Affiliation: University of Michigan
Country: USA


  1. request reprint
    Wang H, Luo W, Eitzman D. Leptin in thrombosis and atherosclerosis. Curr Pharm Des. 2014;20:641-5 pubmed
    ..Therapeutic strategies designed to block leptin-mediated signaling events in cells contributing to vascular disease may prove beneficial in obese subjects at risk for vascular complications. ..
  2. Wang H, Chen Y, Eitzman D. Imaging body fat: techniques and cardiometabolic implications. Arterioscler Thromb Vasc Biol. 2014;34:2217-23 pubmed publisher
    ..Newer techniques capable of imaging fat metabolism and other functions of adipose tissue may provide additional prognostic use and may be useful in guiding therapeutic interventions. ..
  3. Wang H, Wang J, Guo C, Luo W, Kleiman K, Eitzman D. Renal denervation attenuates progression of atherosclerosis in apolipoprotein E-deficient mice independent of blood pressure lowering. Hypertension. 2015;65:758-65 pubmed publisher
    ..0 pg/mL, P<0.05). RDN reduces progression of atherosclerosis in apolipoprotein E-deficient mice. These changes are associated with reduced aldosterone levels, monocyte chemoattractant protein-1, and markers of oxidative stress. ..
  4. Wang H, Wang Q, Venugopal J, Wang J, Kleiman K, Guo C, et al. Obesity-induced Endothelial Dysfunction is Prevented by Neutrophil Extracellular Trap Inhibition. Sci Rep. 2018;8:4881 pubmed publisher
    ..These findings suggest an instrumental role for NETs in obesity-induced endothelial dysfunction. ..
  5. Wang J, Su E, Wang H, Guo C, Lawrence D, Eitzman D. Traumatic Brain Injury Leads to Accelerated Atherosclerosis in Apolipoprotein E Deficient Mice. Sci Rep. 2018;8:5639 pubmed publisher
    ..In conclusion, progression of atherosclerosis is accelerated following TBI. Targeting inflammatory pathways in patients with TBI may reduce subsequent vascular complications. ..
  6. Wang Q, Wang H, Wang J, Venugopal J, Kleiman K, Guo C, et al. Angiotensin II-induced Hypertension is Reduced by Deficiency of P-selectin Glycoprotein Ligand-1. Sci Rep. 2018;8:3223 pubmed publisher
    ..In conclusion, hematopoietic deficiency of Psgl-1 attenuates Ang II-induced hypertension, an effect that may be mediated by reduced IL-17. ..
  7. Wang H, Wang Q, Kleiman K, Guo C, Eitzman D. Hematopoietic Deficiency of miR-223 Attenuates Thrombosis in Response to Photochemical Injury in Mice. Sci Rep. 2017;7:1606 pubmed publisher
    ..This study indicates that platelet miR-223 is a potential therapeutic target for prevention of arterial thrombosis. ..
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    Eitzman D, Westrick R, Nabel E, Ginsburg D. Plasminogen activator inhibitor-1 and vitronectin promote vascular thrombosis in mice. Blood. 2000;95:577-80 pubmed
    ..01 compared to WT mice). These results suggest that endogenous fibrinolysis and its regulation by PAI-1 and VN have important roles in the development of occlusive vascular thrombosis after vascular injury. (Blood. 2000;95:577-580) ..
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    Eitzman D, Westrick R, Xu Z, Tyson J, Ginsburg D. Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery. Blood. 2000;96:4212-5 pubmed
    ..Blood. 2000;96:4212-4215) ..

More Information


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    Eitzman D, Westrick R, Shen Y, Bodary P, Gu S, Manning S, et al. Homozygosity for factor V Leiden leads to enhanced thrombosis and atherosclerosis in mice. Circulation. 2005;111:1822-5 pubmed
    ..02). In conclusion, homozygosity for the FVL mutation in mice leads to enhanced arterial thrombosis and atherosclerosis. The source of the FVL leading to accelerated thrombosis appears to be circulating, non-platelet-derived plasma FVL. ..
  2. Wang H, Wang Q, Wang J, Guo C, Kleiman K, Meng H, et al. Proprotein convertase subtilisin/kexin type 9 (PCSK9) Deficiency is Protective Against Venous Thrombosis in Mice. Sci Rep. 2017;7:14360 pubmed publisher
    ..In conclusion, deficiency of PCSK9 is associated with protection from venous thrombosis. This protection is associated with reduced leukocyte recruitment and NET formation at the site of thrombosis. ..