RITA BRICKMAN EFFROS

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Simultaneous flow cytometric analysis of two cell surface markers, telomere length, and DNA content
    Ingrid Schmid
    Department of Hematology Oncology, David Geffen School of Medicine, University of California, Los Angeles, California
    Cytometry 49:96-105. 2002
  2. ncbi request reprint Replicative senescence of CD8 T cells: potential effects on cancer immune surveillance and immunotherapy
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 90095 1732, USA
    Cancer Immunol Immunother 53:925-33. 2004
  3. pmc T cell replicative senescence in human aging
    Jennifer P Chou
    Dept of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    Curr Pharm Des 19:1680-98. 2013
  4. pmc Sustained CD28 expression delays multiple features of replicative senescence in human CD8 T lymphocytes
    Stanley T Parish
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Clin Immunol 30:798-805. 2010
  5. ncbi request reprint From Hayflick to Walford: the role of T cell replicative senescence in human aging
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Exp Gerontol 39:885-90. 2004
  6. ncbi request reprint T cell replicative senescence: pleiotropic effects on human aging
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Ann N Y Acad Sci 1019:123-6. 2004
  7. ncbi request reprint Costimulatory mechanisms in the elderly
    R B Effros
    Department of Pathology and Laboratory Medicine, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Vaccine 18:1661-5. 2000
  8. ncbi request reprint The role of CD8+ T-cell replicative senescence in human aging
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Immunol Rev 205:147-57. 2005
  9. ncbi request reprint Role of T lymphocyte replicative senescence in vaccine efficacy
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Vaccine 25:599-604. 2007
  10. pmc Telomerase induction in T cells: a cure for aging and disease?
    Rita B Effros
    Department of Pathology and Laboratory Medicine and UCLA AIDS Institute, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, United States
    Exp Gerontol 42:416-20. 2007

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Simultaneous flow cytometric analysis of two cell surface markers, telomere length, and DNA content
    Ingrid Schmid
    Department of Hematology Oncology, David Geffen School of Medicine, University of California, Los Angeles, California
    Cytometry 49:96-105. 2002
    ..We overcame these problems and developed a method for measuring telomere length in cell subsets characterized by the expression of two surface antigens...
  2. ncbi request reprint Replicative senescence of CD8 T cells: potential effects on cancer immune surveillance and immunotherapy
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 90095 1732, USA
    Cancer Immunol Immunother 53:925-33. 2004
    ..Experimental strategies aimed at preventing T-cell replicative senescence are discussed in the context of cancer immunotherapy and vaccines...
  3. pmc T cell replicative senescence in human aging
    Jennifer P Chou
    Dept of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    Curr Pharm Des 19:1680-98. 2013
    ....
  4. pmc Sustained CD28 expression delays multiple features of replicative senescence in human CD8 T lymphocytes
    Stanley T Parish
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Clin Immunol 30:798-805. 2010
    ..These findings further elucidate the central role of CD28 in the replicative senescence program, and may ultimately lead to novel therapies for diseases associated with replicative senescence...
  5. ncbi request reprint From Hayflick to Walford: the role of T cell replicative senescence in human aging
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Exp Gerontol 39:885-90. 2004
    ....
  6. ncbi request reprint T cell replicative senescence: pleiotropic effects on human aging
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Ann N Y Acad Sci 1019:123-6. 2004
    ..Thus, modulation of T cell replicative senescence may provide a comprehensive therapeutic strategy to prevent multiple age-associated pathologies...
  7. ncbi request reprint Costimulatory mechanisms in the elderly
    R B Effros
    Department of Pathology and Laboratory Medicine, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Vaccine 18:1661-5. 2000
    ..This in vitro model has elucidated a novel facet of T cell biology that may explain the increased incidence of infection and cancer in the elderly...
  8. ncbi request reprint The role of CD8+ T-cell replicative senescence in human aging
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Immunol Rev 205:147-57. 2005
    ..The emerging picture is that senescent CD8(+) T cells may modulate both immune and non-immune functions, contributing not only to reduced anti-viral immunity but also to diverse age-related pathologies...
  9. ncbi request reprint Role of T lymphocyte replicative senescence in vaccine efficacy
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Vaccine 25:599-604. 2007
    ..This article discusses some of the challenges involved in custom-designing vaccines for the elderly, and suggests several immunomodulatory strategies that may enhance vaccine responsiveness in this age group...
  10. pmc Telomerase induction in T cells: a cure for aging and disease?
    Rita B Effros
    Department of Pathology and Laboratory Medicine and UCLA AIDS Institute, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, United States
    Exp Gerontol 42:416-20. 2007
    ..These proof-of-principle studies have led to screening for pharmacological approaches that might mimic the gene therapy effects, in a more clinically suitable formulation...
  11. ncbi request reprint The biological sciences section program at the 60th Annual Meeting of the Gerontological Society of America
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    J Gerontol A Biol Sci Med Sci 63:331-7. 2008
    ..Novel animal models, including those showing no evidence of aging, as well as ethical and political implications of embryonic stem cells and alternative medicine are also discussed...
  12. pmc Kleemeier Award Lecture 2008--the canary in the coal mine: telomeres and human healthspan
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    J Gerontol A Biol Sci Med Sci 64:511-5. 2009
    ..These observations suggest possible novel telomerase-based therapeutic approaches to enhancing healthspan in the elderly population...
  13. pmc Telomere/telomerase dynamics within the human immune system: effect of chronic infection and stress
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    Exp Gerontol 46:135-40. 2011
    ....
  14. ncbi request reprint Replicative senescence of CD8 T cells: effect on human ageing
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Exp Gerontol 39:517-24. 2004
    ..Thus, senescent CD8 T cells are associated with a variety of deleterious health-related outcomes, suggesting that these cells may exert pleiotropic negative effects on both immune and non-immune organ systems during ageing...
  15. ncbi request reprint Replicative senescence: the final stage of memory T cell differentiation?
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    Curr HIV Res 1:153-65. 2003
    ..Further characterization of the underlying mechanism leading to the generation of senescent memory CD8 T cells and analysis of their functional attributes will help elucidate their role in HIV disease pathogenesis...
  16. ncbi request reprint Impact of the Hayflick Limit on T cell responses to infection: lessons from aging and HIV disease
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Mech Ageing Dev 125:103-6. 2004
    ..Strategies that retard replicative senescence may, therefore, provide novel approaches to enhancing immune function during aging and HIV disease...
  17. ncbi request reprint In vitro senescence of immune cells
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Exp Gerontol 38:1243-9. 2003
    ....
  18. ncbi request reprint Long-term immunological memory against viruses
    R B Effros
    Department of Pathology and Laboratory Medicine, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Mech Ageing Dev 121:161-71. 2000
    ..Such cells may contribute to compromised viral immunity and response to vaccines, and furthermore, their very presence may negatively influence homeostatic mechanisms that control the size of the memory T cell pool in elderly persons...
  19. ncbi request reprint Problems and solutions to the development of vaccines in the elderly
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732 USA
    Immunol Allergy Clin North Am 23:41-55. 2003
    ....
  20. ncbi request reprint Genetic alterations in the ageing immune system: impact on infection and cancer
    Rita B Effros
    Department of Pathology and Laboratory Medicine, The David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Mech Ageing Dev 124:71-7. 2003
    ..Genetic modulation of this process may yield novel strategies to augment immune function in the elderly...
  21. ncbi request reprint Genetic manipulation of telomerase in HIV-specific CD8+ T cells: enhanced antiviral functions accompany the increased proliferative potential and telomere length stabilization
    Mirabelle Dagarag
    Department of Pathology and Laboratory Medicine, Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Immunol 173:6303-11. 2004
    ..Given the key role of CD8(+) T cell function in controlling a variety of acute and latent viral infections, approaches to retard the functional decrements associated with replicative senescence may lead to novel types of immunotherapy...
  22. pmc Adenosine deaminase modulation of telomerase activity and replicative senescence in human CD8 T lymphocytes
    Stanley T Parish
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 184:2847-54. 2010
    ....
  23. ncbi request reprint Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus
    Hector F Valenzuela
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, 90095, USA
    Clin Immunol 105:117-25. 2002
    ..These findings suggest stringent telomerase regulation in human T cells, a property that may ultimately contribute to telomere shortening, finite replicative potential, and loss of control over certain pathogens...
  24. pmc Differential impairment of lytic and cytokine functions in senescent human immunodeficiency virus type 1-specific cytotoxic T lymphocytes
    Mirabelle Dagarag
    Departments of Pathology and Laboratory Medicine, Geffen School of Medicine, UCLA Medical Center, Los Angeles, California, USA
    J Virol 77:3077-83. 2003
    ..Telomerase transduction could therefore be a tool with which to explore a potential therapeutic approach to an important pathophysiologic process of immune dysfunction in chronic viral infection...
  25. ncbi request reprint Decreased perforin and granzyme B expression in senescent HIV-1-specific cytotoxic T lymphocytes
    Otto O Yang
    Department of Medicine Division of Infectious Diseases, UCLA Medical Center, Los Angeles, CA 90095 1688, USA
    Virology 332:16-9. 2005
    ..These results agree with other studies showing that HIV-1-specific CTL exhibit abnormal phenotypes in vivo, and suggest the possibility that chronic turnover is an important mechanism of antiviral failure in HIV-1 infection...
  26. pmc Autologous CD4/CD8 co-culture assay: a physiologically-relevant composite measure of CD8+ T lymphocyte function in HIV-infected persons
    Steven R Fauce
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, United States
    J Immunol Methods 327:75-81. 2007
    ....
  27. ncbi request reprint Hematopoietic cells and replicative senescence
    Rita B Effros
    Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Molecular Biology Institute, Los Angeles, CA 90095 1732, USA
    Exp Gerontol 37:191-6. 2002
    ..This limited potential should be taken into account both with respect to aging in vivo, and also in terms of attempts to expand these cells ex vivo for therapeutic use...
  28. pmc Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions
    Rita B Effros
    David Geffen School of Medicine at the University of California, Los Angeles, USA
    Clin Infect Dis 47:542-53. 2008
    ..Answers to the questions posed are likely to help prioritize and balance strategies to slow the progression of HIV infection, to address comorbidities and drug toxicity, and to enhance understanding about both HIV infection and aging...
  29. ncbi request reprint CD8 T cells and aging
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, USA
    Crit Rev Immunol 23:45-64. 2003
    ..Age-associated alterations in CD4 T cells and antigen-presenting cells are mentioned insofar as these cells affect CD8 T-cell activation and function. Distinct patterns of immunosenescence in humans and mice are also noted...
  30. pmc Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes
    Steven Russell Fauce
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 181:7400-6. 2008
    ..Our study is the first to use a pharmacological telomerase-based approach to enhance immune function, thus directly addressing the telomere loss immunopathologic facet of chronic viral infection...
  31. pmc PKA-induced receptor activator of NF-kappaB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification
    Wendy Tseng
    Department of Physiological Science, University of California, Los Angeles, California 90095, USA
    J Biol Chem 285:29925-31. 2010
    ..These findings suggest that, as in skeletal tissues, PKA activation induces bone resorptive factors in the vasculature and that aortic SMC calcification specifically induced by PKA, is not mediated by RANKL...
  32. pmc Reduced telomerase activity in human T lymphocytes exposed to cortisol
    Jenny Choi
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Brain Behav Immun 22:600-5. 2008
    ....
  33. pmc Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone loss
    Lucia S Graham
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Clin Immunol 133:265-75. 2009
    ..These findings may help elucidate clinical associations between cardiovascular disease and decreased bone mass, and may also lead to new immune-based approaches to osteoporosis...
  34. ncbi request reprint Age related microsatellite instability in T cells from healthy individuals
    Svetlana Krichevsky
    Department of Medicine, Hadassah University Hospital, POB 12000, Jerusalem 91120, Israel
    Exp Gerontol 39:507-15. 2004
    ..Elucidation of this previously unexplored facet of lymphocyte dynamics in relation to aging may help identify novel mechanisms of immunosenescence and pathways that could serve as targets for interventions to restore immune function...

Research Grants16

  1. The mucosal immune system: effects of aging and chronic antigenic stimulation
    RITA BRICKMAN EFFROS; Fiscal Year: 2010
    ..In addition, if our research shows that accelerated aging of the immune cells in the gut is reversible, this will stimulate efforts to identify novel therapeutic approaches for enhancing immune function in the elderly. ..
  2. CD8 T Cell Replicative Senescence: Impact on Aged Humans
    Rita Effros; Fiscal Year: 2009
    ..abstract_text> ..
  3. CD8 T Cell Replicative Senescence: Impact on Aged Humans
    Rita Effros; Fiscal Year: 2009
    ..abstract_text> ..
  4. Conference on the Biology of Aging
    Rita Effros; Fiscal Year: 2007
    ..The dissemination of information that is useful for maintaining the health and vitality of this age group will have a significant impact on the quality of life of a large number of Americans. ..
  5. CD8 T Cell Replicative Senescence & HIV Disease
    Rita Effros; Fiscal Year: 2007
    ..This novel approach to analysis of the immune exhaustion in HIV disease may yield promising strategies for immunotherapy to retard or prevent progression to AIDS. ..
  6. T Cell Replicative Senescence & Bone Loss During Aging
    Rita Effros; Fiscal Year: 2005
    ....
  7. CD8 T Cell Interaction with Bone Cells in HIV Disease
    Rita Effros; Fiscal Year: 2005
    ..abstract_text> ..