Marissa Ehringer

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. pmc Mutational load analysis of unrelated individuals
    Daniel P Howrigan
    Institute for Behavioral Genetics, University of Colorado at Boulder, 1480 30th Street, Boulder, CO 80303, USA
    BMC Proc 5:S55. 2011
  2. doi request reprint Reduced alcohol consumption in mice with access to a running wheel
    Marissa A Ehringer
    University of Colorado, Institute for Behavioral Genetics, 447 UCB, Boulder, CO 80309 0447, USA
    Alcohol 43:443-52. 2009
  3. pmc Association of CHRN genes with "dizziness" to tobacco
    Marissa A Ehringer
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
    Am J Med Genet B Neuropsychiatr Genet 153:600-9. 2010
  4. ncbi request reprint Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine
    Marissa A Ehringer
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Am J Med Genet B Neuropsychiatr Genet 144:596-604. 2007
  5. ncbi request reprint Genetic and environmental contributions to common psychopathologies of childhood and adolescence: a study of twins and their siblings
    Marissa A Ehringer
    Institute for Behavioral Genetics, University of Colorado at Boulder, 80309, USA
    J Abnorm Child Psychol 34:1-17. 2006
  6. ncbi request reprint The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco
    Joanna S Zeiger
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Hum Mol Genet 17:724-34. 2008
  7. ncbi request reprint An association between the DAT1 polymorphism and smoking behavior in young adults from the National Longitudinal Study of Adolescent Health
    David S Timberlake
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309 0447, USA
    Health Psychol 25:190-7. 2006
  8. pmc Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample
    Nicole R Hoft
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Neuropsychopharmacology 34:698-706. 2009
  9. pmc The genetic components of alcohol and nicotine co-addiction: from genes to behavior
    Isabel R Schlaepfer
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Curr Drug Abuse Rev 1:124-34. 2008
  10. ncbi request reprint The moderating effects of religiosity on the genetic and environmental determinants of smoking initiation
    David S Timberlake
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
    Nicotine Tob Res 8:123-33. 2006

Detail Information

Publications27

  1. pmc Mutational load analysis of unrelated individuals
    Daniel P Howrigan
    Institute for Behavioral Genetics, University of Colorado at Boulder, 1480 30th Street, Boulder, CO 80303, USA
    BMC Proc 5:S55. 2011
    ..Overall, we did not find clear support for mutational load burden on affection status; however, these results are ultimately dependent on and limited by the nature of the Genetic Analysis Workshop 17 simulation...
  2. doi request reprint Reduced alcohol consumption in mice with access to a running wheel
    Marissa A Ehringer
    University of Colorado, Institute for Behavioral Genetics, 447 UCB, Boulder, CO 80309 0447, USA
    Alcohol 43:443-52. 2009
    ..These results suggest that exercise may be a useful approach to consider for treatment for some types of chronic human alcohol problem behaviors, but may be less applicable to human binge drinking...
  3. pmc Association of CHRN genes with "dizziness" to tobacco
    Marissa A Ehringer
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
    Am J Med Genet B Neuropsychiatr Genet 153:600-9. 2010
    ..In addition, a novel finding of association between SNPs in the CHRNA10 gene reached experiment-wide empirical significance (P = 0.048), which implicates another CHRN gene as being involved in early subjective response to tobacco...
  4. ncbi request reprint Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine
    Marissa A Ehringer
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Am J Med Genet B Neuropsychiatr Genet 144:596-604. 2007
    ..This study provides the first evidence for association between the CHRNB2 gene and nicotine- and alcohol-related phenotypes, and suggests that polymorphisms in CHRNB2 may be important in mediating early responses to nicotine and alcohol...
  5. ncbi request reprint Genetic and environmental contributions to common psychopathologies of childhood and adolescence: a study of twins and their siblings
    Marissa A Ehringer
    Institute for Behavioral Genetics, University of Colorado at Boulder, 80309, USA
    J Abnorm Child Psychol 34:1-17. 2006
    ..We found evidence for both genetic and non-shared environmental influences for all disorders. Shared environmental influences also seem to be important for MDD and lifetime GAD...
  6. ncbi request reprint The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco
    Joanna S Zeiger
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Hum Mol Genet 17:724-34. 2008
    ..These results indicate that early subjective response to nicotine may be a valuable endophenotype for genetic studies aimed at uncovering genes contributing to nicotine use and addiction...
  7. ncbi request reprint An association between the DAT1 polymorphism and smoking behavior in young adults from the National Longitudinal Study of Adolescent Health
    David S Timberlake
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309 0447, USA
    Health Psychol 25:190-7. 2006
    ..Never smokers and current nonsmokers had an excess transmission of the 9-repeat allele compared with regular smokers, suggesting a protective effect of the 9-repeat allele, which is hypothesized to alter synaptic dopamine levels...
  8. pmc Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample
    Nicole R Hoft
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Neuropsychopharmacology 34:698-706. 2009
    ..SNPs in CHRNB3 were found to be associated with the number of quit attempts (p=0.0024). Together these results further implicate the region downstream of CHRNA6 and the region upstream of CHRNB3 in risk of nicotine dependence...
  9. pmc The genetic components of alcohol and nicotine co-addiction: from genes to behavior
    Isabel R Schlaepfer
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Curr Drug Abuse Rev 1:124-34. 2008
    ..Future studies aimed at understanding the variation among these genes, and their corresponding functional implications, will help elucidate how natural variants in nicotinic receptor genes contribute to these common co-morbid disorders...
  10. ncbi request reprint The moderating effects of religiosity on the genetic and environmental determinants of smoking initiation
    David S Timberlake
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
    Nicotine Tob Res 8:123-33. 2006
    ..Although all three measures of religiosity were associated with lower rates of smoking initiation, only self-rated religiousness moderated genetic influences on the liability for smoking...
  11. pmc Association of candidate genes with antisocial drug dependence in adolescents
    Robin P Corley
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
    Drug Alcohol Depend 96:90-8. 2008
    ..The custom-designed SNP chip served as an effective and flexible platform for rapid interrogation of a large number of plausible candidate genes...
  12. pmc The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults
    Christie A Hartman
    School of Medicine, University of Colorado at Denver, PO Box 6508, Mail Stop F478, Aurora, CO 80045, USA
    Drug Alcohol Depend 104:11-6. 2009
    ..This study examined the genetic association between variation in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence symptoms...
  13. pmc The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults
    Isabel R Schlaepfer
    Institute for Behavioral Genetics, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Biol Psychiatry 63:1039-46. 2008
    ..Significant results were then replicated in a separate adult population-representative sample...
  14. pmc Subjective effects to marijuana associated with marijuana use in community and clinical subjects
    Joanna S Zeiger
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, United States
    Drug Alcohol Depend 109:161-6. 2010
    ..e. subjective effects). We have examined subjective effects in adolescent, young adult community, and clinical populations to determine how patterns of use may be predicted by an individual's subjective experiences with the drug...
  15. pmc Common genetic and environmental influences on major depressive disorder and conduct disorder
    Anjali Subbarao
    Department of Psychology, University of Colorado, Boulder, CO, USA
    J Abnorm Child Psychol 36:433-44. 2008
    ..Our results suggest that some genetic factors will increase an individual's vulnerability to both MDD and CD in adolescence...
  16. ncbi request reprint Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatment
    Brett C Haberstick
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309 0447, USA
    Am J Med Genet B Neuropsychiatr Genet 135:59-64. 2005
    ..There was, however, a non-significant trend in the predicted direction. Additional studies will be needed before firm conclusions can be drawn about this hypothesized genotype-environment interaction...
  17. ncbi request reprint The human protein kinase C gamma gene (PRKCG) as a susceptibility locus for behavioral disinhibition
    Isabel R Schlaepfer
    Institute for Behavioral Genetics, University of Colorado, Boulder, USA, and Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Addict Biol 12:200-9. 2007
    ..This study provides the first exploration of the PRKCG gene and its association with behavioral disinhibition and warrants further study in other larger population samples...
  18. ncbi request reprint Genes, time to first cigarette and nicotine dependence in a general population sample of young adults
    Brett C Haberstick
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Addiction 102:655-65. 2007
    ..To examine variation in nicotine dependence scores and covariation between different dependence symptoms...
  19. ncbi request reprint Relationship between adolescent marijuana use and young adult illicit drug use
    Jeffrey M Lessem
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
    Behav Genet 36:498-506. 2006
    ..Shared environmental factors mediated much of the relationship between adolescent marijuana use and young adult drug use. The association remained, however, even when controlling for familial environmental and other measured factors...
  20. pmc Dizziness and the genetic influences on subjective experiences to initial cigarette use
    Brett C Haberstick
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 04477, USA
    Addiction 106:391-9. 2011
    ..To examine individual differences in positive and negative subjective experiences to initial cigarette use...
  21. ncbi request reprint Human alcoholism studies of genes identified through mouse quantitative trait locus analysis
    Marissa A Ehringer
    Department of Pharmacology and Human Medical Genetics Program, University of Colorado Health Sciences Center, 4200 East Ninth Avenue C236, Denver, CO 80262, USA
    Addict Biol 7:365-71. 2002
    ....
  22. ncbi request reprint Case-control and within-family tests for association between 5HTTLPR and conduct problems in a longitudinal adolescent sample
    Joseph T Sakai
    Division of Substance Dependence, Department of Psychiatry, University of Colorado School of Medicine, Denver CO 80262, USA
    Psychiatr Genet 17:207-14. 2007
    ..Using a large general population sample, we sought to test for an association between 5HTTLPR and conduct problems, and to explore for a possible 5HTTLPR by maltreatment interaction...
  23. pmc Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents
    Christian J Hopfer
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Med Genet B Neuropsychiatr Genet 141:895-901. 2006
    ..Our findings provide evidence suggesting that a common CNR1 haplotype is associated with developing fewer cannabis dependence symptoms among adolescents who have experimented with cannabis...
  24. ncbi request reprint Genetic influences on quantity of alcohol consumed by adolescents and young adults
    Christian J Hopfer
    Department of Psychiatry, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box C 268 35, Denver, CO 80262, USA
    Drug Alcohol Depend 78:187-93. 2005
    ..To examine genetic and environmental influences on drinking in a nationally representative study of genetically informative adolescents followed into young adulthood...
  25. ncbi request reprint Genomic approaches to the genetics of alcoholism
    Marissa A Ehringer
    Department of Pharmacology, Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Alcohol Res Health 26:181-92. 2002
    ....
  26. ncbi request reprint Variants of kappa-opioid receptor gene and mRNA in alcohol-preferring and alcohol-avoiding mice
    Mariko Saito
    Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Alcohol 29:39-49. 2003
    ..The strain-dependent variation in the expression of alternatively spliced genes can be a significant source of phenotypic variation of complex traits such as alcohol preference...
  27. ncbi request reprint Fine mapping of polymorphic alcohol-related quantitative trait loci candidate genes using interval-specific congenic recombinant mice
    Marissa A Ehringer
    Department of Pharmacology and Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver 80262, USA
    Alcohol Clin Exp Res 26:1603-8. 2002
    ..Here, recently developed interval-specific congenic recombinant mice (ISCRs) have been used to map these genes in relationship to newly narrowed QTL regions...

Research Grants4

  1. Molecular Genetics and Behavior: Alcohol and Tobacco Use
    Marissa Ehringer; Fiscal Year: 2007
    ..It will also promote her long-term career goals of establishing an independent research career in behavior genetics of alcohol and tobacco use and provide a foundation for future studies. ..
  2. Translational studies of nicotinic receptor genes: alcohol and nicotine behaviors
    Marissa A Ehringer; Fiscal Year: 2010
    ..Such knowledge should lead to the development of improved prevention and treatment of individuals who suffer from these disorders. ..