Genomes and Genes
V L Ellingrod
Affiliation: University of Iowa
- Weight gain associated with the -759C/T polymorphism of the 5HT2C receptor and olanzapineVicki L Ellingrod
University of Iowa, College of Pharmacy, Iowa, USA
Am J Med Genet B Neuropsychiatr Genet 134:76-8. 2005..Weight gain from atypical antipsychotic use has become a significant problem. Recent reports have liked the -759 polymorphism of the 5HT2C receptor and obesity as well as weight gain from chlorpromazine, risperidone, and clozapine...
- Distribution of the serotonin 2C (5HT2C) receptor gene -759C/T polymorphism in patients with schizophrenia and normal controlsVicki L Ellingrod
College of Pharmacy, Clinical and Administrative Division, University of Iowa, Iowa City, USA
Psychiatr Genet 14:93-5. 2004....
- Abnormal movements and tardive dyskinesia in smokers and nonsmokers with schizophrenia genotyped for cytochrome P450 2D6Vicki L Ellingrod
College of Pharmacy, University of Iowa, Iowa City 52242, USA
Pharmacotherapy 22:1416-9. 2002..To investigate the relationships between cytochrome P450 (CYP) 2D6 genotype, antipsychotic drug exposure, abnormal movements and tardive dyskinesia, and cigarette smoking...
- CYP2D6 polymorphisms and atypical antipsychotic weight gainVicki L Ellingrod
College of Pharmacy, University of Iowa, Iowa City, Iowa, USA
Psychiatr Genet 12:55-8. 2002..This may be due to increased olanzapine concentrations leading to increased exposure, which may trigger AAP weight gain...
- Comparison of risperidone with olanzapine in elderly patients with dementia and psychosisVicki L Ellingrod
College of Pharmacy, University of Iowa, Iowa City, USA
Pharmacotherapy 22:1-5. 2002..To compare the effects of risperidone and olanzapine on cognition in elderly patients with dementia and psychosis, and to compare the side effects of these drugs...
- Association between cytochrome P4502D6 (CYP2D6) genotype, antipsychotic exposure, and abnormal involuntary movement scale (AIMS) scoreV L Ellingrod
College of Pharmacy, University of Iowa, Iowa City, USA
Psychiatr Genet 10:9-11. 2000..044) compared with (*1/*3 or *4) patients (slope = 0.001). These results suggest patients with a *3 or *4 allele may have a higher risk for developing antipsychotic induced abnormal movements...
- CYP3A5 polymorphism and the ethnic differences in cyclosporine pharmacokinetics in healthy subjectsDavid I Min
Division of Clinical and Administrative Pharmacy, College of Pharmacy, The University of Iowa, Iowa City, Iowa, USA
Ther Drug Monit 26:524-8. 2004..In conclusion, the CYP3A5*3C polymorphism appears to affect AUC and CL/F of oral CsA significantly in healthy subjects, which may partly explain some of the differences of pharmacokinetics in CsA between African Americans and whites...
- Pilot study of the G-protein beta3 subunit gene (C825T) polymorphism and clinical response to olanzapine or olanzapine-related weight gain in persons with schizophreniaJeffrey R Bishop
Department of Pharmacy Practice, College of Pharmacy, University of Illinois, Chicago, IL, USA
Med Sci Monit 12:BR47-50. 2006..The purpose of this investigation was examine associations between the second messenger G-Protein Beta3 Subunit Gene (GNB3) C825T polymorphism and olanzapine response and weight gain treatment...
- The relationship between P-glycoprotein (PGP) polymorphisms and response to olanzapine treatment in schizophreniaYing Chi Lin
Department of Clinical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, 48109, USA
Ther Drug Monit 28:668-72. 2006..The PGP C3435T genotype may help to determine positive symptom reduction from olanzapine clinically, but these findings should be replicated in a larger sample of subjects...
- Association between the polymorphic GRM3 gene and negative symptom improvement during olanzapine treatmentJeffrey R Bishop
University of Iowa College of Pharmacy, Clinical and Administrative Division, S413 Pharmacy Building, Iowa City, IA 52242, USA
Schizophr Res 77:253-60. 2005..The purpose of this study was to determine whether a pharmacogenetic relationship exists between six polymorphisms of GRM3 and clinical improvement during olanzapine treatment in persons with schizophrenia...
- The influence of cognitive impairment and psychiatric symptoms on daily functioning in nursing facilities: a longitudinal studySusan K Schultz
Department of Psychiatry, University of Iowa College of Medicine, 500 Newton Road, Iowa City, Iowa 52242 1000, USA
Ann Clin Psychiatry 14:209-13. 2002..These findings may have implications for treatment interventions that seek to enhance functioning in the skilled nursing setting...
- Pharmacogenetic screening for susceptibility to fetal malformations in womenD C Van Dyke
Children s Hospital of Iowa, University Hospital School, Iowa City 52242, USA
Ann Pharmacother 34:639-45. 2000..To present a review of the literature and research on the pharmacogenetics of congenital defects, with a focus on the need for predictive maternal genotype assays...
- C3435T mutation in exon 26 of the human MDR1 gene and cyclosporine pharmacokinetics in healthy subjectsDavid I Min
Division of Clinical and Administrative Pharmacy, College of Pharmacy, The University of Iowa, 118 Pharmacy Building, Iowa City, IA 52242, USA
Ther Drug Monit 24:400-4. 2002..There were no statistical differences in cyclosporine pharmacokinetics among different MDR1 genotypes in these 14 healthy subjects...
- Variants of the dopamine D2 receptor gene and risperidone-induced hyperprolactinemia in children and adolescentsChadi A Calarge
The University of Iowa Carver College of Medicine, Iowa, USA
Pharmacogenet Genomics 19:373-82. 2009..To investigate the association between hyperprolactinemia and variants of the dopamine D2 receptor (DRD2) gene in children and adolescents in long-term treatment with risperidone...
- The influence of cognitive impairment and behavioral dysregulation on daily functioning in the nursing home settingSusan K Schultz
Department of Psychiatry, University of Iowa College of Medicine, Iowa City, 52242 1000, USA
Am J Psychiatry 160:582-4. 2003..The influence of psychiatric symptoms and cognitive impairment on daily living skills was explored in a series of nursing home residents. Three categories of symptoms were examined: behavioral disturbances, depression, and delusions...
- The association of weight gain and olanzapine plasma concentrationsPaul J Perry
Department of Clinical and Administrative Pharmacy, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA
J Clin Psychopharmacol 25:250-4. 2005..The association of weight gain with plasma concentrations during treatment with olanzapine may support the utilization of plasma drug concentration as a marker for antipsychotic-induced weight gain in the treatment of schizophrenia...
- Association of the CYP3A4*1B 5'-flanking region polymorphism with cyclosporine pharmacokinetics in healthy subjectsDavid I Min
Division of Clinical and Adminictrative Pharmacy, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242, USA
Ther Drug Monit 25:305-9. 2003..2 (G/G) and 19.2 +/- 2.3 (A/G), P = 0.0103 and the mean CL/F (L/hr) were 49.4 +/- 13.9 (A/A), 83.5 +/- 16.0 (G/G), and 52.5 +/- 5.6 (A/G), P = 0.0024. All other parameters were not significantly different among the three genotypes...
- Clozapine-induced weight gain associated with the 5HT2C receptor -759C/T polymorphismDel D Miller
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1000, USA
Am J Med Genet B Neuropsychiatr Genet 133:97-100. 2005..Subjects without the -759T variant allele were at a greater risk for weight gain from clozapine over 6-months compared to those with the -759T allele...
- 5-HT2A receptor promoter polymorphism, -1438G/A and negative symptom response to olanzapine in schizophreniaVicki L Ellingrod
Clinical and Administrative Division, University of Iowa College of Pharmacy, Iowa City, Iowa, USA
Psychopharmacol Bull 37:109-12. 2003..We conclude that the A/A genotype may be associated with olanzapine negative symptom response, seen as a 2-fold greater percent reduction in SANS, and may be clinically relevant...
- Leptin gene -2548G/A variants predict risperidone-associated weight gain in children and adolescentsChadi A Calarge
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
Psychiatr Genet 19:320-7. 2009..We aimed to investigate the association between risperidone-induced weight gain, leptin concentration, and the leptin gene (LEP) -2548G/A variants in youths...
- The association of serotonin transporter genotypes and selective serotonin reuptake inhibitor (SSRI)-associated sexual side effects: possible relationship to oral contraceptivesJeffrey R Bishop
Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Hum Psychopharmacol 24:207-15. 2009..To study the relationship between functional variants in the serotonin transporter gene (SLC6A4) and selective serotonin reuptake inhibitor (SSRI)-associated sexual dysfunction...
- The influence of the brain-derived neurotropic factor Val66Met genotype and HMG-CoA reductase inhibitors on insulin resistance in the schizophrenia and bipolar populationsK J Burghardt
Department of Clinical Social and Administrative Sciences, College of Pharmacy, University of Michigan, Ann Arbor, USA
Clin Transl Sci 5:486-90. 2012..We sought to determine the effect of the BDNF Met variant and statin medication use on insulin resistance in schizophrenia and bipolar disorder using the homeostasis model assessment of insulin resistance (HOMA-IR)...
- Pharmacogenetics of selective serotonin reuptake inhibitors and associated adverse drug reactionsKelan L H Thomas
Clinical Pharmacogenomics Laboratory, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109 1065, USA
Pharmacotherapy 29:822-31. 2009..As we appreciate the many pharmacologic mechanisms related to adverse drug reactions and gain polymorphic functional data, we will have opportunities to refine hypotheses for future pharmacogenetic association analyses...
- Pooled analysis of antidepressant levels in lactating mothers, breast milk, and nursing infantsAlicia M Weissman
Department of Family Medicine, University of Iowa, Iowa City, Iowa 52242, USA
Am J Psychiatry 161:1066-78. 2004....
- Neuropsychiatric pharmacogenetics: moving toward a comprehensive understanding of predicting risks and responseJeffrey R Bishop
University of Iowa College of Pharmacy, Clinical and Administrative Division, S413 Pharmacy Building, Iowa City, IA 52242 1112, USA
Pharmacogenomics 5:463-77. 2004....
- Phobic anxiety in late-life in relationship to cognition and 5HTTLPR polymorphismSusan K Schultz
Psychiatr Genet 15:305-6. 2005..However, in this sample we did not detect a significant association between phobic anxiety and the 5HTTLPR genotype. The interaction between age-related changes in cognition and anxiety remain an important area for future studies...
- 5HT2A and 5HT2C receptor polymorphisms and predicting clinical response to olanzapine in schizophreniaVicki L Ellingrod
J Clin Psychopharmacol 22:622-4. 2002
- Association analysis of the metabotropic glutamate receptor type 3 gene (GRM3) with schizophreniaJeffrey R Bishop
Psychiatr Genet 17:358. 2007
- Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C variantsVicki L Ellingrod
University of Michigan College of Pharmacy, Department of Clinical Sciences, School of Medicine, Ann Arbor 48109, USA
Schizophr Res 98:47-54. 2008....
- Leptin and leptin receptor gene polymorphisms and increases in body mass index (BMI) from olanzapine treatment in persons with schizophreniaVicki L Ellingrod
Department of Psychiatry in the University of Michigan College of Pharmacy and College of Medicine, Ann Arbor, Michigan 48109, USA
Psychopharmacol Bull 40:57-62. 2007..The objective of the current investigation was to determine the relationship between polymorphisms of the leptin system (leptin gene and leptin receptor) and olanzapine-induced weight gain in persons with schizophrenia...
- Serotonin 2A -1438 G/A and G-protein Beta3 subunit C825T polymorphisms in patients with depression and SSRI-associated sexual side-effectsJeffrey R Bishop
University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA
Neuropsychopharmacology 31:2281-8. 2006..6; p=0.046). Furthermore, the 5HT2A -1438 GG genotype was a significant predictor of lower arousal scores (p=0.022) after accounting for other measures. There was no significant relationship between any outcome measure and GNB3 genotype...
- LA allelic heterozygosity of the 5HTTLPR polymorphism is associated with higher cognitive function and lower interpersonal sensitivityJess G Fiedorowicz
Psychiatr Genet 17:3-4. 2007