GUIDO E EIBL

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells
    Guido Eibl
    Section of Gastrointestinal Surgery, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, 72 231 CHS, Los Angeles, CA 90095 6904, USA
    Biochem Biophys Res Commun 306:887-97. 2003
  2. pmc The Role of PPAR-gamma and Its Interaction with COX-2 in Pancreatic Cancer
    Guido Eibl
    Hirshberg Laboratories for Pancreatic Cancer Research, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, 675 Charles E Young Drive South, MRL 2535, Los Angeles, CA 90095, USA
    PPAR Res 2008:326915. 2008
  3. pmc High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model
    David W Dawson
    Department of Surgery, David Geffen School of Medicine, University of California at Los Angeles, 10833 LeConte Avenue, 72 236 CHS, Los Angeles, CA 90095
    Cancer Prev Res (Phila) 6:1064-73. 2013
  4. pmc Baicalein--an intriguing therapeutic phytochemical in pancreatic cancer
    Graham Donald
    UCLA Center for Excellence in Pancreatic Diseases, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Curr Drug Targets 13:1772-6. 2012
  5. pmc Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer
    John P Duffy
    Section of Gastrointestinal Surgery, The David Geffen School of Medicine at UCLA, 72 215 CHS, MC 690418, Los Angeles, CA 90095 6904, USA
    Mol Cancer 2:12. 2003
  6. ncbi request reprint Therapy of microcirculatory disorders in severe acute pancreatitis: what mediators should we block?
    Guido Eibl
    Department of Surgery, Benjamin Franklin Medical Center, Freie Universitat Berlin, Germany
    Intensive Care Med 28:139-46. 2002
  7. ncbi request reprint A xenograft nude mouse model for perineural invasion and recurrence in pancreatic cancer
    Guido Eibl
    Division of General Surgery, David Geffen School of Medicine at UCLA, Hirshberg Pancreatic Cancer Laboratory, Los Angeles, CA 90095 7330, USA
    Pancreas 31:258-62. 2005
  8. ncbi request reprint Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor
    Guido Eibl
    Section of Gastrointestinal Surgery, David Geffen School of Medicine at University of California Los Angeles, 10833 LeConte Avenue, Los Angeles, CA 90095 6904, USA
    Cancer Res 65:982-90. 2005
  9. ncbi request reprint COX and PPAR: possible interactions in pancreatic cancer
    Guido Eibl
    Section of Gastrointestinal Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Pancreas 29:247-53. 2004
  10. ncbi request reprint Endothelin A but not endothelin B receptor blockade reduces capillary permeability in severe experimental pancreatitis
    Guido Eibl
    Department of Surgery, Benjamin Franklin Medical Center, Freie Universitat, Berlin, Germany
    Pancreas 25:e15-20. 2002

Collaborators

Detail Information

Publications29

  1. ncbi request reprint PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells
    Guido Eibl
    Section of Gastrointestinal Surgery, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, 72 231 CHS, Los Angeles, CA 90095 6904, USA
    Biochem Biophys Res Commun 306:887-97. 2003
    ..These data identify a subset of human PaCa cell lines that express functional COX-2 enzyme. PGE(2) generated by specific COX-2 activity increases VEGF secretion in human PaCa cells through an autocrine mechanism...
  2. pmc The Role of PPAR-gamma and Its Interaction with COX-2 in Pancreatic Cancer
    Guido Eibl
    Hirshberg Laboratories for Pancreatic Cancer Research, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, 675 Charles E Young Drive South, MRL 2535, Los Angeles, CA 90095, USA
    PPAR Res 2008:326915. 2008
    ..The current review summarizes the data about PPAR-gamma in pancreatic cancer and highlights the biologically relevant interactions between the cyclooxygenase and PPAR system...
  3. pmc High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model
    David W Dawson
    Department of Surgery, David Geffen School of Medicine, University of California at Los Angeles, 10833 LeConte Avenue, 72 236 CHS, Los Angeles, CA 90095
    Cancer Prev Res (Phila) 6:1064-73. 2013
    ....
  4. pmc Baicalein--an intriguing therapeutic phytochemical in pancreatic cancer
    Graham Donald
    UCLA Center for Excellence in Pancreatic Diseases, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Curr Drug Targets 13:1772-6. 2012
    ..Compounds such as baicalein, offer promise in dietary chemoprevention, as chemotherapeutic adjuvants, or as targeted therapy...
  5. pmc Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer
    John P Duffy
    Section of Gastrointestinal Surgery, The David Geffen School of Medicine at UCLA, 72 215 CHS, MC 690418, Los Angeles, CA 90095 6904, USA
    Mol Cancer 2:12. 2003
    ..Anti-angiogenic treatments for pancreatic cancer will likely be most effective when used as an integral part of a combination chemotherapeutic regimen...
  6. ncbi request reprint Therapy of microcirculatory disorders in severe acute pancreatitis: what mediators should we block?
    Guido Eibl
    Department of Surgery, Benjamin Franklin Medical Center, Freie Universitat Berlin, Germany
    Intensive Care Med 28:139-46. 2002
    ..To compare the effect of different vasoactive mediator antagonists in the same model of severe acute pancreatitis (AP) and to evaluate whether combinations of the agents exhibit synergistic effects...
  7. ncbi request reprint A xenograft nude mouse model for perineural invasion and recurrence in pancreatic cancer
    Guido Eibl
    Division of General Surgery, David Geffen School of Medicine at UCLA, Hirshberg Pancreatic Cancer Laboratory, Los Angeles, CA 90095 7330, USA
    Pancreas 31:258-62. 2005
    ..Perineural invasion correlates with and might be partially responsible for tumor recurrence and poor survival. However, no adequate preclinical animal model is yet available to study this aspect of pancreatic cancer biology...
  8. ncbi request reprint Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor
    Guido Eibl
    Section of Gastrointestinal Surgery, David Geffen School of Medicine at University of California Los Angeles, 10833 LeConte Avenue, Los Angeles, CA 90095 6904, USA
    Cancer Res 65:982-90. 2005
    ..These findings imply that assessing the COX-2 profile of the pancreatic tumor is mandatory before initiating therapy with a selective COX-2 inhibitor...
  9. ncbi request reprint COX and PPAR: possible interactions in pancreatic cancer
    Guido Eibl
    Section of Gastrointestinal Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Pancreas 29:247-53. 2004
  10. ncbi request reprint Endothelin A but not endothelin B receptor blockade reduces capillary permeability in severe experimental pancreatitis
    Guido Eibl
    Department of Surgery, Benjamin Franklin Medical Center, Freie Universitat, Berlin, Germany
    Pancreas 25:e15-20. 2002
    ..Endothelin receptor antagonists (ET-RA) have been shown to stabilize capillary leakage and improve organ function in AP...
  11. ncbi request reprint Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor
    Hitoshi Funahashi
    Hirshberg Laboratories for Pancreatic Cancer Research, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Cancer Res 67:7068-71. 2007
    ..These data highlight the importance of COX-2 in the development of pancreatic cancer. Inhibition of COX-2 may represent an intriguing strategy to prevent pancreatic cancer in high-risk patients...
  12. ncbi request reprint The selective cyclooxygenase-2 inhibitor nimesulide induces apoptosis in pancreatic cancer cells independent of COX-2
    Guido Eibl
    Division of General Surgery, David Geffen School of Medicine, University of California at Los Angeles, California CA 90095 6904, USA
    Pancreas 26:33-41. 2003
    ..This study was designed to investigate the effects of the COX-2 inhibitor nimesulide on the growth of human pancreatic cancer cells...
  13. pmc Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family
    Izumi Ohno
    Veterans Affairs Greater Los Angeles Healthcare System, Departments of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Am J Physiol Gastrointest Liver Physiol 298:G63-73. 2010
    ..Thus rottlerin represents a promising novel agent for pancreatic cancer treatment...
  14. ncbi request reprint The G691S RET polymorphism increases glial cell line-derived neurotrophic factor-induced pancreatic cancer cell invasion by amplifying mitogen-activated protein kinase signaling
    Hirozumi Sawai
    Hirshberg Laboratories for Pancreatic Cancer Research, Department of Surgery, David Geffen School of Medicine, University of California at Los Angeles, 90095, USA
    Cancer Res 65:11536-44. 2005
    ..These findings indicate that the G691S RET single nucleotide polymorphism may directly correlate with the aggressive growth of pancreatic cancers and may function as a genetic modifier or even low-penetrance gene...
  15. ncbi request reprint Activation of peroxisome proliferator-activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system
    Hirozumi Sawai
    Hirshberg Laboratory for Pancreatic Cancer Research, Department of Surgery, David Geffen School of Medicine, University of California at Los Angeles, 675 Charles E Young Drive South, MRL 2535, Los Angeles, CA 90095, USA
    Mol Cancer Res 4:159-67. 2006
    ..These findings further underscore the potential role of PPAR-gamma ligands as therapeutic agents in pancreatic cancer...
  16. pmc Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors
    Hung Pham
    Department of Medicine, Hirshberg Laboratories for Pancreatic Cancer Research, and David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1786, USA
    Pancreas 39:332-9. 2010
    ..Down-regulation of PGDH contributes to PGE2 accumulation in lung and colon cancers but has not been identified in pancreatic cancer...
  17. pmc Quercetin aglycone is bioavailable in murine pancreas and pancreatic xenografts
    Lifeng Zhang
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 58:7252-7. 2010
    ..Gemcitabine cotreatment with quercetin reduced absorption of quercetin in the mouse circulatory system and liver. Results from the study provide important information on the interpretation of the chemotherapeutic efficacy of quercetin...
  18. ncbi request reprint Opposing effects of n-6 and n-3 polyunsaturated fatty acids on pancreatic cancer growth
    Hitoshi Funahashi
    Hirshberg Laboratories for Pancreatic Cancer Research, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Pancreas 36:353-62. 2008
    ..The aim of this study was to evaluate the effects of n-6 and n-3 PUFAs on the growth of pancreatic cancer...
  19. ncbi request reprint 15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice
    Hung Pham
    Department of Medicine, Division of Digestive Diseases, University of California, Los Angeles, California, USA
    Mol Carcinog 47:466-77. 2008
    ..Based on these data, we conclude that PGDH expression suppresses K-Ras(V12)-mediated tumorigenesis in intestinal epithelial cells...
  20. ncbi request reprint Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells
    Yuji Okada
    Section of Gastrointestinal Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 6904, USA
    Clin Exp Metastasis 21:285-92. 2004
    ..These findings support the hypothesis that neurotrophic factors, e.g., NGF, are critically involved in mediating perineural invasion of pancreatic cancer...
  21. ncbi request reprint Expression analysis of the prostaglandin E2 production pathway in human pancreatic cancers
    Sascha Hasan
    Department of Surgery, Hirshberg Laboratories for Pancreatic Cancer Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Pancreas 37:121-7. 2008
    ..This study aimed at analyzing the expression of various proteins involved in the generation of PGE2 in human pancreatic cancers...
  22. pmc Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells
    Eliane Angst
    Hirshberg Laboratories for Pancreatic Cancer Research, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Pancreas 39:675-9. 2010
    ..As the NDRG1 gene possesses a large promoter CpG island, we sought to determine whether its repression is epigenetically mediated in PaCa cells...
  23. ncbi request reprint Omega-3 fatty acid supplementation increases anti-inflammatory cytokines and attenuates systemic disease sequelae in experimental pancreatitis
    Thomas Foitzik
    Department of Surgery, Benjamin Franklin Medical Center, Freie Universitat Berlin, Germany
    JPEN J Parenter Enteral Nutr 26:351-6. 2002
    ..Basic parenteral nutrition delivers omega-6-FA and omega-3-FA at a ratio of approximately 7:1...
  24. pmc Mononuclear cell-derived interleukin-1 beta confers chemoresistance in pancreatic cancer cells by upregulation of cyclooxygenase-2
    Eliane Angst
    Hirshberg Laboratories for Pancreatic Cancer Research, CURE, Digestive Diseases Research Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Surgery 144:57-65. 2008
    ..In addition, cyclooxygenase-2 is thought to be an important mediator of chemoresistance in several malignancies. The aim of this study was to explore the role of mononuclear cells in pancreatic cancer chemoresistance...
  25. ncbi request reprint Estrogen receptors in pancreatic tumors
    Makoto Satake
    Division of General Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7330, USA
    Pancreas 33:119-27. 2006
    ..The aim of the present study was to systematically review the available literature about ER expression in pancreatic tumors and to discuss the potential importance of estrogen signaling in them...
  26. ncbi request reprint The proteasome inhibitor MG132 induces apoptosis in human pancreatic cancer cells
    Moritz N Wente
    Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    Oncol Rep 14:1635-8. 2005
    ..This effect was at least in part mediated by the induction of apoptosis. A combination therapy with standard cytotoxic agents and proteasome inhibitors could potentially be a novel therapeutic strategy in treatment of pancreatic cancer...
  27. ncbi request reprint Glial cell-derived neurotrophic factor upregulates the expression and activation of matrix metalloproteinase-9 in human pancreatic cancer
    Yuji Okada
    Section of Gastrointestinal Surgery, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Surgery 134:293-9. 2003
    ..The purpose of this study was to determine whether GDNF regulates the expression and activation of matrix metalloproteinase-9 (MMP-9) in human pancreatic cancer cells...
  28. pmc Systemic disease-induced salivary biomarker profiles in mouse models of melanoma and non-small cell lung cancer
    Kai Gao
    School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, CA, USA
    PLoS ONE 4:e5875. 2009
    ..Although the rationale for oral diseases applications (e.g. oral cancer) is intuitive, the rationale and relationship between systemic diseases and saliva biomarkers are unclear...
  29. ncbi request reprint Distal pancreatectomy: incidence of postoperative diabetes
    Jonathan King
    Department of Surgery, David Geffen School of Medicine, UCLA, 10833 Le Conte Ave, CHS 72 170, Los Angeles, CA 90095 6904, USA
    J Gastrointest Surg 12:1548-53. 2008
    ..The true rate of diabetes after distal pancreatectomy is not known, but we hypothesize that the risk is nominal...

Research Grants8

  1. The Role of COX-2 and PPAR-Gamma in Pancreatic Cancer
    Guido Eibl; Fiscal Year: 2004
    ..abstract_text> ..
  2. The Role of COX-2 and PPAR-Gamma in Pancreatic Cancer
    Guido Eibl; Fiscal Year: 2005
    ..abstract_text> ..
  3. The Role of COX-2 and PPAR-Gamma in Pancreatic Cancer
    Guido Eibl; Fiscal Year: 2006
    ..abstract_text> ..
  4. The Role of COX-2 and PPAR-Gamma in Pancreatic Cancer
    Guido Eibl; Fiscal Year: 2007
    ..abstract_text> ..
  5. The role of n-3 polyunsaturated fatty acids in pancreatic cancer
    Guido Eibl; Fiscal Year: 2007
    ....
  6. The role of n-3 polyunsaturated fatty acids in pancreatic cancer
    Guido Eibl; Fiscal Year: 2009
    ....
  7. The role of n-3 polyunsaturated fatty acids in pancreatic cancer
    GUIDO ERWIN MICHAEL EIBL; Fiscal Year: 2010
    ....