T M Egan
Affiliation: University of North Carolina
- Nitroglycerin reperfusion reduces ischemia-reperfusion injury in non-heart-beating donor lungsThomas M Egan
Division of Cardiothoracic Surgery, Department of Surgery, School of Medicine, University of North Carolina at Chapel Hill, 27599 7065, USA
J Heart Lung Transplant 25:110-9. 2006..We hypothesized that the administration of the nitric oxide-donor nitroglycerin to lungs from NHBDs would reduce ischemia-reperfusion injury by activation of guanylate cyclase to form guanosine 3',5'-cyclic monophosphate (cGMP)...
- Trigger for intercellular adhesion molecule-1 expression in rat lungs transplanted from non-heart-beating donorsThomas M Egan
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Ann Thorac Surg 77:1048-55; discussion 1055. 2004..Lung transplantation from non-heart-beating donors causes ischemia-reperfusion injury. We sought to determine the trigger for expression of intercellular adhesion molecule-1 (ICAM-1) caused by ischemia-reperfusion injury...
- Non-heart-beating donors in thoracic transplantationThomas M Egan
Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7065, USA
J Heart Lung Transplant 23:3-10. 2004..Aspects of reperfusion injury in this setting are reviewed. The prospect of heart transplant from NHBDs is addressed. The impact of the routine use of NHBDs on lung transplantation is discussed...
- Long term results of lung transplantation for cystic fibrosisT M Egan
Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina at Chapel Hill, 108 Burnett Womack Building, UNC, Chapel Hill, NC 27599 7065, USA
Eur J Cardiothorac Surg 22:602-9. 2002..We reviewed our experience with lung transplant for cystic fibrosis (CF) over a 10-year period to identify factors influencing long-term survival...
- Development of the new lung allocation system in the United StatesT M Egan
Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Am J Transplant 6:1212-27. 2006....
- Ex vivo evaluation of human lungs for transplant suitabilityThomas M Egan
School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7065, USA
Ann Thorac Surg 81:1205-13. 2006..We used human lungs deemed unsuitable for transplant to develop a method to perfuse and ventilate human lungs ex vivo to assess gas exchange and vascular resistance, and to perform bronchoscopic inspection and radiographic evaluation...
- Ethical issues in thoracic organ distribution for transplantThomas M Egan
Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Am J Transplant 3:366-72. 2003..This article reviews the ethical issues that come into consideration as members of the transplant community grapple with ways to improve the distribution algorithm for thoracic organs for transplant...
- Maintenance of cAMP in non-heart-beating donor lungs reduces ischemia-reperfusion injuryS C Hoffmann
Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
Am J Respir Crit Care Med 163:1642-7. 2001..97) lungs. cAMP levels correlated with Kfc (r = 0.93) in iso/roli-reperfused lungs. Pharmacologic augmentation of tissue TAN and cAMP levels might ameliorate the increased capillary permeability observed in lungs retrieved from NHBDs...
- Nitric oxide ventilation of rat lungs from non-heart-beating donors improves posttransplant functionB M Dong
Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina at Chapel Hill, NC, USA
Am J Transplant 9:2707-15. 2009..NO-ventilation had no effect on MAP kinases or NF-kappaB activation. NO administration to NHBDs before and after lung retrieval may improve function of lungs from NHBDs...
- Lung retrieval from non-heart beating cadavers with the use of a rat lung transplant modelA C Kiser
Division of Cardiothoracic Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA
J Thorac Cardiovasc Surg 122:18-23. 2001..CONCLUSIONS: Strategies to ameliorate reperfusion injury may allow for successful lung transplantation from non-heart beating donors...
- Simulation experience enhances medical students' interest in cardiothoracic surgeryLeora J Tesche
Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
Ann Thorac Surg 90:1967-73; discussion 1973-4. 2010..Increased effort in recruiting trainees is paramount. In this study, we test our hypothesis that mentored instruction on cardiothoracic simulators will enhance the interest of junior medical students in cardiothoracic surgery...
- Assessment of real-time 3D visualization for cardiothoracic diagnostic evaluation and surgery planningBradley M Hemminger
Department of Radiology and School of Information and Library Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3360, USA
J Digit Imaging 18:145-53. 2005..We test whether advanced real-time rendering techniques combined with an effective user interface will allow radiologists and surgeons to improve their performance for cardiothoracic surgery planning and diagnostic evaluation...
- Thoracoscopy using a substernal handport for palpationFrank C Detterbeck
Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7065, USA
Ann Thorac Surg 78:1031-6. 2004..A substernal handport allows palpation of the lung and thus circumvents one of the major limitations of thoracoscopy...
- Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edemaGiorgio Zanotti
Division of Cardiothoracic Surgery, Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7065, USA
Am J Physiol Lung Cell Mol Physiol 297:L52-63. 2009..This may be due to a novel mechanism: regulation of endothelial cell cytoskeleton affecting microvascular endothelial cell permeability...
- In vitro modeling of nonhypoxic cold ischemia-reperfusion simulating lung transplantationMonica Casiraghi
Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
J Thorac Cardiovasc Surg 138:760-7. 2009..We developed an in vitro model of nonhypoxic ischemia-reperfusion injury to simulate these events...
- Solid benefit of lung transplantation for some children with cystic fibrosisThomas M Egan
Pediatr Transplant 12:125-8. 2008
- Ex-vivo perfusion and ventilation of rat lungs from non-heart-beating donors before transplantHidetoshi Inokawa
Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
Ann Thorac Surg 82:1219-25. 2006..We developed an ex-vivo circuit to evaluate human lungs retrieved from non-heart-beating donors. We assessed the effect of a similar circuit on the function of transplanted rat lungs retrieved from non-heart-beating donors...
- Inhaled nitric oxide reduces ischemia-reperfusion injury in rat lungs from non-heart-beating donorsSeiki Takashima
Department of Cancer and Thoracic Surgery Surgery II, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
J Thorac Cardiovasc Surg 132:132-9. 2006..We hypothesized that ventilation of rat lungs from non-heart-beating donors with nitric oxide during the period of warm ischemia alone, with reperfusion, or both might reduce ischemia-reperfusion injury...
- Isoproterenol reduces ischemia-reperfusion lung injury despite beta-blockadeSeiki Takashima
Department of Cancer and Thoracic Surgery, University of Okayama Graduate School of Medicine and Dentistry, Okayama, Japan
J Surg Res 126:114-20. 2005..The objective was to determine if this decrease in Kfc was because of beta-stimulation, or would persist despite beta-blockade...
- Trends in lung pH and PO2 after circulatory arrest: implications for non-heart-beating donors and cell culture models of lung ischemia-reperfusion injuryGiovanna Koukoulis
Department of Cardiothoracic Surgery, San Matteo Hospital, University of Pavia, Pavia, Italy
J Heart Lung Transplant 24:2218-25. 2005..A better understanding of lung tissue environment after circulatory arrest would allow more accurate cell culture models to study ischemia-reperfusion lung injury and facilitate retrieval of lungs from non-heart-beating donors...
- Lung transplantation: opportunities for research and clinical advancementDavid S Wilkes
Indiana University School of Medicine, Indianapolis, Indiana, USA
Am J Respir Crit Care Med 172:944-55. 2005..This workshop provides a framework to identify critical issues related to clinical lung transplantation, and to delineate important areas for productive scientific investigation...
- Pro/Con debate: lung allocation should be based on medical urgency and transplant survival and not on waiting timeThomas M Egan
University of Pennsylvania Medical Center, 838 West Gates, 3400 Spruce Street, Philadelphia, PA 19027, USA
Chest 128:407-15. 2005
- Orthotopic lung transplant for sarcoidosisThomas M Egan
Chest 123:962-3; author reply 963. 2003
- The ABCs of LTX for BACThomas M Egan
J Thorac Cardiovasc Surg 125:20-2. 2003
- Pulmonary preservation studies: effects on endothelial function and pulmonary adenine nucleotidesHyo Chae Paik
Kangnamku Dogokdong 146 92, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
Transplantation 75:439-44. 2003..The optimal preservation solution for lung transplantation is unknown. We performed experiments using an isolated perfused rat lung model to test the effect of lung preservation with three solutions commonly used in clinical practice...
- QALYs or quackery? The quagmire of quantifying the cost of breathingThomas M Egan
J Thorac Cardiovasc Surg 123:406-8. 2002
- Cystic fibrosis: when to refer for lung transplantation-is the answer clear?Peadar G Noone
Am J Respir Crit Care Med 166:1531-2. 2002
- ISCHEMIC INJURY IN CADAVER DONORS FOR LUNG TRANSPLANTThomas Egan; Fiscal Year: 2003..This will facilitate the introduction of lung retrieval for transplant from NHBDs, which has the potential to extend the lives of thousands of Americans suffering with a variety of lung diseases. ..