T M Egan

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Nitroglycerin reperfusion reduces ischemia-reperfusion injury in non-heart-beating donor lungs
    Thomas M Egan
    Division of Cardiothoracic Surgery, Department of Surgery, School of Medicine, University of North Carolina at Chapel Hill, 27599 7065, USA
    J Heart Lung Transplant 25:110-9. 2006
  2. ncbi request reprint Trigger for intercellular adhesion molecule-1 expression in rat lungs transplanted from non-heart-beating donors
    Thomas M Egan
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Ann Thorac Surg 77:1048-55; discussion 1055. 2004
  3. ncbi request reprint Non-heart-beating donors in thoracic transplantation
    Thomas M Egan
    Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7065, USA
    J Heart Lung Transplant 23:3-10. 2004
  4. ncbi request reprint Long term results of lung transplantation for cystic fibrosis
    T M Egan
    Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina at Chapel Hill, 108 Burnett Womack Building, UNC, Chapel Hill, NC 27599 7065, USA
    Eur J Cardiothorac Surg 22:602-9. 2002
  5. ncbi request reprint Development of the new lung allocation system in the United States
    T M Egan
    Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Transplant 6:1212-27. 2006
  6. ncbi request reprint Ex vivo evaluation of human lungs for transplant suitability
    Thomas M Egan
    School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7065, USA
    Ann Thorac Surg 81:1205-13. 2006
  7. ncbi request reprint Ethical issues in thoracic organ distribution for transplant
    Thomas M Egan
    Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Am J Transplant 3:366-72. 2003
  8. ncbi request reprint Maintenance of cAMP in non-heart-beating donor lungs reduces ischemia-reperfusion injury
    S C Hoffmann
    Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Am J Respir Crit Care Med 163:1642-7. 2001
  9. doi request reprint Nitric oxide ventilation of rat lungs from non-heart-beating donors improves posttransplant function
    B M Dong
    Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina at Chapel Hill, NC, USA
    Am J Transplant 9:2707-15. 2009
  10. ncbi request reprint Lung retrieval from non-heart beating cadavers with the use of a rat lung transplant model
    A C Kiser
    Division of Cardiothoracic Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    J Thorac Cardiovasc Surg 122:18-23. 2001

Research Grants

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Nitroglycerin reperfusion reduces ischemia-reperfusion injury in non-heart-beating donor lungs
    Thomas M Egan
    Division of Cardiothoracic Surgery, Department of Surgery, School of Medicine, University of North Carolina at Chapel Hill, 27599 7065, USA
    J Heart Lung Transplant 25:110-9. 2006
    ..We hypothesized that the administration of the nitric oxide-donor nitroglycerin to lungs from NHBDs would reduce ischemia-reperfusion injury by activation of guanylate cyclase to form guanosine 3',5'-cyclic monophosphate (cGMP)...
  2. ncbi request reprint Trigger for intercellular adhesion molecule-1 expression in rat lungs transplanted from non-heart-beating donors
    Thomas M Egan
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Ann Thorac Surg 77:1048-55; discussion 1055. 2004
    ..Lung transplantation from non-heart-beating donors causes ischemia-reperfusion injury. We sought to determine the trigger for expression of intercellular adhesion molecule-1 (ICAM-1) caused by ischemia-reperfusion injury...
  3. ncbi request reprint Non-heart-beating donors in thoracic transplantation
    Thomas M Egan
    Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7065, USA
    J Heart Lung Transplant 23:3-10. 2004
    ..Aspects of reperfusion injury in this setting are reviewed. The prospect of heart transplant from NHBDs is addressed. The impact of the routine use of NHBDs on lung transplantation is discussed...
  4. ncbi request reprint Long term results of lung transplantation for cystic fibrosis
    T M Egan
    Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina at Chapel Hill, 108 Burnett Womack Building, UNC, Chapel Hill, NC 27599 7065, USA
    Eur J Cardiothorac Surg 22:602-9. 2002
    ..We reviewed our experience with lung transplant for cystic fibrosis (CF) over a 10-year period to identify factors influencing long-term survival...
  5. ncbi request reprint Development of the new lung allocation system in the United States
    T M Egan
    Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Transplant 6:1212-27. 2006
    ....
  6. ncbi request reprint Ex vivo evaluation of human lungs for transplant suitability
    Thomas M Egan
    School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7065, USA
    Ann Thorac Surg 81:1205-13. 2006
    ..We used human lungs deemed unsuitable for transplant to develop a method to perfuse and ventilate human lungs ex vivo to assess gas exchange and vascular resistance, and to perform bronchoscopic inspection and radiographic evaluation...
  7. ncbi request reprint Ethical issues in thoracic organ distribution for transplant
    Thomas M Egan
    Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Am J Transplant 3:366-72. 2003
    ..This article reviews the ethical issues that come into consideration as members of the transplant community grapple with ways to improve the distribution algorithm for thoracic organs for transplant...
  8. ncbi request reprint Maintenance of cAMP in non-heart-beating donor lungs reduces ischemia-reperfusion injury
    S C Hoffmann
    Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Am J Respir Crit Care Med 163:1642-7. 2001
    ..97) lungs. cAMP levels correlated with Kfc (r = 0.93) in iso/roli-reperfused lungs. Pharmacologic augmentation of tissue TAN and cAMP levels might ameliorate the increased capillary permeability observed in lungs retrieved from NHBDs...
  9. doi request reprint Nitric oxide ventilation of rat lungs from non-heart-beating donors improves posttransplant function
    B M Dong
    Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina at Chapel Hill, NC, USA
    Am J Transplant 9:2707-15. 2009
    ..NO-ventilation had no effect on MAP kinases or NF-kappaB activation. NO administration to NHBDs before and after lung retrieval may improve function of lungs from NHBDs...
  10. ncbi request reprint Lung retrieval from non-heart beating cadavers with the use of a rat lung transplant model
    A C Kiser
    Division of Cardiothoracic Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    J Thorac Cardiovasc Surg 122:18-23. 2001
    ..CONCLUSIONS: Strategies to ameliorate reperfusion injury may allow for successful lung transplantation from non-heart beating donors...
  11. doi request reprint Simulation experience enhances medical students' interest in cardiothoracic surgery
    Leora J Tesche
    Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Ann Thorac Surg 90:1967-73; discussion 1973-4. 2010
    ..Increased effort in recruiting trainees is paramount. In this study, we test our hypothesis that mentored instruction on cardiothoracic simulators will enhance the interest of junior medical students in cardiothoracic surgery...
  12. pmc Assessment of real-time 3D visualization for cardiothoracic diagnostic evaluation and surgery planning
    Bradley M Hemminger
    Department of Radiology and School of Information and Library Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3360, USA
    J Digit Imaging 18:145-53. 2005
    ..We test whether advanced real-time rendering techniques combined with an effective user interface will allow radiologists and surgeons to improve their performance for cardiothoracic surgery planning and diagnostic evaluation...
  13. ncbi request reprint Thoracoscopy using a substernal handport for palpation
    Frank C Detterbeck
    Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7065, USA
    Ann Thorac Surg 78:1031-6. 2004
    ..A substernal handport allows palpation of the lung and thus circumvents one of the major limitations of thoracoscopy...
  14. pmc Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema
    Giorgio Zanotti
    Division of Cardiothoracic Surgery, Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7065, USA
    Am J Physiol Lung Cell Mol Physiol 297:L52-63. 2009
    ..This may be due to a novel mechanism: regulation of endothelial cell cytoskeleton affecting microvascular endothelial cell permeability...
  15. pmc In vitro modeling of nonhypoxic cold ischemia-reperfusion simulating lung transplantation
    Monica Casiraghi
    Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Thorac Cardiovasc Surg 138:760-7. 2009
    ..We developed an in vitro model of nonhypoxic ischemia-reperfusion injury to simulate these events...
  16. doi request reprint Solid benefit of lung transplantation for some children with cystic fibrosis
    Thomas M Egan
    Pediatr Transplant 12:125-8. 2008
  17. ncbi request reprint Ex-vivo perfusion and ventilation of rat lungs from non-heart-beating donors before transplant
    Hidetoshi Inokawa
    Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Ann Thorac Surg 82:1219-25. 2006
    ..We developed an ex-vivo circuit to evaluate human lungs retrieved from non-heart-beating donors. We assessed the effect of a similar circuit on the function of transplanted rat lungs retrieved from non-heart-beating donors...
  18. ncbi request reprint Inhaled nitric oxide reduces ischemia-reperfusion injury in rat lungs from non-heart-beating donors
    Seiki Takashima
    Department of Cancer and Thoracic Surgery Surgery II, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Thorac Cardiovasc Surg 132:132-9. 2006
    ..We hypothesized that ventilation of rat lungs from non-heart-beating donors with nitric oxide during the period of warm ischemia alone, with reperfusion, or both might reduce ischemia-reperfusion injury...
  19. ncbi request reprint Isoproterenol reduces ischemia-reperfusion lung injury despite beta-blockade
    Seiki Takashima
    Department of Cancer and Thoracic Surgery, University of Okayama Graduate School of Medicine and Dentistry, Okayama, Japan
    J Surg Res 126:114-20. 2005
    ..The objective was to determine if this decrease in Kfc was because of beta-stimulation, or would persist despite beta-blockade...
  20. ncbi request reprint Trends in lung pH and PO2 after circulatory arrest: implications for non-heart-beating donors and cell culture models of lung ischemia-reperfusion injury
    Giovanna Koukoulis
    Department of Cardiothoracic Surgery, San Matteo Hospital, University of Pavia, Pavia, Italy
    J Heart Lung Transplant 24:2218-25. 2005
    ..A better understanding of lung tissue environment after circulatory arrest would allow more accurate cell culture models to study ischemia-reperfusion lung injury and facilitate retrieval of lungs from non-heart-beating donors...
  21. pmc Lung transplantation: opportunities for research and clinical advancement
    David S Wilkes
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Respir Crit Care Med 172:944-55. 2005
    ..This workshop provides a framework to identify critical issues related to clinical lung transplantation, and to delineate important areas for productive scientific investigation...
  22. ncbi request reprint Pro/Con debate: lung allocation should be based on medical urgency and transplant survival and not on waiting time
    Thomas M Egan
    University of Pennsylvania Medical Center, 838 West Gates, 3400 Spruce Street, Philadelphia, PA 19027, USA
    Chest 128:407-15. 2005
  23. ncbi request reprint Orthotopic lung transplant for sarcoidosis
    Thomas M Egan
    Chest 123:962-3; author reply 963. 2003
  24. ncbi request reprint The ABCs of LTX for BAC
    Thomas M Egan
    J Thorac Cardiovasc Surg 125:20-2. 2003
  25. ncbi request reprint Pulmonary preservation studies: effects on endothelial function and pulmonary adenine nucleotides
    Hyo Chae Paik
    Kangnamku Dogokdong 146 92, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
    Transplantation 75:439-44. 2003
    ..The optimal preservation solution for lung transplantation is unknown. We performed experiments using an isolated perfused rat lung model to test the effect of lung preservation with three solutions commonly used in clinical practice...
  26. ncbi request reprint QALYs or quackery? The quagmire of quantifying the cost of breathing
    Thomas M Egan
    J Thorac Cardiovasc Surg 123:406-8. 2002
  27. ncbi request reprint Cystic fibrosis: when to refer for lung transplantation-is the answer clear?
    Peadar G Noone
    Am J Respir Crit Care Med 166:1531-2. 2002

Research Grants4

  1. ISCHEMIC INJURY IN CADAVER DONORS FOR LUNG TRANSPLANT
    Thomas Egan; Fiscal Year: 2003
    ..This will facilitate the introduction of lung retrieval for transplant from NHBDs, which has the potential to extend the lives of thousands of Americans suffering with a variety of lung diseases. ..