David Elliott

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Where are we on worms?
    David E Elliott
    Division of Gastroenterology, University of Iowa Carver College of Medicine and VAMC, Iowa City, Iowa 52242, USA
    Curr Opin Gastroenterol 28:551-6. 2012
  2. ncbi request reprint Helminthic therapy: using worms to treat immune-mediated disease
    David E Elliott
    Division of Gastroenterology, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242 1009, USA
    Adv Exp Med Biol 666:157-66. 2009
  3. ncbi request reprint Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production
    David E Elliott
    Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    J Immunol 181:2414-9. 2008
  4. ncbi request reprint Helminths as governors of immune-mediated inflammation
    David E Elliott
    Department of Internal Medicine, University of Iowa, Roy J and Lucille A Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242 1009, USA
    Int J Parasitol 37:457-64. 2007
  5. ncbi request reprint SSTR2A is the dominant somatostatin receptor subtype expressed by inflammatory cells, is widely expressed and directly regulates T cell IFN-gamma release
    D E Elliott
    Department of Internal Medicine, Division of Gastroenterology Hepatology, University of Iowa College of Medicine, Iowa City, USA
    Eur J Immunol 29:2454-63. 1999
  6. ncbi request reprint Helminths and the modulation of mucosal inflammation
    David E Elliott
    Division of Gastroenterology Hepatology, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 1009, USA
    Curr Opin Gastroenterol 21:51-8. 2005
  7. ncbi request reprint Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice
    David E Elliott
    Department of Internal Medicine, Division of Gastroenterology Hepatology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Eur J Immunol 34:2690-8. 2004
  8. ncbi request reprint Exposure to schistosome eggs protects mice from TNBS-induced colitis
    David E Elliott
    Department of Internal Medicine, Division of Gastroenterology Hepatology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Gastrointest Liver Physiol 284:G385-91. 2003
  9. ncbi request reprint Substance P regulates Th1-type colitis in IL-10 knockout mice
    Joel V Weinstock
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 171:3762-7. 2003
  10. ncbi request reprint IL-18 and IL-12 signal through the NF-kappa B pathway to induce NK-1R expression on T cells
    Joel V Weinstock
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 170:5003-7. 2003

Research Grants

Collaborators

Detail Information

Publications32

  1. pmc Where are we on worms?
    David E Elliott
    Division of Gastroenterology, University of Iowa Carver College of Medicine and VAMC, Iowa City, Iowa 52242, USA
    Curr Opin Gastroenterol 28:551-6. 2012
    ..This article reviews current understanding on how helminths influence intestinal inflammation and mucosal immune responses...
  2. ncbi request reprint Helminthic therapy: using worms to treat immune-mediated disease
    David E Elliott
    Division of Gastroenterology, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242 1009, USA
    Adv Exp Med Biol 666:157-66. 2009
    ..These helminth-host immune interactions have potentially important implications for the treatment of immune-mediated diseases...
  3. ncbi request reprint Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production
    David E Elliott
    Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    J Immunol 181:2414-9. 2008
    ..Ab-mediated blockade of IL-17 improves colitis in IL-10-deficient mice. Thus, helminth-associated inhibition of IL-17 production is most likely an important mechanism mediating protection from inappropriate intestinal inflammation...
  4. ncbi request reprint Helminths as governors of immune-mediated inflammation
    David E Elliott
    Department of Internal Medicine, University of Iowa, Roy J and Lucille A Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242 1009, USA
    Int J Parasitol 37:457-64. 2007
    ..This paper summarises work by multiple groups demonstrating that colonization with helminths alters immune reactivity and protects against disease from dysregulated inflammation...
  5. ncbi request reprint SSTR2A is the dominant somatostatin receptor subtype expressed by inflammatory cells, is widely expressed and directly regulates T cell IFN-gamma release
    D E Elliott
    Department of Internal Medicine, Division of Gastroenterology Hepatology, University of Iowa College of Medicine, Iowa City, USA
    Eur J Immunol 29:2454-63. 1999
    ..We show that SOM acts directly on T cells to inhibit TCR-stimulated IFN-gamma release. Thus, SOM may directly regulate T cell IFN-gamma release at inflammatory sites...
  6. ncbi request reprint Helminths and the modulation of mucosal inflammation
    David E Elliott
    Division of Gastroenterology Hepatology, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 1009, USA
    Curr Opin Gastroenterol 21:51-8. 2005
    ..This review summarizes some of the recent findings showing that helminths induce regulatory circuits that could prevent and treat inflammatory bowel disease...
  7. ncbi request reprint Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice
    David E Elliott
    Department of Internal Medicine, Division of Gastroenterology Hepatology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Eur J Immunol 34:2690-8. 2004
    ..polygyrus inhibits ongoing IL-10(-/-) colitis in part through blocking mucosal Th1 cytokine production. Resolution of inflammation is associated with increased IL-13 production and can be adoptively transferred by MLN T cells...
  8. ncbi request reprint Exposure to schistosome eggs protects mice from TNBS-induced colitis
    David E Elliott
    Department of Internal Medicine, Division of Gastroenterology Hepatology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Gastrointest Liver Physiol 284:G385-91. 2003
    ..Intact signal transducer and activator of transcription 6 was required for attenuation of colitis. Exposure to helminths can decrease murine colonic inflammation...
  9. ncbi request reprint Substance P regulates Th1-type colitis in IL-10 knockout mice
    Joel V Weinstock
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 171:3762-7. 2003
    ..NK-1R antagonist reverses ongoing intestinal inflammation attesting to the importance of SP and its receptor in mucosal inflammation...
  10. ncbi request reprint IL-18 and IL-12 signal through the NF-kappa B pathway to induce NK-1R expression on T cells
    Joel V Weinstock
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 170:5003-7. 2003
    ..IL-10, a regulator of the Th1 response, blocks this activation. These data further suggest that SP and NK-1R, which promote IFN-gamma synthesis, are part of the Th1 pathway of immunity...
  11. ncbi request reprint Intestinal helminths protect in a murine model of asthma
    Kunihiko Kitagaki
    Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 177:1628-35. 2006
    ..Helminthic colonization appears to protect against asthma and atopic disorders; the regulatory cytokine, IL-10, may be a critical player...
  12. ncbi request reprint Th2-type granuloma development in acute murine schistosomiasis is only partly dependent on CD4+ T cells as the source of IL-4
    Ahmed Metwali
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    Eur J Immunol 32:1242-52. 2002
    ..Mast cells are not needed to form Th2 granulomas, but influence IL-4 release. Th2 granuloma development in schistosomiasis is only partly dependent on IL-4-producing CD4(+) T cells...
  13. ncbi request reprint T cell substance P receptor governs antigen-elicited IFN-gamma production
    Arthur M Blum
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Gastrointest Liver Physiol 284:G197-204. 2003
    ..Splenocytes and granuloma cells from NK-1R KO mice made less IFN-gamma. The mice also made less IgG2a. Thus T cell NK-1R is important for IFN-gamma regulation...
  14. ncbi request reprint CD4+ T cells from IL-10-deficient mice transfer susceptibility to NSAID-induced Rag colitis
    Arthur M Blum
    Division of Gastroenterology 4607 JCP Univ of Iowa Hospital and Clinics, 200 Hawkins Dr, Iowa City, IA 52242 1009, USA
    Am J Physiol Gastrointest Liver Physiol 287:G320-5. 2004
    ..In conclusion, only CD4(+) T cells from IL-10(-/-) animals leave Rag mice susceptible to NSAID-induced, Th1 colitis. Lamina propria T cells normally make large quantities of IL-10, suggesting that IL-10 from T cells may be protective...
  15. pmc Interleukin-4 receptor alpha chain and STAT6 signaling inhibit gamma interferon but not Th2 cytokine expression within schistosome granulomas
    Ahmed Metwali
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Infect Immun 70:5651-8. 2002
    ..Thus, conventional Th cells in Stat6 KO granulomas produce IFN-gamma and Th2 cytokines. Stat6 limits IFN-gamma production but is unnecessary for Th2-cell development or localization within the granuloma...
  16. ncbi request reprint Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease
    Robert W Summers
    Department of Internal Medicine, James A Clifton Center for Digestive Diseases, University of Iowa Health Care, Iowa City, Iowa, USA
    Am J Gastroenterol 98:2034-41. 2003
    ..Induction of a Th2 immune response by intestinal helminths diminishes Th1 responsiveness. This study evaluates the safety and effectiveness of helminthic ova in the treatment of active IBD...
  17. pmc Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulation
    M Nedim Ince
    Department of Internal Medicine, University of Iowa, Iowa City, USA
    Eur J Immunol 39:1870-8. 2009
    ..Thus, T cell TGF-beta signaling is essential for helminthic stimulation of mucosal IL-10 production, helminthic modulation of intestinal IFN-gamma generation and H. polygyrus-mediated suppression of chronic colitis...
  18. ncbi request reprint The possible link between de-worming and the emergence of immunological disease
    Joel V Weinstock
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Lab Clin Med 139:334-8. 2002
  19. ncbi request reprint Heligmosomoides polygyrus induces TLR4 on murine mucosal T cells that produce TGFbeta after lipopolysaccharide stimulation
    M Nedim Ince
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    J Immunol 176:726-9. 2006
    ..Thus, during helminth infection, LPS challenge induces mucosal T cells to make TGFbeta through a TLR4-dependent process without promoting synthesis of proinflammatory cytokines...
  20. ncbi request reprint Is there a role for helminths in the therapy of inflammatory bowel disease?
    Robert W Summers
    James A Clifton Center for Digestive Disease, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City 52242, USA
    Nat Clin Pract Gastroenterol Hepatol 2:62-3. 2005
  21. ncbi request reprint Role of helminths in regulating mucosal inflammation
    Joel V Weinstock
    Department of Internal Medicine, Division of Gastroenterology Hepatology, University of Iowa, Iowa City, IA 52242 1009, USA
    Springer Semin Immunopathol 27:249-71. 2005
    ..These effects by once ubiquitous organisms may have protected individuals from many of the emerging immune-mediated illnesses like IBD, multiple sclerosis, type I diabetes, and asthma...
  22. ncbi request reprint Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial
    Robert W Summers
    James A Clifton Center for Digestive Diseases, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Gastroenterology 128:825-32. 2005
    ..In animal models, helminths prevent or improve colitis by the induction of regulatory T cells and modulatory cytokines. This study determined the efficacy and safety of the helminth Trichuris suis in therapy of ulcerative colitis...
  23. ncbi request reprint IL-12 induction of mRNA encoding substance P in murine macrophages from the spleen and sites of inflammation
    Razvan Arsenescu
    Department of Internal Medicine, University of Kentucky, Lexington, KY 40515, USA
    J Immunol 174:3906-11. 2005
    ..Thus, macrophages are a source for SP at these sites of chronic inflammation, and IL-12 and STAT4 are regulators of macrophage SP mRNA expression...
  24. pmc Heligmosomoides polygyrus promotes regulatory T-cell cytokine production in the murine normal distal intestine
    Tommy Setiawan
    Division of Gastroenterology 4611 JCP, University of Iowa Hospital and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 1009, USA
    Infect Immun 75:4655-63. 2007
    ..IL-10 is particularly important for limiting the Th1 response. The T-cell origin of these cytokines demonstrates mucosal regulatory T-cell induction...
  25. ncbi request reprint Induction of CD8+ regulatory T cells in the intestine by Heligmosomoides polygyrus infection
    Ahmed Metwali
    Department of Internal Medicine, University of Iowa, Iowa City, USA
    Am J Physiol Gastrointest Liver Physiol 291:G253-9. 2006
    ..Thus H. polygyrus induces a regulatory CD8+ lamina propria T cell that inhibits T cell proliferation and that appears to have a role in control of colitis...
  26. ncbi request reprint Immunologic and molecular mechanisms in inflammatory bowel disease
    M Nedim Ince
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Iowa, Carver College of Medicine, 4611 JCP, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Surg Clin North Am 87:681-96. 2007
    ..Biologic agents that block inflammatory cytokines (anti-TNFalpha antibodies) have been used successfully to treat IBD. Recent advances have also identified mucosal regulatory pathways...
  27. ncbi request reprint IL-4 inhibits vasoactive intestinal peptide production by macrophages
    Ahmed Metwali
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Gastrointest Liver Physiol 283:G115-21. 2002
    ..Thus macrophages can make VIP, which is subject to IL-4 regulation. However, in the Th2 granulomas, other cell types produce VIP, which compensates for loss of macrophages as a source of this molecule...
  28. ncbi request reprint Cutting edge: hemokinin has substance P-like function and expression in inflammation
    Ahmed Metwali
    Department of Internal Medicine, Division of Gastroenterology Hepatology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 172:6528-32. 2004
    ..Two distinct but functionally overlapping tachykinins govern inflammation through NK-1R at sites of chronic inflammation...
  29. pmc Advances in the pathogenesis and treatment of IBD
    Nicholas A Braus
    Doris Duke Clinical Research Fellowship Program Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1009, USA
    Clin Immunol 132:1-9. 2009
    ..Investigational agents include those targeted against other cytokines and costimulatory molecules or designed to promote immune regulation such as exposure to helminths which is a focus of this review...
  30. ncbi request reprint Why Trichuris suis should prove safe for use in inflammatory bowel diseases
    Robert W Summers
    Inflamm Bowel Dis 11:783-4. 2005
  31. ncbi request reprint Therapeutic colonization with Trichuris suis
    Robert W Summers
    Arch Pathol Lab Med 130:1753; author reply 1753-4. 2006
  32. ncbi request reprint Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation
    Fiona A Stennard
    Victor Chang Cardiac Research Institute, St Vincent s Hospital, 384 Victoria Street, Darlinghurst 2010, New South Wales, Australia
    Development 132:2451-62. 2005
    ..These data suggest that mutations in human cardiac transcription factor genes, possibly including TBX20, underlie both congenital heart disease and adult cardiomyopathies...

Research Grants5

  1. Regulation of Inflammation by Somatostatin via SSTR 2
    David Elliott; Fiscal Year: 2006
    ..The results of these studies will provide rationale for novel therapeutic treatment of IBD and other inflammatory diseases. ..