George Eisenbarth

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. doi Prevention of type 1A diabetes mellitus
    George S Eisenbarth
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Endocr Pract 18:745-9. 2012
  2. pmc Congruence as a measurement of extended haplotype structure across the genome
    Erin E Baschal
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Denver, CO 80045, USA
    J Transl Med 10:32. 2012
  3. pmc Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice
    Georgia Fousteri
    Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Diabetes 61:1169-79. 2012
  4. pmc The HLA-B 3906 allele imparts a high risk of diabetes only on specific HLA-DR/DQ haplotypes
    E E Baschal
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, Box B140, Aurora, CO 80045 6511, USA
    Diabetologia 54:1702-9. 2011
  5. pmc Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity
    Béatrice Regnault
    Immunophysiology and Intracellular Parasitism Unit, Department of Parasitology and Mycology, 75015 Paris, France
    BMC Med Genomics 2:63. 2009
  6. pmc Distinguishing persistent insulin autoantibodies with differential risk: nonradioactive bivalent proinsulin/insulin autoantibody assay
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 61:179-86. 2012
  7. ncbi Comparative study of oral versus subcutaneous B:9-23 insulin peptide in Balb/c mice as an experimental model for autoimmune diabetes
    Devasenan Devendra
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Ann N Y Acad Sci 1029:331-3. 2004
  8. ncbi Absence of the T-bet gene coding for the Th1-related transcription factor does not affect diabetes-associated phenotypes in Balb/c mice
    Evie Melanitou
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, Denver, Colorado 80262, USA
    Ann N Y Acad Sci 1005:187-91. 2003
  9. pmc Genetic determinants of 21-hydroxylase autoantibodies amongst patients of the Type 1 Diabetes Genetics Consortium
    Peter Baker
    Barbara Davis Center for Childhood Diabetes, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 97:E1573-8. 2012
  10. ncbi The second murine autoantibody workshop: remarkable interlaboratory concordance for radiobinding assays to identify insulin autoantibodies in nonobese diabetic mice
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Ann N Y Acad Sci 1005:1-12. 2003

Research Grants

  1. IN VIVO NOD EVALUATION OF A PATHOGENIC INSULIN PEPTIDE
    George Eisenbarth; Fiscal Year: 1999
  2. Modeling and Detecting Pathogens of Islet Autoimmunity
    George Eisenbarth; Fiscal Year: 2005
  3. Multiple Autoantigens/Multiple Epitopes of Type 1DM
    George Eisenbarth; Fiscal Year: 2002
  4. Antibodies to Recombinant Autoantigens: Prediction
    George Eisenbarth; Fiscal Year: 2004
  5. Multiple Autoantigens/Multiple Epitopes of Type 1DM
    George Eisenbarth; Fiscal Year: 2004
  6. IN VIVO NOD EVALUATION OF A PATHOGENIC INSULIN PEPTIDE
    George Eisenbarth; Fiscal Year: 2005
  7. In Vivo Evaluation of a "Pathogenic" Insulin Peptide
    George Eisenbarth; Fiscal Year: 2006
  8. Multiple Autoantigens/Multiple Epitopes of Type 1 DM
    George Eisenbarth; Fiscal Year: 2006
  9. In Vivo Evaluation of a "Pathogenic" Insulin Peptide
    George Eisenbarth; Fiscal Year: 2007
  10. Multiple Autoantigens/Multiple Epitopes of Type 1 DM
    George Eisenbarth; Fiscal Year: 2007

Collaborators

  • Liping Yu
  • Marian Rewers
  • Edwin Liu
  • Ezio Bonifacio
  • Mark Atkinson
  • Devasenan Devendra
  • Evie Melanitou
  • Klaus Badenhoop
  • Erin E Baschal
  • Peter Baker
  • Georgia Fousteri
  • Janet C Siebert
  • Peter R Baker
  • E E Baschal
  • Béatrice Regnault
  • Therese Juntti
  • Michael Croft
  • Jean Jasinski
  • Philippe Pagni
  • Hilde Cheroutre
  • Florence Lambolez
  • Maki Nakayama
  • Janet Wenzlau
  • Ghanashyam Sarikonda
  • Pamela R Fain
  • Amy Dave
  • Yang Cheng
  • Theresa A Boyle
  • John Hutton
  • Heinrich Kahles
  • Pam Fain
  • Matthias von Herrath
  • Jean M Jasinski
  • Jennifer M Barker
  • Taylor K Armstrong
  • Pam R Fain
  • P R Baker
  • K R Eyring
  • J C Siebert
  • Taylor M Triolo
  • Peter A Gottlieb
  • J M Jasinski
  • Priyaanka Nanduri
  • Sunanda R Babu
  • José Osorio y Fortéa
  • Dongmei Miao

Detail Information

Publications13

  1. doi Prevention of type 1A diabetes mellitus
    George S Eisenbarth
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Endocr Pract 18:745-9. 2012
    ..To review prediction of type 1 diabetes mellitus in light of current trials for prevention and novel preclinical therapies...
  2. pmc Congruence as a measurement of extended haplotype structure across the genome
    Erin E Baschal
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Denver, CO 80045, USA
    J Transl Med 10:32. 2012
    ..Confronted with high-density SNP data across the major histocompatibility complex (MHC) for 2,300 complete families, compiled by the Type 1 Diabetes Genetics Consortium (T1DGC), we developed software for studying extended haplotypes...
  3. pmc Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice
    Georgia Fousteri
    Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Diabetes 61:1169-79. 2012
    ..They suggest that once central tolerance is bypassed, autoreactive cells arriving in the periphery do not by default follow solely a pathogenic fate upon activation...
  4. pmc The HLA-B 3906 allele imparts a high risk of diabetes only on specific HLA-DR/DQ haplotypes
    E E Baschal
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, Box B140, Aurora, CO 80045 6511, USA
    Diabetologia 54:1702-9. 2011
    ..We investigated the risk associated with HLA-B*39 alleles in the context of specific HLA-DR/DQ haplotypes...
  5. pmc Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity
    Béatrice Regnault
    Immunophysiology and Intracellular Parasitism Unit, Department of Parasitology and Mycology, 75015 Paris, France
    BMC Med Genomics 2:63. 2009
    ..Analysis of gene expression profiles has the potential to provide a global understanding of the disease and to generate novel hypothesis concerning the initiation of the autoimmune process...
  6. pmc Distinguishing persistent insulin autoantibodies with differential risk: nonradioactive bivalent proinsulin/insulin autoantibody assay
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 61:179-86. 2012
    ..We hypothesize that factors related to the mechanism of loss of tolerance leading to diabetes determine high affinity and MSD-IAA reactivity...
  7. ncbi Comparative study of oral versus subcutaneous B:9-23 insulin peptide in Balb/c mice as an experimental model for autoimmune diabetes
    Devasenan Devendra
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Ann N Y Acad Sci 1029:331-3. 2004
    ..The insulin autoantibodies induced react with insulin and not the immunizing peptide. Oral administration of insulin as well as subcutaneous insulin can sensitize to insulin...
  8. ncbi Absence of the T-bet gene coding for the Th1-related transcription factor does not affect diabetes-associated phenotypes in Balb/c mice
    Evie Melanitou
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, Denver, Colorado 80262, USA
    Ann N Y Acad Sci 1005:187-91. 2003
    ..We have therefore investigated whether absence of the T-bet gene influences diabetes-related phenotypes in Balb/c T-bet KO mice...
  9. pmc Genetic determinants of 21-hydroxylase autoantibodies amongst patients of the Type 1 Diabetes Genetics Consortium
    Peter Baker
    Barbara Davis Center for Childhood Diabetes, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 97:E1573-8. 2012
    ..Screening for 21OH-AA in newly diagnosed T1DM patients is a valuable prognostic tool, made stronger when MHC genotype is considered...
  10. ncbi The second murine autoantibody workshop: remarkable interlaboratory concordance for radiobinding assays to identify insulin autoantibodies in nonobese diabetic mice
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Ann N Y Acad Sci 1005:1-12. 2003
    ..In sum, this workshop continued to support the notion that IAA, as determined by RIA, could provide a sensitive and specific marker of anti-beta cell immunity in NOD mice...
  11. pmc Dominant suppression of Addison's disease associated with HLA-B15
    Peter R Baker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045 6511, USA
    J Clin Endocrinol Metab 96:2154-62. 2011
    ..Highest genetic risk is associated with the Major Histocompatibility region (MHC), specifically human leukocyte antigen (HLA)-DR3 haplotypes (containing HLA-B8) and HLA-DR4...

Research Grants32

  1. IN VIVO NOD EVALUATION OF A PATHOGENIC INSULIN PEPTIDE
    George Eisenbarth; Fiscal Year: 1999
    ..3a, and additionally express J-alpha 34 or 45, with the shared J- alpha motif KLTFGKGT. Similar restriction is not apparent in the T cell receptor beta chains of these clones. ..
  2. Modeling and Detecting Pathogens of Islet Autoimmunity
    George Eisenbarth; Fiscal Year: 2005
    ....
  3. Multiple Autoantigens/Multiple Epitopes of Type 1DM
    George Eisenbarth; Fiscal Year: 2002
    ..Pancreas from such individuals would allow histologic analysis, studies of disease pathogenesis (e.g. TCR usage and virology), and we believe most importantly T cell cloning from diseased islets. ..
  4. Antibodies to Recombinant Autoantigens: Prediction
    George Eisenbarth; Fiscal Year: 2004
    ....
  5. Multiple Autoantigens/Multiple Epitopes of Type 1DM
    George Eisenbarth; Fiscal Year: 2004
    ..Pancreas from such individuals would allow histologic analysis, studies of disease pathogenesis (e.g. TCR usage and virology), and we believe most importantly T cell cloning from diseased islets. ..
  6. IN VIVO NOD EVALUATION OF A PATHOGENIC INSULIN PEPTIDE
    George Eisenbarth; Fiscal Year: 2005
    ..4. Evaluate insulin peptide B:9-23 and altered peptide ligand for disease prevention in native NOD mice and mice with altered sequence. ..
  7. In Vivo Evaluation of a "Pathogenic" Insulin Peptide
    George Eisenbarth; Fiscal Year: 2006
    ....
  8. Multiple Autoantigens/Multiple Epitopes of Type 1 DM
    George Eisenbarth; Fiscal Year: 2006
    ....
  9. In Vivo Evaluation of a "Pathogenic" Insulin Peptide
    George Eisenbarth; Fiscal Year: 2007
    ....
  10. Multiple Autoantigens/Multiple Epitopes of Type 1 DM
    George Eisenbarth; Fiscal Year: 2007
    ....
  11. Multiple Autoantigens/Multiple Epitopes of Type 1 DM
    George Eisenbarth; Fiscal Year: 2009
    ..abstract_text> ..
  12. In Vivo Evaluation of a "Pathogenic" Insulin Peptide
    George Eisenbarth; Fiscal Year: 2009
    ..abstract_text> ..
  13. Modeling and Detecting Pathogens of Islet Autoimmunity
    George Eisenbarth; Fiscal Year: 2004
    ....
  14. IN VIVO NOD EVALUATION OF A PATHOGENIC INSULIN PEPTIDE
    George Eisenbarth; Fiscal Year: 2004
    ..4. Evaluate insulin peptide B:9-23 and altered peptide ligand for disease prevention in native NOD mice and mice with altered sequence. ..
  15. Multiple Autoantigens/Multiple Epitopes of Type 1DM
    George Eisenbarth; Fiscal Year: 2003
    ..Pancreas from such individuals would allow histologic analysis, studies of disease pathogenesis (e.g. TCR usage and virology), and we believe most importantly T cell cloning from diseased islets. ..
  16. ANTIBODIES TO RECOMBINENT AUTOANTIGENS--PREDICT
    George Eisenbarth; Fiscal Year: 1999
    ..Of note, even the randomized non-treated (parenteral trial) or placebo treated (oral antigen trial of DPT) will exceed in numbers current "natural" history studies. ..
  17. ANTIBODIES TO RECOMBINENT AUTOANTIGENS--PREDICT
    George Eisenbarth; Fiscal Year: 2000
    ..Of note, even the randomized non-treated (parenteral trial) or placebo treated (oral antigen trial of DPT) will exceed in numbers current "natural" history studies. ..
  18. IN VIVO NOD EVALUATION OF A PATHOGENIC INSULIN PEPTIDE
    George Eisenbarth; Fiscal Year: 2000
    ..3a, and additionally express J-alpha 34 or 45, with the shared J- alpha motif KLTFGKGT. Similar restriction is not apparent in the T cell receptor beta chains of these clones. ..
  19. Multiple Autoantigens/Multiple Epitopes of Type 1DM
    George Eisenbarth; Fiscal Year: 2001
    ..Pancreas from such individuals would allow histologic analysis, studies of disease pathogenesis (e.g. TCR usage and virology), and we believe most importantly T cell cloning from diseased islets. ..
  20. Antibodies to Recombinant Autoantigens: Prediction
    George Eisenbarth; Fiscal Year: 2001
    ....
  21. Modeling and Detecting Pathogens of Islet Autoimmunity
    George Eisenbarth; Fiscal Year: 2002
    ....
  22. IN VIVO NOD EVALUATION OF A PATHOGENIC INSULIN PEPTIDE
    George Eisenbarth; Fiscal Year: 2002
    ..4. Evaluate insulin peptide B:9-23 and altered peptide ligand for disease prevention in native NOD mice and mice with altered sequence. ..
  23. Antibodies to Recombinant Autoantigens: Prediction
    George Eisenbarth; Fiscal Year: 2002
    ....
  24. Modeling and Detecting Pathogens of Islet Autoimmunity
    George Eisenbarth; Fiscal Year: 2003
    ....
  25. IN VIVO NOD EVALUATION OF A PATHOGENIC INSULIN PEPTIDE
    George Eisenbarth; Fiscal Year: 2003
    ..4. Evaluate insulin peptide B:9-23 and altered peptide ligand for disease prevention in native NOD mice and mice with altered sequence. ..
  26. Antibodies to Recombinant Autoantigens: Prediction
    George Eisenbarth; Fiscal Year: 2003
    ....
  27. Multiple Autoantigens/Multiple Epitopes of Type 1 DM
    George S Eisenbarth; Fiscal Year: 2010
    ..abstract_text> ..