H Einat

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. doi request reprint A possible utilization of the mice forced swim test for modeling manic-like increase in vigor and goal-directed behavior
    Shlomit Flaisher-Grinberg
    College of Pharmacy, Duluth, University of Minnesota, Duluth, MN 55812, USA
    J Pharmacol Toxicol Methods 59:141-5. 2009
  2. pmc Strain-specific battery of tests for domains of mania: effects of valproate, lithium and imipramine
    Shlomit Flaisher-Grinberg
    College of Pharmacy, University of Minnesota Duluth, MN, USA
    Front Psychiatry 1:10. 2010
  3. doi request reprint Positive attitude change toward psychiatry in pharmacy students following an active learning psychopharmacology course
    Haim Einat
    University of Minnesota, College of Pharmacy Duluth, Duluth, MN 55812 3003, USA
    Acad Psychiatry 32:515-7. 2008
  4. ncbi request reprint Myo-inositol-1-phosphate (MIP) synthase inhibition: in-vivo study in rats
    H Einat
    Department of Pharmacy Practice and Pharmaceutical Education, College of Pharmacy, University of Minnesota, Duluth, MN, USA
    J Neural Transm 115:55-8. 2008
  5. ncbi request reprint Protein kinase C inhibition by tamoxifen antagonizes manic-like behavior in rats: implications for the development of novel therapeutics for bipolar disorder
    Haim Einat
    University of Minnesota, College of Pharmacy, Duluth, MN 55812, USA
    Neuropsychobiology 55:123-31. 2007
  6. ncbi request reprint Different behaviors and different strains: potential new ways to model bipolar disorder
    Haim Einat
    University of Minnesota, College of Pharmacy, 376 Kirby Plaza, 1208 Kirby Drive, Duluth, MN 55812, USA
    Neurosci Biobehav Rev 31:850-7. 2007
  7. ncbi request reprint Chronic oral administration of ginseng extract results in behavioral change but has no effects in mice models of affective and anxiety disorders
    Haim Einat
    College of Pharmacy, Duluth, University of Minnesota, Duluth, MN 55812, USA
    Phytother Res 21:62-6. 2007
  8. ncbi request reprint Establishment of a battery of simple models for facets of bipolar disorder: a practical approach to achieve increased validity, better screening and possible insights into endophenotypes of disease
    Haim Einat
    College of Pharmacy, Duluth, University of Minnesota, 376 Kirby Plaza, 1208 Kirby Drive, Duluth, MN 55812, USA
    Behav Genet 37:244-55. 2007
  9. ncbi request reprint Sand rats see the light: short photoperiod induces a depression-like response in a diurnal rodent
    Haim Einat
    University of Minnesota, College of Pharmacy, Duluth, MN 55812, USA
    Behav Brain Res 173:153-7. 2006
  10. ncbi request reprint Cellular plasticity cascades: genes-to-behavior pathways in animal models of bipolar disorder
    Haim Einat
    College of Pharmacy, Duluth, University of Minnesota, 55812, USA
    Biol Psychiatry 59:1160-71. 2006

Collaborators

Detail Information

Publications25

  1. doi request reprint A possible utilization of the mice forced swim test for modeling manic-like increase in vigor and goal-directed behavior
    Shlomit Flaisher-Grinberg
    College of Pharmacy, Duluth, University of Minnesota, Duluth, MN 55812, USA
    J Pharmacol Toxicol Methods 59:141-5. 2009
    ..The present study tested the possible utilization of the forced swim test (FST) as a model for the heightened vigor and goal-directed behavior domain of mania, using mice with low baseline immobility...
  2. pmc Strain-specific battery of tests for domains of mania: effects of valproate, lithium and imipramine
    Shlomit Flaisher-Grinberg
    College of Pharmacy, University of Minnesota Duluth, MN, USA
    Front Psychiatry 1:10. 2010
    ....
  3. doi request reprint Positive attitude change toward psychiatry in pharmacy students following an active learning psychopharmacology course
    Haim Einat
    University of Minnesota, College of Pharmacy Duluth, Duluth, MN 55812 3003, USA
    Acad Psychiatry 32:515-7. 2008
    ..This report demonstrates the effects of a specialized elective course in psychopharmacology on doctor of pharmacy students' attitudes toward psychiatric disorders and their treatment...
  4. ncbi request reprint Myo-inositol-1-phosphate (MIP) synthase inhibition: in-vivo study in rats
    H Einat
    Department of Pharmacy Practice and Pharmaceutical Education, College of Pharmacy, University of Minnesota, Duluth, MN, USA
    J Neural Transm 115:55-8. 2008
    ..This lack of effects may stem from the low contribution of de-novo synthesis to cellular inositol supply or to the inhibition of the de-novo synthesis by lithium itself...
  5. ncbi request reprint Protein kinase C inhibition by tamoxifen antagonizes manic-like behavior in rats: implications for the development of novel therapeutics for bipolar disorder
    Haim Einat
    University of Minnesota, College of Pharmacy, Duluth, MN 55812, USA
    Neuropsychobiology 55:123-31. 2007
    ..However, both lithium and valproate exert many biochemical changes and attribution of therapeutic relevance to any molecular findings needs to be based on linking them to behavioral effects...
  6. ncbi request reprint Different behaviors and different strains: potential new ways to model bipolar disorder
    Haim Einat
    University of Minnesota, College of Pharmacy, 376 Kirby Plaza, 1208 Kirby Drive, Duluth, MN 55812, USA
    Neurosci Biobehav Rev 31:850-7. 2007
    ..Both approaches will not culminate to an ideal, all encompassing model of BPD but may provide useful and relatively uncomplicated tools for research of the disorder...
  7. ncbi request reprint Chronic oral administration of ginseng extract results in behavioral change but has no effects in mice models of affective and anxiety disorders
    Haim Einat
    College of Pharmacy, Duluth, University of Minnesota, Duluth, MN 55812, USA
    Phytother Res 21:62-6. 2007
    ..However, the doses and schedule of administration of ginseng used in the present study induced some behavioral changes but did not inssuence affective- and anxiety-like measures...
  8. ncbi request reprint Establishment of a battery of simple models for facets of bipolar disorder: a practical approach to achieve increased validity, better screening and possible insights into endophenotypes of disease
    Haim Einat
    College of Pharmacy, Duluth, University of Minnesota, 376 Kirby Plaza, 1208 Kirby Drive, Duluth, MN 55812, USA
    Behav Genet 37:244-55. 2007
    ..It is further speculated that, pending further research, this paradigm can be combined with additional methods to explore changes in the LHPA axis that may be linked to an important endophenotype of BPD...
  9. ncbi request reprint Sand rats see the light: short photoperiod induces a depression-like response in a diurnal rodent
    Haim Einat
    University of Minnesota, College of Pharmacy, Duluth, MN 55812, USA
    Behav Brain Res 173:153-7. 2006
    ..g., SAD), which in humans is a prevalent disorder, with winter depression episodes and spring/summer remissions...
  10. ncbi request reprint Cellular plasticity cascades: genes-to-behavior pathways in animal models of bipolar disorder
    Haim Einat
    College of Pharmacy, Duluth, University of Minnesota, 55812, USA
    Biol Psychiatry 59:1160-71. 2006
    ....
  11. ncbi request reprint Modelling facets of mania--new directions related to the notion of endophenotypes
    Haim Einat
    Department of Pharmacy Practice and Pharmaceutical Research, College of Pharmacy, University of Minnesota Duluth, Duluth MN 55812, USA
    J Psychopharmacol 20:714-22. 2006
    ....
  12. ncbi request reprint Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: further support for the involvement of mitochondrial function in anxiety disorders
    Haim Einat
    College of Pharmacy, Duluth, University of Minnesota, 376 Kirby Plaza, 1208 Kirby Drive, Duluth, MN 55812, USA
    Behav Brain Res 165:172-80. 2005
    ..Our study, therefore demonstrates that Bcl-2 may be a key factor in anxiety disorders and that its effects may possibly originate from its role in the mitochondria...
  13. ncbi request reprint Behavioral effects of Bcl-2 deficiency: implications for affective disorders
    Renae Lien
    College of Pharmacy, Duluth, University of Minnesota, 123 Life Sciences, 1110 Kirby Drive, Duluth, MN 55812, USA
    Pharmacol Rep 60:490-8. 2008
    ..More precise studies of Bcl-2 in affective and anxiety disorders will be possible when specific pharmacological modulators of Bcl-2 become available...
  14. doi request reprint Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders
    C Cleary
    Integrated Biosciences Graduate Program, University of Minnesota, Duluth, MN 55812, USA
    Brain Res Bull 76:469-73. 2008
    ..Additional studies are now planned to further explore the behavioral range of rapamycin's effects as well as the biological mechanisms underlying these effects...
  15. doi request reprint Attenuation of high sweet solution preference by mood stabilizers: a possible mouse model for the increased reward-seeking domain of mania
    Shlomit Flaisher-Grinberg
    Dept of Pharmacy Practice and Pharmaceutical Sciences, College of Pharmacy, University of Minnesota, Duluth, USA
    J Neurosci Methods 177:44-50. 2009
    ..Such a battery can be effectively utilized to screen new treatments, to distinguish between specific effects of different drugs, and to explore the mechanisms underlying BPD...
  16. ncbi request reprint Taurine trials in animal models offer no support for anxiolytic, antidepressant or stimulant effects
    Brad K Whirley
    University of Minnesota, College of Pharmacy, Duluth, Minnesota, USA
    Isr J Psychiatry Relat Sci 45:11-8. 2008
    ..The present study was designed to test taurine's effects in animal models of affective and anxiety disorders and to evaluate its properties as a stimulant...
  17. ncbi request reprint The role of the extracellular signal-regulated kinase signaling pathway in mood modulation
    Haim Einat
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4405, USA
    J Neurosci 23:7311-6. 2003
    ..These data suggest that the ERK pathway may mediate the antimanic effects of mood stabilizers...
  18. ncbi request reprint Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression
    Jing Du
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 24:6578-89. 2004
    ....
  19. ncbi request reprint AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test
    Todd D Gould
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 3711, USA
    Int J Neuropsychopharmacol 7:387-90. 2004
    ....
  20. pmc Animal models of bipolar disorder and mood stabilizer efficacy: a critical need for improvement
    Todd D Gould
    Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, 701 West Pratt Street, Suite 388, Baltimore, Maryland 21201, USA
    Neurosci Biobehav Rev 31:825-31. 2007
    ..Regardless of the path taken by different researchers to develop better models, we believe that this area of work requires additional attention not only from researchers but also from funding agencies...
  21. ncbi request reprint [Possible involvement of protein kinase C in the pathophysiology and treatment of bipolar disorder]
    Haim Einat
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, HHS, Bethesda, USA
    Harefuah 143:420-5, 462. 2004
    ..Therefore, this pathway may be a promising candidate for the development of new, more specific drugs for the disease...
  22. ncbi request reprint Beta-catenin overexpression in the mouse brain phenocopies lithium-sensitive behaviors
    Todd D Gould
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 3711, USA
    Neuropsychopharmacology 32:2173-83. 2007
    ..By associating the behavioral effects of lithium with beta-catenin levels, these data suggest that increasing beta-catenin might be a novel therapeutic strategy for mood disorders...
  23. ncbi request reprint Chronic inositol treatment reduces depression-like immobility of Flinders Sensitive Line rats in the forced swim test
    Haim Einat
    Beer Sheva Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Depress Anxiety 15:148-51. 2002
    ..Inositol countered the exaggerated immobility of FSL rats in the forced swim test, without affecting control animals. Data support our previous suggestion of inositol as a potential antidepressant...
  24. ncbi request reprint Distinguishing separable domains of cognition in human and animal studies: what separations are optimal for targeting interventions? A summary of recommendations from breakout group 2 at the measurement and treatment research to improve cognition in schiz
    Keith H Nuechterlein
    Department of Psychiatry, University of California, Los Angeles, CA 90095, USA
    Schizophr Bull 31:870-4. 2005
    ..As part of this process, the group noted several existing animal paradigms that have particular promise as measures in the key cognitive domains in schizophrenia identified by the MATRICS Neurocognition Committee...
  25. ncbi request reprint Inflammatory-mediated model of cerebral palsy with developmental sequelae
    Laura Toso
    Unit on Perinatal and Developmental Neurobiology, National Institute of Child and Human Development National Institute of Health, Bethesda, MD 20892 0925, USA
    Am J Obstet Gynecol 193:933-41. 2005
    ..Our objective was to develop an inflammatory model for CP based on chronic lipopolysaccharide (LPS) exposure with a recognizable phenotype in offspring...