Research Topics
Species | Amelia EischSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Publications
Depression and hippocampal neurogenesis: a road to remission?Amelia J Eisch
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
Science 338:72-5. 2012....
Functional and mechanistic exploration of an adult neurogenesis-promoting small moleculeDavid Petrik
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
FASEB J 26:3148-62. 2012..Thus, Isx-9 enhances hippocampal neurogenesis and memory in vivo, and its effects are reliant on Mef2, revealing a novel cell-intrinsic molecular pathway regulating adult neurogenesis...- Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivinVanessa Coremans
KU Leuven, VIB Vesalius Research Center, Herestraat 49, Gasthuisberg O and N1, B3000 Leuven, Belgium
BMC Neurosci 11:2. 2010..Survivin is highly expressed in neural precursor cells in the brain, yet its function there has not been elucidated... 
Opiates, psychostimulants, and adult hippocampal neurogenesis: Insights for addiction and stem cell biologyAmelia J Eisch
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
Hippocampus 16:271-86. 2006....- Adult neurogenesis: can analysis of cell cycle proteins move us "Beyond BrdU"?Amelia J Eisch
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
Curr Pharm Biotechnol 8:147-65. 2007.... - Adult neurogenesis, mental health, and mental illness: hope or hype?Amelia J Eisch
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
J Neurosci 28:11785-91. 2008.... - Adult neurogenesis: implications for psychiatryAmelia J Eisch
Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9070, USA
Prog Brain Res 138:315-42. 2002 - Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's diseaseMichael H Donovan
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA
J Comp Neurol 495:70-83. 2006..The altered neurogenesis in the PDAPP mouse may contribute to the age-related cognitive deficits reported in this model of AD and may be a useful adjunct target for assessing the impact of AD therapies... - Regulation of drug reward by cAMP response element-binding protein: evidence for two functionally distinct subregions of the ventral tegmental areaValerie G Olson
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA
J Neurosci 25:5553-62. 2005..These results suggest a novel role for CREB in mediating drug-induced plasticity in the VTA and establish two functionally distinct subregions of the VTA in which CREB differentially regulates drug reward... - Drug dependence and addiction, II: Adult neurogenesis and drug abuseAmelia J Eisch
Dallas, TX, USA
Am J Psychiatry 161:426. 2004 - Gender and endogenous levels of estradiol do not influence adult hippocampal neurogenesis in miceDiane C Lagace
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Hippocampus 17:175-80. 2007..These findings underscore a distinct regulation of adult neurogenesis in mice vs. other rodents, and are discussed in regard to their implications for the study of adult hippocampal neurogenesis... - Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zoneChitra D Mandyam
Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Texas 75390, USA
J Neurosci Res 76:783-94. 2004.... - Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrusMichael H Donovan
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
Hippocampus 18:435-9. 2008..Furthermore, these findings lay critical groundwork for further exploration of the role of BDNF-TrkB signaling in regulation of adult hippocampal neurogenesis... - Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targetingVaishnav Krishnan
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
Biol Psychiatry 64:336-43. 2008..This study examines the contribution of these AC isoforms to emotional behavior... - Mouse models of Alzheimer's disease: insight into treatmentDwight C German
Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX 75390 9070, USA
Rev Neurosci 15:353-69. 2004..If such treatments can be shown to stop the neurodegenerative process and restore hippocampal neurogenesis, damaged brain circuits may be replaceable in patients with AD... - Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mindJenny Hsieh
Department of Molecular Biology, University of Texas Southwestern Medical Center, TX 75390, USA
Neurobiol Dis 39:73-84. 2010.... - Dynamic contribution of nestin-expressing stem cells to adult neurogenesisDiane C Lagace
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
J Neurosci 27:12623-9. 2007.... - Juvenile administration of methylphenidate attenuates adult hippocampal neurogenesisDiane C Lagace
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Biol Psychiatry 60:1121-30. 2006..These findings suggest that decreased adult neurogenesis is an enduring consequence of early-life exposure to MPH and are discussed for their relevance to humans... - Neurobiology of depressionEric J Nestler
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Neuron 34:13-25. 2002..A neurobiologic understanding of depression also requires identification of the genes that make individuals vulnerable or resistant to the syndrome. These advances will fundamentally improve the treatment and prevention of depression... - Nestin promoter/enhancer directs transgene expression to precursors of adult generated periglomerular neuronsRobert D Beech
Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor, New Haven, CT 06508, USA
J Comp Neurol 475:128-41. 2004..The ability to express different transgenes within this subpopulation of neuronal precursors provides a powerful system to define the signals regulating the differentiation and survival of adult-generated neurons in the olfactory bulb... - CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuliMichel Barrot
Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
Proc Natl Acad Sci U S A 99:11435-40. 2002..This control appears to be independent of the intrinsic appetitive or aversive value of the stimulus. The potential relevance of these data to addiction and mood disorders is discussed... - Alteration of hippocampal cell proliferation in mice lacking the beta 2 subunit of the neuronal nicotinic acetylcholine receptorAlexia Harrist
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
Synapse 54:200-6. 2004.... - Cell-intrinsic signals that regulate adult neurogenesis in vivo: insights from inducible approachesMadeleine A Johnson
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, 75390 9070, USA
BMB Rep 42:245-59. 2009..Understanding this process opens the possibility of understanding brain functions subserved by neurogenesis, such as memory, and also of harnessing neural stem cells for repair of the diseased and injured brain... - Electroconvulsive seizures stimulate glial proliferation and reduce expression of Sprouty2 within the prefrontal cortex of ratsDost Ongur
Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 62:505-12. 2007..In parallel, we examined if ECS also alters the expression of Sprouty2 (SPRY2), an inhibitor of cell proliferation... - Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawalDan Georgescu
Department of Psychiatry, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
J Neurosci 23:3106-11. 2003..Together, these studies support a role for the orexin system in molecular adaptations to morphine, and demonstrate dramatic differences in molecular responses among different populations of LH neurons... - Neurod1 is essential for the survival and maturation of adult-born neuronsZhengliang Gao
Department of Molecular Biology and Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Nat Neurosci 12:1090-2. 2009..Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons... - Withdrawal from cocaine self-administration normalizes deficits in proliferation and enhances maturity of adult-generated hippocampal neuronsMichele A Noonan
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
J Neurosci 28:2516-26. 2008.... - Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depressionAmelia J Eisch
Department of Psychiatry, The University of Texas Southwestern Medical Center, Texas, Dallas 75390-9070, USA
Biol Psychiatry 54:994-1005. 2003..This interpretation is intriguing in that it suggests a role for BDNF in the VTA-NAc that is opposite of the proposed role for BDNF in the hippocampus... - Reduction of adult hippocampal neurogenesis confers vulnerability in an animal model of cocaine addictionMichele A Noonan
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
J Neurosci 30:304-15. 2010..Furthermore, they suggest that therapeutics to specifically increase or stabilize adult hippocampal neurogenesis could aid in preventing initial addiction as well as future relapse... - Hippocampal neurogenesis as a target for the treatment of mental illness: a critical evaluationNathan A DeCarolis
Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9070, USA
Neuropharmacology 58:884-93. 2010.... - Adult hippocampal neurogenesis is functionally important for stress-induced social avoidanceDiane C Lagace
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
Proc Natl Acad Sci U S A 107:4436-41. 2010.... - Notch1 is required for maintenance of the reservoir of adult hippocampal stem cellsJessica L Ables
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Neurosci 30:10484-92. 2010..These data shed light on the complex relationship between Type-1 NSCs, adult neurogenesis, the neurogenic niche, and environmental stimuli... - IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiatesScott J Russo
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
Nat Neurosci 10:93-9. 2007..These findings directly implicate the IRS2-Akt signaling pathway as a critical regulator of dopamine cell morphology and opiate reward... - Cdk5 is essential for adult hippocampal neurogenesisDiane C Lagace
Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
Proc Natl Acad Sci U S A 105:18567-71. 2008..Thus, Cdk5 has an essential role in the survival, but not proliferation, of adult-generated hippocampal neurons through both cell-intrinsic and cell-extrinsic mechanisms... - AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuliVaishnav Krishnan
Department of Psychiatry and Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Biol Psychiatry 64:691-700. 2008..Recent evidence suggests that dopaminergic neurons of the ventral tegmental area (VTA) play a key role in the manifestation of stress vulnerability... - Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cordJames Battiste
Center for Basic Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA
Development 134:285-93. 2007..Furthermore, Ascl1-null cells in the spinal cord have a diminished capacity to undergo neuronal differentiation, with a subset of these cells retaining characteristics of immature glial cells... - Regional, cellular, and subcellular localization of RGS10 in rodent brainJeff L Waugh
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
J Comp Neurol 481:299-313. 2005..Moreover, enrichment of RGS10 in transcriptionally active regions of the nucleus suggests an unforeseen role of RGS10 in modulating gene expression... - Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regionsVaishnav Krishnan
Department of Psychiatry, The University of Texas Southwestern Medical Center UTSWMC, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
Cell 131:391-404. 2007.... - Mood-stabilizing drugs: are their neuroprotective aspects clinically relevant?Diane C Lagace
Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Psychiatr Clin North Am 28:399-414. 2005.... - Phospholipase Cgamma in distinct regions of the ventral tegmental area differentially modulates mood-related behaviorsCarlos A Bolanos
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
J Neurosci 23:7569-76. 2003..Moreover, these data also support a role for drug-induced elevations in PLCgamma1 expression in the VTA in mediating long-term adaptations to drugs of abuse and aversive stimuli... - Hippocampal neurogenesis: a matter of survivalDiane C Lagace
Am J Psychiatry 164:205. 2007 - Differential expression and regulation of the cAMP-selective phosphodiesterase type 4A splice variants in rat brain by chronic antidepressant administrationCarrol D'Sa
Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT 06508, USA
Eur J Neurosci 22:1463-75. 2005.... - Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampusChitra D Mandyam
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, USA
Dev Neurobiol 68:575-89. 2008....
Research Grants
- Opiates and Adult NeurogenesisAmelia J Eisch; Fiscal Year: 2010....
- Opiates and Adult NeurogenesisAmelia J Eisch; Fiscal Year: 2010....
- Regulation of adult neurogenesis by opiatesAmelia Eisch; Fiscal Year: 2007..Importantly, such studies will improve our understanding of the complex mechanisms by which opiates affect brain function. ..
- New Horizons in Adult NeurogenesisAmelia Eisch; Fiscal Year: 2007....
- Regulation of adult neurogenesis by opiatesAmelia Eisch; Fiscal Year: 2007..Importantly, such studies will improve our understanding of the complex mechanisms by which opiates affect brain function. ..
- Opiates and Adult NeurogenesisAmelia J Eisch; Fiscal Year: 2010....