David A Ehrmann

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint Polycystic ovary syndrome
    David A Ehrmann
    University of Chicago, Department of Medicine, Section of Endocrinology, Chicago, USA
    N Engl J Med 352:1223-36. 2005
  2. ncbi request reprint Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome
    David A Ehrmann
    Department of Medicine, Section of Endocrinology, The University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 91:48-53. 2006
  3. pmc Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome
    Toshihide Kawai
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Diabetes Res Clin Pract 86:186-92. 2009
  4. ncbi request reprint Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome
    David A Ehrmann
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 87:4297-300. 2002
  5. pmc Determination of the source of androgen excess in functionally atypical polycystic ovary syndrome by a short dexamethasone androgen-suppression test and a low-dose ACTH test
    Robert L Rosenfield
    Department of Pediatrics and Medicine, The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Hum Reprod 26:3138-46. 2011
  6. ncbi request reprint Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome
    Sergio Y Alcoser
    Department of Biochemistry, The University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 89:2973-6. 2004
  7. ncbi request reprint Genetic contributions to glucose intolerance in polycystic ovary syndrome
    David A Ehrmann
    Department of Medicine, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Reprod Biomed Online 9:28-34. 2004
  8. pmc Treatment of obstructive sleep apnea improves cardiometabolic function in young obese women with polycystic ovary syndrome
    Esra Tasali
    Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 96:365-74. 2011
  9. pmc Antimüllerian hormone levels are independently related to ovarian hyperandrogenism and polycystic ovaries
    Robert L Rosenfield
    Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    Fertil Steril 98:242-9. 2012
  10. pmc Impact of obstructive sleep apnea on insulin resistance and glucose tolerance in women with polycystic ovary syndrome
    Esra Tasali
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 93:3878-84. 2008

Detail Information

Publications34

  1. ncbi request reprint Polycystic ovary syndrome
    David A Ehrmann
    University of Chicago, Department of Medicine, Section of Endocrinology, Chicago, USA
    N Engl J Med 352:1223-36. 2005
  2. ncbi request reprint Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome
    David A Ehrmann
    Department of Medicine, Section of Endocrinology, The University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 91:48-53. 2006
    ..Polycystic ovary syndrome (PCOS) and the metabolic syndrome have many features in common and may share the same pathogenesis...
  3. pmc Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome
    Toshihide Kawai
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Diabetes Res Clin Pract 86:186-92. 2009
    ..59], P=0.022). It was also associated with increased LDL (P=0.007) and total cholesterol levels (P=0.042). These results suggest that genetic variation in PLIN may affect glucose and lipid metabolism in women both with and without PCOS...
  4. ncbi request reprint Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome
    David A Ehrmann
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 87:4297-300. 2002
    ..Thus, individuals with the common IRS-2 Gly/Gly genotype may be at increased risk of developing type 2 diabetes...
  5. pmc Determination of the source of androgen excess in functionally atypical polycystic ovary syndrome by a short dexamethasone androgen-suppression test and a low-dose ACTH test
    Robert L Rosenfield
    Department of Pediatrics and Medicine, The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Hum Reprod 26:3138-46. 2011
    ..The objective of this study was to determine the source of androgen excess in the one-third of PCOS patients who atypically lack this type of ovarian dysfunction (PCOS-A)...
  6. ncbi request reprint Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome
    Sergio Y Alcoser
    Department of Biochemistry, The University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 89:2973-6. 2004
    ..8 pmol/liter). Studies of diabetic and nondiabetic PCOS women of other racial and ethnic backgrounds will be necessary to assess the impact of this and other variants in PPP1R3 upon the phenotype and natural history of women with PCOS...
  7. ncbi request reprint Genetic contributions to glucose intolerance in polycystic ovary syndrome
    David A Ehrmann
    Department of Medicine, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Reprod Biomed Online 9:28-34. 2004
    ..This article reviews the background and recent studies examining the genetic contributions to glucose intolerance in PCOS...
  8. pmc Treatment of obstructive sleep apnea improves cardiometabolic function in young obese women with polycystic ovary syndrome
    Esra Tasali
    Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 96:365-74. 2011
    ..We sought to determine whether continuous positive airway pressure (CPAP) treatment of OSA has beneficial effects on cardiometabolic function in PCOS...
  9. pmc Antimüllerian hormone levels are independently related to ovarian hyperandrogenism and polycystic ovaries
    Robert L Rosenfield
    Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    Fertil Steril 98:242-9. 2012
    ..To determine the relationship of antimüllerian hormone (AMH) levels to polycystic ovaries and ovarian androgenic function...
  10. pmc Impact of obstructive sleep apnea on insulin resistance and glucose tolerance in women with polycystic ovary syndrome
    Esra Tasali
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 93:3878-84. 2008
    ..Obstructive sleep apnea (OSA) has been linked to metabolic dysfunction. We studied women with and without PCOS to determine the extent to which OSA is responsible for insulin resistance and glucose intolerance in PCOS...
  11. ncbi request reprint Effects of race and family history of type 2 diabetes on metabolic status of women with polycystic ovary syndrome
    David A Ehrmann
    Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 90:66-71. 2005
    ..Finally, the fasting glucose concentration was poorly associated with 2-h glucose concentrations among PCOS women with IGT, suggesting that the fasting glucose concentration is inadequate to predict the presence of IGT in PCOS...
  12. ncbi request reprint Relationships between sleep disordered breathing and glucose metabolism in polycystic ovary syndrome
    Esra Tasali
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 91:36-42. 2006
    ..Women with polycystic ovary syndrome (PCOS) are insulin resistant and are at increased risk for sleep apnea, which, in turn, may contribute to insulin resistance...
  13. ncbi request reprint Relationship of calpain-10 genotype to phenotypic features of polycystic ovary syndrome
    David A Ehrmann
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 87:1669-73. 2002
    ..In addition to its association with insulin levels in African-Americans, the 112/121-haplotype combination was associated with an approximate 2-fold increase in risk of PCOS in both African-Americans and whites...
  14. pmc Asymptomatic volunteers with a polycystic ovary are a functionally distinct but heterogeneous population
    Monica Mortensen
    Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, The University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 94:1579-86. 2009
    ..Our objective was to determine the ovarian function of asymptomatic volunteers with a polycystic ovary (V-PCO)...
  15. doi request reprint Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study
    Josiane L Broussard
    University of Chicago, Chicago, IL 60637, USA
    Ann Intern Med 157:549-57. 2012
    ..Yet, a direct link between sleep restriction and alterations in molecular metabolic pathways in any peripheral human tissue has not been shown...
  16. pmc Sleep disturbances and their relationship to glucose tolerance in pregnancy
    Sirimon Reutrakul
    Section of Adult and Pediatric Endocrinology, Diabetes, andMetabolism, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Diabetes Care 34:2454-7. 2011
    ..To explore relationships among sleep disturbances, glucose tolerance, and pregnancy outcomes...
  17. ncbi request reprint Impaired beta-cell compensation to dexamethasone-induced hyperglycemia in women with polycystic ovary syndrome
    David A Ehrmann
    Department of Medicine, Section of Endocrinology, The University of Chicago Pritzker School of Medicine, 5841 South Maryland Ave, MC 1027, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 287:E241-6. 2004
    ..The accelerated deterioration in glucose tolerance in PCOS may result, in part, from a relative attenuation in the response of the beta-cell to the demand placed on it by factors exacerbating insulin resistance...
  18. doi request reprint Cardiometabolic features of polycystic ovary syndrome
    Leslie K Hoffman
    Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 S Maryland Avenue, Mail Code 1027, Chicago, IL 60637, USA
    Nat Clin Pract Endocrinol Metab 4:215-22. 2008
    ..Attention to the metabolic risks associated with PCOS, starting as early as adolescence, is essential to the medical care of these patients...
  19. ncbi request reprint Pharmacologic therapy of polycystic ovary syndrome
    Suma Dronavalli
    Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, The University of Chicago, Chicago, Illinois, USA
    Clin Obstet Gynecol 50:244-54. 2007
    ..Metabolic concerns of PCOS include excess body weight and insulin resistance. Metformin and thiazolidenediones both improve hyperinsulinemia but their differential effects on body weight must be considered...
  20. ncbi request reprint Pharmacologic treatment of polycystic ovary syndrome
    David A Ehrmann
    Department of Medicine, Section of Endocrinology, The University of Chicago, Chicago, Illinois 60637, USA
    Semin Reprod Med 21:277-83. 2003
    ..Options for the treatment of the reproductive abnormalities (menstrual dysfunction and interfility) are presented. Finally, the metabolic manifestations of PCOS are reviewed and their treatment is discussed...
  21. pmc Identification of a functional polymorphism of the human type 5 17beta-hydroxysteroid dehydrogenase gene associated with polycystic ovary syndrome
    Kenan Qin
    Department of Pediatrics, Section of Pediatric Endocrinology, The University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 91:270-6. 2006
    ..Type 5 17beta-hydroxysteroid dehydrogenase (17beta-HSD5) appears to be the major testosterone-forming 17beta-HSD isoenzyme in females...
  22. pmc Characterization of functionally typical and atypical types of polycystic ovary syndrome
    Jennifer Hirshfeld-Cytron
    Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Clin Endocrinol Metab 94:1587-94. 2009
    ..The typical polycystic ovary syndrome (PCOS) phenotype includes 17-hydroxyprogesterone (17OHP) hyperresponsiveness to GnRH agonist (GnRHag) testing. Functionally atypical PCOS lacks this feature...
  23. pmc Metabolic dysfunction in pcos: Relationship to obstructive sleep apnea
    David A Ehrmann
    Section of Endocrinology, Diabetes, and Metabolism, The University of Chicago, 5841 S Maryland Ave, Mail Code 1027, Chicago, IL 60637, USA
    Steroids 77:290-4. 2012
    ..The causes and consequences of OSA in women with PCOS are addressed in this manuscript...
  24. ncbi request reprint Insulin resistance is attenuated in women with polycystic ovary syndrome with the Pro(12)Ala polymorphism in the PPARgamma gene
    Manami Hara
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 87:772-5. 2002
    ..03) and 2 h (688 +/- 103 vs. 10190 +/- 99 pmol/liter; P = 0.04) time points during the oral glucose tolerance test. We conclude that Pro(12)Ala in PPARG is a modifier of insulin resistance in Caucasian women with PCOS...
  25. pmc Slow-wave sleep and the risk of type 2 diabetes in humans
    Esra Tasali
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 105:1044-9. 2008
    ..Furthermore, our data suggest that reduced sleep quality with low levels of SWS, as occurs in aging and in many obese individuals, may contribute to increase the risk of type 2 diabetes...
  26. ncbi request reprint Insulin resistance and polycystic ovary syndrome
    David A Ehrmann
    Department of Medicine, Section of Endocrinology, University of Chicago Pritzker School of Medicine, 5841 South Maryland Avenue, MC 1027, Chicago, IL 60637, USA
    Curr Diab Rep 2:71-6. 2002
    ..quot; These manifestations include obesity, glucose intolerance, hypertension, macrovascular disease, and dyslipidemia. The etiology and manifestations of insulin resistance in PCOS are reviewed in this article...
  27. pmc Potential diagnostic utility of intermittent administration of short-acting gonadotropin-releasing hormone agonist in gonadotropin deficiency
    Carrie A Zimmer
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Fertil Steril 94:2697-702. 2010
    ....
  28. pmc Obstructive sleep apnea and metabolic dysfunction in polycystic ovary syndrome
    Katie Nitsche
    Section of Endocrinology, Diabetes, and Metabolism, The University of Chicago, 5841 S Maryland Ave, Mail Code 1027, Chicago, IL, USA
    Best Pract Res Clin Endocrinol Metab 24:717-30. 2010
    ....
  29. ncbi request reprint The value of the low-dose dexamethasone suppression test in the differential diagnosis of hyperandrogenism in women
    Robert L Rosenfield
    J Clin Endocrinol Metab 88:6115; author reply 6115-6. 2003
  30. ncbi request reprint Androgens and mood dysfunction in women: comparison of women with polycystic ovarian syndrome to healthy controls
    Cindy L Weiner
    Behavioral and Neuropsychological Consultants, LLP, New York, NY 10010, USA
    Psychosom Med 66:356-62. 2004
    ..The purposes of this study were 1) to compare negative mood states of women with PCOS to those of women with normal hormonal levels and 2) to examine the relationship between negative moods and androgens...
  31. ncbi request reprint Troglitazone decreases adrenal androgen levels in women with polycystic ovary syndrome
    Ricardo Azziz
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Fertil Steril 79:932-7. 2003
    ..To determine whether amelioration of insulin resistance in polycystic ovary syndrome (PCOS) with the insulin sensitizer troglitazone (TGZ) decreases circulating adrenal androgens (AAs), as reflected by DHEAS levels...
  32. pmc Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program
    William C Knowler
    George Washington University Biostatistics Center, Rockville, Maryland, USA
    Diabetes 54:1150-6. 2005
    ..Whether other thiazolidinedione drugs used for longer periods can safely prevent diabetes remains to be determined...
  33. pmc Factors associated with diabetes onset during metformin versus placebo therapy in the diabetes prevention program
    John M Lachin
    d, Diabetes Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    Diabetes 56:1153-9. 2007
    ....
  34. doi request reprint Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline
    Kathryn A Martin
    Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:1105-20. 2008
    ..Our objective was to develop clinical practice guidelines for the evaluation and treatment of hirsutism in premenopausal women...