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Genomes and GenesSpecies | David E ElderSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Precursors to melanoma and their mimics: nevi of special sitesDavid E Elder
Department of Pathology and Laboratory Medicine, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
Mod Pathol 19:S4-20. 2006..In this monograph, dysplastic nevi and nevi of special sites are compared and contrasted in relation to melanoma...- Regional nodal metastatic disease is the strongest predictor of survival in patients with thin vertical growth phase melanomas: a case for SLN Staging biopsy in these patientsGiorgos C Karakousis
Department of Surgery, Hospital of the University of Pennsylvania, 4th Floor Silverstein Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
Ann Surg Oncol 14:1596-603. 2007.... - Predicting sentinel node status in AJCC stage I/II primary cutaneous melanomaLaura L Kruper
Melanoma Program of the Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer 107:2436-45. 2006.... - Predictors of regional nodal disease in patients with thin melanomasGiorgos C Karakousis
Department of Surgery, University of Pennsylvania Health System, Abramson Cancer Center, Philadelphia, Pennsylvania 19104, USA
Ann Surg Oncol 13:533-41. 2006..These factors may help to identify subgroups of these patients that have clinically significant risks of SLN positivity... - Identification of high-risk patients among those diagnosed with thin cutaneous melanomasPhyllis A Gimotty
The Melanoma Program of the Abramson Cancer Center, Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Clin Oncol 25:1129-34. 2007..However, some develop metastatic disease that is often fatal. We evaluated established prognostic factors to develop classification schemes with better discrimination than current American Joint Committee on Cancer (AJCC) staging... 
Lymphatic invasion is independently prognostic of metastasis in primary cutaneous melanomaXiaowei Xu
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Clin Cancer Res 18:229-37. 2012..Lymphatic invasion (LI) in primary cutaneous melanomas was recently found to be common. In this study, we evaluated LI as an independent prognostic factor...- Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosisXiaowei Xu
Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Hum Pathol 39:901-9. 2008..Lymphatic invasion is an underobserved phenomenon in primary melanomas that can be better detected by immunohistochemical staining. The presence of lymphatic invasion may be a clinically useful predictor of regionally metastatic disease... - The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytesHong Yu
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
Am J Pathol 174:2367-77. 2009..In summary, these data demonstrate that a subpopulation of melanocytes possesses the ability to survive BRAF(V600E)-induced senescence, and suggest that p53 inactivation may promote malignant transformation of these cells... - Biologic and prognostic significance of dermal Ki67 expression, mitoses, and tumorigenicity in thin invasive cutaneous melanomaPhyllis A Gimotty
Melanoma Program of the Abramson Cancer Center, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
J Clin Oncol 23:8048-56. 2005..In this study, we characterized three biomarkers of proliferation (Ki67 expression, dermal mitotic rate [MR], and tumorigenicity) in thin (< or = 1.00 mm) primary cutaneous melanomas and examined their association with prognosis... - Does MC1R genotype convey information about melanoma risk beyond risk phenotypes?Peter A Kanetsky
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
Cancer 116:2416-28. 2010..A study was carried out to describe associations of MC1R variants and melanoma in a US population and to investigate whether genetic risk is modified by pigmentation characteristics and sun exposure measures... 
An atypical melanocytic lesion without genomic abnormalities shows locoregional metastasisRonnie M Abraham
Department of Pathology, University of Pennsylvania, Philadelphia, PA, USA
J Cutan Pathol 39:21-4. 2012..Further comprehensive study of these lesions is needed...- Expression of Melan-A and Ki-67 in desmoplastic melanoma and desmoplastic neviCynthia Kucher
Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Am J Dermatopathol 26:452-7. 2004..Therefore, we investigated whether immunohistochemical staining for Melan-A and Ki-67 expression can be used to discriminate these lesions, distinguishing between epithelioid and spindle cell compartments of the lesions... - P gene as an inherited biomarker of human eye colorTimothy R Rebbeck
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cancer Epidemiol Biomarkers Prev 11:782-4. 2002..001), or the combination of both variants (P = 0.003). These results suggest that P gene, in part, determines normal phenotypic variation in human eye color and may therefore represent an inherited biomarker of cutaneous cancer risk... - Differentiation of normal skin and melanoma using high resolution hyperspectral imagingDavid T Dicker
Laboratory of Molecular Oncology and Cell Cycle Regulation, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Cancer Biol Ther 5:1033-8. 2006..This would assist multiple laboratories to participate in the input and retrieval of target spectral information... - Functional erythropoietin autocrine loop in melanomaSuresh M Kumar
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
Am J Pathol 166:823-30. 2005..The results suggest that the autocrine and paracrine functions of Epo might play a role in malignant transformation of melanocytes and in the survival of melanoma cells in hypoxia and other adverse conditions... - Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomasKeiran S M Smalley
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
Mol Cancer Ther 7:2876-83. 2008.... - Cutaneous melanoma: estimating survival and recurrence risk based on histopathologic featuresDavid E Elder
Melanoma Program of the Abramson Cancer Center, Divison of Anatomic Pathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
Dermatol Ther 18:369-85. 2005..In this monograph, the focus will be the discussion of factors related to the prognosis of melanomas that at diagnosis are clinically localized to the primary site... - A tumorigenic subpopulation with stem cell properties in melanomasDong Fang
Program of Molecular and Cellular Oncogenesis, The Wistar Institute and Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, PA 19104, USA
Cancer Res 65:9328-37. 2005..Based on these findings, we propose that melanomas can contain a subpopulation of stem cells that contribute to heterogeneity and tumorigenesis. Targeting this population may lead to effective treatments for melanomas... - Mitotic rate as a predictor of sentinel lymph node positivity in patients with thin melanomasSusan B Kesmodel
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Ann Surg Oncol 12:449-58. 2005..To confirm these results, the predictive value of MR for SLN positivity needs to be validated in other populations of thin-melanoma patients... - Thin melanomaDavid E Elder
Department of Pathology and Laboratory Medicine, Division of Anatomic Pathology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
Arch Pathol Lab Med 135:342-6. 2011..These cases can be identified by using prognostic models, including the "standard" American Joint Committee on Cancer criteria, and other attributes identified in follow-up studies... - Angiomatoid Spitz nevus: a clinicopathological study of six cases and a review of the literatureMichael T Tetzlaff
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
J Cutan Pathol 36:471-6. 2009..The features of classic angiomatoid Spitz nevus are described in the context of important differential diagnostic considerations, particularly regressed malignant melanoma... - The approach to the patient with a difficult melanocytic lesionDavid E Elder
Division of Anatomic Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19130, USA
Pathology 36:428-34. 2004..The second principle is to make clinicians and patients specifically aware of the diagnostic difficulty in their lesion, so that management can be undertaken on a true informed consent basis... - Induction of melanoma phenotypes in human skin by growth factors and ultraviolet BCarola Berking
The Wistar Institute, Philadelphia, Pennsylvania, USA
Cancer Res 64:807-11. 2004..This is the first report on human cancer initiation in vivo in which an imbalance of physiological factors combined with an environmental carcinogen can lead to transformation of normal tissue... - Cellular nodules in congenital pattern neviXiaowei Xu
Departments of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, USA
J Cutan Pathol 31:153-9. 2004..Although presumed benign, to date, no published long-term follow-up studies have proved the benignity of this lesion... - Dysplastic naevi: an updateDavid E Elder
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Histopathology 56:112-20. 2010.... - Human leukocyte antigen-A2-restricted CTL responses to mutated BRAF peptides in melanoma patientsRajasekharan Somasundaram
The Wistar Institute, Philadelphia, PA 19104, USA
Cancer Res 66:3287-93. 2006..The high prevalence (approximately 50%) of HLA-A2 among melanoma patients renders HLA-A2-restricted BRAF(V600E) peptides attractive candidate vaccines for these patients... - Gene expression profiling of melanocytic lesionsJohn T Seykora
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Am J Dermatopathol 25:6-11. 2003..Based on this study, DNA microarray technology appears to be a valuable tool for identifying genes that may be specifically expressed in cutaneous lesions... - Pathology of melanomaDavid E Elder
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Clin Cancer Res 12:2308s-2311s. 2006..In the near future, pathologic attributes will also likely be used to predict responses to therapy, as a guide to the selection of specific therapeutic agents such as "small molecule" inhibitors of signaling pathways... - A practical approach to selected problematic melanocytic lesionsXiaowei Xu
Department of Pathology and Laboratory Medicine, Hospital of University of Pennsylvania, Philadelphia 19104, USA
Am J Clin Pathol 121:S3-32. 2004..Immunohistochemical analysis is useful, but it cannot replace careful examination of H&E-stained sections... - Smooth muscle hamartoma associated with a congenital pattern melanocytic nevus, a case report and review of the literatureAlireza Zarineh
Department of Pathology and Laboratory Medicine, Allegheny General Hospital, Pittsburgh, PA 15212, USA
J Cutan Pathol 35:83-6. 2008..Unlike a recently reported case of SMH combined with a melanocytic nevus and basal cell carcinoma, the current lesion did not occur in association with a Becker's nevus... - Variability in nomenclature used for nevi with architectural disorder and cytologic atypia (microscopically dysplastic nevi) by dermatologists and dermatopathologistsMichael Shapiro
Department of Dermatology, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104, USA
J Cutan Pathol 31:523-30. 2004..CONCLUSIONS: Despite attempts to unify nomenclature for microscopically dysplastic nevi through the NIH Consensus Conference, wide variation in terminology persists... - Multiple primary melanoma revisitedM Anne Blackwood
Department of Medicine, Hematology-Oncology Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6145, USA
Cancer 94:2248-55. 2002..Therefore, in addition to the MPM index case, other family members can benefit from screening and regular surveillance for melanoma, DN, and BCC... - Immunoprofile of MITF, tyrosinase, melan-A, and MAGE-1 in HMB45-negative melanomasXiaowei Xu
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Am J Surg Pathol 26:82-7. 2002..Melanocyte-specific transcription factor is not a useful marker for desmoplastic melanoma... - Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulationKapaettu Satyamoorthy
Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Cancer Res 63:756-9. 2003..These data suggest that melanoma growth, invasion, and metastasis are attributable to constitutively activated ERK apparently mediated by excessive growth factors through autocrine mechanisms and BRAF kinase activation... - Nuclear to non-nuclear Pmel17/gp100 expression (HMB45 staining) as a discriminator between benign and malignant melanocytic lesionsBonnie E Gould Rothberg
Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
Mod Pathol 21:1121-9. 2008..80 for distinguishing benign nevi from malignant melanomas. On the basis of this preliminary study, we propose that the ratio of nuclear to non-nuclear HMB45 staining may be useful for diagnostic challenges in melanocytic lesions... - Common sequence variants on 20q11.22 confer melanoma susceptibilityKevin M Brown
Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, Arizona 85028, USA
Nat Genet 40:838-40. 2008..The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases... - Pathology review of cases presenting to a multidisciplinary pigmented lesion clinicKaren S McGinnis
Department of Dermatology, University of Pennsylvania, Philadelphia 19104, USA
Arch Dermatol 138:617-21. 2002..These changes have important implications for clinical decision making, patient outcome, and research data collection... - MC1R variants increase risk of melanomas harboring BRAF mutationsMaria Concetta Fargnoli
Department of Dermatology, University of L Aquila, L Aquila, Italy
J Invest Dermatol 128:2485-90. 2008..This study confirms that the known MC1R-melanoma risk association is confined to subjects whose melanomas harbor BRAF mutations... - Identifying individuals at high risk of melanoma: a practical predictor of absolute riskThomas R Fears
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Clin Oncol 24:3590-6. 2006..We developed a model to estimate the 5-year absolute risk of melanoma to efficiently identify individuals at increased risk of melanoma for potential interventions... - Frontiers in melanocytic pathologyRichard A Scolyer
Pathology 36:385-6. 2004 - Reproductive risk factors for cutaneous melanoma in women: a case-control studyC Suzanne Lea
Statistics and Epidemiology Program, Research Triangle Institute International, Research Triangle Park, NC, USA
Am J Epidemiol 165:505-13. 2007..9, 95% confidence interval: 1.1, 8.1). Oral contraceptive use and hormone replacement therapy were not associated with melanoma risk... - High-risk melanoma susceptibility genes and pancreatic cancer, neural system tumors, and uveal melanoma across GenoMELAlisa M Goldstein
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7236, USA
Cancer Res 66:9818-28. 2006..This GenoMEL study provides the most extensive characterization of mutations in high-risk melanoma susceptibility genes in families with three or more melanoma patients yet available... - Incomplete biopsy of melanocytic lesions can impair the accuracy of pathological diagnosisRichard A Scolyer
Australas J Dermatol 47:71-3; author reply 74-5. 2006 - MC1R germline variants confer risk for BRAF-mutant melanomaMaria Teresa Landi
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Science 313:521-2. 2006..In this tumor subtype, the risk for melanoma associated with MC1R is due to an increase in risk of developing melanomas with BRAF mutations... - Diet and melanoma in a case-control studyAmy E Millen
Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7344, USA
Cancer Epidemiol Biomarkers Prev 13:1042-51. 2004..Malignant melanoma has been one of the most rapidly increasing cancers within the United States with few modifiable risk factors. This study investigates risk related to dietary factors, which are potentially modifiable... - Innovations and challenges in melanoma: summary statement from the first Cambridge conferenceMichael B Atkins
Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Clin Cancer Res 12:2291s-2296s. 2006.... - Average midrange ultraviolet radiation flux and time outdoors predict melanoma riskThomas R Fears
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Res 62:3992-6. 2002..4%). The association between melanoma risk and average annual UVB flux was strong and consistent for men and for women. The association with total adult hours outdoors was notable for men of all skin types and women who develop a suntan... - Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumorsXiaowei Xu
Arch Pathol Lab Med 127:1083-4; author reply 1084-5. 2003 - Validation of prognostic models for melanomaPhyllis A Gimotty
Am J Clin Pathol 118:489-91. 2002 - Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continentsAlisa M Goldstein
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7236, USA
J Med Genet 44:99-106. 2007.... - Reliability and validity of a histologic score as a marker for skin cancer chemoprevention studiesPaul Bozzo
Arizona Cancer Center, Departments of Pathology and Medicine, University of Arizona, P.O. Box 245024, Tucson, Arizona 85724-5024, USA
Anal Quant Cytol Histol 25:285-92. 2003..Additional interrater reliability tests utilizing larger test sets and a rigorous statistical design should be undertaken to establish its portability... - Heterogeneity of risk for melanoma and pancreatic and digestive malignancies: a melanoma case-control studyJoni L Rutter
Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-7236, USA
Cancer 101:2809-16. 2004..Even in a large case-control study, few families that had multiple members with melanoma were identified, and family members with pancreatic malignancies were rare...