George Eisenbarth

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. ncbi Prevention of type 1A diabetes mellitus
    George S Eisenbarth
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Endocr Pract 18:745-9. 2012
  2. ncbi Congruence as a measurement of extended haplotype structure across the genome
    Erin E Baschal
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Denver, CO 80045, USA
    J Transl Med 10:32. 2012
  3. ncbi Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice
    Georgia Fousteri
    Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Diabetes 61:1169-79. 2012
  4. ncbi The HLA-B 3906 allele imparts a high risk of diabetes only on specific HLA-DR/DQ haplotypes
    E E Baschal
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, Box B140, Aurora, CO 80045 6511, USA
    Diabetologia 54:1702-9. 2011
  5. ncbi Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity
    Béatrice Regnault
    Immunophysiology and Intracellular Parasitism Unit, Department of Parasitology and Mycology, 75015 Paris, France
    BMC Med Genomics 2:63. 2009
  6. ncbi Distinguishing persistent insulin autoantibodies with differential risk: nonradioactive bivalent proinsulin/insulin autoantibody assay
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 61:179-86. 2012
  7. ncbi Dominant suppression of Addison's disease associated with HLA-B15
    Peter R Baker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045 6511, USA
    J Clin Endocrinol Metab 96:2154-62. 2011

Research Grants

  1. Antibodies to Recombinant Autoantigens: Prediction
    George Eisenbarth; Fiscal Year: 2004
  2. Multiple Autoantigens/Multiple Epitopes of Type 1DM
    George Eisenbarth; Fiscal Year: 2004
  3. Modeling and Detecting Pathogens of Islet Autoimmunity
    George Eisenbarth; Fiscal Year: 2005
  4. IN VIVO NOD EVALUATION OF A PATHOGENIC INSULIN PEPTIDE
    George Eisenbarth; Fiscal Year: 2005
  5. In Vivo Evaluation of a "Pathogenic" Insulin Peptide
    George Eisenbarth; Fiscal Year: 2007
  6. Multiple Autoantigens/Multiple Epitopes of Type 1 DM
    George Eisenbarth; Fiscal Year: 2007
  7. Multiple Autoantigens/Multiple Epitopes of Type 1 DM
    George Eisenbarth; Fiscal Year: 2009
  8. In Vivo Evaluation of a "Pathogenic" Insulin Peptide
    George Eisenbarth; Fiscal Year: 2009
  9. ANTIBODIES TO RECOMBINENT AUTOANTIGENS--PREDICT
    George Eisenbarth; Fiscal Year: 2000
  10. IN VIVO NOD EVALUATION OF A PATHOGENIC INSULIN PEPTIDE
    George Eisenbarth; Fiscal Year: 2000

Collaborators

  • Marian Rewers
  • Liping Yu
  • Erin E Baschal
  • Georgia Fousteri
  • Janet C Siebert
  • E E Baschal
  • Peter R Baker
  • Béatrice Regnault
  • Therese Juntti
  • Ghanashyam Sarikonda
  • Jean Jasinski
  • Florence Lambolez
  • Jean M Jasinski
  • Michael Croft
  • Philippe Pagni
  • Amy Dave
  • Yang Cheng
  • Maki Nakayama
  • Hilde Cheroutre
  • Theresa A Boyle
  • Matthias von Herrath
  • Pamela R Fain
  • Peter A Gottlieb
  • K R Eyring
  • Taylor K Armstrong
  • J C Siebert
  • Jennifer M Barker
  • J M Jasinski
  • Pam R Fain
  • P R Baker
  • Taylor M Triolo
  • Sunanda R Babu
  • Priyaanka Nanduri
  • Dongmei Miao
  • Evie Melanitou
  • José Osorio y Fortéa

Detail Information

Publications7

  1. ncbi Prevention of type 1A diabetes mellitus
    George S Eisenbarth
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Endocr Pract 18:745-9. 2012
    ..To review prediction of type 1 diabetes mellitus in light of current trials for prevention and novel preclinical therapies...
  2. ncbi Congruence as a measurement of extended haplotype structure across the genome
    Erin E Baschal
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Denver, CO 80045, USA
    J Transl Med 10:32. 2012
    ..Confronted with high-density SNP data across the major histocompatibility complex (MHC) for 2,300 complete families, compiled by the Type 1 Diabetes Genetics Consortium (T1DGC), we developed software for studying extended haplotypes...
  3. ncbi Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice
    Georgia Fousteri
    Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Diabetes 61:1169-79. 2012
    ..They suggest that once central tolerance is bypassed, autoreactive cells arriving in the periphery do not by default follow solely a pathogenic fate upon activation...
  4. ncbi The HLA-B 3906 allele imparts a high risk of diabetes only on specific HLA-DR/DQ haplotypes
    E E Baschal
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, Box B140, Aurora, CO 80045 6511, USA
    Diabetologia 54:1702-9. 2011
    ..We investigated the risk associated with HLA-B*39 alleles in the context of specific HLA-DR/DQ haplotypes...
  5. ncbi Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity
    Béatrice Regnault
    Immunophysiology and Intracellular Parasitism Unit, Department of Parasitology and Mycology, 75015 Paris, France
    BMC Med Genomics 2:63. 2009
    ..Analysis of gene expression profiles has the potential to provide a global understanding of the disease and to generate novel hypothesis concerning the initiation of the autoimmune process...
  6. ncbi Distinguishing persistent insulin autoantibodies with differential risk: nonradioactive bivalent proinsulin/insulin autoantibody assay
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 61:179-86. 2012
    ..We hypothesize that factors related to the mechanism of loss of tolerance leading to diabetes determine high affinity and MSD-IAA reactivity...
  7. ncbi Dominant suppression of Addison's disease associated with HLA-B15
    Peter R Baker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045 6511, USA
    J Clin Endocrinol Metab 96:2154-62. 2011
    ..Highest genetic risk is associated with the Major Histocompatibility region (MHC), specifically human leukocyte antigen (HLA)-DR3 haplotypes (containing HLA-B8) and HLA-DR4...

Research Grants32

  1. Antibodies to Recombinant Autoantigens: Prediction
    George Eisenbarth; Fiscal Year: 2004
    ....
  2. Multiple Autoantigens/Multiple Epitopes of Type 1DM
    George Eisenbarth; Fiscal Year: 2004
    ..Pancreas from such individuals would allow histologic analysis, studies of disease pathogenesis (e.g. TCR usage and virology), and we believe most importantly T cell cloning from diseased islets. ..
  3. Modeling and Detecting Pathogens of Islet Autoimmunity
    George Eisenbarth; Fiscal Year: 2005
    ....
  4. IN VIVO NOD EVALUATION OF A PATHOGENIC INSULIN PEPTIDE
    George Eisenbarth; Fiscal Year: 2005
    ..4. Evaluate insulin peptide B:9-23 and altered peptide ligand for disease prevention in native NOD mice and mice with altered sequence. ..
  5. In Vivo Evaluation of a "Pathogenic" Insulin Peptide
    George Eisenbarth; Fiscal Year: 2007
    ....
  6. Multiple Autoantigens/Multiple Epitopes of Type 1 DM
    George Eisenbarth; Fiscal Year: 2007
    ....
  7. Multiple Autoantigens/Multiple Epitopes of Type 1 DM
    George Eisenbarth; Fiscal Year: 2009
    ..abstract_text> ..
  8. In Vivo Evaluation of a "Pathogenic" Insulin Peptide
    George Eisenbarth; Fiscal Year: 2009
    ..abstract_text> ..
  9. ANTIBODIES TO RECOMBINENT AUTOANTIGENS--PREDICT
    George Eisenbarth; Fiscal Year: 2000
    ..Of note, even the randomized non-treated (parenteral trial) or placebo treated (oral antigen trial of DPT) will exceed in numbers current "natural" history studies. ..
  10. IN VIVO NOD EVALUATION OF A PATHOGENIC INSULIN PEPTIDE
    George Eisenbarth; Fiscal Year: 2000
    ..3a, and additionally express J-alpha 34 or 45, with the shared J- alpha motif KLTFGKGT. Similar restriction is not apparent in the T cell receptor beta chains of these clones. ..
  11. Multiple Autoantigens/Multiple Epitopes of Type 1 DM
    George S Eisenbarth; Fiscal Year: 2010
    ..abstract_text> ..