Research Topics
Species | Benjamin M EllingsonSummaryAffiliation: University of California Country: USA Publications
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Publications
Identifying the mesenchymal molecular subtype of glioblastoma using quantitative volumetric analysis of anatomic magnetic resonance imagesKourosh M Naeini
Corresponding Author Benjamin M Ellingson, PhD, Assistant Professor of Radiology, Biomedical Physics, and Biomedical Engineering, Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, 924 Westwood Blvd, Suite 615, Los Angeles, CA 90024
Neuro Oncol 15:626-34. 2013..Conclusions Results suggest that volume ratio may be a simple, cost-effective, and noninvasive biomarker for quickly identifying MES GBM...
Probabilistic radiographic atlas of glioblastoma phenotypesB M Ellingson
Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90024, USA
AJNR Am J Neuroradiol 34:533-40. 2013....- Quantitative probabilistic functional diffusion mapping in newly diagnosed glioblastoma treated with radiochemotherapyBenjamin M Ellingson
Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 924 Westwood Blvd, Ste 615, Los Angeles, CA 90024, USA
Neuro Oncol 15:382-90. 2013..The current study introduces a probabilistic approach to fDM quantification to overcome some of these limitations... - Comparison between intensity normalization techniques for dynamic susceptibility contrast (DSC)-MRI estimates of cerebral blood volume (CBV) in human gliomasBenjamin M Ellingson
Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024, USA
J Magn Reson Imaging 35:1472-7. 2012..The use of image intensity transformation algorithms provides a mechanism for obtaining quantitatively similar CBV maps with the same intensity scaling... - Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: a radiographic study in 358 de novo human glioblastomasBenjamin M Ellingson
Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Neuroimage 59:908-16. 2012.... - Functional diffusion maps (fDMs) evaluated before and after radiochemotherapy predict progression-free and overall survival in newly diagnosed glioblastomaBenjamin M Ellingson
Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 924 Westwood Blvd, Suite 615, Los Angeles, CA 90024, USA
Neuro Oncol 14:333-43. 2012..The current study supports the hypothesis that fDM is a sensitive imaging biomarker for predicting survival in glioblastoma... - Cell invasion, motility, and proliferation level estimate (CIMPLE) maps derived from serial diffusion MR images in recurrent glioblastoma treated with bevacizumabBenjamin M Ellingson
Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA
J Neurooncol 105:91-101. 2011..0001) as well as overall survival (OS; P = 0.0093). Similarly, the mean proliferation rate was able to stratify patients with early and late PFS as well as OS... - High order diffusion tensor imaging in human glioblastomaBenjamin M Ellingson
Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1721, USA
Acad Radiol 18:947-54. 2011..The purpose of the current study was to examine higher order diffusion characteristics in human glioblastoma prior to surgical resection using the fourth-order diffusion tensor model... - Nonlinear registration of diffusion-weighted images improves clinical sensitivity of functional diffusion maps in recurrent glioblastoma treated with bevacizumabBenjamin M Ellingson
Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
Magn Reson Med 67:237-45. 2012..Results suggest that nonlinear registration of pretreatment ADC maps to post-treatment ADC maps improves the clinical predictability, sensitivity, and specificity of fDMs for both progression-free and overall survival... - Quantification of edema reduction using differential quantitative T2 (DQT2) relaxometry mapping in recurrent glioblastoma treated with bevacizumabBenjamin M Ellingson
Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 924 Westwood Blvd, Suite 650, Los Angeles, CA 90095, USA
J Neurooncol 106:111-9. 2012..5T) following anti-VEGF treatment (Wilcoxon signed rank test, P < 0.0001). An elevated residual, post-treatment, median T2 was predictive of both progression-free (Log-rank, P = 0.0074) and overall survival (Log-rank, P = 0.0393)... - Graded functional diffusion map-defined characteristics of apparent diffusion coefficients predict overall survival in recurrent glioblastoma treated with bevacizumabBenjamin M Ellingson
Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 924 Westwood Blvd, Suite 650, Los Angeles, CA 90024, USA
Neuro Oncol 13:1151-61. 2011..001). These results demonstrate that spatially resolved diffusion-based tumor metrics are a powerful imaging biomarker of survival in patients with recurrent GBM treated with bevacizumab... - Quantitative volumetric analysis of conventional MRI response in recurrent glioblastoma treated with bevacizumabBenjamin M Ellingson
Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Neuro Oncol 13:401-9. 2011..Initial contrast-enhancing volume was predictive of PFS but not OS. The pretreatment relative nonenhancing tumor ratio, defined as the ratio of FLAIR to contrast-enhancing volume, was found to be predictive of both PFS and OS... - Volumetric analysis of functional diffusion maps is a predictive imaging biomarker for cytotoxic and anti-angiogenic treatments in malignant gliomasBenjamin M Ellingson
Translational Brain Tumor Research Program, Medical College of Wisconsin, Milwaukee, WI, USA
J Neurooncol 102:95-103. 2011.... - Spatially quantifying microscopic tumor invasion and proliferation using a voxel-wise solution to a glioma growth model and serial diffusion MRIBenjamin M Ellingson
Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Magn Reson Med 65:1131-43. 2011.... - 18F-FDOPA and 18F-FLT positron emission tomography parametric response maps predict response in recurrent malignant gliomas treated with bevacizumabRobert J Harris
Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA
Neuro Oncol 14:1079-89. 2012.... - Validation of functional diffusion maps (fDMs) as a biomarker for human glioma cellularityBenjamin M Ellingson
Translational Brain Tumor Program, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
J Magn Reson Imaging 31:538-48. 2010..To present comprehensive examinations of the assumptions made in functional diffusion map (fDM) analyses and provide a biological basis for fDM classification... 
Morphology and morphometry in chronic spinal cord injury assessed using diffusion tensor imaging and fuzzy logicBenjamin M Ellingson
Dept of Biomed Eng, Marquette Univ, Milwaukee, WI 53201, USA
Conf Proc IEEE Eng Med Biol Soc 1:1885-8. 2006....- Morphology and morphometry of human chronic spinal cord injury using diffusion tensor imaging and fuzzy logicBenjamin M Ellingson
Department of Biomedical Engineering, Marquette University, P O Box 1881, Milwaukee, WI 53201 1881, USA
Ann Biomed Eng 36:224-36. 2008..We conclude that DTI with fuzzy logic tissue classification has potential for monitoring morphological changes in the spinal cord in people with SCI... - Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: a multi-center studyWhitney B Pope
Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1721, USA
J Neurooncol 108:491-8. 2012..The predictive value of ADC histogram analysis, in which low ADC-L was associated with poor outcome, was confirmed in bevacizumab-treated patients with recurrent GBM in a post hoc analysis from the multi-center (BRAIN) study... - Ex vivo diffusion tensor imaging and quantitative tractography of the rat spinal cord during long-term recovery from moderate spinal contusionBenjamin M Ellingson
Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin 53201 1881, USA
J Magn Reson Imaging 28:1068-79. 2008..To characterize DTI metric changes throughout the length of the entire spinal cord from the acute through chronic stages of spinal cord injury (SCI)... - Gray and white matter delineation in the human spinal cord using diffusion tensor imaging and fuzzy logicBenjamin M Ellingson
Department of Biomedical Engineering, Marquette University, Milwaukee, WI 53201 1881, USA
Acad Radiol 14:847-58. 2007..Our approach involved creating anisotropy indices based on the difference between eigenvalues and mean diffusivity then using a fuzzy inference system (FIS) to delineate between gray and white matter in the human cervical spinal cord... - High-resolution in vivo diffusion tensor imaging of the injured cat spinal cord using self-navigated, interleaved, variable-density spiral acquisition (SNAILS-DTI)Benjamin M Ellingson
Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Magn Reson Imaging 28:1353-60. 2010..Results demonstrate high-quality, high-resolution (546 μm×546 μm) in vivo DTI images of the cat spinal cord after traumatic spinal cord injury... - Three-dimensional visualization of subdural electrodes for presurgical planningPeter S LaViolette
Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Neurosurgery 68:152-60; discussion 160-1. 2011..Accurate localization and visualization of subdural electrodes implanted for intracranial electroencephalography in cases of medically refractory epilepsy remains a challenging clinical problem... - Lesion growth and degeneration patterns measured using diffusion tensor 9.4-T magnetic resonance imaging in rat spinal cord injuryBenjamin M Ellingson
Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53201, USA
J Neurosurg Spine 13:181-92. 2010..Using diffusion tensor MR imaging, the authors conducted a study to explore lesion growth and degeneration patterns, from the acute through chronic stages of spinal cord injury (SCI), in an experimental animal model... - Pre- and post-contrast three-dimensional double inversion-recovery MRI in human glioblastomaRobert J Harris
Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA
J Neurooncol 112:257-66. 2013..Additional discrepancies between FLAIR and DIR abnormal regions were also observed, together suggesting DIR may provide additional information beyond that of FLAIR... - Combined analysis of O6-methylguanine-DNA methyltransferase protein expression and promoter methylation provides optimized prognostication of glioblastoma outcomeShadi Lalezari
Department of Neurology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA
Neuro Oncol 15:370-81. 2013.... - Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of originAlbert Lai
David Geffen School of Medicine at theUniversity of California at Los Angeles, Los Angeles, CA, USA
J Clin Oncol 29:4482-90. 2011..To determine how GBMs arising with IDH1(R132MUT) differ from other GBMs, we undertook a comprehensive comparison of patients presenting clinically with primary GBM as a function of IDH1(R132) mutation status... - Advances in MRI assessment of gliomas and response to anti-VEGF therapyWhitney B Pope
Department of Radiological Sciences, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, BL 428 CHS, Los Angeles, CA 90095 1721, USA
Curr Neurol Neurosci Rep 11:336-44. 2011..An active area of research is the use of physiologic imaging, which can potentially detect treatment effects before changes in tumor size are evident... - Utility of functional diffusion maps to monitor a patient diagnosed with gliomatosis cerebriBenjamin M Ellingson
Translational Brain Tumor Program, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
J Neurooncol 97:419-23. 2010..Results of this study demonstrate the value of fDMs, applied to regions of FLAIR abnormal signal intensity, for localizing regions of hypercellularity and for monitoring overall tumor status... - In vivo diffusion tensor imaging of the rat spinal cord at 9.4TBenjamin M Ellingson
Department of Biomedical Engineering, Marquette University, Milwaukee, WI 53201 1881, USA
J Magn Reson Imaging 27:634-42. 2008..To determine differences in diffusion measurements in white matter (WM) and gray matter (GM) regions of the rat cervical, thoracic, and cauda equina spinal cord using in vivo diffusion tensor imaging (DTI) with a 9.4T MR scanner... - 3D visualization of subdural electrode shift as measured at craniotomy reopeningPeter S LaViolette
Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Epilepsy Res 94:102-9. 2011..This study quantifies electrode shift with respect to the cortical surface occurring between electrode placement and subsequent reopening... - 3'-deoxy-3'-18F-fluorothymidine PET and MRI for early survival predictions in patients with recurrent malignant glioma treated with bevacizumabJohannes Schwarzenberg
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California 90005 6942, USA
J Nucl Med 53:29-36. 2012..This study compares the value of 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) PET and MRI for early outcome predictions in patients with recurrent malignant glioma on bevacizumab therapy... - Characteristics of mid- to long-latency spinal somatosensory evoked potentials following spinal trauma in the ratBenjamin M Ellingson
Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin 53201 1881, USA
J Neurotrauma 25:1323-34. 2008..The technique and data presented in this study may be useful in future studies aimed at quantifying spinal cord integrity following injury and treatment using the rat model of SCI... - A new technique for imaging the human spinal cord in vivoBenjamin M Ellingson
Department of Biomedical Engineering, Marquette University, Milwaukee, WI 53201, USA
Biomed Sci Instrum 42:255-60. 2006..Results indicated larger contrast between gray and white matter compared to the traditional fractional anisotropy index and thus presents a superior technique for determining precise morphology of the spinal cord... - Functional correlates of diffusion tensor imaging in spinal cord injuryBenjamin M Ellingson
Department of Biomedical Engineering, Marquette University, Milwaukee, WI, USA
Biomed Sci Instrum 44:28-33. 2008..Results provide evidence that diffusion measurements may be able to predict electrophysiological function, illustrating the possibility of using spinal cord DTI as a functional as well as structural prognostic tool... - Detection of 2-hydroxyglutaric acid in vivo by proton magnetic resonance spectroscopy in U87 glioma cells overexpressing isocitrate dehydrogenase-1 mutationJelena Lazovic
Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California, USA
Neuro Oncol 14:1465-72. 2012..Our results establish a model system where 2-HG can be monitored noninvasively, which should be helpful in validating 2-HG levels as a prognostic and/or predictive biomarker in glioma... - Diffusion tensor magnetic resonance tractography of the prostate: feasibility for mapping periprostatic fibersDavid S Finley
Department of Urology, Kaiser Permanente, Los Angeles Medical Center, Los Angeles, CA 90027, USA
Urology 80:219-23. 2012..To evaluate the feasibility of diffusion tensor imaging (DTI) tractography of the prostate for mapping of periprostatic neurovascular anatomy...