E I Eger

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart
    E I Eger
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco 94143 0464, USA
    Anesth Analg 88:1395-400. 1999
  2. ncbi request reprint Nonimmobilizers and transitional compounds may produce convulsions by two mechanisms
    E I Eger
    Department of Anesthesia, University of California, San Francisco 94143 0464, USA
    Anesth Analg 88:884-92. 1999
  3. ncbi request reprint Mouse strain modestly influences minimum alveolar anesthetic concentration and convulsivity of inhaled compounds
    J M Sonner
    Department of Anesthesia, University of California, San Francisco 94143 0464, USA
    Anesth Analg 89:1030-4. 1999
  4. ncbi request reprint The convulsant and anesthetic properties of cis-trans isomers of 1,2-dichlorohexafluorocyclobutane and 1,2-dichloroethylene
    E I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 93:922-7. 2001
  5. ncbi request reprint Recovery and kinetic characteristics of desflurane and sevoflurane in volunteers after 8-h exposure, including kinetics of degradation products
    E I Eger
    Department of Anesthesia, University of California, San Francisco 94143 0464, USA
    Anesthesiology 87:517-26. 1997
  6. ncbi request reprint Desflurane and the nonimmobilizer 1,2-dichlorohexafluorocyclobutane suppress learning by a mechanism independent of the level of unconditioned stimulation
    J M Sonner
    Department of Anesthesia, University of California San Francisco 94143 0464, USA
    Anesth Analg 87:200-5. 1998
  7. ncbi request reprint Luciferase as a model for the site of inhaled anesthetic action
    Y Zhang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143-0464, USA
    Anesth Analg 93:1246-52. 2001
  8. ncbi request reprint Ethanol concentrations approaching minimum alveolar anesthetic concentration are required to suppress learning in a fear-potentiated startle paradigm in rats
    J M Sonner
    Department of Anesthesia, University of California San Francisco, 94143 0464, USA
    Anesth Analg 87:1398-403. 1998
  9. ncbi request reprint Desflurane and nitrous oxide, but not nonimmobilizers, affect nociceptive responses
    J Sonner
    Department of Anesthesia, University of California San Francisco, 94143 0464, USA
    Anesth Analg 86:629-34. 1998
  10. ncbi request reprint Repetitive rapid increases in desflurane concentration blunt transient cardiovascular stimulation in humans
    R B Weiskopf
    Department of Anesthesia, University of California, San Francisco 94143 0648
    Anesthesiology 81:843-9. 1994

Detail Information

Publications17

  1. ncbi request reprint Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart
    E I Eger
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco 94143 0464, USA
    Anesth Analg 88:1395-400. 1999
    ..This reasoning suggests that a distance equivalent to a four or five carbon atom chain, approximately 5 A, separates the two sites...
  2. ncbi request reprint Nonimmobilizers and transitional compounds may produce convulsions by two mechanisms
    E I Eger
    Department of Anesthesia, University of California, San Francisco 94143 0464, USA
    Anesth Analg 88:884-92. 1999
    ..Implications: Nonimmobilizers and transitional compounds may produce convulsions by two mechanisms. One correlates with lipophilicity (nonpolarity), and the other correlates with an action on GABA(A) receptors...
  3. ncbi request reprint Mouse strain modestly influences minimum alveolar anesthetic concentration and convulsivity of inhaled compounds
    J M Sonner
    Department of Anesthesia, University of California, San Francisco 94143 0464, USA
    Anesth Analg 89:1030-4. 1999
    ....
  4. ncbi request reprint The convulsant and anesthetic properties of cis-trans isomers of 1,2-dichlorohexafluorocyclobutane and 1,2-dichloroethylene
    E I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 93:922-7. 2001
    ..These isomeric effects may be as useful in defining receptor-anesthetic interactions as those found with optical isomers...
  5. ncbi request reprint Recovery and kinetic characteristics of desflurane and sevoflurane in volunteers after 8-h exposure, including kinetics of degradation products
    E I Eger
    Department of Anesthesia, University of California, San Francisco 94143 0464, USA
    Anesthesiology 87:517-26. 1997
    ..The authors determined the kinetic characteristics of desflurane and sevoflurane and those of compound A [CH2F-O-C(=CF2)(CF3)], a nephrotoxic degradation product of sevoflurane...
  6. ncbi request reprint Desflurane and the nonimmobilizer 1,2-dichlorohexafluorocyclobutane suppress learning by a mechanism independent of the level of unconditioned stimulation
    J M Sonner
    Department of Anesthesia, University of California San Francisco 94143 0464, USA
    Anesth Analg 87:200-5. 1998
    ..We conclude that suppression of learning and memory by desflurane and 2N does not result from decreased sensitivity to the unconditioned stimulus (the footshock) and that the potency of 2N is consistent with its lipophilicity...
  7. ncbi request reprint Luciferase as a model for the site of inhaled anesthetic action
    Y Zhang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143-0464, USA
    Anesth Analg 93:1246-52. 2001
    ..Luciferase may not provide a good surrogate for the site at which anesthetics act...
  8. ncbi request reprint Ethanol concentrations approaching minimum alveolar anesthetic concentration are required to suppress learning in a fear-potentiated startle paradigm in rats
    J M Sonner
    Department of Anesthesia, University of California San Francisco, 94143 0464, USA
    Anesth Analg 87:1398-403. 1998
    ..This finding is consistent with the hypothesis that the capacity of anesthetics and nonimmobilizers to impair learning and memory depends mostly on an action at a nonpolar site...
  9. ncbi request reprint Desflurane and nitrous oxide, but not nonimmobilizers, affect nociceptive responses
    J Sonner
    Department of Anesthesia, University of California San Francisco, 94143 0464, USA
    Anesth Analg 86:629-34. 1998
    ..In addition, we found that 0.1 MAC desflurane had a hyperalgesic effect (shortened TFL)...
  10. ncbi request reprint Repetitive rapid increases in desflurane concentration blunt transient cardiovascular stimulation in humans
    R B Weiskopf
    Department of Anesthesia, University of California, San Francisco 94143 0648
    Anesthesiology 81:843-9. 1994
    ..We hypothesized that the initial increase in concentration would produce greater changes than subsequent increases...
  11. ncbi request reprint Neither GABA(A) nor strychnine-sensitive glycine receptors are the sole mediators of MAC for isoflurane
    Y Zhang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143-0464, USA
    Anesth Analg 92:123-7. 2001
    ..They are not, however, the only receptors that contribute to isoflurane-induced immobility (i.e., that determine the MAC of isoflurane)...
  12. ncbi request reprint Cardiovascular effects of I653 in swine
    R B Weiskopf
    Department of Anesthesia, University of California, San Francisco
    Anesthesiology 69:303-9. 1988
    ..2 MAC, 120 +/- 4 at 1.6 MAC). Systemic vascular resistance increased slightly at 1.6 MAC compared to the values at 0.8 and 1.2 MAC, but was always less than in the conscious condition.(ABSTRACT TRUNCATED AT 250 WORDS)..
  13. ncbi request reprint Naturally occurring variability in anesthetic potency among inbred mouse strains
    J M Sonner
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0464, USA
    Anesth Analg 91:720-6. 2000
    ..Our results suggest that multiple genes underlie the observed variability in anesthetic potency...
  14. ncbi request reprint Halothane, but not the nonimmobilizers perfluoropentane and 1,2-dichlorohexafluorocyclobutane, depresses synaptic transmission in hippocampal CA1 neurons in rats
    D M Taylor
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0648, USA
    Anesth Analg 89:1040-5. 1999
    ..IMPLICATIONS: Halothane, but not the nonimmobilizers 1,2-dichlorohexafluorocyclobutane and perfluoropentane, inhibits hippocampal synaptic transmission at Schaffer collateral-CA1 synapses...
  15. ncbi request reprint The effect of rigidity, shape, unsaturation, and length on the anesthetic potency of hydrocarbons
    E I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 92:1477-82. 2001
    ..0055 atm) and that 3-hexyne was more potent (MAC 0.0146 +/- 0.0014 atm) than n-hexane (MAC 0.0467 +/- 0.0055 atm). We conclude that the site of anesthetic action can accommodate straight rigid structures of up to six carbons in length...
  16. ncbi request reprint Changing from isoflurane to desflurane toward the end of anesthesia does not accelerate recovery in humans
    M A Neumann
    Department of Anesthesia, University of California, San Francisco, 94143, USA
    Anesthesiology 88:914-21. 1998
    ..The authors tried to determine whether substituting desflurane for isoflurane in the last 30 min of a 120-min anesthetic would accelerate recovery...
  17. ncbi request reprint Age, minimum alveolar anesthetic concentration, and minimum alveolar anesthetic concentration-awake
    E I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 93:947-53. 2001
    ..This article provides an algorithm that might be used to produce such a display, including provision of an estimate of the effect of nitrous oxide...