Michael H Elliott
Affiliation: University of Oklahoma Health Sciences Center
Reagan A, Gu X, Paudel S, Ashpole N, Zalles M, Sonntag W, et al
. Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency. Neurobiol Aging. 2018;71:1-12 pubmed publisher
Elliott M, Fliesler S, Ghalayini A. Cholesterol-dependent association of caveolin-1 with the transducin alpha subunit in bovine photoreceptor rod outer segments: disruption by cyclodextrin and guanosine 5'-O-(3-thiotriphosphate). Biochemistry. 2003;42:7892-903 pubmed
..These results strongly suggest that the association between Talpha and caveolin-1 occurs in cholesterol-rich, detergent-resistant membranes and is likely to be dependent upon the activation state of Talpha. ..
Reagan A, Gu X, Hauck S, Ash J, Cao G, Thompson T, et al
. Retinal Caveolin-1 Modulates Neuroprotective Signaling. Adv Exp Med Biol. 2016;854:411-8 pubmed publisher
..Thus, Cav-1 modulates neuroprotective signaling by regulating the endogenous production of neuroprotective factors. ..
Sethna S, Chamakkala T, Gu X, Thompson T, Cao G, Elliott M, et al
. Regulation of Phagolysosomal Digestion by Caveolin-1 of the Retinal Pigment Epithelium Is Essential for Vision. J Biol Chem. 2016;291:6494-506 pubmed publisher
..Taken together, our results reveal a novel role for intracellular caveolin-1 in modulating phagolysosomal function. Moreover, they show, for the first time, that organellar caveolin-1 significantly affects tissue functionality in vivo. ..
Gu X, Reagan A, McClellan M, Elliott M. Caveolins and caveolae in ocular physiology and pathophysiology. Prog Retin Eye Res. 2017;56:84-106 pubmed publisher
..This review highlights the importance of caveolae domains and their components in ocular physiology and pathophysiology and emphasizes the need to better understand these important modulators of cellular function. ..
Elliott M, Ghalayini A. Phosphorylation of caveolin-1 in bovine rod outer segments in vitro by an endogenous tyrosine kinase. Adv Exp Med Biol. 2008;613:335-41 pubmed publisher
Gu X, Fliesler S, Zhao Y, Stallcup W, Cohen A, Elliott M. Loss of caveolin-1 causes blood-retinal barrier breakdown, venous enlargement, and mural cell alteration. Am J Pathol. 2014;184:541-55 pubmed publisher
..Our results are relevant to clinically significant retinal disorders with vascular pathologies, including diabetic retinopathy, uveoretinitis, and primary open-angle glaucoma. ..
McClellan M, Elliott M. Analysis of Fatty Acid and Cholesterol Content from Detergent-Resistant and Detergent-Free Membrane Microdomains. Methods Mol Biol. 2017;1609:185-194 pubmed publisher