David Eide

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Zinc and the Msc2 zinc transporter protein are required for endoplasmic reticulum function
    Charissa D Ellis
    Department of Biochemistry, University of Missouri, Columbia 65211, USA
    J Cell Biol 166:325-35. 2004
  2. pmc Differential control of Zap1-regulated genes in response to zinc deficiency in Saccharomyces cerevisiae
    Chang Yi Wu
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    BMC Genomics 9:370. 2008
  3. pmc Promotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers-Danlos syndrome
    Jeeyon Jeong
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 109:E3530-8. 2012
  4. doi request reprint An "inordinate fondness for transporters" explained?
    David J Eide
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Sci Signal 5:pe5. 2012
  5. ncbi request reprint Zinc transporters and the cellular trafficking of zinc
    David J Eide
    Department of Nutritional Sciences, University of Wisconsin Madison, 1415 Linden Drive, Room 340B, Madison, WI 53706 1571, USA
    Biochim Biophys Acta 1763:711-22. 2006
  6. pmc Characterization of the yeast ionome: a genome-wide analysis of nutrient mineral and trace element homeostasis in Saccharomyces cerevisiae
    David J Eide
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Genome Biol 6:R77. 2005
  7. pmc Homeostatic and adaptive responses to zinc deficiency in Saccharomyces cerevisiae
    David J Eide
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 284:18565-9. 2009
  8. doi request reprint The oxidative stress of zinc deficiency
    David J Eide
    Department of Nutritional Sciences, University of Wisconsin Madison, 1415 Linden Drive, Room 340B, Madison, WI 53706 1571, USA
    Metallomics 3:1124-9. 2011
  9. pmc Zinc binding to a regulatory zinc-sensing domain monitored in vivo by using FRET
    Wei Qiao
    Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 103:8674-9. 2006
  10. ncbi request reprint Zap1 activation domain 1 and its role in controlling gene expression in response to cellular zinc status
    Andrew Herbig
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI, USA
    Mol Microbiol 57:834-46. 2005

Research Grants

  1. REGULATION OF CELLULAR ZINC HOMEOSTASIS
    David J Eide; Fiscal Year: 2010
  2. Zinc Transporters and Intracellular Zinc Trafficking
    David Eide; Fiscal Year: 2007
  3. REGULATION OF CELLULAR ZINC HOMEOSTASIS
    David Eide; Fiscal Year: 2007
  4. Mammalian Zinc Transporters and Zinc Homeostasis
    David J Eide; Fiscal Year: 2010
  5. REGULATION OF CELLULAR ZINC HOMEOSTASIS
    David Eide; Fiscal Year: 2009
  6. REGULATION OF CELLULAR ZINC HOMEOSTASIS
    David Eide; Fiscal Year: 1999
  7. REGULATION OF CELLULAR ZINC HOMEOSTASIS
    David Eide; Fiscal Year: 2003
  8. 2004 FASEB Summer Conference on Trace Element Metabolism
    David Eide; Fiscal Year: 2004

Collaborators

Detail Information

Publications36

  1. pmc Zinc and the Msc2 zinc transporter protein are required for endoplasmic reticulum function
    Charissa D Ellis
    Department of Biochemistry, University of Missouri, Columbia 65211, USA
    J Cell Biol 166:325-35. 2004
    ..Finally, zinc deficiency up-regulates the mammalian ER stress response indicating a conserved requirement for zinc in ER function among eukaryotes...
  2. pmc Differential control of Zap1-regulated genes in response to zinc deficiency in Saccharomyces cerevisiae
    Chang Yi Wu
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    BMC Genomics 9:370. 2008
    ..We previously used transcriptome profiling with DNA microarrays to identify 46 potential Zap1 target genes in the yeast genome. In this new study, we used complementary methods to identify additional Zap1 target genes...
  3. pmc Promotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers-Danlos syndrome
    Jeeyon Jeong
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 109:E3530-8. 2012
    ..We propose that SCD-EDS is the result of vesicular zinc trapping and ER zinc deficiency rather than overload...
  4. doi request reprint An "inordinate fondness for transporters" explained?
    David J Eide
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Sci Signal 5:pe5. 2012
    ..Thus, this creative study provides a previously unconsidered explanation for the abundance of dual-transporter systems in biology...
  5. ncbi request reprint Zinc transporters and the cellular trafficking of zinc
    David J Eide
    Department of Nutritional Sciences, University of Wisconsin Madison, 1415 Linden Drive, Room 340B, Madison, WI 53706 1571, USA
    Biochim Biophys Acta 1763:711-22. 2006
    ..Thus, cells require zinc transport mechanisms to allow cells to efficiently accumulate the metal ion and distribute it within the cell. Our current knowledge of these transport systems in eukaryotes is the focus of this review...
  6. pmc Characterization of the yeast ionome: a genome-wide analysis of nutrient mineral and trace element homeostasis in Saccharomyces cerevisiae
    David J Eide
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Genome Biol 6:R77. 2005
    ..We refer to the resulting accumulation profile as the yeast 'ionome'...
  7. pmc Homeostatic and adaptive responses to zinc deficiency in Saccharomyces cerevisiae
    David J Eide
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 284:18565-9. 2009
    ..The Zap1 zinc-responsive transcription factor regulates several genes in yeast, and the identity of these genes has led to new insights regarding how cells respond to the stress of zinc deficiency...
  8. doi request reprint The oxidative stress of zinc deficiency
    David J Eide
    Department of Nutritional Sciences, University of Wisconsin Madison, 1415 Linden Drive, Room 340B, Madison, WI 53706 1571, USA
    Metallomics 3:1124-9. 2011
    ..In addition, through studies of the model eukaryotic cell, Saccharomyces cerevisiae, we are now beginning to understand the strategies cells use to limit this stress and reduce its damage...
  9. pmc Zinc binding to a regulatory zinc-sensing domain monitored in vivo by using FRET
    Wei Qiao
    Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 103:8674-9. 2006
    ..Last, we show that these properties are evolutionarily conserved indicating their importance to Zap1 function. These results indicate that the kinetic lability of ZF1/2 in vivo is a key component of Zap1 zinc responsiveness...
  10. ncbi request reprint Zap1 activation domain 1 and its role in controlling gene expression in response to cellular zinc status
    Andrew Herbig
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI, USA
    Mol Microbiol 57:834-46. 2005
    ..Finally, our results indicate that, in the context of the full-length Zap1 protein, AD1 and AD2 are both critical to the full control of gene expression in response to zinc...
  11. ncbi request reprint Regulation of the yeast TSA1 peroxiredoxin by ZAP1 is an adaptive response to the oxidative stress of zinc deficiency
    Chang Yi Wu
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 282:2184-95. 2007
    ..Thus, we conclude that TSA1 induction by Zap1p is an adaptive response to deal with the increased oxidative stress caused by zinc deficiency...
  12. pmc Repression of sulfate assimilation is an adaptive response of yeast to the oxidative stress of zinc deficiency
    Chang Yi Wu
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 284:27544-56. 2009
    ..These studies have led to new insights into how cells adapt to nutrient-limiting growth conditions...
  13. ncbi request reprint Multiple regulatory mechanisms maintain zinc homeostasis in Saccharomyces cerevisiae
    David J Eide
    Department of Nutritional Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    J Nutr 133:1532S-5S. 2003
    ..The activity of these transporters is regulated at both transcriptional and posttranscriptional levels in response to zinc. These different mechanisms work together to precisely balance zinc uptake and its storage and utilization...
  14. pmc Zinc fingers can act as Zn2+ sensors to regulate transcriptional activation domain function
    Amanda J Bird
    Department of Nutritional Sciences, 217 Gwynn Hall, University of Missouri, Columbia, MO 65211, USA
    EMBO J 22:5137-46. 2003
    ..These studies suggest that these zinc fingers play an unprecedented role as zinc sensors to control activation domain function...
  15. pmc Zinc status and vacuolar zinc transporters control alkaline phosphatase accumulation and activity in Saccharomyces cerevisiae
    Wei Qiao
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Mol Microbiol 72:320-34. 2009
    ..These data suggest that Pho8 receives its metal cofactor in the vacuole rather than in earlier compartments of the secretory pathway...
  16. pmc Cytosolic superoxide dismutase (SOD1) is critical for tolerating the oxidative stress of zinc deficiency in yeast
    Chang Yi Wu
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 4:e7061. 2009
    ..Thus, these data indicate that while Sod1 activity is critical for low zinc growth, diminished Sod1 activity is not a major source of the elevated ROS observed under these conditions...
  17. ncbi request reprint Heteromeric protein complexes mediate zinc transport into the secretory pathway of eukaryotic cells
    Charissa D Ellis
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 280:28811-8. 2005
    ..These results suggest that heteromeric complexes formed by different CDF members may be a common phenomenon for this ubiquitous family of metal ion transporters...
  18. pmc Saccharomyces cerevisiae vacuole in zinc storage and intracellular zinc distribution
    Claudia Simm
    Department of Nutritional Sciences, 1415 Linden Drive, University of Wisconsin Madison, Madison, WI 53706, USA
    Eukaryot Cell 6:1166-77. 2007
    ..Our results implicate zinc as a major determinant of the ability of the cell to store these other important nutrients...
  19. ncbi request reprint A cytosolic domain of the yeast Zrt1 zinc transporter is required for its post-translational inactivation in response to zinc and cadmium
    Raad S Gitan
    Department of Nutritional Sciences and Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 278:39558-64. 2003
    ..Using mutant alleles defective for metal-responsive inactivation, we also show that Zrt1 inactivation may be an important mechanism for preventing cadmium uptake and toxicity in zinc-limited cells...
  20. pmc Differential metal selectivity and gene expression of two zinc transporters from rice
    Sunita A Ramesh
    Commonwealth Scientific and Industrial Research Organization Plant Industry Horticulture Unit, Glen Osmond, South Australia 5064, Australia
    Plant Physiol 133:126-34. 2003
    ..Comparisons of the protein sequences, ionic selectivity, and gene expression patterns of the two transporters suggest that they may play different roles in the physiology of the whole plant...
  21. ncbi request reprint The SLC39 family of metal ion transporters
    David J Eide
    Departments of Nutritional Sciences and Biochemistry, University of Missouri, 217 Gwynn Hall, Columbia, MO 65211, USA
    Pflugers Arch 447:796-800. 2004
    ..Mutations in SLC39A4 have been identified in patients with acrodermatitis enteropathica, a genetic disease of zinc deficiency...
  22. ncbi request reprint Induction of the ZRC1 metal tolerance gene in zinc-limited yeast confers resistance to zinc shock
    Colin W MacDiarmid
    Departments of Nutritional Sciences and Physiology, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 278:15065-72. 2003
    ..We propose that this "proactive" strategy of homeostatic regulation, such as we document here for ZRC1, may represent a common but largely unrecognized phenomenon...
  23. pmc Repression of ADH1 and ADH3 during zinc deficiency by Zap1-induced intergenic RNA transcripts
    Amanda J Bird
    Departments of Medicine and Biochemistry, University of Utah Health Sciences Center, 50 North 1900 East, Salt Lake City, UT 84132, USA
    EMBO J 25:5726-34. 2006
    ..We found that ADH3, the major mitochondrial alcohol dehydrogenase, is regulated in a manner similar to ADH1. Thus, during zinc deficiency, Zap1 mediates the repression of two of the most abundant zinc-requiring enzymes...
  24. ncbi request reprint Biochemical properties of vacuolar zinc transport systems of Saccharomyces cerevisiae
    Colin W MacDiarmid
    Departments of Nutritional Sciences and Physiology, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 277:39187-94. 2002
    ..Moreover, these systems had high affinities for zinc with apparent K(m) values in the 100-200 nm range. These results provide biochemical insight into the important role of Zrc1 and related proteins in eukaryotic zinc homeostasis...
  25. ncbi request reprint Combinatorial control of yeast FET4 gene expression by iron, zinc, and oxygen
    Brian M Waters
    Department of Agronomy, University of Missouri, Columbia, MO 65211, USA
    J Biol Chem 277:33749-57. 2002
    ..Derepression of FET4 may allow the Fet4 transporter to play an even greater role in metal acquisition under anaerobic conditions. Thus, Fet4 is a multisubstrate metal ion transporter under combinatorial control by iron, zinc, and oxygen...
  26. pmc The Zap1 transcriptional activator also acts as a repressor by binding downstream of the TATA box in ZRT2
    Amanda J Bird
    Department of Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    EMBO J 23:1123-32. 2004
    ..These results indicate that the unusual pattern of ZRT2 regulation among Zap1 target genes involves the antagonistic effect of Zap1 binding to a low-affinity ZRE repressor site and high-affinity ZREs required for activation...
  27. ncbi request reprint Zinc-stimulated endocytosis controls activity of the mouse ZIP1 and ZIP3 zinc uptake transporters
    Fudi Wang
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 279:24631-9. 2004
    ..Moreover, our results indicate that zinc-responsive endocytosis is a conserved mechanism controlling activity of many mammalian zinc uptake transporters...
  28. pmc Metalloregulation of yeast membrane steroid receptor homologs
    Thomas J Lyons
    Department of Chemistry, University of Florida, P O Box 117200, Gainesville, FL 32611, USA
    Proc Natl Acad Sci U S A 101:5506-11. 2004
    ..We propose that the IZH genes affect zinc homeostasis either directly or indirectly by altering sterol metabolism...
  29. ncbi request reprint The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells
    Fudi Wang
    Departments of Biochemistry and Nutritional Sciences, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 279:51433-41. 2004
    ..Furthermore, given its expression in tissues important to zinc homeostasis, we propose that Zip5 plays a central role in controlling organismal zinc status...
  30. ncbi request reprint Characterization of a Glomus intraradices gene encoding a putative Zn transporter of the cation diffusion facilitator family
    Manuel González-Guerrero
    Departamento de Microbiologia del Suelo y Sistemas Simbioticos, Estacion Experimental del Zaidin, CSIC, Profesor Albareda, 1, 18008 Granada, Spain
    Fungal Genet Biol 42:130-40. 2005
    ..These data suggest a role of GintZnT1 in Zn compartmentalization and in the protection of G. intraradices against Zn stress...
  31. ncbi request reprint Drosophila fear of intimacy encodes a Zrt/IRT-like protein (ZIP) family zinc transporter functionally related to mammalian ZIP proteins
    Wendy R Mathews
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Biol Chem 280:787-95. 2005
    ..In addition, this work indicates that the control of zinc by ZIP transporters may play a critical role in regulating developmental processes...
  32. ncbi request reprint Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane
    Byung Eun Kim
    Departments of Nutritional Sciences and Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 279:4523-30. 2004
    ..These findings suggest that zinc-regulated trafficking of human and mouse ZIP4 is a key mechanism controlling dietary zinc absorption and cellular zinc homeostasis...
  33. ncbi request reprint A histidine-rich cluster mediates the ubiquitination and degradation of the human zinc transporter, hZIP4, and protects against zinc cytotoxicity
    Xiaoqing Mao
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 282:6992-7000. 2007
    ....
  34. ncbi request reprint Acrodermatitis enteropathica mutations affect transport activity, localization and zinc-responsive trafficking of the mouse ZIP4 zinc transporter
    Fudi Wang
    Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
    Hum Mol Genet 13:563-71. 2004
    ..These effects suggest a zinc sensing mechanism for regulating Zip4 trafficking in response to zinc...
  35. ncbi request reprint Zinc metalloregulation of the zinc finger pair domain
    Amanda J Bird
    University of Utah Health Sciences Center, Department of Medicine and Biochemistry, Salt Lake City, Utah 84132, USA
    J Biol Chem 281:25326-35. 2006
    ..The present results demonstrate that zinc regulation of AD activity of ZF2 is dependent on determinants in ZF1 as well as the alpha-helix segment of ZF2...
  36. pmc Characterization of FRO1, a pea ferric-chelate reductase involved in root iron acquisition
    Brian M Waters
    Department of Agronomy, University of Missouri, Columbia, Missouri 65211, USA
    Plant Physiol 129:85-94. 2002
    ..These results indicate differential regulation of FRO1 in roots and shoots, and improper FRO1 regulation in response to a shoot-derived signal of iron status in the roots of the brz and dgl mutants...

Research Grants22

  1. REGULATION OF CELLULAR ZINC HOMEOSTASIS
    David J Eide; Fiscal Year: 2010
    ....
  2. Zinc Transporters and Intracellular Zinc Trafficking
    David Eide; Fiscal Year: 2007
    ....
  3. REGULATION OF CELLULAR ZINC HOMEOSTASIS
    David Eide; Fiscal Year: 2007
    ..The fourth mechanism we will assess is if DBD function per se is Zn regulated. These studies will lead to fundamental insights into metallosensing and Zn homeostasis. ..
  4. Mammalian Zinc Transporters and Zinc Homeostasis
    David J Eide; Fiscal Year: 2010
    ..This proposal is focused on Zip13, a zinc transporter recently linked to some cases of Ehlers-Danlos Syndrome, and the role this protein plays in controlling the vesicular storage of zinc. ..
  5. REGULATION OF CELLULAR ZINC HOMEOSTASIS
    David Eide; Fiscal Year: 2009
    ....
  6. REGULATION OF CELLULAR ZINC HOMEOSTASIS
    David Eide; Fiscal Year: 1999
    ..4) Identify potential intermolecular repressors of Zap1p activity. 5) Characterize zinc-binding by Zap1p in vitro. These experiments will lead to a greater understanding of zinc homeostasis in human cells. ..
  7. REGULATION OF CELLULAR ZINC HOMEOSTASIS
    David Eide; Fiscal Year: 2003
    ..These studies should provide greater insight into the processes of zinc homeostasis in all eukaryotes. ..
  8. 2004 FASEB Summer Conference on Trace Element Metabolism
    David Eide; Fiscal Year: 2004
    ..These individuals will be encouraged to present posters to be displayed in two poster sessions. We also will obtain funds to provide travel awards for up to 10 postdocs or senior graduate students. ..