Research Topics
Genomes and Genes
| G S EisenbarthSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Publications
Conserved T cell receptor alpha-chain induces insulin autoantibodiesMasakazu Kobayashi
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 105:10090-4. 2008..We suggest that a major part of the mystery as to why islet autoimmunity develops relates to recognition of a primary insulin peptide by a conserved alpha chain T cell receptor...
Insulin autoimmunity: immunogenetics/immunopathogenesis of type 1A diabetesGeorge S Eisenbarth
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Ann N Y Acad Sci 1005:109-18. 2003..Nevertheless, at present, routine measurement of anti-insulin T lymphocytes is not standardized. Better assays to monitor such autoreactivity are likely to be essential for the development and evaluation of preventive therapies...- The frequent and conserved DR3-B8-A1 extended haplotype confers less diabetes risk than other DR3 haplotypesE E Baschal
Barbara Davis Center for Childhood Diabetes, Department of Pediatrics, University of Colorado Denver, Aurora, CO, USA
Diabetes Obes Metab 11:25-30. 2009.... - Banting Lecture 2009: An Unfinished Journey: Molecular Pathogenesis to Prevention of Type 1A DiabetesGeorge S Eisenbarth
Corresponding author George S Eisenbarth
Diabetes 59:759-74. 2010..He presented the Banting Lecture, An Unfinished Journey-Type 1 Diabetes-Molecular Pathogenesis to Prevention, on Sunday, June 7, 2009... - Insulin autoimmunity: prediction/precipitation/prevention type 1A diabetesGeorge S Eisenbarth
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 140, Denver, CO 80262, USA
Autoimmun Rev 1:139-45. 2002..An expanding set of resources are now available for the development and testing in man of therapies to prevent type 1 diabetes, and a number of trials utilizing insulin peptides are now underway... - The natural history of type 1A diabetesGeorge S Eisenbarth
Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, CO, USA
Arq Bras Endocrinol Metabol 52:146-55. 2008..We can also prevent type 1A diabetes in animal models and a major goal is the prevention of type 1A diabetes in man with multiple clinical trials underway... - Trials of immunotherapy to preserve beta-cell function of prediabetic and new-onset patient trialsGeorge S Eisenbarth
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, Denver, CO 80262, USA
Curr Diab Rep 4:85-6. 2004 - Disease prevention with islet autoantigensGeorge S Eisenbarth
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B-140, Denver, CO 80262, USA
Endocrinol Metab Clin North Am 33:59-73, viii. 2004 - Update in type 1 diabetesGeorge S Eisenbarth
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Mail Stop B140, P O Box 6511, Aurora, Colorado 80045 6511, USA
J Clin Endocrinol Metab 92:2403-7. 2007..Type 1 diabetes is a heterogeneous disorder characterized by severe beta-cell loss. The great majority of patients have type 1A or immune-mediated diabetes... - Autoimmune polyendocrine syndromesGeorge S Eisenbarth
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
N Engl J Med 350:2068-79. 2004 - Enumerating autoreactive T cells in peripheral blood: a big step in diabetes predictionGeorge S Eisenbarth
Department of Pediatrics, Barbara Davis Diabetes Center for Childhood Diabetes, Denver, Colorado, USA
J Clin Invest 111:179-81. 2003 - Italian Society of Diabetology Mentor Award. The stages of Type 1A diabetes: retrospective and prospectiveG S Eisenbarth
Barbara Davis Center for Childhood Diabetes, University of Colorado, Health Sciences Center, Denver, CO 80262, USA
Diabetes Nutr Metab 17:374-85. 2004..Despite this increase in knowledge of the natural history of Type 1A diabetes and pathogenesis in animal models, much remains to be defined to allow efficient and successful disease prevention... - Long-term prevention of diabetes and marked suppression of insulin autoantibodies and insulitis in mice lacking native insulin B9-23 sequenceM Nakayama
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P.O. Box 6511, Aurora, CO 80045, USA
Ann N Y Acad Sci 1079:122-9. 2006..Insulin peptide B9-23 is likely a crucial target for initiation of islet autoimmunity and further mutation of the sequence will be tested to attempt to eliminate all anti-islet autoimmunity... - A new model of insulin-deficient diabetes: male NOD mice with a single copy of Ins1 and no Ins2N Babaya
Barbara Davis Center for Childhood Diabetes, University of Colorado, 1775 N Ursula St, Aurora, CO 80045 6511, USA
Diabetologia 49:1222-8. 2006..We describe a novel model of insulin-deficient diabetes with a single copy of the gene encoding insulin 1 (Ins1) and no gene encoding insulin 2 (Ins2)... - Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetesTaylor M Triolo
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Health Science Center, Aurora, CO 80045, USA
J Clin Endocrinol Metab 94:4517-23. 2009..Subjects with type 1 diabetes (T1D) are at increased risk for AD. Genetic factors including HLA-DRB1*0404 and MICA have been associated with AD in populations with and without T1D... - Rapid assays for detection of anti-islet autoantibodies: implications for organ donor screeningA K Maniatis
The Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver 80262, USA
J Autoimmun 16:71-6. 2001.... - Evidence for oligogenic inheritance of type 1 diabetes in a large Bedouin Arab familyC F Verge
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262 0001, USA
J Clin Invest 102:1569-75. 1998..D10S554 and D10S592 and the closest flanking markers are contained in a 1,240-kb yeast artificial chromosome, a region small enough to proceed with positional cloning... - Immunopathogenesis and immunotherapeutic approaches to type 1A diabetesAnita Azam
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
Expert Opin Biol Ther 4:1569-75. 2004..As T cells are the primary mediators of islet beta cell destruction, it is likely that improved therapies and monitoring of T cell autoimmunity will be necessary to develop a safe and effective therapy for type 1A diabetes... - Lack of association between early childhood immunizations and beta-cell autoimmunityP M Graves
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver 80262, USA
Diabetes Care 22:1694-7. 1999..To determine whether early childhood immunization history affects the risk of developing the beta-cell autoimmunity that precedes type 1 diabetes... - Peptide and major histocompatibility complex-specific breaking of humoral tolerance to native insulin with the B9-23 peptide in diabetes-prone and normal miceN Abiru
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 E. 9th Ave, Denver, CO 80262, USA
Diabetes 50:1274-81. 2001..Our results indicate that B-cell tolerance to intact insulin is readily broken with the presentation of the B9-23 insulin peptide, depending on the host's specific MHC... - Differential effects of DRB1*0301 and DQA1*0501-DQB1*0201 on the activation and progression of islet cell autoimmunityE Eller
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Genes Immun 8:628-33. 2007..Overall, our results emphasize the importance of prospective genetic studies that examine the full range of variation in the initiation, progression and expression of autoimmune disease... - Millennium award recipient contribution. Identification of children with early onset and high incidence of anti-islet autoantibodiesDavid T Robles
Barbara Davis Center, Department of Immunology, University of Colorado, Denver, Colorado 80262, USA
Clin Immunol 102:217-24. 2002..These results suggest that a high incidence and early appearance of islet autoantibodies for siblings of patients with type 1A diabetes are associated with DR3/4, DQB1*0302 and potentially increased with HLA-A genotype A1, A2... 
Triple chimeric islet autoantigen IA2-ZnT8WR to facilitate islet autoantibody determinationLiping Yu
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, United States
J Immunol Methods 353:20-3. 2010..The chimeric assay provides an efficient and economical technique to screen for islet autoantibodies reacting with IA-2 and ZnT8...- Investigation of the vitamin D receptor gene (VDR) and its interaction with protein tyrosine phosphatase, non-receptor type 2 gene (PTPN2) on risk of islet autoimmunity and type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY)B Frederiksen
Colorado School of Public Health, University of Colorado, Aurora, CO, USA
J Steroid Biochem Mol Biol 133:51-7. 2013..62). These findings should be replicated in larger cohorts for confirmation. The interaction between VDR and PTPN2 polymorphisms in the risk of progression to T1D offers insight concerning the role of vitamin D in the etiology of T1D... - Additional association of intra-MHC genes, MICA and D6S273, with Addison's diseaseY S Park
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, CO 80262, USA
Tissue Antigens 60:155-63. 2002..1/DRB1*0404-D6S273*134-MICA-A5.1 genotypes compared with that conferred by the DR3/4 controls. Susceptibility to Addison's disease is influenced by the genes around MICA and D6S273 for both the HLA DR3-DQ2 and DR4-DQ8 haplotypes... - Differential immune response to B:9-23 insulin 1 and insulin 2 peptides in animal models of type 1 diabetesD Devendra
Barbara Davis Center for Childhood Diabetes, 4200 East 9th Avenue, Box B140, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Autoimmun 23:17-26. 2004..This may relate to the protection conferred by the insulin 1 knockout when bred onto NOD mice in contrast to acceleration of disease with an insulin 2 knockout... - Genetics of type 1A diabetesM J Redondo
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
Recent Prog Horm Res 56:69-89. 2001..Studying the genetics of type 1A diabetes will allow us to better define this disease, to improve our ability to identify individuals at risk, and to predict the risk of associated disorders... - Transient insulin autoantibody expression independent of development of diabetes: comparison of NOD and NOR strainsN Abiru
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
J Autoimmun 17:1-6. 2001..In addition, this data is not consistent with the hypothesis that the time-course of autoantibodies simply reflects the destruction of beta-cells with development of diabetes... - Chronic autoimmunity of type I diabetesE Simone
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, USA
Horm Metab Res 28:332-6. 1996..We favor the hypothesis that insulin may be the primary autoantigen for type I diabetes, and therapies which after the immune response to insulin may lead to safe and effective preventive modalities... - Dimorphic histopathology of long-standing childhood-onset diabetesR Gianani
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Court, Aurora, CO 80055, USA
Diabetologia 53:690-8. 2010..The aim of this study was to characterise the pancreases of childhood-onset diabetes in order to define the pathological basis of this heterogeneity... - T cell receptor gene polymorphisms associated with anti-insulin, autoimmune T cells in diabetes-prone NOD miceE A Simone
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
J Autoimmun 10:317-21. 1997..We hypothesize that the presence and frequent utilization of the V alpha 13.3 T cell receptor element is involved in targeting insulin B-(9-23) and may be related to diabetes susceptibility of NOD mice... - Animal models of insulin-dependent diabetesEdwin Liu
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
Methods Mol Med 102:195-212. 2004..In summary, animal models have become necessary in the study of type 1 diabetes and provide researchers important tools to conduct studies that could not otherwise be performed in humans... - Defining multiple common "completely" conserved major histocompatibility complex SNP haplotypesErin E Baschal
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Building M20, Aurora, CO 80045 6511, USA
Clin Immunol 132:203-14. 2009..Such common identity, specifically across the MHC, impacts type 1 diabetes susceptibility and may impact transplantation between unrelated individuals... - Genetic determination of islet cell autoimmunity in monozygotic twin, dizygotic twin, and non-twin siblings of patients with type 1 diabetes: prospective twin studyM J Redondo
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B 140, Denver, CL 80262, USA
BMJ 318:698-702. 1999.... - Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjectsJ M Wenzlau
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
J Clin Endocrinol Metab 95:4712-9. 2010..Zinc transporter 8 (ZnT8) is a newly discovered islet autoantigen in human type 1A diabetes (T1D)... - Insulin as a primary autoantigen for type 1A diabetesJ M Jasinski
Human Medical Genetics Program, Aurora, CO 80010, USA
Clin Dev Immunol 12:181-6. 2005..We are pursuing the hypothesis that insulin is a primary autoantigen for type 1 diabetes, and thus the pathogenesis of the disease relates to specific recognition of one or more peptides... - Transracial evidence for the influence of the homologous HLA DR-DQ haplotype on transmission of HLA DR4 haplotypes to diabetic childrenY S Park
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA
Tissue Antigens 57:185-91. 2001..This might contribute not only to the synergistic effect of DR3/4, but also to the susceptibility influence of HLA DQB1*0401 alleles confined to DR4/X... - Expression of GAD65 and islet cell antibody (ICA512) autoantibodies among cytoplasmic ICA+ relatives is associated with eligibility for the Diabetes Prevention Trial-Type 1L Yu
Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver, Colorado 80262, USA
Diabetes 50:1735-40. 2001..Positivity for biochemically determined autoantibodies among cytoplasmic antibody-positive relatives is associated with eligibility for the DPT-1 study... - Haplotype analysis discriminates genetic risk for DR3-associated endocrine autoimmunity and helps define extreme risk for Addison's diseasePeter R Baker
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045 6511, USA
J Clin Endocrinol Metab 95:E263-70. 2010..Multiple autoimmune disorders (e.g. Addison's disease, type 1 diabetes, celiac disease) are associated with HLA-DR3, but it is likely that alleles of additional genes in linkage disequilibrium with HLA-DRB1 contribute to disease... - Genetic differentiation of poly I:C from B:9-23 peptide induced experimental autoimmune diabetesJohanna Paronen
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B140, Denver, CO 80262, USA
J Autoimmun 22:307-13. 2004..Interaction of genes and environment (antigenic epitope and viral mimic) can be important in the pathogenesis of immune mediated diabetes and activation of the innate immune system (e.g. Poly I:C) may be one key determinant... - Role of autoantibodies in type 1 diabetesDongmei Miao
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 1775 N Ursula Street, Aurora, Colorado 80010, USA
Front Biosci 12:1889-98. 2007..The ability to detect specific anti-islet autoantibodies provides the foundation for developing and testing these preventive therapies... - Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)Lars C Stene
Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO 80045-6511, USA
Pediatr Diabetes 7:247-53. 2006..4, 95% confidence interval 1.02-1.8, per SD of 1.1 mmol/L). CONCLUSIONS: Normal but increasing Hb1Ac may be useful in early detection of type 1 diabetes, whereas random plasma glucose levels were less predictive... - The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetesJanet M Wenzlau
Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, 1775 North Ursula Street, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 104:17040-5. 2007..The combination of bioinformatics and molecular engineering used here will potentially generate other diabetes autoimmunity markers and is also broadly applicable to other autoimmune disorders... - Murine high specificity/sensitivity competitive europium insulin autoantibody assayNaru Babaya
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado 80045 6511, USA
Diabetes Technol Ther 11:227-33. 2009..There is thus a need for simpler assay formats that do not utilize radioactivity, yet retain the high specificity and sensitivity of radioassays... - Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptideHiroaki Moriyama
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 99:5539-44. 2002..These first PolyIC/insulin-induced murine models should provide an important tool to study the pathogenesis of type 1 diabetes with experimental autoimmune diabetes... - The HLA-B 3906 allele imparts a high risk of diabetes only on specific HLA-DR/DQ haplotypesE E Baschal
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, Box B140, Aurora, CO 80045 6511, USA
Diabetologia 54:1702-9. 2011..We investigated the risk associated with HLA-B*39 alleles in the context of specific HLA-DR/DQ haplotypes... - Diagnosis and treatment of pre-insulin dependent diabetesP A Gottlieb
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
Annu Rev Med 49:391-405. 1998..This review discusses relevant aspects of the genetics and diagnosis of pre-diabetes, and both current and future clinical trials that are attempting to prevent the full expression of clinical diabetes in these individuals... - rs2476601 T allele (R620W) defines high-risk PTPN22 type I diabetes-associated haplotypes with preliminary evidence for an additional protective haplotypeA K Steck
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045 6511, USA
Genes Immun 10:S21-6. 2009..81, P=0.0005). This novel finding requires replication in independent populations. We conclude the major association of PTPN22 with T1D is likely due to the recognized non-synonymous SNP rs2476601 (R620W)... - Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United StatesM J Redondo
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140, 4200 East 9th Avenue, Denver, CO 80262, USA
Diabetologia 44:354-62. 2001..An age-related heterogeneity was observed, with higher progression to diabetes for twins of patients diagnosed at a younger age... - Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunityMaki Nakayama
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center UCHSC, Aurora, CO 80045 6511, USA
J Clin Invest 117:1835-43. 2007..Our findings demonstrate dependence on B16 alanine versus tyrosine of insulin B:9-23 for both the initial priming and the effector phase of NOD anti-islet autoimmunity... - Type 1 diabetes: chronic progressive autoimmune diseaseLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, CO 80010, USA
Novartis Found Symp 292:85-94; discussion 94-8, 122-9, 202-3. 2008..Given the ability to predict type 1A diabetes trials at all stages of the disorder to prevent beta cell destruction are now possible... - Homozygosity for premature stop codon of the MHC class I chain-related gene A (MIC-A) is associated with early activation of islet autoimmunity of DR3/4-DQ2/8 high risk DAISY relativesAkane Ide
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 1775 N Ursula Street, Aurora, Colorado, 80010, USA
J Clin Immunol 25:303-8. 2005..1 homozygosity suggesting that there are additional factors contributing to the marked risk of relatives compared to the general population with the DR3-DQ2/DR4-DQ8 genotype... - Dietary glycemic index, development of islet autoimmunity, and subsequent progression to type 1 diabetes in young childrenMolly M Lamb
University of Colorado, Denver, Colorado 80262, USA
J Clin Endocrinol Metab 93:3936-42. 2008..Dietary factors may trigger or exacerbate the autoimmune disease process... - Insulin autoantibodies are associated with islet inflammation but not always related to diabetes progression in NOD congenic miceDavid T Robles
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
Diabetes 52:882-6. 2003..It is likely that patients with type 1 diabetes will also show non-major histocompatibility complex genetically determined variation in expression of autoantibodies and progression to diabetes... - Extreme genetic risk for type 1A diabetesTheresa A Aly
Barbara Davis Center for Childhood Diabetes and Human Medical Genetics Program, University Colorado Health Sciences Center, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 103:14074-9. 2006..A subset of siblings at extremely high risk for T1D can now be identified at birth for trials to prevent islet autoimmunity... - Nondepleting anti-CD4 monoclonal antibody prevents diabetes and blocks induction of insulin autoantibodies following insulin peptide B:9-23 immunization in the NOD mouseEdwin Liu
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B140, Denver, CO 80262, USA
J Autoimmun 21:213-9. 2003..9) in NOD mice confers long-term protection from diabetes and insulitis and profoundly blocks spontaneous and B:9-23 peptide-induced insulin autoantibodies... - Association of the PTPN22/LYP gene with type 1 diabetesAndrea K Steck
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO, USA
Pediatr Diabetes 7:274-8. 2006..The goal of this study was to verify the association between type 1 diabetes (T1D) and the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene in non-Hispanic whites (NHWs) and Hispanics from Colorado... - The genetics of autoimmune polyendocrine syndrome type IIDavid T Robles
Medical Scientist Training Program, Department of Immunology, University of Colorado Health Sciences Center, Box B140, 4200 East 9th Ave, Denver, CO 80262, USA
Endocrinol Metab Clin North Am 31:353-68, vi-vii. 2002.... - Early and quantal (by litter) expression of insulin autoantibodies in the nonobese diabetic mice predict early diabetes onsetEvie Melanitou
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Immunol 173:6603-10. 2004..Pathological progression to autoimmunity is marked by the presence of immunological windows relating early steps with final disease onset... - Deleting islet autoimmunityEdwin Liu
Barbara Davis Center for Childhood Diabetes, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO, USA
Cell Biochem Biophys 48:177-82. 2007..In this article, we review current literature regarding insulin as an autoantigen and potential approaches to deleting insulin-reactive T cells through the use of peptide vaccines and targeted T cell receptor immunizations... - Genetic determinants of type 1 diabetes across populationsMohamed M Jahromi
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, PO Box 6511, Aurora, CO 80010, USA
Ann N Y Acad Sci 1079:289-99. 2006..In this article, we discuss global variations in genetic susceptibility to T1D in view of current genetic understanding... - HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY populationErin E Baschal
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045 6511, USA
Diabetes 56:2405-9. 2007.... - Prime role for an insulin epitope in the development of type 1 diabetes in NOD miceMaki Nakayama
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Nature 435:220-3. 2005.... - Two subsets of HLA-DQA1 alleles mark phenotypic variation in levels of insulin autoantibodies in first degree relatives at risk for insulin-dependent diabetesA Pugliese
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262
J Clin Invest 93:2447-52. 1994..Thus, HLA-DQB1 GL alleles, or other genes on haplotypes (e.g., DR3) that carry these DQA1 alleles, may confer recessive low responsiveness to insulin... - Conserved epitopes in the protein tyrosine phosphatase family of diabetes autoantigensY Liu
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
Ann N Y Acad Sci 1150:245-7. 2008..1% to FLYDA, and 33.7% to IDA. The majority of sera that bound FLYDA and/or IDA also recognized IA2. This raises the possibility that in some cases reactivity to IA2 may have arisen by molecular mimicry... - Thymic expression of mutated B16:A preproinsulin messenger RNA does not reverse acceleration of NOD diabetes associated with insulin 2 (thymic expressed insulin) knockoutM Nakayama
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Mail Stop B 140, P O Box 6511, Aurora, CO 80045, USA
J Autoimmun 25:193-8. 2005..Further experiments varying native insulin message expression in thymus is necessary for direct comparison, but the current study provides additional evidence of the potential important role of a specific insulin B chain epitope... - Humoral autoreactivity to an alternatively spliced variant of ICA512/IA-2 in Type I diabetesY S Park
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
Diabetologia 43:1293-301. 2000..We investigated whether alternative splicing could affect humoral autoreactivity to the molecule... - Clinical features of children with screening-identified evidence of celiac diseaseEdward J Hoffenberg
Department of Pediatrics, Children s Hospital, and the University of Colorado School of Medicine, Denver, Colorado, USA
Pediatrics 113:1254-9. 2004..However, the clinical significance of a positive test remains uncertain. The objective of this study was to evaluate growth and clinical features of children who test positive for an autoantibody associated with CD... - Prediction of type 1 diabetes: the natural history of the prediabetic periodGeorge S Eisenbarth
Barbara Davis Center for Childhood Diabetes, University of Colorado, Health Sciences Center, Denver, USA
Adv Exp Med Biol 552:268-90. 2004 - Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouseHiroaki Moriyama
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 100:10376-81. 2003..These observations indicate that loss of either insulin gene can influence progression to diabetes of NOD mice and suggest that the preproinsulin 1 gene is crucial for the spontaneous development of NOD insulitis and diabetes... - A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetesJanet M Wenzlau
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
Diabetes 57:2693-7. 2008..The type 2 diabetes nonsynonymous single nucleotide polymorphism (SNP) affecting aa(325) lies within the region of highest ZnT8 autoantibody (ZnT8A) binding, prompting an investigation of its relationship to type 1 diabetes... - Differential immune induction with subcutaneous versus oral administration of a diabetogenic insulin peptide in the NOD mouseDevasenan Devendra
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Ann N Y Acad Sci 1029:328-30. 2004..Given in oral form with multiple different vehicles, it did not alter expression of insulin autoantibodies in contrast to subcutaneous administration... - "Extended" A1, B8, DR3 haplotype shows remarkable linkage disequilibrium but is similar to nonextended haplotypes in terms of diabetes riskAkane Ide
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Ave, Box B140, Denver, CO 80262, USA
Diabetes 54:1879-83. 2005.... - Identification of a major humoral epitope in Slc30A8 (ZnT8)Janet M Wenzlau
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
Ann N Y Acad Sci 1150:252-5. 2008..9%) of ZnT8(+) sera. We conclude that the C-terminal domain of human ZnT8 contains at least two discrete epitopes, one of which is critically dependent upon the arginine residue at position 325... - Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chainsLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
J Autoimmun 33:42-9. 2009.... - Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal studyLars C Stene
Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, Colorado 80045-6511, USA
Am J Gastroenterol 101:2333-40. 2006..CONCLUSIONS: This prospective study provides the first indication that a high frequency of rotavirus infections may increase the risk of celiac disease autoimmunity in childhood in genetically predisposed individuals... - Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23Edwin Liu
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA
J Clin Invest 110:1021-7. 2002..Thus, the insulin peptides B:9-23 and B:13-23, even when administered subcutaneously in the absence of adjuvant, can induce a dramatic humoral response leading to fatal anaphylaxis in NOD mice... - Type 1A diabetes mellitus-associated autoimmunityEdwin Liu
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140, 4200 East 9th Ave, Denver, CO 80262, USA
Endocrinol Metab Clin North Am 31:391-410, vii-viii. 2002..This article reviews autoimmune disorders associated with type 1A diabetes mellitus... - Pancreatic autoimmunity induction with insulin B:9-23 peptide and viral mimics in the NZB mouseDevasenan Devendra
Barbara Davis Center for Childhood Diabetes, P O Box 6511, Aurora, CO 80010, USA
Ann N Y Acad Sci 1079:135-7. 2006..We demonstrate insulin autoimmunity in the NZB mouse using the insulin peptide B:9-23 and viral mimics. The reason for the protection from diabetes despite the presence of autoimmunity is currently not established... - Strategies for preventing type I diabetes mellitusC F Verge
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
West J Med 164:249-55. 1996..The disease may be preventable, and several large clinical trials are now underway to test whether interventions such as administering low-dose insulin or the use of nicotinamide can prevent the onset of diabetes in at-risk relatives... - Cellular and molecular pathogenesis of type 1A diabetesM M Jahromi
Barbara Davis Center for Childhood Diabetes, University of Colorado, Health Sciences Center, Aurora, CO 80010, USA
Cell Mol Life Sci 64:865-72. 2007..It is now possible using genetic and autoantibody assays to predict the development of type 1A diabetes in the majority of individuals, and trials of diabetes prevention are underway... - Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockoutJean M Jasinski
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P O Box 6511, MS B140, Aurora, CO 80045 6511, USA
Diabetes 55:1978-84. 2006..scid mouse. The current study demonstrates that the BDC12-4.1 TCR is sufficient to cause diabetes at NOD backcross 1, bypassing polygenic inhibition of insulitis and diabetogenesis... - ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodiesDongmei Miao
Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver 80262, USA
J Autoimmun 18:191-6. 2002.... - Genetics of type 1A (immune mediated) diabetesEvie Melanitou
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B140, Denver, CO 80262, USA
J Autoimmun 21:93-8. 2003..Further understanding of both common and rare genetic determinants of type 1A diabetes will contribute to understanding the pathogenesis of diabetes and of autoimmunity... - Insulin-specific tolerance in diabetesPeter A Gottlieb
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Clin Immunol 102:2-11. 2002..Insulin is one of a number of islet autoantigens, but it is likely that immune responses to insulin will be central to both pathogenesis and immunologic protection... - Ethnic differences in the associations between the HLA-DRB1*04 subtypes and type 1 diabetesAmanda Rewers
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Ann N Y Acad Sci 1005:301-9. 2003..Although the associations between diabetes and *0401 and *0405 appear to differ somewhat between Hispanics and NHWs, overall there is no significant difference between these two ethnic groups... - Humoral autoimmunityLiping Yu
Barbara Davis Center for Childhood Diabetes, University of Colorado, Health Sciences Center, Denver, USA
Adv Exp Med Biol 552:247-67. 2004 - Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetesJeesuk Yu
University of Colorado Health Sciences Center, Aurora, Colorado, USA
J Clin Endocrinol Metab 94:504-10. 2009..There is controversy as to whether type 2 diabetes genetic susceptibility contributes to type 1 diabetes, and it is not known what proportion of islet autoantibody-negative new onset subjects have type 2 diabetes risk alleles... - Newborn HLA-DR,DQ genotype screening: age- and ethnicity-specific type 1 diabetes risk estimatesLisa M Emery
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO, USA
Pediatr Diabetes 6:136-44. 2005..To characterize the role of the HLA-DR,DQ genotype and ethnicity on the onset age of T1DM, we analyzed these factors in patients with T1DM and the general population... - Prospective study of enteroviral infections and development of beta-cell autoimmunity. Diabetes autoimmunity study in the young (DAISY)Patricia M Graves
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Diabetes Res Clin Pract 59:51-61. 2003..Further study is needed to assess whether persistent or repeated EV infections occur frequently in individuals with beta-cell autoimmunity... - Extreme genetic risk for type 1A diabetes in the post-genome eraErin E Baschal
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045 6511, USA
J Autoimmun 31:1-6. 2008..Current prediction algorithms will likely be greatly improved for the general population when the additional contributing loci of the MHC are defined... - Genetic control of autoimmunity in Type I diabetes and associated disordersM J Redondo
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
Diabetologia 45:605-22. 2002.... - Autoimmune polyendocrine syndrome type 1 (APS-1) as a model for understanding autoimmune polyendocrine syndrome type 2 (APS-2)A W Michels
Department of Medicine, Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver, Aurora, Colorado 80045, United States
J Intern Med 265:530-40. 2009..With continued basic and clinical research, therapies aimed at treating the underlying autoimmunity and disease prevention should become possible... - Initial results of screening of nondiabetic organ donors for expression of islet autoantibodiesR Gianani
The Barbara Davis Center, Department of Pathology, University of Colorado at Denver and Health Science Center, Aurora, Colorado 80010, USA
J Clin Endocrinol Metab 91:1855-61. 2006..Nevertheless, we lack data on the pancreatic pathology of subjects who are positive for islet autoantibodies (to islet autoantigens GAD65, insulin, and ICA512)... - Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?Andrea K Steck
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
Diabetes 58:1028-33. 2009..We examined whether some of these alleles influence development of islet autoimmunity or progression from persistent islet autoimmunity to type 1 diabetes in children with high-risk HLA-DR,DQ genotypes... - Genetic testing: who should do the testing and what is the role of genetic testing in the setting of celiac disease?Edwin Liu
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Gastroenterology 128:S33-7. 2005.... - Timing of initial cereal exposure in infancy and risk of islet autoimmunityJill M Norris
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver 80262, USA
JAMA 290:1713-20. 2003..Dietary exposures in infancy have been implicated, albeit inconsistently, in the etiology of type 1 diabetes mellitus (DM)... - Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetesE Kawasaki
Barbara Davis Center for Childhood Diabetes, University of Colorado, Health Sciences Center, Denver 80262, USA
Biochem Biophys Res Commun 227:440-7. 1996..Phogrin is an additional major autoantigen for type 1 diabetes and the isolation of the cDNA of this molecule from human islets will aid in studies of the pathogenesis of type 1 diabetes... - Type 1A diabetes induced by infection and immunizationD T Robles
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA
J Autoimmun 16:355-62. 2001..With the ability to detect children in the first year of life activating autoimmunity, prospective studies may in the future document additional environmental factors either increasing or decreasing diabetes risk... - Interferon alpha--a potential link in the pathogenesis of viral-induced type 1 diabetes and autoimmunityD Devendra
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Clin Immunol 111:225-33. 2004..In multiple animal models, given specific genetic susceptibility, poly-IC can induce insulitis or diabetes. Therapeutic agents targeting IFN-alpha may potentially be beneficial in the prevention of type 1 diabetes and autoimmunity... - Detection of four diabetes specific autoantibodies in a single radioimmunoassay: an innovative high-throughput approach for autoimmune diabetes screeningC Tiberti
Department of Clinical Sciences, University of Rome Sapienza, Rome, Italy
Clin Exp Immunol 166:317-24. 2011..It appears to be particularly appropriate as a first-line approach for large-scale population-based screenings of anti-islet autoimmunity...
Research Grants
- International Congress of the Immunology of Diabetes SocGeorge Eisenbarth; Fiscal Year: 2002..Travel grants for young investigators will be chosen by numerical rating of submitted abstracts and additional travel funding will be applied to plenary lectures chosen by the international organizing committee. ..