M B Elam

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. ncbi Increased hepatic VLDL secretion, lipogenesis, and SREBP-1 expression in the corpulent JCR:LA-cp rat
    M B Elam
    Department of Veterans Affairs Medical Center, Memphis, TN, USA
    J Lipid Res 42:2039-48. 2001
  2. doi Hepatic gene expression in morbidly obese women: implications for disease susceptibility
    Marshall B Elam
    Department of Medicine and Research Service, Veterans Affairs Medical Center, Memphis, Tennessee, USA
    Obesity (Silver Spring) 17:1563-73. 2009
  3. pmc Dysregulation of sterol regulatory element binding protein-1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling-3 and signal transducer and activator of transcription-1 signaling
    Marshall B Elam
    Department of Medicine and Research Service, Department of Veterans Affairs Medical Center, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA
    Metabolism 59:587-98. 2010
  4. ncbi Apolipoprotein B mRNA editing and apolipoprotein gene expression in the liver of hyperinsulinemic fatty Zucker rats: relationship to very low density lipoprotein composition
    M B Elam
    Veterans Affairs Medical Center, Division of Clinical Pharmacology, University of Tennessee, Memphis 38163, USA
    Lipids 34:809-16. 1999
  5. ncbi Regulation of the rat SREBP-1c promoter in primary rat hepatocytes
    Xiong Deng
    Department of Veterans Affairs Medical Center, Memphis, Tennessee, USA
    Biochem Biophys Res Commun 290:256-62. 2002
  6. ncbi Posttranslational processing of SREBP-1 in rat hepatocytes is regulated by insulin and cAMP
    Chandrahasa R Yellaturu
    Department of Veterans Affairs Medical Center, Memphis, TN, USA
    Biochem Biophys Res Commun 332:174-80. 2005
  7. ncbi Dietary olive oil and menhaden oil mitigate induction of lipogenesis in hyperinsulinemic corpulent JCR:LA-cp rats: microarray analysis of lipid-related gene expression
    Xiong Deng
    Department of Medicine, Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    Endocrinology 145:5847-61. 2004
  8. ncbi Emerging noninvasive biochemical measures to predict cardiovascular risk
    M Pahor
    Department of Preventive Medicine, University of Tennessee, Memphis 38105, USA
    Arch Intern Med 159:237-45. 1999
  9. ncbi Expression of the rat sterol regulatory element-binding protein-1c gene in response to insulin is mediated by increased transactivating capacity of specificity protein 1 (Sp1)
    Xiong Deng
    Medical and Research Service, Department of Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    J Biol Chem 282:17517-29. 2007
  10. doi SREBPs: the crossroads of physiological and pathological lipid homeostasis
    Rajendra Raghow
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Trends Endocrinol Metab 19:65-73. 2008

Research Grants

Collaborators

Detail Information

Publications26

  1. ncbi Increased hepatic VLDL secretion, lipogenesis, and SREBP-1 expression in the corpulent JCR:LA-cp rat
    M B Elam
    Department of Veterans Affairs Medical Center, Memphis, TN, USA
    J Lipid Res 42:2039-48. 2001
    ..Greater secretion of VLDL in the cp/cp rat in part results from higher endogenous fatty acid synthesis, which in turn may occur in response to increased expression of the lipogenic enzyme regulator SREBP-1c...
  2. doi Hepatic gene expression in morbidly obese women: implications for disease susceptibility
    Marshall B Elam
    Department of Medicine and Research Service, Veterans Affairs Medical Center, Memphis, Tennessee, USA
    Obesity (Silver Spring) 17:1563-73. 2009
    ..The significance of altered expression of these genes to obesity-related disease is discussed...
  3. pmc Dysregulation of sterol regulatory element binding protein-1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling-3 and signal transducer and activator of transcription-1 signaling
    Marshall B Elam
    Department of Medicine and Research Service, Department of Veterans Affairs Medical Center, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA
    Metabolism 59:587-98. 2010
    ....
  4. ncbi Apolipoprotein B mRNA editing and apolipoprotein gene expression in the liver of hyperinsulinemic fatty Zucker rats: relationship to very low density lipoprotein composition
    M B Elam
    Veterans Affairs Medical Center, Division of Clinical Pharmacology, University of Tennessee, Memphis 38163, USA
    Lipids 34:809-16. 1999
    ....
  5. ncbi Regulation of the rat SREBP-1c promoter in primary rat hepatocytes
    Xiong Deng
    Department of Veterans Affairs Medical Center, Memphis, Tennessee, USA
    Biochem Biophys Res Commun 290:256-62. 2002
    ..This is the first report that insulin, cAMP, and polyunsaturated fatty acids modulate the proximal SREBP-1c promoter in rat hepatocytes mirroring physiological regulation of SREBP-1c in vivo...
  6. ncbi Posttranslational processing of SREBP-1 in rat hepatocytes is regulated by insulin and cAMP
    Chandrahasa R Yellaturu
    Department of Veterans Affairs Medical Center, Memphis, TN, USA
    Biochem Biophys Res Commun 332:174-80. 2005
    ..Insulin increased the half-life of constitutively expressed nSREBP-1c, and this effect of insulin was also inhibited by db-cAMP...
  7. ncbi Dietary olive oil and menhaden oil mitigate induction of lipogenesis in hyperinsulinemic corpulent JCR:LA-cp rats: microarray analysis of lipid-related gene expression
    Xiong Deng
    Department of Medicine, Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    Endocrinology 145:5847-61. 2004
    ....
  8. ncbi Emerging noninvasive biochemical measures to predict cardiovascular risk
    M Pahor
    Department of Preventive Medicine, University of Tennessee, Memphis 38105, USA
    Arch Intern Med 159:237-45. 1999
    ..Further epidemiological studies are needed to characterize the actual predictive and clinical value of these new emerging cardiovascular biomarkers...
  9. ncbi Expression of the rat sterol regulatory element-binding protein-1c gene in response to insulin is mediated by increased transactivating capacity of specificity protein 1 (Sp1)
    Xiong Deng
    Medical and Research Service, Department of Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    J Biol Chem 282:17517-29. 2007
    ..These studies identify a novel mechanism by which maximal activation of the rat SREBP-1c gene expression by insulin is mediated by Sp1 and its enhanced ability to interact with other transcriptional regulatory proteins...
  10. doi SREBPs: the crossroads of physiological and pathological lipid homeostasis
    Rajendra Raghow
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Trends Endocrinol Metab 19:65-73. 2008
    ....
  11. pmc Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles
    Chandrahasa R Yellaturu
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 284:7518-32. 2009
    ..This effect of insulin is tightly linked to phosphoinositide 3-kinase and PKB/Akt-dependent serine phosphorylation of the precursor SREBP-1c protein...
  12. ncbi Peroxisomal proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) enhances the thyroid hormone induction of carnitine palmitoyltransferase I (CPT-I alpha)
    Yi Zhang
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 279:53963-71. 2004
    ..Our data demonstrate that PGC-1 alpha participates in the stimulation of CPT-I alpha gene expression by thyroid hormone and suggest that PGC-1 alpha is a coactivator for thyroid hormone...
  13. pmc Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements
    Lauren M Cagen
    Department of Pharmacology, The University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Biochem J 385:207-16. 2005
    ..We propose that the combined actions of the SRE, LXREs, Sp1 and NF-Y elements constitute an insulin-responsive cis-acting unit of the SREBP-1c gene in the liver...
  14. pmc Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex
    Chandrahasa R Yellaturu
    Department of Pharmacology, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 284:31726-34. 2009
    ..Thus, insulin-induced reduction in Insig-2a protein leads to an enhanced export of the SCAP.SREBP-1c complex from ER to the Golgi...
  15. ncbi Effect of the novel antiplatelet agent cilostazol on plasma lipoproteins in patients with intermittent claudication
    M B Elam
    Departments of Pharmacology and Medicine, University of Tennessee Health Science Center and Veterans Affairs Medical Center, Memphis, Tennessee, USA
    Arterioscler Thromb Vasc Biol 18:1942-7. 1998
    ..001). These results indicate that in addition to improving the symptoms of IC, cilostazol also favorably modifies plasma lipoproteins in patients with peripheral arterial disease. The mechanism of this effect is currently unknown...
  16. pmc Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin
    Sara Connaughton
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Mol Cell Endocrinol 315:159-67. 2010
    ..Our data demonstrate that glucocorticoids and insulin each modulate PDK4 gene expression through complex hormone response units that contain multiple factors...
  17. ncbi Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression
    Yi Zhang
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 281:39897-906. 2006
    ..Insulin suppresses PDK4 expression in part through the dissociation of FoxO1 and PGC-1alpha from the PDK4 promoter. Our data demonstrate a key role for the ERRs in the induction of hepatic PDK4 gene expression...
  18. pmc N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXRalpha
    George Howell
    Department of Pharmacology, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA
    Biochim Biophys Acta 1791:1190-6. 2009
    ....
  19. pmc Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by thyroid hormone: role of the peroxisome proliferator-activated receptor gamma coactivator (PGC-1 alpha)
    Ramy R Attia
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 285:2375-85. 2010
    ..Our results indicate that T(3) regulates PGC-1 alpha abundance and association with hepatic genes, and in turn PGC-1 alpha is an important participant in the T(3) induction of selected genes...
  20. pmc Peroxisome proliferator activated receptor alpha (PPARalpha) and PPAR gamma coactivator (PGC-1alpha) induce carnitine palmitoyltransferase IA (CPT-1A) via independent gene elements
    Shulan Song
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, United States
    Mol Cell Endocrinol 325:54-63. 2010
    ..Overall, our studies indicated that PPARalpha and PGC-1alpha stimulate transcription of the CPT-1A gene through different regions of the CPT-1A gene...
  21. ncbi Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
    H B Rubins
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    N Engl J Med 341:410-8. 1999
    ....
  22. pmc Regulation of carnitine palmitoyltransferase I (CPT-Ialpha) gene expression by the peroxisome proliferator activated receptor gamma coactivator (PGC-1) isoforms
    Prabodh Sadana
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Mol Cell Endocrinol 267:6-16. 2007
    ..Overall, our results demonstrate that PGC-1beta is a coactivator in the T3 induction of CPT-Ialpha and that PGC-1beta has similarities and differences with the PGC-1alpha isoform...
  23. ncbi Cloning of the rat pyruvate dehydrogenase kinase 4 gene promoter: activation of pyruvate dehydrogenase kinase 4 by the peroxisome proliferator-activated receptor gamma coactivator
    Ke Ma
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, 38163, USA
    J Biol Chem 280:29525-32. 2005
    ..Our data suggest that by inducing PDK genes PGC-1alpha will direct pyruvate away from metabolism into acetyl-CoA and toward the formation of oxaloacetate and into the gluconeogenic pathway...
  24. ncbi Effect of niacin, warfarin, and antioxidant therapy on coagulation parameters in patients with peripheral arterial disease in the Arterial Disease Multiple Intervention Trial (ADMIT)
    C M Chesney
    Departments of Medicine and Pathology, University of Tennessee, Memphis, USA
    Am Heart J 140:631-6. 2000
    ..The objective of this study was to assess the effect of the ADMIT interventions on coagulation...
  25. ncbi Peroxisomal proliferator activated receptor gamma coactivator (PGC-1alpha) stimulates carnitine palmitoyltransferase I (CPT-Ialpha) through the first intron
    Shulan Song
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Biochim Biophys Acta 1679:164-73. 2004
    ..Our results indicate that PGC-1alpha elevates the expression of CPT-Ialpha via a unique mechanism that utilizes elements within the intron...
  26. ncbi Diabetes, plasma insulin, and cardiovascular disease: subgroup analysis from the Department of Veterans Affairs high-density lipoprotein intervention trial (VA-HIT)
    Hanna Bloomfield Rubins
    Section of General Internal Medicine 111O, Veterans Affairs Medical Center, 1 Veterans Dr, Minneapolis, MN 55417
    Arch Intern Med 162:2597-604. 2002
    ..Diabetes mellitus, impaired fasting glucose level, or insulin resistance are associated with increased risk of cardiovascular disease...

Research Grants1

  1. Regulation of SREBP-1c Processing by Insulin and Cyclic-AMP
    MARSHALL ELAM; Fiscal Year: 2007
    ..The goal of this research is to identify new treatments for hyperlipidemia by understanding the mechanisms by which insulin regulates this protein. ..