David E Elder

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Precursors to melanoma and their mimics: nevi of special sites
    David E Elder
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Mod Pathol 19:S4-20. 2006
  2. ncbi request reprint Regional nodal metastatic disease is the strongest predictor of survival in patients with thin vertical growth phase melanomas: a case for SLN Staging biopsy in these patients
    Giorgos C Karakousis
    Department of Surgery, Hospital of the University of Pennsylvania, 4th Floor Silverstein Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Ann Surg Oncol 14:1596-603. 2007
  3. ncbi request reprint Predictors of regional nodal disease in patients with thin melanomas
    Giorgos C Karakousis
    Department of Surgery, University of Pennsylvania Health System, Abramson Cancer Center, Philadelphia, Pennsylvania 19104, USA
    Ann Surg Oncol 13:533-41. 2006
  4. ncbi request reprint Predicting sentinel node status in AJCC stage I/II primary cutaneous melanoma
    Laura L Kruper
    Melanoma Program of the Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer 107:2436-45. 2006
  5. ncbi request reprint Identification of high-risk patients among those diagnosed with thin cutaneous melanomas
    Phyllis A Gimotty
    The Melanoma Program of the Abramson Cancer Center, Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Oncol 25:1129-34. 2007
  6. pmc Lymphatic invasion is independently prognostic of metastasis in primary cutaneous melanoma
    Xiaowei Xu
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Cancer Res 18:229-37. 2012
  7. pmc The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes
    Hong Yu
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Pathol 174:2367-77. 2009
  8. pmc Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosis
    Xiaowei Xu
    Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Pathol 39:901-9. 2008
  9. ncbi request reprint Biologic and prognostic significance of dermal Ki67 expression, mitoses, and tumorigenicity in thin invasive cutaneous melanoma
    Phyllis A Gimotty
    Melanoma Program of the Abramson Cancer Center, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Clin Oncol 23:8048-56. 2005
  10. pmc Lymphatic invasion predicts aggressive behavior in melanocytic tumors of uncertain malignant potential (MELTUMP)
    Ronnie M Abraham
    Department of Pathology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Surg Pathol 37:669-75. 2013

Detail Information

Publications54

  1. ncbi request reprint Precursors to melanoma and their mimics: nevi of special sites
    David E Elder
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Mod Pathol 19:S4-20. 2006
    ..In this monograph, dysplastic nevi and nevi of special sites are compared and contrasted in relation to melanoma...
  2. ncbi request reprint Regional nodal metastatic disease is the strongest predictor of survival in patients with thin vertical growth phase melanomas: a case for SLN Staging biopsy in these patients
    Giorgos C Karakousis
    Department of Surgery, Hospital of the University of Pennsylvania, 4th Floor Silverstein Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Ann Surg Oncol 14:1596-603. 2007
    ....
  3. ncbi request reprint Predictors of regional nodal disease in patients with thin melanomas
    Giorgos C Karakousis
    Department of Surgery, University of Pennsylvania Health System, Abramson Cancer Center, Philadelphia, Pennsylvania 19104, USA
    Ann Surg Oncol 13:533-41. 2006
    ..In this study, we evaluated a large population of patients with thin melanoma from the pre-SLN era to identify predictors of regional nodal disease (RND) that may serve as a surrogate for SLN positivity...
  4. ncbi request reprint Predicting sentinel node status in AJCC stage I/II primary cutaneous melanoma
    Laura L Kruper
    Melanoma Program of the Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer 107:2436-45. 2006
    ....
  5. ncbi request reprint Identification of high-risk patients among those diagnosed with thin cutaneous melanomas
    Phyllis A Gimotty
    The Melanoma Program of the Abramson Cancer Center, Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Oncol 25:1129-34. 2007
    ..However, some develop metastatic disease that is often fatal. We evaluated established prognostic factors to develop classification schemes with better discrimination than current American Joint Committee on Cancer (AJCC) staging...
  6. pmc Lymphatic invasion is independently prognostic of metastasis in primary cutaneous melanoma
    Xiaowei Xu
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Cancer Res 18:229-37. 2012
    ..Lymphatic invasion (LI) in primary cutaneous melanomas was recently found to be common. In this study, we evaluated LI as an independent prognostic factor...
  7. pmc The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes
    Hong Yu
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Pathol 174:2367-77. 2009
    ..In summary, these data demonstrate that a subpopulation of melanocytes possesses the ability to survive BRAF(V600E)-induced senescence, and suggest that p53 inactivation may promote malignant transformation of these cells...
  8. pmc Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosis
    Xiaowei Xu
    Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Pathol 39:901-9. 2008
    ..Lymphatic invasion is an underobserved phenomenon in primary melanomas that can be better detected by immunohistochemical staining. The presence of lymphatic invasion may be a clinically useful predictor of regionally metastatic disease...
  9. ncbi request reprint Biologic and prognostic significance of dermal Ki67 expression, mitoses, and tumorigenicity in thin invasive cutaneous melanoma
    Phyllis A Gimotty
    Melanoma Program of the Abramson Cancer Center, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Clin Oncol 23:8048-56. 2005
    ..In this study, we characterized three biomarkers of proliferation (Ki67 expression, dermal mitotic rate [MR], and tumorigenicity) in thin (< or = 1.00 mm) primary cutaneous melanomas and examined their association with prognosis...
  10. pmc Lymphatic invasion predicts aggressive behavior in melanocytic tumors of uncertain malignant potential (MELTUMP)
    Ronnie M Abraham
    Department of Pathology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Surg Pathol 37:669-75. 2013
    ....
  11. pmc Does MC1R genotype convey information about melanoma risk beyond risk phenotypes?
    Peter A Kanetsky
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Cancer 116:2416-28. 2010
    ..A study was carried out to describe associations of MC1R variants and melanoma in a US population and to investigate whether genetic risk is modified by pigmentation characteristics and sun exposure measures...
  12. doi request reprint An atypical melanocytic lesion without genomic abnormalities shows locoregional metastasis
    Ronnie M Abraham
    Department of Pathology, University of Pennsylvania, Philadelphia, PA, USA
    J Cutan Pathol 39:21-4. 2012
    ..Further comprehensive study of these lesions is needed...
  13. pmc Functional erythropoietin autocrine loop in melanoma
    Suresh M Kumar
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Pathol 166:823-30. 2005
    ..The results suggest that the autocrine and paracrine functions of Epo might play a role in malignant transformation of melanocytes and in the survival of melanoma cells in hypoxia and other adverse conditions...
  14. ncbi request reprint P gene as an inherited biomarker of human eye color
    Timothy R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Epidemiol Biomarkers Prev 11:782-4. 2002
    ..001), or the combination of both variants (P = 0.003). These results suggest that P gene, in part, determines normal phenotypic variation in human eye color and may therefore represent an inherited biomarker of cutaneous cancer risk...
  15. ncbi request reprint Expression of Melan-A and Ki-67 in desmoplastic melanoma and desmoplastic nevi
    Cynthia Kucher
    Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Dermatopathol 26:452-7. 2004
    ..Therefore, we investigated whether immunohistochemical staining for Melan-A and Ki-67 expression can be used to discriminate these lesions, distinguishing between epithelioid and spindle cell compartments of the lesions...
  16. ncbi request reprint Differentiation of normal skin and melanoma using high resolution hyperspectral imaging
    David T Dicker
    Laboratory of Molecular Oncology and Cell Cycle Regulation, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer Biol Ther 5:1033-8. 2006
    ..This would assist multiple laboratories to participate in the input and retrieval of target spectral information...
  17. pmc Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas
    Keiran S M Smalley
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Mol Cancer Ther 7:2876-83. 2008
    ....
  18. ncbi request reprint Cutaneous melanoma: estimating survival and recurrence risk based on histopathologic features
    David E Elder
    Melanoma Program of the Abramson Cancer Center, Divison of Anatomic Pathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Dermatol Ther 18:369-85. 2005
    ..In this monograph, the focus will be the discussion of factors related to the prognosis of melanomas that at diagnosis are clinically localized to the primary site...
  19. ncbi request reprint A tumorigenic subpopulation with stem cell properties in melanomas
    Dong Fang
    Program of Molecular and Cellular Oncogenesis, The Wistar Institute and Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, PA 19104, USA
    Cancer Res 65:9328-37. 2005
    ..Based on these findings, we propose that melanomas can contain a subpopulation of stem cells that contribute to heterogeneity and tumorigenesis. Targeting this population may lead to effective treatments for melanomas...
  20. doi request reprint Local immune response predicts survival in patients with thick (t4) melanomas
    Jessica A Cintolo
    Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA
    Ann Surg Oncol 20:3610-7. 2013
    ..We examined the prognostic role of these variables in patients with high risk (T4) primary melanomas in a large series of patients with long-term follow-up...
  21. ncbi request reprint Mitotic rate as a predictor of sentinel lymph node positivity in patients with thin melanomas
    Susan B Kesmodel
    Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann Surg Oncol 12:449-58. 2005
    ..We sought to determine whether mitotic rate (MR) is associated with SLN positivity in thin-melanoma patients and, therefore, whether it may be used to risk-stratify and select patients for LM/SL...
  22. ncbi request reprint Induction of melanoma phenotypes in human skin by growth factors and ultraviolet B
    Carola Berking
    The Wistar Institute, Philadelphia, Pennsylvania, USA
    Cancer Res 64:807-11. 2004
    ..This is the first report on human cancer initiation in vivo in which an imbalance of physiological factors combined with an environmental carcinogen can lead to transformation of normal tissue...
  23. doi request reprint Angiomatoid Spitz nevus: a clinicopathological study of six cases and a review of the literature
    Michael T Tetzlaff
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    J Cutan Pathol 36:471-6. 2009
    ..The features of classic angiomatoid Spitz nevus are described in the context of important differential diagnostic considerations, particularly regressed malignant melanoma...
  24. doi request reprint Thin melanoma
    David E Elder
    Department of Pathology and Laboratory Medicine, Division of Anatomic Pathology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Arch Pathol Lab Med 135:342-6. 2011
    ..These cases can be identified by using prognostic models, including the "standard" American Joint Committee on Cancer criteria, and other attributes identified in follow-up studies...
  25. ncbi request reprint The approach to the patient with a difficult melanocytic lesion
    David E Elder
    Division of Anatomic Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19130, USA
    Pathology 36:428-34. 2004
    ..The second principle is to make clinicians and patients specifically aware of the diagnostic difficulty in their lesion, so that management can be undertaken on a true informed consent basis...
  26. ncbi request reprint Human leukocyte antigen-A2-restricted CTL responses to mutated BRAF peptides in melanoma patients
    Rajasekharan Somasundaram
    The Wistar Institute, Philadelphia, PA 19104, USA
    Cancer Res 66:3287-93. 2006
    ..The high prevalence (approximately 50%) of HLA-A2 among melanoma patients renders HLA-A2-restricted BRAF(V600E) peptides attractive candidate vaccines for these patients...
  27. doi request reprint Dysplastic naevi: an update
    David E Elder
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Histopathology 56:112-20. 2010
    ....
  28. ncbi request reprint Cellular nodules in congenital pattern nevi
    Xiaowei Xu
    Departments of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, USA
    J Cutan Pathol 31:153-9. 2004
    ..Although presumed benign, to date, no published long-term follow-up studies have proved the benignity of this lesion...
  29. ncbi request reprint Gene expression profiling of melanocytic lesions
    John T Seykora
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Am J Dermatopathol 25:6-11. 2003
    ..Based on this study, DNA microarray technology appears to be a valuable tool for identifying genes that may be specifically expressed in cutaneous lesions...
  30. ncbi request reprint Pathology of melanoma
    David E Elder
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 12:2308s-2311s. 2006
    ..In the near future, pathologic attributes will also likely be used to predict responses to therapy, as a guide to the selection of specific therapeutic agents such as "small molecule" inhibitors of signaling pathways...
  31. ncbi request reprint A practical approach to selected problematic melanocytic lesions
    Xiaowei Xu
    Department of Pathology and Laboratory Medicine, Hospital of University of Pennsylvania, Philadelphia 19104, USA
    Am J Clin Pathol 121:S3-32. 2004
    ..Immunohistochemical analysis is useful, but it cannot replace careful examination of H&E-stained sections...
  32. doi request reprint Smooth muscle hamartoma associated with a congenital pattern melanocytic nevus, a case report and review of the literature
    Alireza Zarineh
    Department of Pathology and Laboratory Medicine, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    J Cutan Pathol 35:83-6. 2008
    ..Unlike a recently reported case of SMH combined with a melanocytic nevus and basal cell carcinoma, the current lesion did not occur in association with a Becker's nevus...
  33. ncbi request reprint Multiple primary melanoma revisited
    M Anne Blackwood
    Department of Medicine, Hematology Oncology Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6145, USA
    Cancer 94:2248-55. 2002
    ....
  34. ncbi request reprint Variability in nomenclature used for nevi with architectural disorder and cytologic atypia (microscopically dysplastic nevi) by dermatologists and dermatopathologists
    Michael Shapiro
    Department of Dermatology, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104, USA
    J Cutan Pathol 31:523-30. 2004
    ..A 1992 National Institutes of Health (NIH) Consensus Conference sought to unify nomenclature and suggested that the term "nevus with architectural disorder" be used along with a comment on melanocytic atypia...
  35. ncbi request reprint Immunoprofile of MITF, tyrosinase, melan-A, and MAGE-1 in HMB45-negative melanomas
    Xiaowei Xu
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Surg Pathol 26:82-7. 2002
    ..Melanocyte-specific transcription factor is not a useful marker for desmoplastic melanoma...
  36. ncbi request reprint Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation
    Kapaettu Satyamoorthy
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 63:756-9. 2003
    ..These data suggest that melanoma growth, invasion, and metastasis are attributable to constitutively activated ERK apparently mediated by excessive growth factors through autocrine mechanisms and BRAF kinase activation...
  37. pmc Nuclear to non-nuclear Pmel17/gp100 expression (HMB45 staining) as a discriminator between benign and malignant melanocytic lesions
    Bonnie E Gould Rothberg
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Mod Pathol 21:1121-9. 2008
    ..80 for distinguishing benign nevi from malignant melanomas. On the basis of this preliminary study, we propose that the ratio of nuclear to non-nuclear HMB45 staining may be useful for diagnostic challenges in melanocytic lesions...
  38. ncbi request reprint Incomplete biopsy of melanocytic lesions can impair the accuracy of pathological diagnosis
    Richard A Scolyer
    Australas J Dermatol 47:71-3; author reply 74-5. 2006
  39. ncbi request reprint Pathology review of cases presenting to a multidisciplinary pigmented lesion clinic
    Karen S McGinnis
    Department of Dermatology, University of Pennsylvania, Philadelphia 19104, USA
    Arch Dermatol 138:617-21. 2002
    ..To determine if pathology review, within the context of a multidisciplinary pigmented lesion clinic, results in changes in diagnosis of melanocytic lesions and to ascertain if the change in diagnosis altered clinical management and outcome...
  40. pmc Common sequence variants on 20q11.22 confer melanoma susceptibility
    Kevin M Brown
    Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, Arizona 85028, USA
    Nat Genet 40:838-40. 2008
    ..The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases...
  41. pmc MC1R variants increase risk of melanomas harboring BRAF mutations
    Maria Concetta Fargnoli
    Department of Dermatology, University of L Aquila, L Aquila, Italy
    J Invest Dermatol 128:2485-90. 2008
    ..This study confirms that the known MC1R-melanoma risk association is confined to subjects whose melanomas harbor BRAF mutations...
  42. ncbi request reprint Reproductive risk factors for cutaneous melanoma in women: a case-control study
    C Suzanne Lea
    Statistics and Epidemiology Program, Research Triangle Institute International, Research Triangle Park, NC, USA
    Am J Epidemiol 165:505-13. 2007
    ..9, 95% confidence interval: 1.1, 8.1). Oral contraceptive use and hormone replacement therapy were not associated with melanoma risk...
  43. ncbi request reprint Frontiers in melanocytic pathology
    Richard A Scolyer
    Pathology 36:385-6. 2004
  44. ncbi request reprint High-risk melanoma susceptibility genes and pancreatic cancer, neural system tumors, and uveal melanoma across GenoMEL
    Alisa M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7236, USA
    Cancer Res 66:9818-28. 2006
    ..This GenoMEL study provides the most extensive characterization of mutations in high-risk melanoma susceptibility genes in families with three or more melanoma patients yet available...
  45. ncbi request reprint Identifying individuals at high risk of melanoma: a practical predictor of absolute risk
    Thomas R Fears
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Oncol 24:3590-6. 2006
    ..We developed a model to estimate the 5-year absolute risk of melanoma to efficiently identify individuals at increased risk of melanoma for potential interventions...
  46. ncbi request reprint MC1R germline variants confer risk for BRAF-mutant melanoma
    Maria Teresa Landi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Science 313:521-2. 2006
    ..In this tumor subtype, the risk for melanoma associated with MC1R is due to an increase in risk of developing melanomas with BRAF mutations...
  47. ncbi request reprint Innovations and challenges in melanoma: summary statement from the first Cambridge conference
    Michael B Atkins
    Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Clin Cancer Res 12:2291s-2296s. 2006
    ....
  48. ncbi request reprint Average midrange ultraviolet radiation flux and time outdoors predict melanoma risk
    Thomas R Fears
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 62:3992-6. 2002
    ..4%). The association between melanoma risk and average annual UVB flux was strong and consistent for men and for women. The association with total adult hours outdoors was notable for men of all skin types and women who develop a suntan...
  49. ncbi request reprint Validation of prognostic models for melanoma
    Phyllis A Gimotty
    Am J Clin Pathol 118:489-91. 2002
  50. pmc Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents
    Alisa M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7236, USA
    J Med Genet 44:99-106. 2007
    ....
  51. ncbi request reprint Heterogeneity of risk for melanoma and pancreatic and digestive malignancies: a melanoma case-control study
    Joni L Rutter
    Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 7236, USA
    Cancer 101:2809-16. 2004
    ....
  52. ncbi request reprint Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors
    Xiaowei Xu
    Arch Pathol Lab Med 127:1083-4; author reply 1084-5. 2003
  53. ncbi request reprint Reliability and validity of a histologic score as a marker for skin cancer chemoprevention studies
    Paul Bozzo
    Arizona Cancer Center, Departments of Pathology and Medicine, University of Arizona, P O Box 245024, Tucson, Arizona 85724 5024, USA
    Anal Quant Cytol Histol 25:285-92. 2003
    ..To develop a reliable and valid scoring system for grading skin biopsies from actinic keratosis (AK) and sun-damaged skin for use in evaluating the efficacy of skin cancer chemopreventive agents...
  54. ncbi request reprint Diet and melanoma in a case-control study
    Amy E Millen
    Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7344, USA
    Cancer Epidemiol Biomarkers Prev 13:1042-51. 2004
    ..Malignant melanoma has been one of the most rapidly increasing cancers within the United States with few modifiable risk factors. This study investigates risk related to dietary factors, which are potentially modifiable...