RICHARD EISENSTEIN

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi Isolation, characterization, and functional studies of rat liver iron regulatory protein 1
    R S Eisenstein
    Department of Nutritional Sciences, University of Wisconsin, Madison 53706, USA
    Arch Biochem Biophys 343:81-91. 1997
  2. ncbi Iron regulatory proteins and the molecular control of mammalian iron metabolism
    R S Eisenstein
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Annu Rev Nutr 20:627-62. 2000
  3. ncbi Novel roles for iron regulatory proteins in the adaptive response to iron deficiency
    Richard S Eisenstein
    Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA
    J Nutr 133:1510S-6S. 2003
  4. ncbi Iron deficiency decreases mitochondrial aconitase abundance and citrate concentration without affecting tricarboxylic acid cycle capacity in rat liver
    Kerry L Ross
    Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA
    J Nutr 132:643-51. 2002
  5. ncbi Evidence that phosphorylation of iron regulatory protein 1 at Serine 138 destabilizes the [4Fe-4S] cluster in cytosolic aconitase by enhancing 4Fe-3Fe cycling
    Kathryn M Deck
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    J Biol Chem 284:12701-9. 2009
  6. ncbi Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster
    Stephen L Clarke
    Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA
    EMBO J 25:544-53. 2006
  7. ncbi Multiple determinants within iron-responsive elements dictate iron regulatory protein binding and regulatory hierarchy
    Jeremy B Goforth
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    RNA 16:154-69. 2010
  8. ncbi Detection of a [3Fe-4S] cluster intermediate of cytosolic aconitase in yeast expressing iron regulatory protein 1. Insights into the mechanism of Fe-S cluster cycling
    Nina M Brown
    Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Biol Chem 277:7246-54. 2002
  9. ncbi An iron responsive element-like stem-loop regulates alpha-hemoglobin-stabilizing protein mRNA
    Camila O Dos Santos
    Division of Hematology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 283:26956-64. 2008
  10. ncbi Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis
    Oliver Stehling
    Institut für Zytobiologie und Zytopathologie, Philipps Universitat, Robert Koch Str 6, 35033 Marburg, Germany
    Mol Cell Biol 28:5517-28. 2008

Research Grants

  1. Biological Function of Iron Responsive Elements
    RICHARD EISENSTEIN; Fiscal Year: 2009
  2. Biological Function of Iron Responsive Elements
    RICHARD EISENSTEIN; Fiscal Year: 2007
  3. IRON METABOLISM AND PHOSPHORYLATION OF IRPS BY PKC
    RICHARD EISENSTEIN; Fiscal Year: 2002
  4. Biological Function of Iron Responsive Elements
    RICHARD EISENSTEIN; Fiscal Year: 2009

Collaborators

  • An Sheng Zhang
  • Michael K Georgieff
  • Kathryn M Deck
  • Sheila A Anderson
  • Jeremy B Goforth
  • Corinne Pondarre
  • Stephen L Clarke
  • Oliver Stehling
  • Camila O Dos Santos
  • Kerry L Ross
  • Aparna Vasanthakumar
  • Michelle L Wallander
  • Mark D Fleming
  • M Claire Kennedy
  • William E Antholine
  • Elizabeth A Leibold
  • Jenni Bradley
  • Nina M Brown
  • Nadia Gorman
  • Cindy N Roy
  • Christopher P Nizzi
  • Suresh G Shelat
  • Wei Wang
  • Louis C Dore
  • Helene Puccio
  • Antonio J Pierik
  • Daili J A Netz
  • Eric Valentine
  • Brigitte Niggemeyer
  • Fernando F Costa
  • Ralf Rösser
  • Manik Ghosh
  • Mitchell J Weiss
  • Ross C Hardison
  • Roland Lill
  • Jeffery L Kutok
  • An Ping Han
  • Amy Medlock
  • Cheryl M Koh
  • Joseph S Pitula
  • Charles J Epstein
  • Eric L Greer
  • Alice McDonald
  • Brendan B Antiochos
  • Dean R Campagna
  • An-Ping Han
  • Kimberly B Zumbrennen
  • Stephen Clarke
  • Jane D Wobken
  • Z Leah Harris
  • Peter R Sinclair
  • Timothy P Dalton
  • Paige S Davies
  • Emily L Anderson
  • William E Walden
  • Daniel W Nebert
  • Jacqueline F Sinclair
  • Glenn S Gerhard
  • Juliana G Szakacs
  • Kenneth P Blemings
  • Caroline A Enns
  • William J Bement
  • Heidi S Walton

Detail Information

Publications16

  1. ncbi Isolation, characterization, and functional studies of rat liver iron regulatory protein 1
    R S Eisenstein
    Department of Nutritional Sciences, University of Wisconsin, Madison 53706, USA
    Arch Biochem Biophys 343:81-91. 1997
    ....
  2. ncbi Iron regulatory proteins and the molecular control of mammalian iron metabolism
    R S Eisenstein
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Annu Rev Nutr 20:627-62. 2000
    ....
  3. ncbi Novel roles for iron regulatory proteins in the adaptive response to iron deficiency
    Richard S Eisenstein
    Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA
    J Nutr 133:1510S-6S. 2003
    ..We conclude that IRP are required for the regulation of physiological pathways that include but are not limited to iron metabolism, and as such, IRP are critical factors in the adaptive response to iron deficiency...
  4. ncbi Iron deficiency decreases mitochondrial aconitase abundance and citrate concentration without affecting tricarboxylic acid cycle capacity in rat liver
    Kerry L Ross
    Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA
    J Nutr 132:643-51. 2002
    ....
  5. ncbi Evidence that phosphorylation of iron regulatory protein 1 at Serine 138 destabilizes the [4Fe-4S] cluster in cytosolic aconitase by enhancing 4Fe-3Fe cycling
    Kathryn M Deck
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    J Biol Chem 284:12701-9. 2009
    ....
  6. ncbi Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster
    Stephen L Clarke
    Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA
    EMBO J 25:544-53. 2006
    ..Our results reveal a mechanism for regulating IRP1 action relevant to the control of iron homeostasis during cell proliferation, inflammation, and in response to diseases altering cytosolic Fe-S cluster assembly or disassembly...
  7. ncbi Multiple determinants within iron-responsive elements dictate iron regulatory protein binding and regulatory hierarchy
    Jeremy B Goforth
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    RNA 16:154-69. 2010
    ....
  8. ncbi Detection of a [3Fe-4S] cluster intermediate of cytosolic aconitase in yeast expressing iron regulatory protein 1. Insights into the mechanism of Fe-S cluster cycling
    Nina M Brown
    Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Biol Chem 277:7246-54. 2002
    ..Further, our results support the view that phosphorylation of IRP1 can modulate its response to iron through effects on Fe-S cluster stability and turnover...
  9. ncbi An iron responsive element-like stem-loop regulates alpha-hemoglobin-stabilizing protein mRNA
    Camila O Dos Santos
    Division of Hematology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 283:26956-64. 2008
    ..In addition, we illustrate a new mechanism through which hemoglobin may be modulated according to iron status...
  10. ncbi Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis
    Oliver Stehling
    Institut für Zytobiologie und Zytopathologie, Philipps Universitat, Robert Koch Str 6, 35033 Marburg, Germany
    Mol Cell Biol 28:5517-28. 2008
    ....
  11. ncbi Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin
    An Sheng Zhang
    Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 282:12547-56. 2007
    ..The finding that neither BMP4 nor its antagonist, noggin, was able to alter HJV shedding support the lack of involvement of BMP signaling pathway in this process...
  12. ncbi Molecular control of vertebrate iron homeostasis by iron regulatory proteins
    Michelle L Wallander
    Department of Oncological Sciences, University of Utah, 15N. 2030E, Salt Lake City, UT 84112, USA
    Biochim Biophys Acta 1763:668-89. 2006
    ....
  13. ncbi The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis
    Corinne Pondarre
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 15:953-64. 2006
    ..Altogether, these studies demonstrate the essential nature of Abcb7 in mammals and further substantiate a central role for mitochondria in the biogenesis of cytosolic Fe-S proteins...
  14. ncbi Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells
    Cindy N Roy
    Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon 97201-3098, USA
    J Cell Physiol 190:218-26. 2002
    ..These results all point to the direct effect of the interaction of HFE with transferrin receptor in lowering the intracellular labile iron pool and establishing a new set point for iron regulation within the cell...
  15. ncbi Influence of gestational age and fetal iron status on IRP activity and iron transporter protein expression in third-trimester human placenta
    Jenni Bradley
    University of Minnesota, Mayo Mail Code 39, 420 Delaware St. SE, Minneapolis, MN 55455, USA
    Am J Physiol Regul Integr Comp Physiol 287:R894-901. 2004
    ..IRP-1 may have a more dominant role than IRP-2 activity in regulating ferritin expression...
  16. ncbi Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron
    Nadia Gorman
    VA Medical Center, White River Junction, VT 05009, USA
    Hepatology 35:912-21. 2002
    ....

Research Grants11

  1. Biological Function of Iron Responsive Elements
    RICHARD EISENSTEIN; Fiscal Year: 2009
    ..abstract_text> ..
  2. Biological Function of Iron Responsive Elements
    RICHARD EISENSTEIN; Fiscal Year: 2007
    ..abstract_text> ..
  3. IRON METABOLISM AND PHOSPHORYLATION OF IRPS BY PKC
    RICHARD EISENSTEIN; Fiscal Year: 2002
    ....
  4. Biological Function of Iron Responsive Elements
    RICHARD EISENSTEIN; Fiscal Year: 2009
    ..This proposal focuses on elucidating the role of each IRP in the control of liver iron metabolism and function and its impact on the maintenance of whole body iron homeostasis. ..