Stephen M Eggan

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Development of cannabinoid 1 receptor protein and messenger RNA in monkey dorsolateral prefrontal cortex
    Stephen M Eggan
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cereb Cortex 20:1164-74. 2010
  2. ncbi Cannabinoid CB1 receptor immunoreactivity in the prefrontal cortex: Comparison of schizophrenia and major depressive disorder
    Stephen M Eggan
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 35:2060-71. 2010
  3. ncbi Relationship of cannabinoid CB1 receptor and cholecystokinin immunoreactivity in monkey dorsolateral prefrontal cortex
    S M Eggan
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuroscience 169:1651-61. 2010
  4. ncbi Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression: implications for schizophrenia
    Stephen M Eggan
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 71:114-9. 2012
  5. ncbi Alterations in metabotropic glutamate receptor 1α and regulator of G protein signaling 4 in the prefrontal cortex in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Psychiatry 167:1489-98. 2010
  6. ncbi Serotonin1A receptors at the axon initial segment of prefrontal pyramidal neurons in schizophrenia
    Dianne A Cruz
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Psychiatry 161:739-42. 2004
  7. ncbi Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia
    Stephen M Eggan
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara St, W1651 BST, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 65:772-84. 2008
  8. ncbi Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia
    Takanori Hashimoto
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 23:6315-26. 2003
  9. ncbi Immunocytochemical distribution of the cannabinoid CB1 receptor in the primate neocortex: a regional and laminar analysis
    Stephen M Eggan
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cereb Cortex 17:175-91. 2007
  10. ncbi Postnatal development of pre- and postsynaptic GABA markers at chandelier cell connections with pyramidal neurons in monkey prefrontal cortex
    Dianne A Cruz
    Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
    J Comp Neurol 465:385-400. 2003

Collaborators

Detail Information

Publications11

  1. ncbi Development of cannabinoid 1 receptor protein and messenger RNA in monkey dorsolateral prefrontal cortex
    Stephen M Eggan
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cereb Cortex 20:1164-74. 2010
    ..These findings provide a potential substrate for discrete, age-dependent effects of cannabis exposure on the maturation of primate DLPFC circuitry...
  2. ncbi Cannabinoid CB1 receptor immunoreactivity in the prefrontal cortex: Comparison of schizophrenia and major depressive disorder
    Stephen M Eggan
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 35:2060-71. 2010
    ..Thus, the lower levels of CB1R immunoreactivity may be common in schizophrenia, conserved across DLPFC regions, not present in MDD, and not attributable to other factors, and thus a reflection of the underlying disease process...
  3. ncbi Relationship of cannabinoid CB1 receptor and cholecystokinin immunoreactivity in monkey dorsolateral prefrontal cortex
    S M Eggan
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuroscience 169:1651-61. 2010
    ..These axons target the perisomatic region of pyramidal neurons, providing a potential anatomical substrate for the impaired function of the DLPFC associated with cannabis use and schizophrenia...
  4. ncbi Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression: implications for schizophrenia
    Stephen M Eggan
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 71:114-9. 2012
    ..However, whether this correlation reflects a cause-effect relationship is unknown...
  5. ncbi Alterations in metabotropic glutamate receptor 1α and regulator of G protein signaling 4 in the prefrontal cortex in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Psychiatry 167:1489-98. 2010
    ..The status of endocannabinoid ligands, such as 2-arachidonoylglycerol, can be inferred in part through measures of diacylglycerol lipase and monoglyceride lipase, which synthesize and degrade 2-arachidonoylglycerol, respectively...
  6. ncbi Serotonin1A receptors at the axon initial segment of prefrontal pyramidal neurons in schizophrenia
    Dianne A Cruz
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Psychiatry 161:739-42. 2004
    ..CONCLUSIONS: The findings do not support a role for altered serotonin transmission by means of the 5-HT(1A) receptor in dysfunction of prefrontal cortex pyramidal neurons in schizophrenia...
  7. ncbi Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia
    Stephen M Eggan
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara St, W1651 BST, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 65:772-84. 2008
    ....
  8. ncbi Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia
    Takanori Hashimoto
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 23:6315-26. 2003
    ....
  9. ncbi Immunocytochemical distribution of the cannabinoid CB1 receptor in the primate neocortex: a regional and laminar analysis
    Stephen M Eggan
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cereb Cortex 17:175-91. 2007
    ....
  10. ncbi Postnatal development of pre- and postsynaptic GABA markers at chandelier cell connections with pyramidal neurons in monkey prefrontal cortex
    Dianne A Cruz
    Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
    J Comp Neurol 465:385-400. 2003
    ....
  11. ncbi Role of glutamic acid decarboxylase 67 in regulating cortical parvalbumin and GABA membrane transporter 1 expression: implications for schizophrenia
    Allison A Curley
    Department of Psychiatry, W1653 Biomedical Science Tower, 200 Lothrop St University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurobiol Dis 50:179-86. 2013
    ..Together, these findings suggest that the correlated decrements in cortical GAD67, PV and GAT1 mRNAs in schizophrenia may be a common consequence of some other upstream factor...