E I Eger

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart
    E I Eger
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco 94143 0464, USA
    Anesth Analg 88:1395-400. 1999
  2. ncbi Nonimmobilizers and transitional compounds may produce convulsions by two mechanisms
    E I Eger
    Department of Anesthesia, University of California, San Francisco 94143 0464, USA
    Anesth Analg 88:884-92. 1999
  3. ncbi Mouse strain modestly influences minimum alveolar anesthetic concentration and convulsivity of inhaled compounds
    J M Sonner
    Department of Anesthesia, University of California, San Francisco 94143 0464, USA
    Anesth Analg 89:1030-4. 1999
  4. ncbi The convulsant and anesthetic properties of cis-trans isomers of 1,2-dichlorohexafluorocyclobutane and 1,2-dichloroethylene
    E I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 93:922-7. 2001
  5. ncbi Recovery and kinetic characteristics of desflurane and sevoflurane in volunteers after 8-h exposure, including kinetics of degradation products
    E I Eger
    Department of Anesthesia, University of California, San Francisco 94143 0464, USA
    Anesthesiology 87:517-26. 1997
  6. ncbi Desflurane and the nonimmobilizer 1,2-dichlorohexafluorocyclobutane suppress learning by a mechanism independent of the level of unconditioned stimulation
    J M Sonner
    Department of Anesthesia, University of California San Francisco 94143 0464, USA
    Anesth Analg 87:200-5. 1998
  7. ncbi Luciferase as a model for the site of inhaled anesthetic action
    Y Zhang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143-0464, USA
    Anesth Analg 93:1246-52. 2001
  8. ncbi Ethanol concentrations approaching minimum alveolar anesthetic concentration are required to suppress learning in a fear-potentiated startle paradigm in rats
    J M Sonner
    Department of Anesthesia, University of California San Francisco, 94143 0464, USA
    Anesth Analg 87:1398-403. 1998
  9. ncbi Desflurane and nitrous oxide, but not nonimmobilizers, affect nociceptive responses
    J Sonner
    Department of Anesthesia, University of California San Francisco, 94143 0464, USA
    Anesth Analg 86:629-34. 1998
  10. ncbi Repetitive rapid increases in desflurane concentration blunt transient cardiovascular stimulation in humans
    R B Weiskopf
    Department of Anesthesia, University of California, San Francisco 94143 0648
    Anesthesiology 81:843-9. 1994

Detail Information

Publications17

  1. ncbi Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart
    E I Eger
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco 94143 0464, USA
    Anesth Analg 88:1395-400. 1999
    ..IMPLICATIONS: Volatile anesthetics may produce immobility by a concurrent action on two sites five carbon atom lengths apart...
  2. ncbi Nonimmobilizers and transitional compounds may produce convulsions by two mechanisms
    E I Eger
    Department of Anesthesia, University of California, San Francisco 94143 0464, USA
    Anesth Analg 88:884-92. 1999
    ..Implications: Nonimmobilizers and transitional compounds may produce convulsions by two mechanisms. One correlates with lipophilicity (nonpolarity), and the other correlates with an action on GABA(A) receptors...
  3. ncbi Mouse strain modestly influences minimum alveolar anesthetic concentration and convulsivity of inhaled compounds
    J M Sonner
    Department of Anesthesia, University of California, San Francisco 94143 0464, USA
    Anesth Analg 89:1030-4. 1999
    ....
  4. ncbi The convulsant and anesthetic properties of cis-trans isomers of 1,2-dichlorohexafluorocyclobutane and 1,2-dichloroethylene
    E I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 93:922-7. 2001
    ..Such isomeric effects may be as useful as those found with optical isomers in defining receptor-anesthetic interactions...
  5. ncbi Recovery and kinetic characteristics of desflurane and sevoflurane in volunteers after 8-h exposure, including kinetics of degradation products
    E I Eger
    Department of Anesthesia, University of California, San Francisco 94143 0464, USA
    Anesthesiology 87:517-26. 1997
    ..The authors determined the kinetic characteristics of desflurane and sevoflurane and those of compound A [CH2F-O-C(=CF2)(CF3)], a nephrotoxic degradation product of sevoflurane...
  6. ncbi Desflurane and the nonimmobilizer 1,2-dichlorohexafluorocyclobutane suppress learning by a mechanism independent of the level of unconditioned stimulation
    J M Sonner
    Department of Anesthesia, University of California San Francisco 94143 0464, USA
    Anesth Analg 87:200-5. 1998
    ..Using an animal model, we refuted the hypothesis that lack of recall results from the analgesia (i.e., the reduced response to painful stimuli produced by inhaled drugs) rather than from a direct effect on learning...
  7. ncbi Luciferase as a model for the site of inhaled anesthetic action
    Y Zhang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143-0464, USA
    Anesth Analg 93:1246-52. 2001
    ..Luciferase may not provide a good surrogate for the site at which anesthetics act...
  8. ncbi Ethanol concentrations approaching minimum alveolar anesthetic concentration are required to suppress learning in a fear-potentiated startle paradigm in rats
    J M Sonner
    Department of Anesthesia, University of California San Francisco, 94143 0464, USA
    Anesth Analg 87:1398-403. 1998
    ..IMPLICATIONS: Abolition of learning and memory is an important property of inhaled anesthetics. This effect primarily results from an action at a lipid (nonpolar) site, rather than a polar site or a water-lipid interface...
  9. ncbi Desflurane and nitrous oxide, but not nonimmobilizers, affect nociceptive responses
    J Sonner
    Department of Anesthesia, University of California San Francisco, 94143 0464, USA
    Anesth Analg 86:629-34. 1998
    ..Nonimmobilizers had no effect on these responses; at a low partial pressure, desflurane was hyperalgesic; nitrous oxide and, at higher partial pressures, desflurane were antinociceptive...
  10. ncbi Repetitive rapid increases in desflurane concentration blunt transient cardiovascular stimulation in humans
    R B Weiskopf
    Department of Anesthesia, University of California, San Francisco 94143 0648
    Anesthesiology 81:843-9. 1994
    ..We hypothesized that the initial increase in concentration would produce greater changes than subsequent increases...
  11. ncbi Neither GABA(A) nor strychnine-sensitive glycine receptors are the sole mediators of MAC for isoflurane
    Y Zhang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143-0464, USA
    Anesth Analg 92:123-7. 2001
    ..They are not, however, the only receptors that contribute to isoflurane-induced immobility (i.e., that determine the MAC of isoflurane)...
  12. ncbi Cardiovascular effects of I653 in swine
    R B Weiskopf
    Department of Anesthesia, University of California, San Francisco
    Anesthesiology 69:303-9. 1988
    ..2 MAC, 120 +/- 4 at 1.6 MAC). Systemic vascular resistance increased slightly at 1.6 MAC compared to the values at 0.8 and 1.2 MAC, but was always less than in the conscious condition.(ABSTRACT TRUNCATED AT 250 WORDS)..
  13. ncbi Naturally occurring variability in anesthetic potency among inbred mouse strains
    J M Sonner
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0464, USA
    Anesth Analg 91:720-6. 2000
    ..IMPLICATIONS: Laboratory mouse strains differ significantly in susceptibility to anesthetics. These phenotypic differences may be exploited to help determine the genetic basis of anesthetic-induced immobility...
  14. ncbi Halothane, but not the nonimmobilizers perfluoropentane and 1,2-dichlorohexafluorocyclobutane, depresses synaptic transmission in hippocampal CA1 neurons in rats
    D M Taylor
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0648, USA
    Anesth Analg 89:1040-5. 1999
    ..IMPLICATIONS: Halothane, but not the nonimmobilizers 1,2-dichlorohexafluorocyclobutane and perfluoropentane, inhibits hippocampal synaptic transmission at Schaffer collateral-CA1 synapses...
  15. ncbi The effect of rigidity, shape, unsaturation, and length on the anesthetic potency of hydrocarbons
    E I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 92:1477-82. 2001
    ..0055 atm) and that 3-hexyne was more potent (MAC 0.0146 +/- 0.0014 atm) than n-hexane (MAC 0.0467 +/- 0.0055 atm). We conclude that the site of anesthetic action can accommodate straight rigid structures of up to six carbons in length...
  16. ncbi Changing from isoflurane to desflurane toward the end of anesthesia does not accelerate recovery in humans
    M A Neumann
    Department of Anesthesia, University of California, San Francisco, 94143, USA
    Anesthesiology 88:914-21. 1998
    ..The authors tried to determine whether substituting desflurane for isoflurane in the last 30 min of a 120-min anesthetic would accelerate recovery...
  17. ncbi Age, minimum alveolar anesthetic concentration, and minimum alveolar anesthetic concentration-awake
    E I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 93:947-53. 2001
    ..Thus, these defining effects may be monitored and the results displayed if the concentrations are known and corrected for the effects of age and temperature...