Steven Ellis

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
    Benjamin L Ebert
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 451:335-9. 2008
  2. ncbi request reprint Nucleolar stress in Diamond Blackfan anemia pathophysiology
    Steven R Ellis
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40292, USA Electronic address
    Biochim Biophys Acta 1842:765-8. 2014
  3. ncbi request reprint Diamond Blackfan anemia: A paradigm for a ribosome-based disease
    Steven R Ellis
    Department of Biochemistry and Molecular Biology, University of Louisville, 319 Abraham Flexner Way, Louisville, KY 40292, USA
    Med Hypotheses 66:643-8. 2006
  4. doi request reprint Diamond Blackfan anemia: ribosomal proteins going rogue
    Steven R Ellis
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40292, USA
    Semin Hematol 48:89-96. 2011
  5. pmc Ribosomal proteins Rps0 and Rps21 of Saccharomyces cerevisiae have overlapping functions in the maturation of the 3' end of 18S rRNA
    Amy Tabb-Massey
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40292, USA
    Nucleic Acids Res 31:6798-805. 2003
  6. doi request reprint Diamond Blackfan anemia: a disorder of red blood cell development
    Steven R Ellis
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, Kentucky, USA
    Curr Top Dev Biol 82:217-41. 2008
  7. pmc Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits
    Johan Flygare
    Department of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University Hospital, Sweden
    Blood 109:980-6. 2007
  8. pmc Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia
    Jason E Farrar
    Division of Pediatric Oncology, Department of Oncology, Kimmel Comprehensive Cancer Center
    Blood 112:1582-92. 2008
  9. ncbi request reprint Ribosomes and marrow failure: coincidental association or molecular paradigm?
    Johnson M Liu
    Feinstein Institute for Medical Research, Manhasset, NY, USA
    Blood 107:4583-8. 2006

Research Grants

  1. Ribosomal Function and Diamond-Blackfan Anemia
    Steven Ellis; Fiscal Year: 2004
  2. Ribosomal Function and Diamond-Blackfan Anemia
    Steven Ellis; Fiscal Year: 2005
  3. Ribosomal Function and Diamond-Blackfan Anemia
    Steven Ellis; Fiscal Year: 2006
  4. Ribosomal Function and Diamond-Blackfan Anemia
    Steven Ellis; Fiscal Year: 2007

Collaborators

  • Jeffrey Lipton
  • Jeanne Kowalski
  • Hanna T Gazda
  • Johnson M Liu
  • Johan Flygare
  • Benjamin L Ebert
  • Jason E Farrar
  • Amy Tabb-Massey
  • Adrianna Vlachos
  • Edyta Niewiadomska
  • Paul Meltzer
  • Jocelyn Bosco
  • Diane Esposito
  • Michael A McDevitt
  • Eyal Attar
  • Hal E Schneider
  • Michelle Nater
  • Agnieszka Grabowska
  • Alan H Beggs
  • Colin A Sieff
  • Eva Atsidaftos
  • Cindy Y Chang
  • David E Root
  • Pablo Tamayo
  • Emi Caywood
  • Robert J Arceci
  • Sarah E Ball
  • C Conover Talbot
  • Todd R Golub
  • Naomi Galili
  • Clifford M Takemoto
  • Jennifer Pretz
  • Azra Raza
  • Paula Logsden
  • Stephen Taylor
  • John O Trent
  • Jacqueline M Caffrey

Detail Information

Publications9

  1. pmc Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
    Benjamin L Ebert
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 451:335-9. 2008
    ..These results indicate that the 5q- syndrome is caused by a defect in ribosomal protein function and suggest that RNAi screening is an effective strategy for identifying causal haploinsufficiency disease genes...
  2. ncbi request reprint Nucleolar stress in Diamond Blackfan anemia pathophysiology
    Steven R Ellis
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40292, USA Electronic address
    Biochim Biophys Acta 1842:765-8. 2014
    ..The growing number of ribosomopathies provides additional challenges for linking molecular mechanisms with clinical phenotypes. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease. ..
  3. ncbi request reprint Diamond Blackfan anemia: A paradigm for a ribosome-based disease
    Steven R Ellis
    Department of Biochemistry and Molecular Biology, University of Louisville, 319 Abraham Flexner Way, Louisville, KY 40292, USA
    Med Hypotheses 66:643-8. 2006
    ..Therefore, these factors represent targets for the development of new therapies to treat Diamond Blackfan anemia and other ribosome based diseases...
  4. doi request reprint Diamond Blackfan anemia: ribosomal proteins going rogue
    Steven R Ellis
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40292, USA
    Semin Hematol 48:89-96. 2011
    ..Despite this, considerable strides have been made over that past few years demonstrating that several factors involved in the synthesis of ribosomes are targets of disease-causing mutations...
  5. pmc Ribosomal proteins Rps0 and Rps21 of Saccharomyces cerevisiae have overlapping functions in the maturation of the 3' end of 18S rRNA
    Amy Tabb-Massey
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40292, USA
    Nucleic Acids Res 31:6798-805. 2003
    ..Together, these data link the Rps0 and Rps21 proteins together functionally in promoting maturation of the 3' end of 18S rRNA and formation of active 40S ribosomal subunits...
  6. doi request reprint Diamond Blackfan anemia: a disorder of red blood cell development
    Steven R Ellis
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, Kentucky, USA
    Curr Top Dev Biol 82:217-41. 2008
    ..This chapter also attempts to demonstrate how the marriage of laboratory and clinical science may enhance each and permit insights into human disease that neither alone can accomplish...
  7. pmc Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits
    Johan Flygare
    Department of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University Hospital, Sweden
    Blood 109:980-6. 2007
    ..This defect was observed to a lesser extent in CD34+ cells from patients with DBA who have mutations in RPS19...
  8. pmc Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia
    Jason E Farrar
    Division of Pediatric Oncology, Department of Oncology, Kimmel Comprehensive Cancer Center
    Blood 112:1582-92. 2008
    ..The results also establish that haploinsufficiency of large ribosomal subunit proteins contributes to bone marrow failure and potentially cancer predisposition...
  9. ncbi request reprint Ribosomes and marrow failure: coincidental association or molecular paradigm?
    Johnson M Liu
    Feinstein Institute for Medical Research, Manhasset, NY, USA
    Blood 107:4583-8. 2006
    ..Delineation of the precise role of each gene product in ribosomal biogenesis and in hematopoietic development may have both therapeutic and prognostic importance and perhaps even direct the search for new bone marrow failure genes...

Research Grants5

  1. Ribosomal Function and Diamond-Blackfan Anemia
    Steven Ellis; Fiscal Year: 2004
    ..4. characterize the phenotype of mice hemizygous for LAMR1 including hematological analysis, cancer incidence, and the presence of other congenital abnormalities. ..
  2. Ribosomal Function and Diamond-Blackfan Anemia
    Steven Ellis; Fiscal Year: 2005
    ..4. characterize the phenotype of mice hemizygous for LAMR1 including hematological analysis, cancer incidence, and the presence of other congenital abnormalities. ..
  3. Ribosomal Function and Diamond-Blackfan Anemia
    Steven Ellis; Fiscal Year: 2006
    ..4. characterize the phenotype of mice hemizygous for LAMR1 including hematological analysis, cancer incidence, and the presence of other congenital abnormalities. ..
  4. Ribosomal Function and Diamond-Blackfan Anemia
    Steven Ellis; Fiscal Year: 2007
    ..4. characterize the phenotype of mice hemizygous for LAMR1 including hematological analysis, cancer incidence, and the presence of other congenital abnormalities. ..