Peter Elias

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The skin barrier as an innate immune element
    Peter M Elias
    Department of Dermatology, University of California San Francisco Medical Center, San Francisco, CA, USA
    Semin Immunopathol 29:3-14. 2007
  2. doi request reprint Lipid abnormalities and lipid-based repair strategies in atopic dermatitis
    Peter M Elias
    Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, CA, USA Electronic address
    Biochim Biophys Acta 1841:323-30. 2014
  3. doi request reprint Role of cholesterol sulfate in epidermal structure and function: lessons from X-linked ichthyosis
    Peter M Elias
    Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, CA USA Electronic address
    Biochim Biophys Acta 1841:353-61. 2014
  4. doi request reprint Formation and functions of the corneocyte lipid envelope (CLE)
    Peter M Elias
    Dermatology Services, Veterans Affairs Medical Center, San Francisco, CA, USA Department of Dermatology, University of California, San Francisco, CA, USA Electronic address
    Biochim Biophys Acta 1841:314-8. 2014
  5. ncbi request reprint Update on the structure and function of the skin barrier: atopic dermatitis as an exemplar of clinical implications
    Peter M Elias
    Department of Dermatology, University of California, San Francisco, USA
    Semin Cutan Med Surg 32:S21-4. 2013
  6. pmc Structure and function of the stratum corneum extracellular matrix
    Peter M Elias
    Veterans Affairs Medical Center, Dermatology Service, UCSF, San Francisco, California 94121, USA
    J Invest Dermatol 132:2131-3. 2012
  7. pmc Abnormal barrier function in the pathogenesis of ichthyosis: therapeutic implications for lipid metabolic disorders
    Peter M Elias
    Dermatology Service, Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Clin Dermatol 30:311-22. 2012
  8. pmc Skin barrier function
    Peter M Elias
    Dermatology Service 190, VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Curr Allergy Asthma Rep 8:299-305. 2008
  9. pmc Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism
    Peter M Elias
    Dermatology Services, Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
    J Lipid Res 49:697-714. 2008
  10. ncbi request reprint Abnormal skin barrier in the etiopathogenesis of atopic dermatitis
    Peter M Elias
    Dermatology Service 190, VA Medical Center, San Francisco, CA 94121, USA
    Curr Allergy Asthma Rep 9:265-72. 2009

Detail Information

Publications82

  1. ncbi request reprint The skin barrier as an innate immune element
    Peter M Elias
    Department of Dermatology, University of California San Francisco Medical Center, San Francisco, CA, USA
    Semin Immunopathol 29:3-14. 2007
    ..But antimicrobial peptide synthesis and delivery to the SC interstices accelerates after external insults to the barrier...
  2. doi request reprint Lipid abnormalities and lipid-based repair strategies in atopic dermatitis
    Peter M Elias
    Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, CA, USA Electronic address
    Biochim Biophys Acta 1841:323-30. 2014
    ..This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias.
  3. doi request reprint Role of cholesterol sulfate in epidermal structure and function: lessons from X-linked ichthyosis
    Peter M Elias
    Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, CA USA Electronic address
    Biochim Biophys Acta 1841:353-61. 2014
    ..This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias.
  4. doi request reprint Formation and functions of the corneocyte lipid envelope (CLE)
    Peter M Elias
    Dermatology Services, Veterans Affairs Medical Center, San Francisco, CA, USA Department of Dermatology, University of California, San Francisco, CA, USA Electronic address
    Biochim Biophys Acta 1841:314-8. 2014
    ..This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias.
  5. ncbi request reprint Update on the structure and function of the skin barrier: atopic dermatitis as an exemplar of clinical implications
    Peter M Elias
    Department of Dermatology, University of California, San Francisco, USA
    Semin Cutan Med Surg 32:S21-4. 2013
    ..The clinical implications of how the skin barrier works--and is supported and restored--can be seen in the current and emerging understanding of atopic dermatitis management...
  6. pmc Structure and function of the stratum corneum extracellular matrix
    Peter M Elias
    Veterans Affairs Medical Center, Dermatology Service, UCSF, San Francisco, California 94121, USA
    J Invest Dermatol 132:2131-3. 2012
    ..Static models of the epidermis may not do justice to the ECM, which is metabolically active, as it changes both structure and function as it transits to the surface...
  7. pmc Abnormal barrier function in the pathogenesis of ichthyosis: therapeutic implications for lipid metabolic disorders
    Peter M Elias
    Dermatology Service, Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Clin Dermatol 30:311-22. 2012
    ....
  8. pmc Skin barrier function
    Peter M Elias
    Dermatology Service 190, VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Curr Allergy Asthma Rep 8:299-305. 2008
    ..Therapy based upon this new view of pathogenesis should emphasize approaches that correct the primary abnormality in barrier function, which drives downstream inflammation and allows unrestricted antigen access...
  9. pmc Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism
    Peter M Elias
    Dermatology Services, Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
    J Lipid Res 49:697-714. 2008
    ..The barrier abnormality provokes the clinical phenotype in these disorders not only by stimulating epidermal proliferation, but also by inducing inflammation...
  10. ncbi request reprint Abnormal skin barrier in the etiopathogenesis of atopic dermatitis
    Peter M Elias
    Dermatology Service 190, VA Medical Center, San Francisco, CA 94121, USA
    Curr Allergy Asthma Rep 9:265-72. 2009
    ..This article reviews emerging evidence that the inflammation in AD results from inherited and acquired insults to the barrier, as well as the therapeutic implications of this new paradigm...
  11. pmc Abnormal skin barrier in the etiopathogenesis of atopic dermatitis
    Peter M Elias
    Veterans Affairs Medical Center, Department of Dermatology, University of California, San Francisco, 94121, USA
    Curr Opin Allergy Clin Immunol 9:437-46. 2009
    ..We will review here emerging evidence that the inflammation in atopic dermatitis results from inherited and acquired insults to the barrier and the therapeutic implications of this new paradigm...
  12. pmc Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms
    Peter M Elias
    Dermatology Service, Veterans Affairs Medical Center, San Francisco, Calif 94121, USA
    J Allergy Clin Immunol 121:1337-43. 2008
    ..In this review we will assess emerging evidence that inflammation in AD results from inherited and acquired insults to the barrier and the therapeutic implications of this paradigm...
  13. pmc Barrier requirements as the evolutionary "driver" of epidermal pigmentation in humans
    Peter M Elias
    Dermatology Services, Veterans Affairs Medical Center, San Francisco, California, USA
    Am J Hum Biol 22:526-37. 2010
    ..We summarize evidence here that epidermal interfollicular pigmentation in early hominids likely evolved in response to stress to the permeability barrier...
  14. pmc "Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis
    Peter M Elias
    Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 128:1067-70. 2008
    ..This cycle comprises an "outside-inside-outside" model of AD pathogenesis (Elias et al., in press)...
  15. pmc Epidermal vascular endothelial growth factor production is required for permeability barrier homeostasis, dermal angiogenesis, and the development of epidermal hyperplasia: implications for the pathogenesis of psoriasis
    Peter M Elias
    Dermatology Service 190, VA Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Am J Pathol 173:689-99. 2008
    ....
  16. doi request reprint Therapeutic implications of a barrier-based pathogenesis of atopic dermatitis
    Peter M Elias
    Dermatology Service, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Clin Rev Allergy Immunol 41:282-95. 2011
    ..In contrast, "barrier repair" therapy, with a ceramide-dominant triple-lipid mixture of stratum corneum lipids, is more logical, of proven efficacy, and it provides a far-improved safety profile...
  17. ncbi request reprint Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes
    Matthias Schmuth
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 122:971-83. 2004
    ..Together, these studies indicate that PPAR-beta/delta activation stimulates keratinocyte differentiation, is anti-inflammatory, improves barrier homeostasis, and stimulates TG accumulation in keratinocytes...
  18. ncbi request reprint Topical liver x receptor activators accelerate postnatal acidification of stratum corneum and improve function in the neonate
    Joachim W Fluhr
    Dermatology and Medical Service, Veterans Affairs Medical Center, San Francisco, California, USA
    J Invest Dermatol 125:1206-14. 2005
    ..These results demonstrate that LXR activators stimulate the formation of an acidic SC and improve both permeability barrier homeostasis and SC integrity/cohesion...
  19. pmc Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges
    Mao Qiang Man
    Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 128:79-86. 2008
    ..Because of its reproducibility, predictability, and low cost, this model could prove useful for evaluating both pathogenic mechanisms and potential therapies for AD...
  20. ncbi request reprint Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation
    Man Mao-Qiang
    Department of Dermatology, University of California, San Francisco and VA Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 123:305-12. 2004
    ..These observations suggest that thiazolidindiones and perhaps other PPAR-gamma activators maybe useful in the treatment of cutaneous disorders...
  21. ncbi request reprint Serine protease signaling of epidermal permeability barrier homeostasis
    Jean Pierre Hachem
    Department of Dermatology and Medical Services Metabolism, VA Medical Center, San Francisco, California, USA
    J Invest Dermatol 126:2074-86. 2006
    ....
  22. ncbi request reprint PPAR and LXR activators regulate ABCA12 expression in human keratinocytes
    Yan J Jiang
    Metabolism Section, Department of Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 128:104-9. 2008
    ..Together, our data demonstrate that PPAR and LXR activators increase ABCA12 expression, providing an additional mechanism by which PPAR and LXR activators promote epidermal permeability barrier homeostasis...
  23. ncbi request reprint Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis
    Laszlo G Komuves
    Department of Dermatology, University of California, San Francisco, California, USA
    J Invest Dermatol 118:25-34. 2002
    ..The ability of oxysterols to reverse epidermal hyperplasia suggests that these agents could be beneficial for the treatment of skin disorders associated with hyperproliferation and/or altered differentiation...
  24. pmc Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization
    Dusko Ilic
    Dermatology Service, Veterans Affairs Medical Center, San Francisco, CA, USA
    Am J Pathol 170:2055-67. 2007
    ..Thus, for plasma membrane localization in terminally differentiated keratinocytes, Na(+)/H(+) exchanger 1 requires an intact actin cytoskeleton, which is impaired in FAK-deficient cells...
  25. ncbi request reprint Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing
    Mao Qiang Man
    Department of Dermatology, University of California and VA Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 126:386-92. 2006
    ..Since the liposensors are activated by endogenous lipid metabolites, they may serve as unique regulators of barrier homeostasis...
  26. pmc pH-regulated mechanisms account for pigment-type differences in epidermal barrier function
    Roshan Gunathilake
    Department of Dermatology, Veteran Affairs Medical Center, University of California San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 129:1719-29. 2009
    ..These studies show marked pigment-type differences in epidermal structure and function that are pH driven...
  27. ncbi request reprint Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero
    Matthias Schmuth
    Departments of Medicine Dermatology, University of California San Francisco, California 94121, USA
    J Invest Dermatol 119:1298-303. 2002
    ..The transient and incomplete nature of the developmental delay, however, is consistent with regulation of the late stages of epidermal development by multiple factors...
  28. ncbi request reprint Hyaluronan-CD44 interaction stimulates keratinocyte differentiation, lamellar body formation/secretion, and permeability barrier homeostasis
    Lilly Y W Bourguignon
    Department of Medicine, University of California San Francisco and VA Medical Center, San Francisco, California, USA lilly bourguignon ucsf edu
    J Invest Dermatol 126:1356-65. 2006
    ..HA-CD44 signaling could comprise a novel approach to treat skin disorders characterized by abnormalities in differentiation, lipid synthesis, and/or barrier function...
  29. ncbi request reprint Regulation of ABCA1 expression in human keratinocytes and murine epidermis
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121, USA
    J Lipid Res 47:2248-58. 2006
    ....
  30. pmc Acute modulations in permeability barrier function regulate epidermal cornification: role of caspase-14 and the protease-activated receptor type 2
    Marianne Demerjian
    Dermatology and Medical Metabolism Services, Veterans Administration Medical Center, 4510 Clement St, San Francisco, CA 94121, USA
    Am J Pathol 172:86-97. 2008
    ....
  31. ncbi request reprint Scavenger receptor class B type I is expressed in cultured keratinocytes and epidermis. Regulation in response to changes in cholesterol homeostasis and barrier requirements
    Hiroki Tsuruoka
    Dermatology and Medical Metabolism Services, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 277:2916-22. 2002
    ..Second, the increase in SR-BI following barrier disruption suggests that SR-BI expression increases to facilitate cholesterol uptake leading to barrier restoration...
  32. pmc Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California, San Francisco, California 94121, USA
    J Biol Chem 284:18942-52. 2009
    ....
  33. ncbi request reprint Imiquimod-induced interleukin-1 alpha stimulation improves barrier homeostasis in aged murine epidermis
    Chantel O Barland
    Department of Dermatology, University of California at San Francisco, and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 122:330-6. 2004
    ....
  34. pmc The role of CD44 in cutaneous inflammation
    Mona Man
    Department of Dermatology, University of California School of Medicine, San Francisco, CA, USA
    Exp Dermatol 18:962-8. 2009
    ....
  35. pmc Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis
    Marianne Demerjian
    Department of Dermatology, UCSF and VA Medical Center, San Francisco, CA 94121, USA
    Exp Dermatol 18:643-9. 2009
    ..Together, these studies demonstrate that PPAR and LXR activators can prevent several of the adverse effects of topical GC on the epidermis...
  36. pmc Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis
    Yutaka Hatano
    Dermatology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 129:1824-35. 2009
    ..These results provide direct evidence for the "outside-inside" pathogenesis of AD and further suggest that maintenance of an acidic SC pH could prevent the emergence of AD in humans...
  37. ncbi request reprint Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities
    Jack S Kao
    Dermatology and Medical Services Metabolism, VA Medical Center San Francisco and Department of Dermatology, University of California San Francisco, San Francisco, California, U S A
    J Invest Dermatol 120:456-64. 2003
    ..Finally, topical replenishment with epidermal physiologic lipids could represent a potential method to reduce the adverse cutaneous effects of both topical glucocorticoid treatment and Cushing's syndrome...
  38. ncbi request reprint pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion
    Jean Pierre Hachem
    University of California San Francisco Medical Center, Department of Dermatology, San Francisco, California, USA
    J Invest Dermatol 121:345-53. 2003
    ....
  39. ncbi request reprint Stratum corneum acidification is impaired in moderately aged human and murine skin
    Eung Ho Choi
    Department of Dermatology, University of California San Francisco and Dermatology Service, Veteran s Administration Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 127:2847-56. 2007
    ..These abnormalities were normalized by exogenously acidifying the SC, suggesting a basis for the well-known acidification therapies that are widely used to treat the pathologic xerosis/eczema seen in moderately aged humans...
  40. pmc Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens
    Tiffany C Scharschmidt
    Department of Dermatology, Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, Calif 94121, USA
    J Allergy Clin Immunol 124:496-506, 506.e1-6. 2009
    ..Yet additional acquired stressors might be necessary because the same mutations can result in a noninflammatory disorder, ichthyosis vulgaris...
  41. ncbi request reprint Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis)
    Matthias Schmuth
    Dermatology and Metabolism Medicine Services, Veterans Affairs Medical Center, San Francisco, USA
    J Invest Dermatol 122:909-22. 2004
    ..But in contrast to lamellar ichthyosis, the CE scaffold partially normalizes in the outer SC in loricrin keratoderma...
  42. ncbi request reprint Functional consequences of a neutral pH in neonatal rat stratum corneum
    Joachim W Fluhr
    Dermatology and Medical Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 123:140-51. 2004
    ..The delay in acidification of neonatal SC results in abnormalities in permeability barrier homeostasis and SC integrity and are likely due to pH-induced modulations in enzyme activity...
  43. ncbi request reprint Pathophysiologic basis for growth failure in children with ichthyosis: an evaluation of cutaneous ultrastructure, epidermal permeability barrier function, and energy expenditure
    David G Moskowitz
    Department of Dermatolog, University of California San Francisco, and the Department of Veterans Affairs Medical Center, San Francisco, 94143, USA
    J Pediatr 145:82-92. 2004
    ..Because an impaired epidermal permeability barrier is present in many of the ichthyoses, we examined the contribution of barrier failure to caloric requirements in children with ichthyosis and growth failure...
  44. ncbi request reprint Mechanisms by which psychologic stress alters cutaneous permeability barrier homeostasis and stratum corneum integrity
    Eung Ho Choi
    Dermatology and Medical Services Metabolism, VA Medical Center San Francisco, San Francisco, California, USA
    J Invest Dermatol 124:587-95. 2005
    ..These studies suggest that topical treatment with epidermal physiologic lipids could be beneficial in stress-induced, barrier-associated dermatoses, such as psoriasis and atopic dermatitis...
  45. ncbi request reprint LXR and PPAR activators stimulate cholesterol sulfotransferase type 2 isoform 1b in human keratinocytes
    Yan J Jiang
    Department of Medicine, University of California San Francisco, San Francisco, CA 94121, USA
    J Lipid Res 46:2657-66. 2005
    ..Thus, LXR and PPAR activators regulate the expression of SULT2B1b, the key enzyme in the synthesis of CS, which is a potent regulator of epidermal differentiation and corneocyte desquamation...
  46. doi request reprint Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification
    Joachim W Fluhr
    Dermatology and Medical Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 129:365-74. 2009
    ..Hence, PPARalpha activators might be useful to prevent or treat certain common neonatal dermatoses...
  47. pmc Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators
    Yutaka Hatano
    Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
    J Allergy Clin Immunol 125:160-9.e1-5. 2010
    ..Additionally, some of these activators exhibit potent antihyperplastic and anti-inflammatory activity in irritant contact dermatitis and acute allergic contact dermatitis murine models...
  48. doi request reprint Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB
    Yoshikazu Uchida
    Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA
    J Invest Dermatol 130:2472-80. 2010
    ..Thus, Cer → sphingosine → S1Pmetabolic conversion protects against UVB-induced, Cer-mediated apoptosis in keratinocytes, but excessive UVB overwhelms this mechanism, thereby leading to keratinocyte apoptosis...
  49. pmc Ichthyosis update: towards a function-driven model of pathogenesis of the disorders of cornification and the role of corneocyte proteins in these disorders
    Matthias Schmuth
    Department of Dermatology, University of California, VAMC Metabolism 111F, 4150 Clement Street, San Francisco, CA 94121, USA
    Adv Dermatol 23:231-56. 2007
  50. ncbi request reprint The potential of metabolic interventions to enhance transdermal drug delivery
    Peter M Elias
    Dermatology Service, Veterans Affairs Medical Center, Department of Dermatology and Medicine, University of California San Francisco, California 94121, USA
    J Investig Dermatol Symp Proc 7:79-85. 2002
    ..Yet, while these new approaches hold great promise, if equally effective in human skin, they pose new questions about the risks of a highly permeabilized stratum corneum...
  51. pmc Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation
    Yuko Oda
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 129:1367-78. 2009
    ..In contrast, DRIP silencing had no apparent effect on these processes indicating that the two classes of coactivators are differentially utilized...
  52. pmc Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers
    Karin M Aberg
    Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, California, USA
    J Invest Dermatol 128:917-25. 2008
    ..These studies demonstrate that (1) the permeability and antimicrobial barriers are coordinately regulated by permeability barrier requirements and (2) CRAMP is required for permeability barrier homeostasis...
  53. pmc Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands
    Hubert C Chen
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
    J Clin Invest 109:175-81. 2002
    ..Our findings indicate that DGAT1 plays an important role in normal fur and sebaceous gland physiology and provide evidence that leptin modulates these processes in the skin...
  54. ncbi request reprint Stratum corneum acidification in neonatal skin: secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum
    Joachim W Fluhr
    Dermatology and Medical Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, 94121, USA
    J Invest Dermatol 122:320-9. 2004
    ..Conversely, the impaired acidification of neonatal SC, which has important functional and clinical consequences, can be explained by the relatively low activities of one or both of these mechanisms at birth...
  55. ncbi request reprint Enlightened therapy of the disorders of cornification
    Mary L Williams
    Department of Dermatology, University of California School of Medicine, San Francisco 94143, USA
    Clin Dermatol 21:269-73. 2003
  56. ncbi request reprint Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function
    Martin J Behne
    Department of Dermatology, University of California San Francisco, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 120:998-1006. 2003
    ..Thus, full barrier competence appears to require the extension of acidification in microdomains from the SC/SG interface outward toward the skin surface in the immediate postnatal period...
  57. ncbi request reprint Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice
    Joachim W Fluhr
    Dermatology Services, Veterans Administration Medical Center, and Department of Dermatology University of California, San Francisco, California, USA
    J Invest Dermatol 120:728-37. 2003
    ..These results show that sebaceous-gland-derived glycerol is a major contributor to stratum corneum hydration...
  58. ncbi request reprint Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production
    Ashley J Fowler
    Department of Dermatology, University of California, San Francisco, USA
    J Invest Dermatol 120:246-55. 2003
    ..LXR activators could provide a new class of therapeutic agents for the treatment of cutaneous inflammatory disorders...
  59. ncbi request reprint Modulations in epidermal calcium regulate the expression of differentiation-specific markers
    Peter M Elias
    Dermatology and Medical Services, Veterans Administration Medical Center, University of California School of Medicine, San Francisco 94121, USA
    J Invest Dermatol 119:1128-36. 2002
    ....
  60. ncbi request reprint NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging
    Martin J Behne
    Dermatology Service, Veterans Affairs Medical Center and Department of Dermatology, University of California, San Francisco, California 94121, USA
    J Biol Chem 277:47399-406. 2002
    ....
  61. ncbi request reprint Basis for the permeability barrier abnormality in lamellar ichthyosis
    Peter M Elias
    Dermatology Service and Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Exp Dermatol 11:248-56. 2002
    ....
  62. ncbi request reprint The aged epidermal permeability barrier: basis for functional abnormalities
    Peter M Elias
    Department of Dermatology, University of California, San Francisco, USA
    Clin Geriatr Med 18:103-20, vii. 2002
    ..Barrier repair therapy can be effective in restoring normal function if a cholesterol-dominant mixture of the three key physiologic lipids, including ceramides and free fatty acids, is emphasized...
  63. ncbi request reprint Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models
    Mary Y Sheu
    Department of Medicine, University of California San Francisco School of Medicine, San Francisco, California, USA
    J Invest Dermatol 118:94-101. 2002
    ....
  64. ncbi request reprint The effect of LXR activators on AP-1 proteins in keratinocytes
    Matthias Schmuth
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 123:41-8. 2004
    ..These results indicate that oxysterols induce specific AP-1 proteins, thereby activating involucrin, one of the genes required for epidermal differentiation...
  65. ncbi request reprint Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation
    Mao Qiang Man
    Department of Dermatology, University of California San Francisco and VA Medical Center San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 128:370-7. 2008
    ..Together, these results further demonstrate that PPARbeta/delta in the epidermis: (1) is required for permeability barrier homeostasis; (2) regulates keratinocyte proliferation; and (3) modulates cutaneous inflammation...
  66. ncbi request reprint Interactions among stratum corneum defensive functions
    Peter M Elias
    Dermatology Service, VA Medical Center, University of California, San Francisco, CA 94121, USA
    Exp Dermatol 14:719-26. 2005
    ..In this short review, we explore the ways in which the multiple defensive functions of the SC are linked and interrelated, either by their shared localization or by common biochemical processes...
  67. ncbi request reprint Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation
    Yoshikazu Uchida
    Department of Dermatology, School of Medicine, University of California, San Francisco, CA, USA
    J Biol Chem 282:13211-9. 2007
    ..Thus, late differentiation-linked increases in FA2H expression are essential for epidermal permeability barrier homeostasis...
  68. ncbi request reprint Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity
    Jean Pierre Hachem
    Dermatology, VA Medical Center, University of California, San Francisco, 94121, USA
    J Invest Dermatol 125:510-20. 2005
    ..In conclusion, prolonged SC neutralization provokes profound abnormalities in SC function, due to pH-induced high SP activity that, in turn, degrades lipid processing enzymes and CD proteins...
  69. ncbi request reprint Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis
    Biao Lu
    Dermatology and Medicine Services, Veterans Administration Medical Center and University of California School of Medicine, San Francisco, CA 94121, USA
    J Lipid Res 46:2448-57. 2005
    ..Because upregulation of mAGPAT mRNAs after tape-stripping could be partially reversed by artificial barrier restoration by occlusion, these studies suggest that an increase in the expression of AGPATs is linked to barrier requirements...
  70. ncbi request reprint Abrupt decreases in environmental humidity induce abnormalities in permeability barrier homeostasis
    Junko Sato
    Shiseido Research Center, Yokohama, Japan
    J Invest Dermatol 119:900-4. 2002
    ..The present study demonstrates that sudden changes from a high to a low humidity environment results in abnormal barrier function, which could adversely influence the incidence and/or severity of skin disorders...
  71. pmc Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death
    Vidyullatha Vasireddy
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA
    Hum Mol Genet 16:471-82. 2007
    ..These findings demonstrate that ELOVL4 is required for generating VLFA critical for epidermal barrier function, and that the lack of epidermal omega-O-acylceramides is incompatible with survival in a desiccating environment...
  72. doi request reprint Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology
    Matthias Schmuth
    Department of Dermatology, University of California, San Francisco, CA, USA
    J Lipid Res 49:499-509. 2008
    ..Because of their broad profile of beneficial effects on skin homeostasis, PPAR and LXR have great potential to serve as drug targets for common skin diseases such as psoriasis, atopic dermatitis, and skin cancer...
  73. ncbi request reprint The regulation of permeability barrier homeostasis
    Kenneth R Feingold
    Department of Medicine, University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 127:1574-6. 2007
    ..Ikeyama and colleagues provide data that the nitric oxide signaling pathway also regulates barrier homeostasis...
  74. ncbi request reprint Stratum corneum defensive functions: an integrated view
    Peter M Elias
    Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 125:183-200. 2005
    ..Finally, the clinical consequences and therapeutic implications of this integrated perspective are provided...
  75. pmc On the effects of topical synthetic pseudoceramides: comparison of possible keratinocyte toxicities provoked by the pseudoceramides, PC104 and BIO391, and natural ceramides
    Yoshikazu Uchida
    Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, CA, USA
    J Dermatol Sci 51:37-43. 2008
    ..However, since the metabolic fates of each pseudo-Cer remain unknown, their widespread deployment in topical agents has raised concern about potential toxicities...
  76. ncbi request reprint Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome
    Jean Pierre Hachem
    Dienst Dermatologie, Academisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium
    J Invest Dermatol 126:1609-21. 2006
    ..These studies provide a mechanistic basis for phenotypic variations in NS, and describe compensatory mechanisms that permit survival of NS patients in the face of unrelenting SP attack...
  77. ncbi request reprint Role for ELOVL3 and fatty acid chain length in development of hair and skin function
    Rolf Westerberg
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    J Biol Chem 279:5621-9. 2004
    ..A functional consequence of this is that Elovl3-ablated mice exhibited a severe defect in water repulsion and increased trans-epidermal water loss...
  78. pmc Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 102:12501-6. 2005
    ....
  79. ncbi request reprint The epidermal permeability barrier: from the early days at Harvard to emerging concepts
    Peter M Elias
    Department of Veterans Affairs Medical Center, University of California San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 122:xxxvi-xxxix. 2004
  80. ncbi request reprint Epidermal-specific defect of GPI anchor in Pig-a null mice results in Harlequin ichthyosis-like features
    Mariko Hara-Chikuma
    Basic Research Laboratory, Kanebo Ltd, 5 chome Kotobuki cho, Odawara shi, Kanagawa ken 250 0002, Japan
    J Invest Dermatol 123:464-9. 2004
    ....
  81. ncbi request reprint A homolog of Drosophila grainy head is essential for epidermal integrity in mice
    Stephen B Ting
    Rotary Bone Marrow Research Laboratories, c o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria, Australia 3050
    Science 308:411-3. 2005
    ..These findings suggest that the functional mechanisms involving protein cross-linking that maintain the epidermal barrier and induce tissue repair are conserved across 700 million years of evolution...
  82. ncbi request reprint Transepidermal water loss reflects permeability barrier status: validation in human and rodent in vivo and ex vivo models
    Joachim W Fluhr
    Department of Dermatology and Allergology, Friedrich Schiller University Jena, Germany
    Exp Dermatol 15:483-92. 2006
    ..Together, these results verify the utility of TEWL as a measure of permeability barrier status. Moreover, all tested instruments are reliable tools for the assessment of variations in permeability barrier function...

Research Grants26

  1. Risk Factors for Eczema Vaccinatum in Atopic Dermatitis
    Peter Elias; Fiscal Year: 2005
    ..immunogenetic abnormalities for the development of disseminated viral infections in patients with AD. ..
  2. NATURE OF MAMMALIAN CUTANEOUS PERMEABILITY BARRIER
    Peter Elias; Fiscal Year: 2006
    ..Then, we will explore how such pathway influence the three key functions. The information from these studies could lead to entirely new approaches to the therapy of common skin disorders. ..
  3. Nature of mamalian Cutaneous Permeablilty Barrier
    Peter M Elias; Fiscal Year: 2010
    ..apos; ..
  4. NATURE OF MAMMALIAN CUTANEOUS PERMEABILITY BARRIER
    Peter Elias; Fiscal Year: 1991
    ..These studies should provide new strategies for the regulation of cutaneous barrier function that could result in novel forms of therapy for burn wounds, and improved delivery of topical drugs...
  5. NATURE OF THE MAMMALIAN CUTANEOUS PERMEABILITY BARRIER
    Peter Elias; Fiscal Year: 1993
    ..These studies could lead to novel approaches to enhance transdermal drug delivery, potentially allowing whole new classes of formerly excluded compounds to access the internal environment...
  6. Nature of mamalian Cutaneous Permeablilty Barrier
    Peter Elias; Fiscal Year: 2009
    ..apos; ..
  7. Melanocyte-Keratinocyte Cross-Talk In Relation To Barrier Function
    Peter M Elias; Fiscal Year: 2010
    ..Our research could point to straight-forward methods that could improve the health status of individuals at risk due to fair pigmentation, including veterans with atopic dermatitis and psoriasis. ..
  8. NATURE OF MAMMALIAN CUTANEOUS PERMEABILITY BARRIER
    Peter Elias; Fiscal Year: 2001
    ....