R Efendiev

Summary

Affiliation: University of Houston
Country: USA

Publications

  1. pmc Localization of intracellular compartments that exchange Na,K-ATPase molecules with the plasma membrane in a hormone-dependent manner
    R Efendiev
    College of Pharmacy, University of Houston, 4800 Calhoun Road, Houston, TX 77204, USA
    Br J Pharmacol 151:1006-13. 2007
  2. ncbi request reprint FRET analysis reveals a critical conformational change within the Na,K-ATPase alpha1 subunit N-terminus during GPCR-dependent endocytosis
    Riad Efendiev
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 4800 Calhoun Road, Houston, TX 77204 5037, USA
    FEBS Lett 580:5067-70. 2006
  3. ncbi request reprint Contrary to rat-type, human-type Na,K-ATPase is phosphorylated at the same amino acid by hormones that produce opposite effects on enzyme activity
    Riad Efendiev
    University of Houston, College of Pharmacy, 4800 Calhoun Boulevard, Houston, TX 77204 5037, USA
    J Am Soc Nephrol 17:31-8. 2006
  4. ncbi request reprint Intracellular Na+ regulates dopamine and angiotensin II receptors availability at the plasma membrane and their cellular responses in renal epithelia
    Riad Efendiev
    College of Pharmacy, University of Houston, Houston, Texas 77204, USA
    J Biol Chem 278:28719-26. 2003
  5. ncbi request reprint Inhibition of Na,K-ATPase by dopamine in proximal tubule epithelial cells
    Carlos H Pedemonte
    College of Pharmacy, University of Houston, Houston, TX 77204, USA
    Semin Nephrol 25:322-7. 2005
  6. ncbi request reprint Agonist-dependent regulation of renal Na+,K+-ATPase activity is modulated by intracellular sodium concentration
    Riad Efendiev
    College of Pharmacy, University of Houston, Houston, Texas 77204, USA
    J Biol Chem 277:11489-96. 2002
  7. pmc G-protein-coupled receptor-mediated traffic of Na,K-ATPase to the plasma membrane requires the binding of adaptor protein 1 to a Tyr-255-based sequence in the alpha-subunit
    Riad Efendiev
    College of Pharmacy, University of Houston, Houston, Texas 77204, USA
    J Biol Chem 283:17561-7. 2008
  8. pmc Hormonal-dependent recruitment of Na+,K+-ATPase to the plasmalemma is mediated by PKC beta and modulated by [Na+]i
    Claudia E Budu
    College of Pharmacy, University of Houston, Houston, Texas, TX 77204, U S A
    Br J Pharmacol 137:1380-6. 2002
  9. ncbi request reprint Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu2 phosphorylation and impaired Na+,K+-ATPase trafficking in response to GPCR signals and intracellular sodium
    Riad Efendiev
    Department of Medicine, Atherosclerosis Research Unit, Membrane Signaling Networks, Karolinska Institutet, Karolinska University Hospital, S 171 76 Stockholm, Sweden
    Circ Res 95:1100-8. 2004
  10. pmc Analysis of Na+,K+-ATPase motion and incorporation into the plasma membrane in response to G protein-coupled receptor signals in living cells
    Alejandro M Bertorello
    Department of Medicine, Atherosclerosis Research Unit, Karolinska Institutet, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Mol Biol Cell 14:1149-57. 2003

Collaborators

  • Carlos H Pedemonte
  • Rafael T Krmar
  • Alejandro M Bertorello
  • Ingo B Leibiger
  • Zongpei Chen
  • Jacob I Sznajder
  • Adrian I Katz
  • Stefania Cotta DonĂ©
  • Claudia E Budu
  • Laura Dada
  • Kristen Smith
  • Yulia Komarova
  • Gary Borisy
  • Angel M Cinelli
  • Barbara Leibiger
  • Per Olof Berggren

Detail Information

Publications14

  1. pmc Localization of intracellular compartments that exchange Na,K-ATPase molecules with the plasma membrane in a hormone-dependent manner
    R Efendiev
    College of Pharmacy, University of Houston, 4800 Calhoun Road, Houston, TX 77204, USA
    Br J Pharmacol 151:1006-13. 2007
    ..We have previously demonstrated several aspects of the molecular mechanism by which dopamine induces Na,K-ATPase endocytosis; however, the location of intracellular compartments containing Na,K-ATPase molecules has not been identified...
  2. ncbi request reprint FRET analysis reveals a critical conformational change within the Na,K-ATPase alpha1 subunit N-terminus during GPCR-dependent endocytosis
    Riad Efendiev
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 4800 Calhoun Road, Houston, TX 77204 5037, USA
    FEBS Lett 580:5067-70. 2006
    ..This is consistent with a protein conformational change that results in the N-terminal end of alpha1 moving closer to the internal face of the plasma membrane...
  3. ncbi request reprint Contrary to rat-type, human-type Na,K-ATPase is phosphorylated at the same amino acid by hormones that produce opposite effects on enzyme activity
    Riad Efendiev
    University of Houston, College of Pharmacy, 4800 Calhoun Boulevard, Houston, TX 77204 5037, USA
    J Am Soc Nephrol 17:31-8. 2006
    ..This is similar to what was demonstrated previously in cells that express the rat-type Na,K-ATPase...
  4. ncbi request reprint Intracellular Na+ regulates dopamine and angiotensin II receptors availability at the plasma membrane and their cellular responses in renal epithelia
    Riad Efendiev
    College of Pharmacy, University of Houston, Houston, Texas 77204, USA
    J Biol Chem 278:28719-26. 2003
    ..Thus, one or more proteins may act as an intracellular Na+ concentration sensor and play a major regulatory role on the effect of hormones that regulate proximal tubule Na+ reabsorption...
  5. ncbi request reprint Inhibition of Na,K-ATPase by dopamine in proximal tubule epithelial cells
    Carlos H Pedemonte
    College of Pharmacy, University of Houston, Houston, TX 77204, USA
    Semin Nephrol 25:322-7. 2005
    ..Plasma membrane phosphorylated NKA is internalized to specialized intracellular compartments where the NKA will be dephosphorylated. The NKA internalization results in a reduced Na+ transport by proximal tubule epithelial cells...
  6. ncbi request reprint Agonist-dependent regulation of renal Na+,K+-ATPase activity is modulated by intracellular sodium concentration
    Riad Efendiev
    College of Pharmacy, University of Houston, Houston, Texas 77204, USA
    J Biol Chem 277:11489-96. 2002
    ..These results suggest that the level of intracellular sodium modulates whether hormones stimulate, inhibit, or have no effect on the Na(+),K(+)-ATPase activity leading to a tight control of sodium reabsorption...
  7. pmc G-protein-coupled receptor-mediated traffic of Na,K-ATPase to the plasma membrane requires the binding of adaptor protein 1 to a Tyr-255-based sequence in the alpha-subunit
    Riad Efendiev
    College of Pharmacy, University of Houston, Houston, Texas 77204, USA
    J Biol Chem 283:17561-7. 2008
    ....
  8. pmc Hormonal-dependent recruitment of Na+,K+-ATPase to the plasmalemma is mediated by PKC beta and modulated by [Na+]i
    Claudia E Budu
    College of Pharmacy, University of Houston, Houston, Texas, TX 77204, U S A
    Br J Pharmacol 137:1380-6. 2002
    ..Thus, besides the antagonistic effects of dopamine and 8-OH-DPAT, intracellular sodium modulates whether an activation or an inhibition of Na(+),K(+)-ATPase is produced...
  9. ncbi request reprint Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu2 phosphorylation and impaired Na+,K+-ATPase trafficking in response to GPCR signals and intracellular sodium
    Riad Efendiev
    Department of Medicine, Atherosclerosis Research Unit, Membrane Signaling Networks, Karolinska Institutet, Karolinska University Hospital, S 171 76 Stockholm, Sweden
    Circ Res 95:1100-8. 2004
    ....
  10. pmc Analysis of Na+,K+-ATPase motion and incorporation into the plasma membrane in response to G protein-coupled receptor signals in living cells
    Alejandro M Bertorello
    Department of Medicine, Atherosclerosis Research Unit, Karolinska Institutet, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Mol Biol Cell 14:1149-57. 2003
    ..Thus, recruitment of new Na(+),K(+)-ATPase molecules into the plasma membrane appears to be a major mechanism by which dopamine increases total cell Na(+),K(+)-ATPase activity...
  11. pmc Phosphorylation of adaptor protein-2 mu2 is essential for Na+,K+-ATPase endocytosis in response to either G protein-coupled receptor or reactive oxygen species
    Zongpei Chen
    Department of Medicine, Membrane Signaling Networks, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    Am J Respir Cell Mol Biol 35:127-32. 2006
    ..We conclude that phosphorylation of AP-2 mu2 subunit is essential for Na+,K+-ATPase endocytosis in response to a variety of signals, such as dopamine or reactive oxygen species...
  12. ncbi request reprint Relevance of dopamine signals anchoring dynamin-2 to the plasma membrane during Na+,K+-ATPase endocytosis
    Riad Efendiev
    Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, Karolinska Institutet, Karolinska Hospital, S 171 76 Stockholm, Sweden
    J Biol Chem 277:44108-14. 2002
    ....
  13. ncbi request reprint Tyrosine 537 within the Na+,K+-ATPase alpha-subunit is essential for AP-2 binding and clathrin-dependent endocytosis
    Stefania Cotta Doné
    Department of Molecular Medicine, Karolinska Institutet, The Rolf Luft Centrum for Diabetes Research, Karolinska Hospital, 171 76 Stockholm, Sweden
    J Biol Chem 277:17108-11. 2002
    ....
  14. ncbi request reprint The 14-3-3 protein translates the NA+,K+-ATPase {alpha}1-subunit phosphorylation signal into binding and activation of phosphoinositide 3-kinase during endocytosis
    Riad Efendiev
    Department of Medicine, Atherosclerosis Research Unit, Membrane Signaling Networks, Karolinska Institutet, Karolinska University Hospital Solna, S 171 76 Stockholm, Sweden
    J Biol Chem 280:16272-7. 2005
    ..Thus, the 14-3-3 protein represents a critical linking mechanism for recruiting phosphoinositide 3-kinase to the site of Na(+),K(+)-ATPase endocytosis...