Amelia Eisch

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Early postnatal in vivo gliogenesis from nestin-lineage progenitors requires cdk5
    David Petrik
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    PLoS ONE 8:e72819. 2013
  2. pmc Depression and hippocampal neurogenesis: a road to remission?
    Amelia J Eisch
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Science 338:72-5. 2012
  3. pmc Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule
    David Petrik
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    FASEB J 26:3148-62. 2012
  4. pmc Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin
    Vanessa Coremans
    KU Leuven, VIB Vesalius Research Center, Herestraat 49, Gasthuisberg O and N1, B3000 Leuven, Belgium
    BMC Neurosci 11:2. 2010
  5. ncbi request reprint Adult neurogenesis: implications for psychiatry
    Amelia J Eisch
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Prog Brain Res 138:315-42. 2002
  6. pmc Adult neurogenesis, mental health, and mental illness: hope or hype?
    Amelia J Eisch
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:11785-91. 2008
  7. ncbi request reprint Opiates, psychostimulants, and adult hippocampal neurogenesis: Insights for addiction and stem cell biology
    Amelia J Eisch
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Hippocampus 16:271-86. 2006
  8. ncbi request reprint Adult neurogenesis: can analysis of cell cycle proteins move us "Beyond BrdU"?
    Amelia J Eisch
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Curr Pharm Biotechnol 8:147-65. 2007
  9. ncbi request reprint Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease
    Michael H Donovan
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Comp Neurol 495:70-83. 2006
  10. ncbi request reprint Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zone
    Chitra D Mandyam
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Texas 75390, USA
    J Neurosci Res 76:783-94. 2004

Research Grants

  1. Opiates and Adult Neurogenesis
    Amelia J Eisch; Fiscal Year: 2010
  2. Opiates and Adult Neurogenesis
    Amelia J Eisch; Fiscal Year: 2010
  3. Regulation of adult neurogenesis by opiates
    Amelia Eisch; Fiscal Year: 2007
  4. New Horizons in Adult Neurogenesis
    Amelia Eisch; Fiscal Year: 2007
  5. Regulation of adult neurogenesis by opiates
    Amelia Eisch; Fiscal Year: 2007
  6. Opiates and Adult Neurogenesis
    Amelia J Eisch; Fiscal Year: 2010

Collaborators

Detail Information

Publications44

  1. pmc Early postnatal in vivo gliogenesis from nestin-lineage progenitors requires cdk5
    David Petrik
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    PLoS ONE 8:e72819. 2013
    ..Thus, glial cells that originate from nestin-expressing cells and their progeny require Cdk5 for proper development during the early postnatal period. ..
  2. pmc Depression and hippocampal neurogenesis: a road to remission?
    Amelia J Eisch
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Science 338:72-5. 2012
    ....
  3. pmc Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule
    David Petrik
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    FASEB J 26:3148-62. 2012
    ..Thus, Isx-9 enhances hippocampal neurogenesis and memory in vivo, and its effects are reliant on Mef2, revealing a novel cell-intrinsic molecular pathway regulating adult neurogenesis...
  4. pmc Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin
    Vanessa Coremans
    KU Leuven, VIB Vesalius Research Center, Herestraat 49, Gasthuisberg O and N1, B3000 Leuven, Belgium
    BMC Neurosci 11:2. 2010
    ..Survivin is highly expressed in neural precursor cells in the brain, yet its function there has not been elucidated...
  5. ncbi request reprint Adult neurogenesis: implications for psychiatry
    Amelia J Eisch
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Prog Brain Res 138:315-42. 2002
  6. pmc Adult neurogenesis, mental health, and mental illness: hope or hype?
    Amelia J Eisch
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:11785-91. 2008
    ....
  7. ncbi request reprint Opiates, psychostimulants, and adult hippocampal neurogenesis: Insights for addiction and stem cell biology
    Amelia J Eisch
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Hippocampus 16:271-86. 2006
    ....
  8. ncbi request reprint Adult neurogenesis: can analysis of cell cycle proteins move us "Beyond BrdU"?
    Amelia J Eisch
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Curr Pharm Biotechnol 8:147-65. 2007
    ....
  9. ncbi request reprint Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease
    Michael H Donovan
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Comp Neurol 495:70-83. 2006
    ..The altered neurogenesis in the PDAPP mouse may contribute to the age-related cognitive deficits reported in this model of AD and may be a useful adjunct target for assessing the impact of AD therapies...
  10. ncbi request reprint Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zone
    Chitra D Mandyam
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Texas 75390, USA
    J Neurosci Res 76:783-94. 2004
    ....
  11. ncbi request reprint Regulation of drug reward by cAMP response element-binding protein: evidence for two functionally distinct subregions of the ventral tegmental area
    Valerie G Olson
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 25:5553-62. 2005
    ..These results suggest a novel role for CREB in mediating drug-induced plasticity in the VTA and establish two functionally distinct subregions of the VTA in which CREB differentially regulates drug reward...
  12. ncbi request reprint Gender and endogenous levels of estradiol do not influence adult hippocampal neurogenesis in mice
    Diane C Lagace
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Hippocampus 17:175-80. 2007
    ..These findings underscore a distinct regulation of adult neurogenesis in mice vs. other rodents, and are discussed in regard to their implications for the study of adult hippocampal neurogenesis...
  13. ncbi request reprint Drug dependence and addiction, II: Adult neurogenesis and drug abuse
    Amelia J Eisch
    Dallas, TX, USA
    Am J Psychiatry 161:426. 2004
  14. pmc Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrus
    Michael H Donovan
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Hippocampus 18:435-9. 2008
    ..Furthermore, these findings lay critical groundwork for further exploration of the role of BDNF-TrkB signaling in regulation of adult hippocampal neurogenesis...
  15. pmc Dynamic contribution of nestin-expressing stem cells to adult neurogenesis
    Diane C Lagace
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 27:12623-9. 2007
    ....
  16. pmc Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind
    Jenny Hsieh
    Department of Molecular Biology, University of Texas Southwestern Medical Center, TX 75390, USA
    Neurobiol Dis 39:73-84. 2010
    ....
  17. pmc Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targeting
    Vaishnav Krishnan
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Biol Psychiatry 64:336-43. 2008
    ..This study examines the contribution of these AC isoforms to emotional behavior...
  18. ncbi request reprint Juvenile administration of methylphenidate attenuates adult hippocampal neurogenesis
    Diane C Lagace
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Biol Psychiatry 60:1121-30. 2006
    ..Here we examine the impact of juvenile MPH exposure on adult hippocampal neurogenesis...
  19. ncbi request reprint Mouse models of Alzheimer's disease: insight into treatment
    Dwight C German
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX 75390 9070, USA
    Rev Neurosci 15:353-69. 2004
    ..If such treatments can be shown to stop the neurodegenerative process and restore hippocampal neurogenesis, damaged brain circuits may be replaceable in patients with AD...
  20. ncbi request reprint Neurobiology of depression
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Neuron 34:13-25. 2002
    ..A neurobiologic understanding of depression also requires identification of the genes that make individuals vulnerable or resistant to the syndrome. These advances will fundamentally improve the treatment and prevention of depression...
  21. pmc CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli
    Michel Barrot
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 99:11435-40. 2002
    ..This control appears to be independent of the intrinsic appetitive or aversive value of the stimulus. The potential relevance of these data to addiction and mood disorders is discussed...
  22. ncbi request reprint Nestin promoter/enhancer directs transgene expression to precursors of adult generated periglomerular neurons
    Robert D Beech
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor, New Haven, CT 06508, USA
    J Comp Neurol 475:128-41. 2004
    ..The ability to express different transgenes within this subpopulation of neuronal precursors provides a powerful system to define the signals regulating the differentiation and survival of adult-generated neurons in the olfactory bulb...
  23. ncbi request reprint Alteration of hippocampal cell proliferation in mice lacking the beta 2 subunit of the neuronal nicotinic acetylcholine receptor
    Alexia Harrist
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Synapse 54:200-6. 2004
    ....
  24. ncbi request reprint Electroconvulsive seizures stimulate glial proliferation and reduce expression of Sprouty2 within the prefrontal cortex of rats
    Dost Ongur
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 62:505-12. 2007
    ..In parallel, we examined if ECS also alters the expression of Sprouty2 (SPRY2), an inhibitor of cell proliferation...
  25. ncbi request reprint Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal
    Dan Georgescu
    Department of Psychiatry, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 23:3106-11. 2003
    ..Together, these studies support a role for the orexin system in molecular adaptations to morphine, and demonstrate dramatic differences in molecular responses among different populations of LH neurons...
  26. pmc Cell-intrinsic signals that regulate adult neurogenesis in vivo: insights from inducible approaches
    Madeleine A Johnson
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, 75390 9070, USA
    BMB Rep 42:245-59. 2009
    ..Understanding this process opens the possibility of understanding brain functions subserved by neurogenesis, such as memory, and also of harnessing neural stem cells for repair of the diseased and injured brain...
  27. ncbi request reprint Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression
    Amelia J Eisch
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Texas, Dallas 75390 9070, USA
    Biol Psychiatry 54:994-1005. 2003
    ..Here we show that BDNF in the ventral tegmental area-nucleus accumbens (VTA-NAc) pathway is also involved in the development of a depression-like phenotype...
  28. doi request reprint Withdrawal from cocaine self-administration normalizes deficits in proliferation and enhances maturity of adult-generated hippocampal neurons
    Michele A Noonan
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:2516-26. 2008
    ....
  29. pmc Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells
    Jessica L Ables
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 30:10484-92. 2010
    ..These data shed light on the complex relationship between Type-1 NSCs, adult neurogenesis, the neurogenic niche, and environmental stimuli...
  30. pmc Adult hippocampal neurogenesis is functionally important for stress-induced social avoidance
    Diane C Lagace
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 107:4436-41. 2010
    ....
  31. pmc Hippocampal neurogenesis as a target for the treatment of mental illness: a critical evaluation
    Nathan A DeCarolis
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuropharmacology 58:884-93. 2010
    ....
  32. pmc Reduction of adult hippocampal neurogenesis confers vulnerability in an animal model of cocaine addiction
    Michele A Noonan
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 30:304-15. 2010
    ..Furthermore, they suggest that therapeutics to specifically increase or stabilize adult hippocampal neurogenesis could aid in preventing initial addiction as well as future relapse...
  33. pmc Neurod1 is essential for the survival and maturation of adult-born neurons
    Zhengliang Gao
    Department of Molecular Biology and Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Neurosci 12:1090-2. 2009
    ..Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons...
  34. ncbi request reprint Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord
    James Battiste
    Center for Basic Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Development 134:285-93. 2007
    ..Furthermore, Ascl1-null cells in the spinal cord have a diminished capacity to undergo neuronal differentiation, with a subset of these cells retaining characteristics of immature glial cells...
  35. ncbi request reprint IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates
    Scott J Russo
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 10:93-9. 2007
    ..These findings directly implicate the IRS2-Akt signaling pathway as a critical regulator of dopamine cell morphology and opiate reward...
  36. pmc Cdk5 is essential for adult hippocampal neurogenesis
    Diane C Lagace
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 105:18567-71. 2008
    ..Thus, Cdk5 has an essential role in the survival, but not proliferation, of adult-generated hippocampal neurons through both cell-intrinsic and cell-extrinsic mechanisms...
  37. ncbi request reprint Regional, cellular, and subcellular localization of RGS10 in rodent brain
    Jeff L Waugh
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Comp Neurol 481:299-313. 2005
    ..Moreover, enrichment of RGS10 in transcriptionally active regions of the nucleus suggests an unforeseen role of RGS10 in modulating gene expression...
  38. pmc AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli
    Vaishnav Krishnan
    Department of Psychiatry and Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Biol Psychiatry 64:691-700. 2008
    ..Recent evidence suggests that dopaminergic neurons of the ventral tegmental area (VTA) play a key role in the manifestation of stress vulnerability...
  39. ncbi request reprint Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions
    Vaishnav Krishnan
    Department of Psychiatry, The University of Texas Southwestern Medical Center UTSWMC, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Cell 131:391-404. 2007
    ....
  40. ncbi request reprint Phospholipase Cgamma in distinct regions of the ventral tegmental area differentially modulates mood-related behaviors
    Carlos A Bolanos
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 23:7569-76. 2003
    ..Moreover, these data also support a role for drug-induced elevations in PLCgamma1 expression in the VTA in mediating long-term adaptations to drugs of abuse and aversive stimuli...
  41. ncbi request reprint Mood-stabilizing drugs: are their neuroprotective aspects clinically relevant?
    Diane C Lagace
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Psychiatr Clin North Am 28:399-414. 2005
    ....
  42. ncbi request reprint Hippocampal neurogenesis: a matter of survival
    Diane C Lagace
    Am J Psychiatry 164:205. 2007
  43. ncbi request reprint Differential expression and regulation of the cAMP-selective phosphodiesterase type 4A splice variants in rat brain by chronic antidepressant administration
    Carrol D'Sa
    Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT 06508, USA
    Eur J Neurosci 22:1463-75. 2005
    ....
  44. pmc Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampus
    Chitra D Mandyam
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, USA
    Dev Neurobiol 68:575-89. 2008
    ....

Research Grants16

  1. Opiates and Adult Neurogenesis
    Amelia J Eisch; Fiscal Year: 2010
    ....
  2. Opiates and Adult Neurogenesis
    Amelia J Eisch; Fiscal Year: 2010
    ....
  3. Regulation of adult neurogenesis by opiates
    Amelia Eisch; Fiscal Year: 2007
    ..Importantly, such studies will improve our understanding of the complex mechanisms by which opiates affect brain function. ..
  4. New Horizons in Adult Neurogenesis
    Amelia Eisch; Fiscal Year: 2007
    ....
  5. Regulation of adult neurogenesis by opiates
    Amelia Eisch; Fiscal Year: 2007
    ..Importantly, such studies will improve our understanding of the complex mechanisms by which opiates affect brain function. ..
  6. Opiates and Adult Neurogenesis
    Amelia J Eisch; Fiscal Year: 2010
    ....