Ronald Ellis

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men
    Patricia K Riggs
    Center for Medicinal Cannabis Research CMCR and HIV Neurobehavioral Research Center HNRC, University of California, San Diego, USA
    Brain Res 1431:46-52. 2012
  2. ncbi HIV-associated neurocognitive disorders in sub-Saharan Africa: a pilot study in Cameroon
    Georgette D Kanmogne
    Department of Pharmacology and Experimental Neurosciences, University of Nebraska Medical Center, Omaha, NE, USA
    BMC Neurol 10:60. 2010
  3. ncbi NeuroAIDS in Brazil
    Ronald J Ellis
    Department of Neurosciences, HIV Neurobehavioral Research Center, University of California, San Diego, San Diego, California 92103, USA
    J Neurovirol 13:89-96. 2007
  4. ncbi Continued high prevalence and adverse clinical impact of human immunodeficiency virus-associated sensory neuropathy in the era of combination antiretroviral therapy: the CHARTER Study
    Ronald J Ellis
    HIV Neurobehavioral Research Center, Department of Neurosciences, University of California, San Diego, San Diego, CA 92103, USA
    Arch Neurol 67:552-8. 2010
  5. ncbi Human immunodeficiency virus protease inhibitors and risk for peripheral neuropathy
    Ronald J Ellis
    University of California, San Diego, San Diego, CA, USA
    Ann Neurol 64:566-72. 2008
  6. ncbi HIV and antiretroviral therapy: impact on the central nervous system
    Ronald Ellis
    University of California, San Diego, 150 W Washington St, San Diego, CA 92103, USA
    Prog Neurobiol 91:185-7. 2010
  7. ncbi Increased human immunodeficiency virus loads in active methamphetamine users are explained by reduced effectiveness of antiretroviral therapy
    Ronald J Ellis
    Department of Neurosciences, University of California San Diego, San Diego, California, USA
    J Infect Dis 188:1820-6. 2003
  8. ncbi CD4 nadir is a predictor of HIV neurocognitive impairment in the era of combination antiretroviral therapy
    Ronald J Ellis
    University of California, San Diego, USA
    AIDS 25:1747-51. 2011
  9. ncbi Human immunodeficiency virus-1 RNA levels in cerebrospinal fluid exhibit a set point in clinically stable patients not receiving antiretroviral therapy
    Ronald J Ellis
    Department of Neurosciences and HIV Neurobehavioral Research Center, University of California San Diego, San Diego, CA 92103, USA
    J Infect Dis 187:1818-21. 2003
  10. ncbi HIV infection and the central nervous system: a primer
    Ronald J Ellis
    University of California, San Diego, San Diego, CA 92103, USA
    Neuropsychol Rev 19:144-51. 2009

Research Grants

  1. SOURCES AND NEUROCOGNITIVE CORRELATES ON CSF HIV RNA
    Ronald Ellis; Fiscal Year: 1999
  2. HIV Neurocognitive Disorders: A Randomized Clinical Trial of CNS-Targeted HAART
    Ronald Ellis; Fiscal Year: 2009
  3. HIV Neurocognitive Disorders: A Randomized Clinical Trial of CNS-Targeted HAART
    Ronald Ellis; Fiscal Year: 2007
  4. HIV Clade on Cognitive and Neurological Disorders Brazil
    Ronald Ellis; Fiscal Year: 2007
  5. HIV NEUROCOGNITIVE DISORDERS--CSF HIV RNA AND CHEMOKINES
    Ronald Ellis; Fiscal Year: 2006
  6. HIV Neurocognitive Disorders: A Randomized Clinical Trial of CNS-Targeted HAART
    Ronald J Ellis; Fiscal Year: 2010

Detail Information

Publications76

  1. ncbi A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men
    Patricia K Riggs
    Center for Medicinal Cannabis Research CMCR and HIV Neurobehavioral Research Center HNRC, University of California, San Diego, USA
    Brain Res 1431:46-52. 2012
    ..Exogenous cannabinoids such as tetrahydrocannabinol (THC) stimulate appetite and food intake. However, there are no controlled observations directly linking THC to changes of most of the appetite hormones...
  2. ncbi HIV-associated neurocognitive disorders in sub-Saharan Africa: a pilot study in Cameroon
    Georgette D Kanmogne
    Department of Pharmacology and Experimental Neurosciences, University of Nebraska Medical Center, Omaha, NE, USA
    BMC Neurol 10:60. 2010
    ..The objectives of this study were to determine whether Western neuropsychological (NP) methods are appropriate for use in Cameroon, and to evaluate cognitive function in a sample of HIV-infected adults...
  3. ncbi NeuroAIDS in Brazil
    Ronald J Ellis
    Department of Neurosciences, HIV Neurobehavioral Research Center, University of California, San Diego, San Diego, California 92103, USA
    J Neurovirol 13:89-96. 2007
    ..Topics addressed ranged from clinical neurobehavioral aspects to molecular biology. Experts attending the meeting considered fruitful directions for future research...
  4. ncbi Continued high prevalence and adverse clinical impact of human immunodeficiency virus-associated sensory neuropathy in the era of combination antiretroviral therapy: the CHARTER Study
    Ronald J Ellis
    HIV Neurobehavioral Research Center, Department of Neurosciences, University of California, San Diego, San Diego, CA 92103, USA
    Arch Neurol 67:552-8. 2010
    ..To provide updated estimates of the prevalence and clinical impact of human immunodeficiency virus-associated sensory neuropathy (HIV-SN) and neuropathic pain due to HIV-SN in the combination antiretroviral therapy (CART) era...
  5. ncbi Human immunodeficiency virus protease inhibitors and risk for peripheral neuropathy
    Ronald J Ellis
    University of California, San Diego, San Diego, CA, USA
    Ann Neurol 64:566-72. 2008
    ..Confirmation of peripheral nerve toxicity with PIs could substantially limit their long-term use in highly active ARV therapy...
  6. ncbi HIV and antiretroviral therapy: impact on the central nervous system
    Ronald Ellis
    University of California, San Diego, 150 W Washington St, San Diego, CA 92103, USA
    Prog Neurobiol 91:185-7. 2010
    ..Optimizing neurocognitive recovery is likely to require the development of better CNS penetrating antiretroviral regimens and the use of neuroprotective agents...
  7. ncbi Increased human immunodeficiency virus loads in active methamphetamine users are explained by reduced effectiveness of antiretroviral therapy
    Ronald J Ellis
    Department of Neurosciences, University of California San Diego, San Diego, California, USA
    J Infect Dis 188:1820-6. 2003
    ..In contrast, abstinent former METH abusers (METH(+)Tox-) receiving HAART effectively suppressed viral replication. These data suggest that abstinence programs are a key component of effective treatment of HIV in METH-abusing populations...
  8. ncbi CD4 nadir is a predictor of HIV neurocognitive impairment in the era of combination antiretroviral therapy
    Ronald J Ellis
    University of California, San Diego, USA
    AIDS 25:1747-51. 2011
    ..The present study evaluated the probability of neuropsychological impairment (NPI) and HAND as a function of CD4 nadir in an HIV-positive cohort...
  9. ncbi Human immunodeficiency virus-1 RNA levels in cerebrospinal fluid exhibit a set point in clinically stable patients not receiving antiretroviral therapy
    Ronald J Ellis
    Department of Neurosciences and HIV Neurobehavioral Research Center, University of California San Diego, San Diego, CA 92103, USA
    J Infect Dis 187:1818-21. 2003
    ....
  10. ncbi HIV infection and the central nervous system: a primer
    Ronald J Ellis
    University of California, San Diego, San Diego, CA 92103, USA
    Neuropsychol Rev 19:144-51. 2009
    ..Finally, we describe what is known about how HIV injures the nervous system, leading to HAND, and discuss potential strategies for preventing or treating the effects of HIV on the nervous system...
  11. ncbi Neurocognitive impairment is an independent risk factor for death in HIV infection. San Diego HIV Neurobehavioral Research Center Group
    R J Ellis
    Department of Neurosciences, University of California, Department of Medicine, San Diego, USA
    Arch Neurol 54:416-24. 1997
    ..To determine if mortality is increased in individuals with human immunodeficiency virus type 1 (HIV-1)-associated neurocognitive disorders less severe than frank dementia...
  12. ncbi Progression to neuropsychological impairment in human immunodeficiency virus infection predicted by elevated cerebrospinal fluid levels of human immunodeficiency virus RNA
    Ronald J Ellis
    HIV Neurobehavioral Research Center, University of California, San Diego, 150 W Washington St, 2nd Floor, San Diego, CA 92103, USA
    Arch Neurol 59:923-8. 2002
    ....
  13. ncbi Diagnostic validity of the dementia questionnaire for Alzheimer disease
    R J Ellis
    Department of Neurosciences, University of California, San Diego, La Jolla 92093 0948, USA
    Arch Neurol 55:360-5. 1998
    ..To determine the sensitivity and specificity of postmortem dementia diagnoses based on a retrospective informant interview by comparison with criterion standard neuropathological diagnoses and the results of previous clinical examinations...
  14. ncbi Cerebrospinal fluid tau protein is not elevated in HIV-associated neurologic disease in humans. HIV Neurobehavioral Research Center Group (HNRC)
    R J Ellis
    Department of Neurosciences, University of California, San Diego, USA
    Neurosci Lett 254:1-4. 1998
    ..251 +/- 185; P = 23). In summary, CSF tau levels were not elevated in patients with HIV-associated neurologic disease...
  15. ncbi HIV and antiretroviral therapy in the brain: neuronal injury and repair
    Ronald Ellis
    Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Rev Neurosci 8:33-44. 2007
    ....
  16. ncbi Cerebrospinal fluid HIV RNA originates from both local CNS and systemic sources
    R J Ellis
    Department of Neurosciences, HIV Neurobehavioral Research Center, University of California, San Diego, USA
    Neurology 54:927-36. 2000
    ..To identify the sources of HIV virions in CSF by modeling treatment-associated HIV dynamics...
  17. ncbi Clinical trials in HIV CNS disease and treatment management
    Ronald J Ellis
    Department of Neurosciences and HIV Neurobehavioral Research Center, University of California, 150 West Washington St, San Diego, CA 92103, USA
    J Neuroimmune Pharmacol 2:20-5. 2007
    ..Flexner) are described in detail here. The remaining four talks (those by R. Ellis, R. Price, S. Letendre, and R. Robertson) are briefly introduced here, and full-length papers may be found elsewhere in this issue of the Journal...
  18. ncbi Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial
    Ronald J Ellis
    Department of Neurosciences, University of California, San Diego, CA 92103, USA
    Neuropsychopharmacology 34:672-80. 2009
    ..Smoked cannabis was generally well tolerated and effective when added to concomitant analgesic therapy in patients with medically refractory pain due to HIV DSPN...
  19. ncbi Clinical validation of the NeuroScreen
    Ronald J Ellis
    Department of Neurosciences, UCSD AntiViral Research Center and HIV Neurobehavioral Research Center, University of California, San Diego, California 92103, USA
    J Neurovirol 11:503-11. 2005
    ..However, because it yields substantial numbers of false positives and negatives, the NeuroScreen may be less useful in evaluating individual patients...
  20. ncbi Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signaling
    Amy D Paulino
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0624, USA
    J Neurovirol 17:327-40. 2011
    ..These pathways provide novel targets for development of neuroprotective treatments for HCV involvement of the CNS...
  21. ncbi Low atazanavir concentrations in cerebrospinal fluid
    Brookie M Best
    Skaggs School of Pharmacy andPharmaceutical Sciences, School of Medicine, Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, MC 0719, La Jolla, CA 92093 0719, USA
    AIDS 23:83-7. 2009
    ..The objective of this study was to determine atazanavir penetration into cerebrospinal fluid (CSF)...
  22. ncbi Cerebrospinal fluid human immunodeficiency virus viral load in patients with neurosyphilis
    Sergio Monteiro de Almeida
    HIV Neurobehavioral Research Center, University of California San Diego, San Diego, USA
    J Neurovirol 16:6-12. 2010
    ..Because elevated CSF VL is associated with subsequent neurocognitive decline, future studies should evaluate the impact of neurosyphilis on the course of central nervous system (CNS) HIV infection...
  23. ncbi Efavirenz concentrations in CSF exceed IC50 for wild-type HIV
    Brookie M Best
    University of California San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA, USA
    J Antimicrob Chemother 66:354-7. 2011
    ..This study's objective was to determine penetration of a commonly prescribed antiretroviral drug, efavirenz, into CSF...
  24. ncbi Dynamics of monocyte chemoattractant protein type one (MCP-1) and HIV viral load in human cerebrospinal fluid and plasma
    Sergio Monteiro de Almeida
    HIV Neurobehavioral Research Center, UCSD, 150 West Washington St, 2nd Flr, San Diego, CA 92103, USA
    J Neuroimmunol 169:144-52. 2005
    ..CONCLUSION: The close temporal relationship of the increase of MCP-1 and CSF VL suggests that they are co-regulated, or that one is a stimulus for the other...
  25. ncbi Synergistic effects of HIV infection and older age on daily functioning
    Erin E Morgan
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Acquir Immune Defic Syndr 61:341-8. 2012
    ..To determine whether HIV infection and aging act synergistically to disrupt everyday functioning...
  26. ncbi Meeting practical challenges of a trial involving a multitude of treatment regimens: an example of a multi-center randomized controlled clinical trial in neuroAIDS
    Susanne May
    Division of Biostatistics and Bioinformatics, Department of Family and Preventive Medicine, and Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive M C 0717, La Jolla, CA 92093 0717, USA
    J Neuroimmune Pharmacol 2:97-104. 2007
    ..A small pilot study demonstrated the feasibility and acceptability to providers. In conclusion, an innovative design can provide solutions to challenging practical issues in trials with multiple treatment options...
  27. ncbi Pathogenesis of hepatitis C virus coinfection in the brains of patients infected with HIV
    Scott Letendre
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0624, USA
    J Infect Dis 196:361-70. 2007
    ..The results support the hypothesis that HCV traffics into the HIV-infected brain, where it might lead to a productive coinfection associated with cognitive impairment...
  28. ncbi The monocyte chemotactic protein-1 -2578G allele is associated with elevated MCP-1 concentrations in cerebrospinal fluid
    Scott Letendre
    Department of Medicine, The HIV Neurobehavioral Research Center, 150 West Washington Street, San Diego, CA 92103, USA
    J Neuroimmunol 157:193-6. 2004
    ..Our findings suggest that this MCP-1 promoter polymorphism influences HIV neuropathogenesis by regulating MCP-1 protein expression in the central nervous system (CNS)...
  29. ncbi Genetic composition of human immunodeficiency virus type 1 in cerebrospinal fluid and blood without treatment and during failing antiretroviral therapy
    M C Strain
    University of California, San Diego, La Jolla, CA, USA
    J Virol 79:1772-88. 2005
    ....
  30. ncbi The impact of HIV-related neuropsychological dysfunction on driving behavior. The HNRC Group
    T D Marcotte
    University of California at San Diego, Department of Psychiatry, USA
    J Int Neuropsychol Soc 5:579-92. 1999
    ..Although it would be premature to extrapolate these findings to impairment in on-the-road driving, they do argue for greater attention to the impact that even mild HIV-related NP deficits may have on driving skills...
  31. ncbi Indinavir population pharmacokinetics in plasma and cerebrospinal fluid. The HIV Neurobehavioral Research Center Group
    S L Letendre
    HIV Neurobehavioral Research Center, University of California, San Diego, California 92103, USA
    Antimicrob Agents Chemother 44:2173-5. 2000
    ..We conclude that CSF indinavir concentrations are lower than levels in plasma but exceed the clinical 95% inhibitory concentration range...
  32. ncbi A multimodal assessment of driving performance in HIV infection
    T D Marcotte
    Department of Psychiatry, University of California, San Diego, CA, USA
    Neurology 63:1417-22. 2004
    ..To examine if HIV-seropositive (HIV+) individuals are at risk for impaired driving...
  33. ncbi Dynamics of cognitive change in impaired HIV-positive patients initiating antiretroviral therapy
    L A Cysique
    Department of Psychiatry, University of California at San Diego, CA, USA
    Neurology 73:342-8. 2009
    ....
  34. ncbi Neurocognitive dysfunction predicts postmortem findings of HIV encephalitis
    M Cherner
    Departments of Psychiatry, University of California at San Diego, CA 92103, USA
    Neurology 59:1563-7. 2002
    ..To investigate the value of antemortem cognitive functioning in predicting postmortem evidence of HIV encephalitis (HIVE)...
  35. ncbi HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study
    R K Heaton
    University of California, San Diego, USA
    Neurology 75:2087-96. 2010
    ....
  36. ncbi Impact of long-term treatment with neurotoxic dideoxynucleoside antiretrovirals: implications for clinical care in resource-limited settings
    C F Hung
    University of California, San Diego, CA, USA
    HIV Med 9:731-7. 2008
    ..Therefore, we evaluated the safety of continuing d-drug therapy...
  37. ncbi Progressive cerebral volume loss in human immunodeficiency virus infection: a longitudinal volumetric magnetic resonance imaging study. HIV Neurobehavioral Research Center Group
    J C Stout
    Department of Psychiatry, University of California, San Diego, USA
    Arch Neurol 55:161-8. 1998
    ..To compare rates and anatomical patterns of brain atrophy during 3 stages of human immunodeficiency virus (HIV) disease...
  38. ncbi Effect of methamphetamine dependence on inhibitory deficits in a novel human open-field paradigm
    Brook L Henry
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Psychopharmacology (Berl) 215:697-707. 2011
    ..Previous work demonstrated that manic bipolar subjects exhibit a disinhibited pattern of behavior in the hBPM characterized by increased object interactions...
  39. ncbi Estimating selection pressures on HIV-1 using phylogenetic likelihood models
    S L Kosakovsky Pond
    Department of Pathology, University of California, San Diego, CA 92093, USA
    Stat Med 27:4779-89. 2008
    ..To illustrate our methods, we present an analysis of compartment-specific evolution of HIV-1 env in blood and cerebrospinal fluid and of site-to-site variation in the gag gene of subtype C HIV-1...
  40. ncbi Extrapyramidal motor signs in clinically diagnosed Alzheimer disease
    R J Ellis
    Department of Neurosciences, University of California, San Diego, USA
    Alzheimer Dis Assoc Disord 10:103-14. 1996
    ..Investigators should report frequencies for individual parkinsonian signs in addition to the overall prevalence of EPS to facilitate meaningful comparisons across studies...
  41. ncbi The role of cohort studies in drug development: clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous system
    Scott L Letendre
    University of California, 150 W Washington St, San Diego, CA 92103, USA
    J Neuroimmune Pharmacol 2:120-7. 2007
    ..Some of these drugs, such as serotonin reuptake inhibitors (SRIs) and HMG-CoA reductase inhibitors (statins), may do so by reducing HIV replication in the CNS and are already widely used by HIV-infected individuals...
  42. ncbi Selegiline transdermal system (STS) for HIV-associated cognitive impairment: open-label report of ACTG 5090
    Scott R Evans
    Harvard School of Public Health, Boston, Massachusetts, USA
    HIV Clin Trials 8:437-46. 2007
    ..To assess the long-term safety (primary aim) and efficacy (secondary aim) of the MAO-B inhibitor Selegiline Transdermal System (STS) for the treatment of HIV-associated cognitive impairment...
  43. ncbi Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system
    Scott Letendre
    University of California, San Diego, 150 W Washington St, San Diego, CA 92103, USA
    Arch Neurol 65:65-70. 2008
    ..To evaluate whether penetration of a combination regimen into the central nervous system (CNS), as estimated by the CNS Penetration-Effectiveness (CPE) rank, is associated with lower cerebrospinal fluid (CSF) viral load...
  44. ncbi Role of psychiatric medications as adjunct therapy in the treatment of HIV associated neurocognitive disorders
    Beau M Ances
    Department of Neurosciences, University of California, San Diego, California, USA
    Int Rev Psychiatry 20:89-93. 2008
    ..The present brief review focuses on these drugs and assesses their possible adjunct roles in the treatment of HIV-infected individuals...
  45. ncbi Prospective memory in HIV infection: is "remembering to remember" a unique predictor of self-reported medication management?
    Steven Paul Woods
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Arch Clin Neuropsychol 23:257-70. 2008
    ..The potential benefits of individualized remediation strategies that are informed by conceptual models of ProM and specifically target medication adherence warrant further exploration...
  46. ncbi Osteopontin is increased in HIV-associated dementia
    Tricia H Burdo
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, USA
    J Infect Dis 198:715-22. 2008
    ....
  47. ncbi Variable patterns of neuropsychological performance in HIV-1 infection
    S Dawes
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California San Diego, San Diego, CA 92093 0603, USA
    J Clin Exp Neuropsychol 30:613-26. 2008
    ..Thus, there does not appear to be a single, prototypical pattern of neuropsychological impairment associated with HIV infection for this battery of representative neuropsychological tests...
  48. ncbi Effects of HIV-1 infection and aging on neurobehavioral functioning: preliminary findings
    Marianna Cherner
    Department of Psychiatry, University of California San Diego, La Jolla, 92093-0603, USA
    AIDS 18:S27-34. 2004
    ..CONCLUSION: Although further studies with larger and older samples are needed, this investigation suggests that older adults may be at greater risk of HIV-related neurocognitive dysfunction...
  49. ncbi Two-year prospective study of major depressive disorder in HIV-infected men
    J Hampton Atkinson
    Department of Psychiatry, University of California San Diego, School of Medicine, La Jolla, California 92093, USA
    J Affect Disord 108:225-34. 2008
    ..This 2-year prospective study compared cumulative rates and predictors of a major depressive episode in HIV-infected (HIV+) men (N=297) and uninfected (HIV-) risk-group controls (N=90)...
  50. ncbi Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity
    Robert H Paul
    Department of Behavioral Neuroscience, University of Missouri, St Louis, St Louis, MO 63121, USA
    J Neuropsychiatry Clin Neurosci 19:283-92. 2007
    ..Prospective studies are needed to elucidate the evolution of these changes in the setting of antiretroviral therapy...
  51. ncbi A battery approach for measuring neuropsychological change
    Steven Paul Woods
    University of California, HIV Neurobehavioral Research Center, Department of Psychiatry 0603 H, 150 West Washington Street, 2nd Floor, San Diego, CA 92103, USA
    Arch Clin Neuropsychol 21:83-9. 2006
    ..Findings from this study may be useful for both clinicians and researchers seeking normative standards for determining reliable changes in performance across a commonly used battery of neuropsychological tests...
  52. ncbi Effects of methamphetamine dependence and HIV infection on cerebral morphology
    Terry L Jernigan
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 9151B, USA
    Am J Psychiatry 162:1461-72. 2005
    ..The authors examined the separate and combined effects of methamphetamine dependence and HIV infection on brain morphology...
  53. ncbi Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid
    Edmund V Capparelli
    Pediatric Pharmacology Research Unit PPRU, University of California, San Diego, 200 West Arbor Drive, MC 8214, San Diego, CA 92103 8214, USA
    Antimicrob Agents Chemother 49:2504-6. 2005
    ..The abacavir CSF/plasma ratio averaged 36% and increased throughout the dose interval. Abacavir penetrates into the CSF in adequate concentrations to inhibit local human immunodeficiency virus replication...
  54. ncbi CCR2 polymorphisms affect neuropsychological impairment in HIV-1-infected adults
    Kumud K Singh
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    J Neuroimmunol 157:185-92. 2004
    ....
  55. ncbi Altered P-glycoprotein expression in AIDS patients with HIV encephalitis
    Dianne Langford
    Department of Pathology, University of California San Diego, La Jolla, CA 92093 0624, USA
    J Neuropathol Exp Neurol 63:1038-47. 2004
    ..Taken together, our data suggest that P-gp may be part of a central pathway mediating viral compartmentalization in the brains of HIV-infected individuals and may play a significant part in HIV disease progression in the brain...
  56. ncbi Regional patterns of brain metabolites in AIDS dementia complex
    Constantin T Yiannoutsos
    Division of Biostatistics, Indiana University School of Medicine, 1050 Wishard Boulevard, RG 4101, Indianapolis, IN 46202, USA
    Neuroimage 23:928-35. 2004
    ..We conclude that by using factor analysis, we are able to combine multiple metabolites across brain regions in a biologically plausible manner and construct a predictive model of ADC adjusting for relevant factors such as age...
  57. ncbi Enhancing antiretroviral therapy for human immunodeficiency virus cognitive disorders
    Scott L Letendre
    HIV Neurobehavioral Research Center, University of California at San Diego, San Diego, CA 92103, USA
    Ann Neurol 56:416-23. 2004
    ..Including CSF-penetrating drugs in the ART regimen and monitoring CSF viral load may be indicated for individuals with HIV-associated cognitive impairment...
  58. ncbi Correlation of in vivo neuroimaging abnormalities with postmortem human immunodeficiency virus encephalitis and dendritic loss
    Sarah L Archibald
    Department of Psychiatry, University of California, San Diego, and Veterans Affairs San Diego Healthcare System, La Jolla, 92093, USA
    Arch Neurol 61:369-76. 2004
    ..Although previous studies have linked brain viral levels to these alterations, other neuropathological mechanisms might also contribute to them...
  59. ncbi Patterns of selective neuronal damage in methamphetamine-user AIDS patients
    Dianne Langford
    Department of Pathology, University of California at San Francisco, La Jolla, CA 92093-0624, USA
    J Acquir Immune Defic Syndr 34:467-74. 2003
    ..In combination, METH and HIV may increase neuronal cell injury and death, thereby enhancing brain metabolic disturbances observed in clinical populations of HIV-positive METH abusers...
  60. ncbi Prediction of incident neurocognitive impairment by plasma HIV RNA and CD4 levels early after HIV seroconversion
    Thomas D Marcotte
    Department of Psychiatry, University of California San Diego, 92103, USA
    Arch Neurol 60:1406-12. 2003
    ..Neuropsychological (NP) impairment is a relatively common sequela in human immunodeficiency virus (HIV)-infected individuals with advanced disease. Early antecedents of NP dysfunction, however, remain poorly understood...
  61. ncbi Computerized reaction time battery versus a traditional neuropsychological battery: detecting HIV-related impairments
    Raul Gonzalez
    HIV Neurobehavioral Research Center HNRC, University of California, San Diego, 150 West Washington Street, 2nd Floor, San Diego, CA 92103, USA
    J Int Neuropsychol Soc 9:64-71. 2003
    ..44). Data from this study suggest that traditional NP batteries and computerized reaction time tests do not measure the same thing, and are not interchangeable in examining HIV-related NP impairments...
  62. ncbi Brain mitochondrial injury in human immunodeficiency virus-seropositive (HIV+) individuals taking nucleoside reverse transcriptase inhibitors
    Brian C Schweinsburg
    VA San Diego Healthcare System, San Diego, California 92103, USA
    J Neurovirol 11:356-64. 2005
    ..Measurement of brain metabolites sensitive to impairments in energy metabolism, including NAA, may aid in early detection of subclinical NRTI-mediated mitochondrial toxicity...
  63. ncbi The effects of hepatitis C, HIV, and methamphetamine dependence on neuropsychological performance: biological correlates of disease
    Scott L Letendre
    Department of Medicine, University of California San Diego, CA 92103, USA
    AIDS 19:S72-8. 2005
    ..To determine the effects of hepatitis C virus (HCV) infection on neuropsychological (NP) performance...
  64. ncbi Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study
    Giovanni Schifitto
    University of Rochester, Rochester, New York 14620, USA
    AIDS 21:1877-86. 2007
    ..To assess the safety and efficacy of memantine, an uncompetitive antagonist of the N-methyl-D-aspartate receptor as treatment of HIV-associated cognitive impairment...
  65. ncbi HIV suppression by HAART preserves cognitive function in advanced, immune-reconstituted AIDS patients
    J Allen McCutchan
    University of California San Diego, 150 West Washington Street, San Diego, CA 92103, USA
    AIDS 21:1109-17. 2007
    ..Epidemiological observations suggest that neuropsychological impairment might progress despite successful HAART therapy, but available prevalence estimates are based on populations that were selected for impairment...
  66. ncbi Neurologic complications of HIV disease and their treatment
    Scott Letendre
    Department of Medicine, Division of Infectious Diseases, University of California San Diego, San Diego, CA, USA
    Top HIV Med 15:32-9. 2007
    ..The conference also included an important focus on JC virus encephalitis (also known as progressive multifocal leukoencephalopathy)...
  67. ncbi Neuropathologic confirmation of definitional criteria for human immunodeficiency virus-associated neurocognitive disorders
    Mariana Cherner
    Departments of Psychiatry, University of California San Diego, San Diego, California 92103, USA
    J Neurovirol 13:23-8. 2007
    ..The modifications to the AAN 1991 criteria proposed by the HNRC and others in the field have served as a point of departure for a recently revised consensus nomenclature...
  68. ncbi Dementia and neurocognitive disorders due to HIV-1 infection
    Beau M Ances
    Department of Neuroscience, University of California San Diego, La Jolla, California, USA
    Semin Neurol 27:86-92. 2007
    ..Accordingly, the present review focuses on primary HIV-induced disease of the central nervous system, rather than its opportunistic complications...
  69. ncbi Valproic acid does not affect markers of human immunodeficiency virus disease progression
    Beau M Ances
    Department of Neurosciences, University of California, San Diego, California, USA
    J Neurovirol 12:403-6. 2006
    ..VPA patients had a trend towards lower CD4+ cells (P = .08) at follow-up. Concurrent antiretrovirals did not alter these relationships. VPA does not induce viremia or promote disease progression and may be safe for clinical intervention...
  70. ncbi Lithium improves HIV-associated neurocognitive impairment
    Scott L Letendre
    Department of Medicine, University of California, San Diego, California 92103, USA
    AIDS 20:1885-8. 2006
    ..To determine the effects of low-dose oral lithium on the neuropsychological performance of individuals diagnosed with HIV-associated neurocognitive impairment...
  71. ncbi Relationship of antiretroviral treatment to postmortem brain tissue viral load in human immunodeficiency virus-infected patients
    Dianne Langford
    Department of Pathology, University of California, San Diego, La Jolla, California 92093, USA
    J Neurovirol 12:100-7. 2006
    ..Furthermore, such strategies might help to prevent the development of ARV resistance...
  72. ncbi Genetic attributes of cerebrospinal fluid-derived HIV-1 env
    Satish K Pillai
    University of California San Diego, Department of Medicine NCIRE, La Jolla, CA 94121, USA
    Brain 129:1872-83. 2006
    ..Furthermore, neurological impairment may be influenced by mutations within the viral V3 loop sequence...
  73. ncbi Neurologic complications of HIV disease and their treatments
    Scott Letendre
    Department of Medicine, University of California San Diego, CA, USA
    Top HIV Med 14:21-6. 2006
    ..Together, these findings heighten concern for persistent neurologic diseases in antiretroviral therapy-treated individuals but provide guidance for their improved identification and treatment...
  74. ncbi Cortical and subcortical neurodegeneration is associated with HIV neurocognitive impairment
    David J Moore
    HIV Neurobehavioral Research Center and University of California, San Diego, California 92161, USA
    AIDS 20:879-87. 2006
    ..To determine the association of markers of regional neurodegeneration (ND) at autopsy to degree of neurocognitive impairment in persons with HIV...
  75. ncbi Severe, demyelinating leukoencephalopathy in AIDS patients on antiretroviral therapy
    T Dianne Langford
    Department of Pathology, University of California, San Diego, CA, USA
    AIDS 16:1019-29. 2002
    ..This condition warrants further study and increased vigilance among those who provide care for HIV-infected individuals...
  76. ncbi Increased glutamate in CSF and plasma of patients with HIV dementia
    Michael Graham Espey
    Neurology 58:1439; author reply 1439-40. 2002

Research Grants12

  1. SOURCES AND NEUROCOGNITIVE CORRELATES ON CSF HIV RNA
    Ronald Ellis; Fiscal Year: 1999
    ....
  2. HIV Neurocognitive Disorders: A Randomized Clinical Trial of CNS-Targeted HAART
    Ronald Ellis; Fiscal Year: 2009
    ..The proposed clinical trial would provide the level of evidence needed to formulate ART guidelines specific to HNCI. ..
  3. HIV Neurocognitive Disorders: A Randomized Clinical Trial of CNS-Targeted HAART
    Ronald Ellis; Fiscal Year: 2007
    ..The proposed clinical trial would provide the level of evidence needed to formulate ART guidelines specific to HNCI. ..
  4. HIV Clade on Cognitive and Neurological Disorders Brazil
    Ronald Ellis; Fiscal Year: 2007
    ..UCSD investigators will train and guide the administration and interpretation of the clinical assessment instruments, transfer technology to the Brazilian site. ..
  5. HIV NEUROCOGNITIVE DISORDERS--CSF HIV RNA AND CHEMOKINES
    Ronald Ellis; Fiscal Year: 2006
    ..abstract_text> ..
  6. HIV Neurocognitive Disorders: A Randomized Clinical Trial of CNS-Targeted HAART
    Ronald J Ellis; Fiscal Year: 2010
    ..The proposed clinical trial would provide the level of evidence needed to formulate ART guidelines specific to HNCI. ..