Uri Elkayam

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi Peripartum cardiomyopathy
    Uri Elkayam
    Division of Cardiology, Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Cardiol Clin 30:435-40. 2012
  2. ncbi Valvular heart disease and pregnancy: part II: prosthetic valves
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    J Am Coll Cardiol 46:403-10. 2005
  3. ncbi Valvular heart disease and pregnancy part I: native valves
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    J Am Coll Cardiol 46:223-30. 2005
  4. ncbi Pregnancy-associated cardiomyopathy: clinical characteristics and a comparison between early and late presentation
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Medicine, and Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Circulation 111:2050-5. 2005
  5. ncbi Intravenous nitroglycerin in the treatment of decompensated heart failure: potential benefits and limitations
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
    J Cardiovasc Pharmacol Ther 9:227-41. 2004
  6. ncbi Vasodilators in the management of acute heart failure
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
    Crit Care Med 36:S95-105. 2008
  7. ncbi Effects of nitrates and hydralazine in heart failure: clinical evidence before the african american heart failure trial
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Disease, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Am J Cardiol 96:37i-43i. 2005
  8. ncbi Anticoagulation in pregnant women with prosthetic heart valves
    Uri Elkayam
    Division of Cardiovascular Medicine, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    J Cardiovasc Pharmacol Ther 9:107-15. 2004
  9. ncbi Comparison of effects on left ventricular filling pressure of intravenous nesiritide and high-dose nitroglycerin in patients with decompensated heart failure
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Am J Cardiol 93:237-40. 2004
  10. ncbi Assessment of renal hemodynamic effects of nesiritide in patients with heart failure using intravascular Doppler and quantitative angiography
    Uri Elkayam
    Division of Cardiology, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    JACC Cardiovasc Imaging 1:765-71. 2008

Detail Information

Publications44

  1. ncbi Peripartum cardiomyopathy
    Uri Elkayam
    Division of Cardiology, Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Cardiol Clin 30:435-40. 2012
    ..This article discusses the cause, clinical presentation, prognosis, and treatment of PPCM, as well as other related topics...
  2. ncbi Valvular heart disease and pregnancy: part II: prosthetic valves
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    J Am Coll Cardiol 46:403-10. 2005
    ....
  3. ncbi Valvular heart disease and pregnancy part I: native valves
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    J Am Coll Cardiol 46:223-30. 2005
    ..The purpose of this paper is to review the available clinical data and provide recommendations for the management of patients with VHD during gestation...
  4. ncbi Pregnancy-associated cardiomyopathy: clinical characteristics and a comparison between early and late presentation
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Medicine, and Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Circulation 111:2050-5. 2005
    ..Cardiomyopathy associated with pregnancy was first described more than half a century ago. However, because of its rare occurrence and geographical differences, the clinical profile of this condition has remained incompletely defined...
  5. ncbi Intravenous nitroglycerin in the treatment of decompensated heart failure: potential benefits and limitations
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
    J Cardiovasc Pharmacol Ther 9:227-41. 2004
    ....
  6. ncbi Vasodilators in the management of acute heart failure
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
    Crit Care Med 36:S95-105. 2008
    ..This article reviews the results of previous studies evaluating the pharmacologic and clinical effects and safety profiles of these drugs in patients with heart failure...
  7. ncbi Effects of nitrates and hydralazine in heart failure: clinical evidence before the african american heart failure trial
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Disease, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Am J Cardiol 96:37i-43i. 2005
    ..Concomitant use of HYD with a nitrate, both in an animal model and in patients with CHF, has been shown to prevent the development of nitrate tolerance and maintain the favorable hemodynamic effect of nitrates...
  8. ncbi Anticoagulation in pregnant women with prosthetic heart valves
    Uri Elkayam
    Division of Cardiovascular Medicine, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    J Cardiovasc Pharmacol Ther 9:107-15. 2004
    ....
  9. ncbi Comparison of effects on left ventricular filling pressure of intravenous nesiritide and high-dose nitroglycerin in patients with decompensated heart failure
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Am J Cardiol 93:237-40. 2004
    ....
  10. ncbi Assessment of renal hemodynamic effects of nesiritide in patients with heart failure using intravascular Doppler and quantitative angiography
    Uri Elkayam
    Division of Cardiology, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    JACC Cardiovasc Imaging 1:765-71. 2008
    ..We evaluated the magnitude and site of action of the nesiritide mediated renal vasodilatory effect in patients with heart failure (HF)...
  11. ncbi Clinical characteristics of peripartum cardiomyopathy in the United States: diagnosis, prognosis, and management
    Uri Elkayam
    Division of Cardiology, Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    J Am Coll Cardiol 58:659-70. 2011
    ..The purposes of this review are to describe the clinical profile of peripartum cardiomyopathy in the United States and to provide recommendations for the diagnosis and the management of this disease...
  12. ncbi Variable response of conductance and resistance coronary arteries to endothelial stimulation in patients with heart failure due to nonischemic dilated cardiomyopathy
    Fahed Bitar
    Heart Failure Program, Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
    J Cardiovasc Pharmacol Ther 11:197-202. 2006
    ..Furthermore, coronary endothelial function cannot be predicted by demographic and hemo-dynamic parameters or left ventricular ejection fraction...
  13. ncbi Effects of tolvaptan, a vasopressin antagonist, in patients hospitalized with worsening heart failure: a randomized controlled trial
    Mihai Gheorghiade
    Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    JAMA 291:1963-71. 2004
    ..In contrast to diuretics, the vasopressin antagonist tolvaptan may increase net volume loss in heart failure without adversely affecting electrolytes and renal function...
  14. ncbi Clinical profile and predictors of complications in peripartum cardiomyopathy
    Sorel Goland
    Department of Cardiology and Biostatistics Division, Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
    J Card Fail 15:645-50. 2009
    ..Clinical profile and predictors of major adverse events (MAE) associated with peripartum cardiomyopathy (PPCM) have not been characterized...
  15. ncbi Effect of elevated admission serum creatinine and its worsening on outcome in hospitalized patients with decompensated heart failure
    Mohammed W Akhter
    Heart Failure Program, Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Am J Cardiol 94:957-60. 2004
    ..Similarly, an increase in serum creatinine (>0.5 mg/dl) in the hospital results in a significantly longer length of stay and has an independent effect on long-term mortality...
  16. ncbi Evaluation of the clinical relevance of baseline left ventricular ejection fraction as a predictor of recovery or persistence of severe dysfunction in women in the United States with peripartum cardiomyopathy
    Sorel Goland
    Division of Cardiovascular Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    J Card Fail 17:426-30. 2011
    ..Baseline left ventricular ejection fraction (LVEF) has been shown to be associated with likelihood of recovery in patients with peripartum cardiomyopathy (PPCM). The clinical relevance of this association for individual patients is unclear...
  17. ncbi Favorable outcome of pregnancy with an elective use of epoprostenol and sildenafil in women with severe pulmonary hypertension
    Sorel Goland
    Department of Medicine, Division of Cardiology and Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
    Cardiology 115:205-8. 2010
    ..Pulmonary hypertension carries significant maternal and fetal risk during pregnancy and the postpartum period. As maternal mortality is high, specific targeted therapy for pulmonary hypertension may be required during pregnancy...
  18. ncbi Survey of the use of organic nitrates for the treatment of chronic congestive heart failure in the United States
    Fahed Bitar
    Heart Failure Program, Division of Cardiovascular Medicine, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Am J Cardiol 94:1465-8. 2004
    ..Nitrates were always combined with hydralazine in 25% of patients and occasionally combined with hydralazine in 67%...
  19. ncbi Impact of acute serum creatinine elevation in patients treated with nesiritide
    Uri Elkayam
    University of Southern California, Los Angeles, California, USA
    Clin Cardiol 32:215-9. 2009
    ..We assessed the effect of increases in serum creatinine on mortality in nesiritide-treated versus control subjects with acute decompensated heart failure (ADHF)...
  20. ncbi Physiologic changes during normal pregnancy and delivery
    Joseph G Ouzounian
    University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Cardiol Clin 30:317-29. 2012
    ..CO increases up to 30% in the first stage of labor, primarily because of increased stroke volume; maternal pushing efforts in the second stage of labor can increase CO by as much as 50%...
  21. ncbi Left atrial thrombosis in pregnant women with mitral stenosis and sinus rhythm
    Afshan Hameed
    Department of Obstetrics and Gynecology, University of California, Irvine, CA, USA
    Am J Obstet Gynecol 193:501-4. 2005
    ..Anticoagulation therefore should be strongly considered in this group...
  22. ncbi Use and impact of inotropes and vasodilator therapy in hospitalized patients with severe heart failure
    Uri Elkayam
    University of Southern California School of Medicine, Los Angeles, CA 90033, USA
    Am Heart J 153:98-104. 2007
    ..Treatment of decompensated heart failure often includes the use of intravenous vasoactive medications, but the effect on outcome has not been clearly defined...
  23. ncbi Effect of pulmonary stenosis on pregnancy outcomes--a case-control study
    Afshan B Hameed
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Irvine, CA, USA
    Am Heart J 154:852-4. 2007
    ..Pulmonary stenosis (PS) accounts for 10% to 12% of congenital heart disease in adults, and the probability of survival to child bearing age is high. The impact of PS on pregnancy has not been extensively studied in the recent era...
  24. ncbi Nesiritide: a new drug for the treatment of decompensated heart failure
    Uri Elkayam
    Heart Failure Program-Division of Cardiology, University of Southern California School of Medicine, 1200 N State Street, Los Angeles, CA 90033, USA
    J Cardiovasc Pharmacol Ther 7:181-94. 2002
    ..At the recommended dose of nesiritide, headache was reported during the first 24 hours of treatment in 8% of patients and symptomatic hypotension in 4% of patients, compared to 20% and 5% in nitroglycerin-treated patients...
  25. ncbi Longitudinal changes in the B-type natriuretic peptide levels in normal pregnancy and postpartum
    Afshan Batool Hameed
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of California, Irvine, California, USA
    Clin Cardiol 32:E60-2. 2009
    ..In conclusion, pregnancy is associated with a significant, but small increase in the BNP levels compared with nonpregnant women...
  26. ncbi Evaluation of myocardial blood flow reserve in patients with chronic congestive heart failure due to idiopathic dilated cardiomyopathy
    Menahem Canetti
    Heart Failure Program, Division of Cardiology, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Am J Cardiol 92:1246-9. 2003
    ..An association between decreased response to adenosine and acetylcholine supports previous observations indicating that adenosine-induced vasodilation of coronary microcirculation is dependent on endothelial nitric oxide production...
  27. ncbi Cardiovascular drugs in pregnancy
    William H Frishman
    Department of Medicine, New York Medical College Westchester Medical Center, Munger Pavilion, Room 263, Valhalla, NY 10595, USA
    Cardiol Clin 30:463-91. 2012
    ..Many drugs are also transferred into human milk with potential adverse effects on the nursing infant. This article summarizes some of the literature concerning the risks and benefits of using cardiovascular drugs during pregnancy...
  28. ncbi Left ventricular noncompaction
    Radha J Sarma
    ABIM, Internal Medicine and Cardiovascular Diseases, University of Southern California, Keck School of Medicine, Division of Cardiovascular Medicine, Los Angeles, CA 90033, USA
    Prog Cardiovasc Dis 52:264-73. 2010
    ..However, it seems prognosis is much better than initially reported. The current status of diagnosis, prognosis, and management of isolated noncompaction in adults is discussed in this review...
  29. ncbi Clinical experience with low-dose continuous infusion of furosemide in acute heart failure: assessment of efficacy and safety
    Tien M H Ng
    1School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    J Cardiovasc Pharmacol Ther 17:373-81. 2012
    ..Our purpose was to evaluate the efficacy and safety of low-dose continuous infusion of furosemide on diuretic response, renal function, and patient outcomes...
  30. ncbi Comparative effects of nesiritide and nitroglycerin on renal function, and incidence of renal injury by traditional and RIFLE criteria in acute heart failure
    Tien M H Ng
    University of Southern California School of Pharmacy, Los Angeles, CA 90033, USA
    J Cardiovasc Pharmacol Ther 17:79-85. 2012
    ..Hypothesis: Nesiritide and nitroglycerin are associated with differing effects on the incidence of acute renal injury and glomerular filtration rate changes...
  31. ncbi Safety of exercise testing in the chest pain unit: 31-mm ST elevation in variant angina
    Fausan S Tsai
    Department of Medicine, University of Southern California Los Angeles County Medical Center, Los Angeles, CA 90033, USA
    J Electrocardiol 39:309. 2006
    ..Further studies are needed to determine if the magnitude of ST elevation during exercise testing carries prognostic significance...
  32. ncbi A low-literacy medication education tool for safety-net hospital patients
    Kristina M Cordasco
    VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard 111G, Los Angeles, CA 90073, USA
    Am J Prev Med 37:S209-16. 2009
    ..To improve medication adherence in cardiac patients, in partnership with a safety-net provider, this research team developed and evaluated a low-literacy medication education tool...
  33. ncbi Impaired endothelium-mediated vasodilation in heart failure: clinical evidence and the potential for therapy
    Uri Elkayam
    Heart Failure Program, Division of Cardiology, Department of Medicine, University of Southern California School of Medicine, Los Angeles, CA 90033, USA
    J Card Fail 8:15-20. 2002
    ..This association suggests a therapeutic role for improvement of endothelial function in patients with chronic heart failure...
  34. ncbi Rationale and study design for a multicenter, randomized, double-blind, placebo-controlled study of the effects of tolvaptan on the acute and chronic outcomes of patients hospitalized with worsening congestive heart failure
    Mihai Gheorghiade
    Division of Cardiology, Northwestern University, Feinberg School of Medicine, Chicago, Ill 60611, USA
    Am Heart J 145:S51-4. 2003
  35. ncbi Peripartum cardiomyopathy
    Karen Sliwa
    Soweto Cardiovascular Research Unit, Department of Cardiology, Chris Hani Baragwanath Hospital, University of the Witwatersrand, P O Bertsham 2013, Johannesburg, South Africa
    Lancet 368:687-93. 2006
    ....
  36. ncbi The clinical challenge of bridging anticoagulation with low-molecular-weight heparin in patients with mechanical prosthetic heart valves: an evidence-based comparative review focusing on anticoagulation options in pregnant and nonpregnant patients
    Niranjan Seshadri
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am Heart J 150:27-34. 2005
    ..Future large-scale, randomized trials are warranted...
  37. ncbi Effect of nesiritide (B-type natriuretic peptide) and dobutamine on ventricular arrhythmias in the treatment of patients with acutely decompensated congestive heart failure: the PRECEDENT study
    Andrew J Burger
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Am Heart J 144:1102-8. 2002
    ..In this randomized, multicenter trial, we compared the safety and clinical effectiveness of the cardiac hormone nesiritide (human B-type natriuretic peptide) with dobutamine in hospitalized patients with decompensated CHF...
  38. ncbi Effect of nesiritide versus dobutamine on short-term outcomes in the treatment of patients with acutely decompensated heart failure
    Marc A Silver
    Heart Failure Institute, Advocate Christ Medical Center, Oak Lawn, Illinois 60453, USA
    J Am Coll Cardiol 39:798-803. 2002
    ....
  39. ncbi Hemodynamic and clinical effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients hospitalized for acute decompensated heart failure
    Guillermo Torre-Amione
    Section of Cardiology, Methodist DeBakey Heart Center and Baylor College of Medicine, Texas Medical Center, One Baylor Plaza, Houston, TX 77030, USA
    J Am Coll Cardiol 42:140-7. 2003
    ..We sought to investigate the efficacy and safety of tezosentan, a dual endothelin receptor antagonist, in patients hospitalized for acute heart failure (HF)...
  40. ncbi Comparison of 60-day mortality in hospitalized heart failure patients with versus without hypothermia
    Saeed Payvar
    Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas, USA
    Am J Cardiol 98:1485-8. 2006
    ..In conclusion, hypothermia appears to be a strong predictor of mortality in patients with HF...
  41. ncbi Letter regarding article by Wang et al, "nesiritide does not improve renal function in patients with chronic heart failure and worsening serum creatinine"
    Uri Elkayam
    Circulation 111:e182-3; author reply e182-3. 2005
  42. ncbi What resting heart rate should one aim for when treating patients with heart failure with a beta-blocker? Experiences from the Metoprolol Controlled Release/Extended Release Randomized Intervention Trial in Chronic Heart Failure (MERIT-HF)
    Lars Gullestad
    Baerums Sykehus, Baerum, Norway
    J Am Coll Cardiol 45:252-9. 2005
    ..The goal of this study was to explore the question: what resting heart rate (HR) should one aim for when treating patients with heart failure with a beta-blocker?..
  43. ncbi Acute myocardial infarction associated with pregnancy
    Arie Roth
    Department of Cardiology Tel Aviv Sourasky Medical Center, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
    J Am Coll Cardiol 52:171-80. 2008
    ....
  44. ncbi Cardiovascular pharmacotherapeutic considerations during pregnancy and lactation
    Shadi A Qasqas
    Departments of Medicine, Washington University School of Medicine/Barnes-Jewish Hospital, St. Louis, Missouri, USA
    Cardiol Rev 12:240-61. 2004
    ..Table 2 summarizes the recommendations regarding the use of cardiovascular drugs during pregnancy and lactation...