Research Topics
Species | Rif S El-MallakhSummaryAffiliation: University of Louisville Country: USA Publications
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Publications
Evaluation of consequences of implementation of police crisis intervention team in LouisvilleRif S El-Mallakh
Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
J Ky Med Assoc 106:435-7. 2008..8% in 2004, P < 0.01). The data suggests that the introduction of CIT has had an overall positive effect on outcomes of situations in which mentally ill subjects are confronted by police officers...- Smoking is associated with greater symptom load in bipolar disorder patientsMohamedlatif Saiyad
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, USA E mail
Ann Clin Psychiatry 24:305-9. 2012..Nicotine has several effects on mood and cognition. After many studies, the nature of the effect of smoking on mental illness is not clear... - Waiting room crowding and agitation in a dedicated psychiatric emergency serviceRif S El-Mallakh
Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
Ann Clin Psychiatry 24:140-2. 2012..Emergency department crowding is a growing problem that impacts patient care and safety. The effect of crowding has not been examined in emergency psychiatric services... 
A 40-week double-blind aripiprazole versus lithium follow-up of a 12-week acute phase study (total 52 weeks) in bipolar I disorderRif S El-Mallakh
University of Louisville, Louisville, KY 40202, USA
J Affect Disord 136:258-66. 2012..This is the only long-term, double-blind study comparing lithium and aripiprazole...- Studies of long-term use of antidepressants: how should the data from them be interpreted?Rif S El-Mallakh
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, USA
CNS Drugs 26:97-109. 2012.... - Switching from other agents to extended-release carbamazepine in acute maniaRif S El-Mallakh
Department of Psychiatry and Behavioral Sciences, University of Louisvilile School of Medicine, Louisville, KY, USA
Psychopharmacol Bull 41:52-8. 2008..There is a dearth of available knowledge relating to the efficacy of switching from one psychotropic agent to another in treating patients with acute mania... - Use of antidepressants to treat depression in bipolar disorderRif S El-Mallakh
Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Kentucky 40292, USA
Psychiatr Serv 53:580-4. 2002..Antidepressants should be used with caution in the treatment of bipolar depression... - Adverse event load in bipolar participants receiving either carbamazepine immediate-release or extended-release capsules: a blinded, randomized studyRif S El-Mallakh
Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Int Clin Psychopharmacol 24:145-9. 2009..2+/-1.7 vs. IR 7.2+/-1.3 microg/ml, P = 0.005). Total AE load was directly related to CBZ level only in participants receiving the IR formulation. In conclusion, ERCC is better tolerated than IR CBZ in bipolar patients... - Bipolar II disorder: current and future treatment optionsRif El-Mallakh
Dept of Psychiatry, University of Louisville School of Medicine, Louisville, KY 40202, USA
Ann Clin Psychiatry 18:259-66. 2006..This review attempts to summarize available data on agents useful in treating patients with the disease... - Comorbid anxiety in bipolar disorder alters treatment and prognosisRif S El-Mallakh
Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Medcenter One, 501 E Broadway, Louisville, KY 40202, USA
Psychiatr Q 79:139-50. 2008..Identification of anxiety disorders in bipolar patients is important. The treatment plan needs to balance the potential benefit and harm of antidepressant administration... - Medication adherence and the use of long-acting antipsychotics in bipolar disorderRif S El-Mallakh
Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
J Psychiatr Pract 13:79-85. 2007..The availability of a long-acting atypical antipsychotic raises the possibility of using this agent to prevent bipolar relapse... - MDMA (Ecstasy)Rif S El-Mallakh
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
Ann Clin Psychiatry 19:45-52. 2007..Its use in Western countries appears to be increasing, particularly among young individuals... - Medical decision-making by psychiatry residentsRif El-Mallakh
Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
Acad Psychiatry 31:326-8. 2007.... - Chronic depression in bipolar disorderRif S El-Mallakh
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40292, USA
Am J Psychiatry 163:1337-41; quiz 1478. 2006 - A blinded, randomized comparison of immediate-release and extended-release carbamazepine capsules in manic and depressed bipolar subjectsRif S El-Mallakh
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
Ann Clin Psychiatry 22:3-8. 2010..It is available in 2 formulations: immediate-release (IR) and extended-release carbamazepine capsules (ERCC). The relative efficacy of these formulations in acutely ill bipolar patients has not been previously investigated... - Lithiated lemon-lime sodasRif S El-Mallakh
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Medcenter One, 501 E. Broadway, Louisville, KY 40202, USA
Am J Psychiatry 164:1662. 2007 - Tardive dysphoria: the role of long term antidepressant use in-inducing chronic depressionRif S El-Mallakh
Mood Disorders Research Program, The University of Louisville Depression Center, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
Med Hypotheses 76:769-73. 2011..This is an emerging evidence that, in some individuals, persistent use of antidepressants may be prodepressant... - A comparison of two fixed doses of aripiprazole with placebo in acutely relapsed, hospitalized patients with bipolar disorder I (manic or mixed) in subpopulations (CN138-007)Rif S El Mallakh
Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, USA
Eur Neuropsychopharmacol 20:776-83. 2010..A high placebo response rate may have accounted for the lack of separation between treatment groups... - Bipolar disorder: an updateRif S El-Mallakh
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
Postgrad Med 122:24-31. 2010..The use of multiple agents appears to be superior to monotherapy in relapse prevention. Despite the many advances in the pharmacotherapy of bipolar disorder, the overall prognosis of this severe illness does not appear to have changed... - Follow-up after inpatient psychiatric hospitalization with partial control of the system responsiveness variableRif S El-Mallakh
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40291, USA
Psychiatry 67:294-8. 2004..35, p = .067). Despite partial control of the system responsiveness variable, compliance with aftercare was suboptimal. This was due to a combination of client vulnerability variables and uncontrollable system responsiveness factors... - Aberrant regulation of endogenous ouabain-like factor in bipolar subjectsRif S El-Mallakh
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Psychiatry Res 178:116-20. 2010..15) in bipolar subjects compared to non-psychiatric controls. Other endogenous cardenolides did not vary significantly. The endogenous cardenolide, OLF, may be aberrantly controlled in bipolar illness... - Long-term use of pramipexole in bipolar depression: a naturalistic retrospective chart reviewRif S El-Mallakh
School of Medicine, University of Louisville, Louisville, KY, USA
Psychiatr Q 81:207-13. 2010..There were no changes in mania ratings for up to 36 months. Long-term outcome of adjunctive pramipexole appears to be adequate, with apparent maintenance of effect for over 9 months... - Hallucinations, psuedohallucinations, and parahallucinationsRif S El-Mallakh
Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine in Louisville, Kentucky 40202, USA
Psychiatry 73:34-42. 2010..There are several clinical phenomena that resemble hallucinations which are inadequately studied because the terminology defining them is inadequate... - Intracerebroventricular administration of ouabain as a model of mania in ratsRif S El-Mallakh
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40292, USA
Bipolar Disord 5:362-5. 2003.... - Response of sodium pump to ouabain challenge in human glioblastoma cells in cultureXian Huang
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, KY, USA
World J Biol Psychiatry 10:884-92. 2009..These results suggest that disturbance of ion regulation induces changes in glial cell sodium regulatory systems which are normalized by lithium treatment... - Effect of ethacrynic acid on the sodium- and potassium-activated adenosine triphosphatase activity and expression in Old Order Amish bipolar individualsMary O Huff
Department of Biology, Bellarmine University, Louisville, Kentucky, USA
J Affect Disord 123:303-7. 2010..However, all of these studies have been in out-bred populations. In an attempt to reduce the genetic variability associated with this observation, we examined this phenomenon within an isolated breeding population... - Memantine reduces mania-like symptoms in animal modelsYonglin Gao
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40202, United States
Psychiatry Res 188:366-71. 2011..0 μM). Ouabain-induced hyperlocomotion was normalized with acute and chronic lithium and chronic use of memantine. Memantine delayed the onset of ouabain-induced-cycling in hippocampal slices. Memantine may have antimanic properties... - Hallucinations, pseudohallucinations, and severity of suicidal ideation among emergency psychiatry patientsPraveen Penagaluri
Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, USA
Crisis 31:53-6. 2010..This study investigated relative relationships between auditory hallucinations and nonpsychotic hallucinations (pseudohallucinations), and suicidal risk... - Antidepressant discontinuation in bipolar depression: a Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) randomized clinical trial of long-term effectiveness and safetyS Nassir Ghaemi
Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington St, Box 1007, Boston, MA 02111, USA
J Clin Psychiatry 71:372-80. 2010..To assess long-term effectiveness and safety of randomized antidepressant discontinuation after acute recovery from bipolar depression... - Sleep disturbances in euthymic bipolar patientsSharon Brill
Mood Disorders Research Program, Department of Psychiatry and Behavioral Science, University of Louisville School of Medicine, Louisville, KY, USA
Ann Clin Psychiatry 23:113-6. 2011..Sleep disturbance has been implicated in both prodromal and syndromal phases of bipolar illness... - Efficacy of olanzapine and haloperidol in an animal model of maniaRif S El-Mallakh
Mood Disorders Research Program, University of Louisville School of Medicine, Louisville, Kentucky 40292, United States
Prog Neuropsychopharmacol Biol Psychiatry 30:1261-4. 2006..Antipsychotic agents have demonstrated efficacy in the management of acute mania. This study was undertaken to determine the prophylactic efficacy of olanzapine and haloperidol in the ouabain mania model... - Psychiatric disposition of patients brought in by crisis intervention team police officersGordon Strauss
Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kenfucky, USA
Community Ment Health J 41:223-8. 2005..7% vs. 33.3%, ns). CONCLUSIONS: CIT officers appear to do a good job at identifying patients in need of psychiatric care... - Is bipolar disorder overdiagnosed among patients with substance abuse?Christopher Stewart
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
Bipolar Disord 9:646-8. 2007.... - Lithium normalizes elevated intracellular sodiumXian Huang
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Loiusville, KY 40292, USA
Bipolar Disord 9:298-300. 2007..Reduction of sodium influx is a proposed shared mechanism of action of effective mood stabilizers, but direct documentation of this effect for lithium has never been demonstrated... - Naturalistic long-term use of methylphenidate in bipolar disorderEric Lydon
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
J Clin Psychopharmacol 26:516-8. 2006..3 +/- 9.9 to 69.3 +/- 10.6 (P = 0.006). Methylphenidate seems to be safe in the naturalistic setting. Controlled studies are needed to confirm its efficacy and safety in bipolar depression... - Antidepressant exposure in bipolar childrenDavid Cicero
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Psychiatry 66:317-22. 2003..Although far from conclusive, these data are consistent with the hypothesis that antidepressant treatment is associated with a manic episode earlier than might occur spontaneously... - Antipsychotic medications in the treatment of bipolar disorderAnton A Subuh Surja
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Curr Drug Targets 7:1217-24. 2006..Finally, there are a small number of interesting studies suggesting utility in bipolar depression. This paper will critically review available randomized clinical trials utilizing antipsychotic agents in bipolar disorder... - Effect of ionic stress on apoptosis and the expression of TRPM2 in human olfactory neuroepithelial-derived progenitorsYonglin Gao
Department of Psychiatry and Behavioral Sciences, University of Louisville, School of Medicine, Louisville, KY 40292, USA
World J Biol Psychiatry 11:972-84. 2010..TRPM2, a nonselective cation channel, is involved in apoptosis and is possibly linked with BD. In this study, monensin, a sodium ionophore, was used to model the increase [Na(+)](in) and [Ca(2+)](in) seen in BD patients... - Effect of dopamine on intracellular sodium: a common pathway for pharmacological mechanism of action in bipolar illnessRona J Roberts
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
World J Biol Psychiatry 11:181-7. 2010..The recent increase of reports of documented efficacy of first- and second-generation antipsychotics in the control of mania offers a new opportunity to gain insight into the pathophysiological mechanism of bipolar disorder... - Positron emission tomography with fluorodeoxyglucose-F18 in an animal model of maniaMatthew Tyler Hougland
Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, United States
Psychiatry Res 164:166-71. 2008..Pretreatment with lithium normalized (18)FDG uptake. These results mirror human studies... - Fertility and childhood bipolar disorderAnton Agus S Surja
University of Louisville, Department of Psychiatry, 501 E Broadway, Suite 340, Louisville, KY 40202, United States
Med Hypotheses 69:587-9. 2007..These pharmacologic and social changes may have all conspired to increase reproductive success of bipolar subjects, giving rise to a new generation of bipolar patients with earlier onset and more severe manifestation of their disorder... - When to suspect bipolar disorderMuruga Loganathan
Allegheny General Hospital, Pittsburgh, PA, USA
J Fam Pract 59:682-8. 2010..Bipolar disease is often misdiagnosed, sometimes repeatedly. The screening tool and tips you'll find here will help you identify patients without delay... - Differential response of bipolar and normal control lymphoblastoid cell sodium pump to ethacrynic acidRena Li
Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, KY 40292, USA
J Affect Disord 80:11-7. 2004..CONCLUSIONS: The results suggest that bipolar illness is associated with an abnormality in cellular sodium homeostatic regulation... - Mimicking human bipolar ion dysregulation models mania in ratsLaura Herman
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Neurosci Biobehav Rev 31:874-81. 2007..While additional characterization of the model is required, the ouabain model for bipolar illness is the only available animal model that fulfills the three criteria for an adequate animal model for bipolar illness... - Antidepressant-associated chronic irritable dysphoria (ACID) in STEP-BD patientsRif S El-Mallakh
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, 501 East Broadway, Medcenter One, Suite 340, Louisville, Kentucky 40202, United States
J Affect Disord 111:372-7. 2008..This phenomenon has only been described in case series format, and has not been prospectively validated... - Patient outcome after treatment in a community-based crisis stabilization unitCharlotte L Adams
University of Louisville School of Nursing, Louisville, KY, USA
J Behav Health Serv Res 36:396-9. 2009..Nonetheless, community-based crisis stabilization units appear to be cost-effective alternatives to inpatient hospitalization for selected patients... - Implementation of a crisis intervention program for police response to mental health emergencies in LouisvilleRif S El-Mallakh
Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA
J Ky Med Assoc 101:241-3. 2003 - Barometric pressure, emergency psychiatric visits, and violent actsThomas J Schory
Mood Disorders Research Program, Department of Psychiatry and Behavioural Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
Can J Psychiatry 48:624-7. 2003..CONCLUSIONS: While alternate conclusions can be drawn, we propose that the data support the interpretation that low barometric pressure is associated with an increase in impulsive behaviours. Additional investigation is warranted... - Event-related potential study of the effects of emotional facial expressions on task performance in euthymic bipolar patientsEstate M Sokhadze
Cognitive Neuroscience Laboratory, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, 401 East Chestnut Street, Louisville, KY 40202, USA
Appl Psychophysiol Biofeedback 36:1-13. 2011..ERP responses to facial emotion in BD subjects varied significantly from normal controls. These variations are consistent with the common depressive symptomology seen in long term studies of bipolar subjects... - The effect of extreme marijuana use on the long-term course of bipolar I illness: a single case studyRif S El Mallakh
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
J Psychoactive Drugs 39:201-2. 2007..While not conclusive, the data suggest that marijuana may indeed have an effect on mood in bipolar patients that needs to be systematically examined... - Glial cell number and neuron/glial cell ratios in postmortem brains of bipolar individualsRebecca A Brauch
Mood Disorders Research Program, Department of Psychiatry, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
J Affect Disord 91:87-90. 2006..The size reduction may be reflective of glial dysfunction. LIMITATIONS: Postmortem interval of 29.4 +/- S.D. 13.4 h may have affected cellular structure and reduced the quality of the staining... - Validation of a diagnostic screening blood test for bipolar disorderDouglas B Woodruff
Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
Ann Clin Psychiatry 24:135-9. 2012..78 and a specificity of .88. The current study was performed as a validation of the initial study... - BDNF expression in lymphoblastoid cell lines carrying BDNF SNPs associated with bipolar disorderYonglin Gao
Mood Disorder Research Program, Department of Psychiatry and Behavioral Science, School of Medicine, University of Louisville, Louisville, Kentucky 40292, USA
Psychiatr Genet 22:253-5. 2012..To determine whether single nucleotide polymorphisms (SNPs) of the brain-derived neurotrophic factor (BDNF) that have been associated with bipolar illness are associated with physiological dysfunction... - Dialysis of saliva improves accuracy of saliva lithium determinationsRif S El-Mallakh
Mood Disorders Research Program, Department of Psychiatry, School of Public Health and Information Sciences, University of Louisville, Louisville, KY 40292, USA
Bipolar Disord 6:87-9. 2004..Saliva lithium (Li) determinations have been explored as a potential alternative to plasma levels. Unfortunately, this method has been shown to be unreliable. Saliva has two major components: the aqueous and the mucopolysaccharide portions... - Weight gain occurs after onset of bipolar illness in overweight bipolar patientsAmy Shah
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
Ann Clin Psychiatry 18:239-41. 2006..Subsequent weight gain is probably related to illness and treatment variables... 
Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophreniaHader A Mansour
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Bipolar Disord 11:701-10. 2009..The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders...- Effect of ethacrynic acid on sodium pump alpha isoforms in SH-SY5Y cellsRenee M Valdes
Department of Psychiatry and Behavioral Science, University of Louisville School of Medicine, Louisville, KY 40202, USA
Bipolar Disord 5:123-8. 2003..As alpha3 isoform is not expressed in lymphocytes, however, we conclude that lymphocytes are an incomplete model of neural tissue... - Adjunctive antidepressant treatment for bipolar depressionRif S El-Mallakh
N Engl J Med 357:615; author reply 615-6. 2007 - Stimulating research: a prospective, randomized, double-blind, sham-controlled study of slow transcranial magnetic stimulation in depressed bipolar patientsRebecca L Tamas
J Neuropsychiatry Clin Neurosci 19:198-9. 2007 - Serious rash with lamotrigine after carbamazepine discontinuation: a case reportAnton A Subuh Surja
J Clin Psychiatry 66:400-1. 2005 - RE: Patient satisfaction in an inpatient dual psychiatric and substance dependence treatment programRif S El-Mallakh
J Ky Med Assoc 105:596-7. 2007 - Schizophrenia and the origins of shamanism among the Kwakiutl maritime cultures of Northwest North America: a hypothesisRif S El-Mallakh
Schizophr Res 86:329-30. 2006 - Post lumbar-puncture headaches in schizophrenic and psychiatrically normal control subjectsRif S El-Mallakh
Schizophr Res 77:111-2. 2005 - Serotonin gene polymorphisms and bipolar I disorder: focus on the serotonin transporterHader A Mansour
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, U S A
Ann Med 37:590-602. 2005..Our analyses do not support association between SLC6A4 and BDI families. Further studies using sub-groups of BDI are worthwhile...