryland Psychiatric Research Center, School of Medicine, University of Maryland, Baltimore, Maryland, USA
    Behav Neurosci 117:464-77. 2003
    ..Results suggest that well-designed tests may considerably enhance replicability across laboratories...
  21. ncbi request reprint New replicable anxiety-related measures of wall vs center behavior of mice in the open field
    Dina Lipkind
    Department of Zoology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel 69978
    J Appl Physiol 97:347-59. 2004
    ..The entire set of end points can be used on various genetic and pharmacological models of anxiety with good prospects of providing fine discrimination in a replicable manner...
  22. ncbi request reprint Activity density in the open field: a measure for differentiating the effect of psychostimulants
    Neri Kafkafi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Maple and Locust Sts, P O Box 21247, Baltimore, MD 21228, USA
    Pharmacol Biochem Behav 80:239-49. 2005
    ..The newly developed activity density measure thus provides a more general measure than stereotypy of the path, and can differentiate the effects of AMPH and COC both within and across genotypes...
  23. ncbi request reprint Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia
    James I Koenig
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Behav Brain Res 156:251-61. 2005
    ..Interestingly, the behaviors that are altered have been used to validate animal models of schizophrenia and therefore, suggest that this preparation may be useful to learn more about some aspects of the pathophysiology of schizophrenia...
  24. ncbi request reprint Associating quantitative behavioral traits with gene expression in the brain: searching for diamonds in the hay
    Anat Reiner-Benaim
    Department of Statistics and Operation Research, Tel Aviv University
    Bioinformatics 23:2239-46. 2007
    ..The hierarchical FDR testing strategies presented here can serve beyond the structure of our motivating example study to any complex microarray study. Supplementary information: Supplementary data are available at Bioinformatics online...

Research Grants7

  1. Microarray analysis of morphine's behavioral effects
    GREGORY ELMER; Fiscal Year: 2007
    ..abstract_text> ..
  2. Algorithm for drug discovery
    GREGORY ELMER; Fiscal Year: 2007
    ..Second, it will establish a core database for data mining and provide a template for use in screening novel compounds with potential clinical efficacy. ..
  3. Pattern array: in vivo mining for novel psychoactive drug discovery
    GREGORY ELMER; Fiscal Year: 2009
    ..The strategy outlined in this application could be used to screen novel compounds for their similarity to proven therapeutics, thus providing a relatively rapid means to identify new molecular entities with unique therapeutic utility. ..
  4. Pattern array: in vivo mining for novel psychoactive drug discovery
    Neri Kafkafi; Fiscal Year: 2010
    ..The strategy outlined in this application could be used to screen novel compounds for their similarity to proven therapeutics, thus providing a relatively rapid means to identify new molecular entities with unique therapeutic utility. ..