Alan D Elbein

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. ncbi New insights on trehalose: a multifunctional molecule
    Alan D Elbein
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Glycobiology 13:17R-27R. 2003
  2. ncbi A novel trehalase from Mycobacterium smegmatis - purification, properties, requirements
    J David Carroll
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    FEBS J 274:1701-14. 2007
  3. doi Trehalose synthase converts glycogen to trehalose
    Yuan Tseng Pan
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    FEBS J 275:3408-20. 2008
  4. ncbi Cloning and expression of the trehalose-phosphate phosphatase of Mycobacterium tuberculosis: comparison to the enzyme from Mycobacterium smegmatis
    Vineetha Koroth Edavana
    Department of Biochemistry and Molecular Biology, The University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Arch Biochem Biophys 426:250-7. 2004
  5. ncbi Trehalose synthase of Mycobacterium smegmatis: purification, cloning, expression, and properties of the enzyme
    Yuan T Pan
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Eur J Biochem 271:4259-69. 2004
  6. pmc Last step in the conversion of trehalose to glycogen: a mycobacterial enzyme that transfers maltose from maltose 1-phosphate to glycogen
    Alan D Elbein
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 285:9803-12. 2010
  7. ncbi Purification, cloning, expression, and properties of mycobacterial trehalose-phosphate phosphatase
    Stacey Klutts
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    J Biol Chem 278:2093-100. 2003
  8. ncbi Trehalose-based oligosaccharides isolated from the cytoplasm of Mycobacterium smegmatis. Relation to trehalose-based oligosaccharides attached to lipid
    Masaya Ohta
    Department of Biochemistry, Fukuyuma University, Japan
    Eur J Biochem 269:3142-9. 2002

Collaborators

  • J D Carroll
  • Naoki Asano
  • Irena Pastuszak
  • Vineetha Koroth Edavana
  • Yuan Tseng Pan
  • Yuan T Pan
  • Prajitha Thampi
  • Edathera C Abraham
  • Stacey Klutts
  • Masaya Ohta
  • Vineetha K Edavana
  • William J Jourdian
  • Rick Edmondson
  • Y T Pan
  • Roger A Laine

Detail Information

Publications8

  1. ncbi New insights on trehalose: a multifunctional molecule
    Alan D Elbein
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Glycobiology 13:17R-27R. 2003
    ..Recent studies in yeast indicate that the enzymes involved in trehalose synthesis (TPS, TPP) exist together in a complex that is highly regulated at the activity level as well as at the genetic level...
  2. ncbi A novel trehalase from Mycobacterium smegmatis - purification, properties, requirements
    J David Carroll
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    FEBS J 274:1701-14. 2007
    ..The enzyme has a pH optimum of 7.1, and is active in various buffers, as long as inorganic phosphate and Mg(2+) are present. Glucose was the only product produced by the trehalase in the presence of either phosphate or arsenate...
  3. doi Trehalose synthase converts glycogen to trehalose
    Yuan Tseng Pan
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    FEBS J 275:3408-20. 2008
    ..These data indicate that trehalose and TreS are both involved in the production of glycogen, and that the metabolism of trehalose and glycogen is interconnected...
  4. ncbi Cloning and expression of the trehalose-phosphate phosphatase of Mycobacterium tuberculosis: comparison to the enzyme from Mycobacterium smegmatis
    Vineetha Koroth Edavana
    Department of Biochemistry and Molecular Biology, The University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Arch Biochem Biophys 426:250-7. 2004
    ..The product of the other gene, Rv2006, is a 159kDa protein with no detectable phosphatase activity. Thus, its function is currently unknown...
  5. ncbi Trehalose synthase of Mycobacterium smegmatis: purification, cloning, expression, and properties of the enzyme
    Yuan T Pan
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Eur J Biochem 271:4259-69. 2004
    ..TreS also catalyzes production of a glucosamine disaccharide from maltose and glucosamine, suggesting that this enzyme may be valuable in carbohydrate synthetic chemistry...
  6. pmc Last step in the conversion of trehalose to glycogen: a mycobacterial enzyme that transfers maltose from maltose 1-phosphate to glycogen
    Alan D Elbein
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 285:9803-12. 2010
    ....
  7. ncbi Purification, cloning, expression, and properties of mycobacterial trehalose-phosphate phosphatase
    Stacey Klutts
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    J Biol Chem 278:2093-100. 2003
    ..TPP may play a key role in the biosynthesis of trehalose compounds, such as trehalose mycolates, and therefore may represent an excellent target site for chemotherapy against tuberculosis and other mycobacterial diseases...
  8. ncbi Trehalose-based oligosaccharides isolated from the cytoplasm of Mycobacterium smegmatis. Relation to trehalose-based oligosaccharides attached to lipid
    Masaya Ohta
    Department of Biochemistry, Fukuyuma University, Japan
    Eur J Biochem 269:3142-9. 2002
    ....