Robert Edwards

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters
    Jean Luc Boulland
    Institute of Basic Medical Sciences and the Centre for Molecular Biology and Neuroscience, University of Oslo, N 0317 Oslo, Norway
    J Comp Neurol 480:264-80. 2004
  2. ncbi request reprint Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling
    Susan M Voglmaier
    Department of Neurology, Graduate Programs in Cell Biology, Neuroscience and Biomedical Sciences, UCSF School of Medicine, 600 16th Street, San Francisco, California 94143, USA
    Neuron 51:71-84. 2006
  3. ncbi request reprint Synaptic vesicles: half full or half empty?
    Thomas S Hnasko
    Department of Neurology, School of Medicine, University of California San Francisco, 600 16th Street, GH N272B, San Francisco, CA 94158, USA
    Neuron 51:523-4. 2006
  4. pmc Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions
    Juliette Johnson
    Department of Ophthalmology, University of California School of Medicine, San Francisco, California 94143, USA
    J Neurosci 27:7245-55. 2007
  5. pmc Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3
    Rebecca P Seal
    Department of Physiology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 57:263-75. 2008
  6. pmc Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors
    Rebecca P Seal
    Department of Physiology, University of California, San Francisco School of Medicine, California 94143, USA
    Nature 462:651-5. 2009
  7. pmc Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport
    Germaine Y Goh
    Department of Physiology, Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, California, USA
    Nat Neurosci 14:1285-92. 2011
  8. pmc RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway
    Cédric S Asensio
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 191:1173-87. 2010
  9. pmc Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3
    Daniel W Sirkis
    Graduate Program in Pharmaceutical Sciences and Pharmacogenomics, University of California San Francisco, San Francisco, California, United States of America Departments of Physiology and Neurology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 9:e1003812. 2013
  10. doi request reprint What the neuron tells glia
    Robert Edwards
    Department of Neurology, University of California, San Francisco, School of Medicine, San Francisco, CA 94158, USA
    Neuron 61:811-2. 2009

Research Grants

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters
    Jean Luc Boulland
    Institute of Basic Medical Sciences and the Centre for Molecular Biology and Neuroscience, University of Oslo, N 0317 Oslo, Norway
    J Comp Neurol 480:264-80. 2004
    ..In skeletal muscle, VGLUT3 localizes to granular organelles in the axon terminal as well as in the muscle sarcoplasm. The results suggest novel mechanisms and roles for regulated transmitter release...
  2. ncbi request reprint Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling
    Susan M Voglmaier
    Department of Neurology, Graduate Programs in Cell Biology, Neuroscience and Biomedical Sciences, UCSF School of Medicine, 600 16th Street, San Francisco, California 94143, USA
    Neuron 51:71-84. 2006
    ..After stimulation, however, inhibition of the AP3 pathway prevents the full recovery of VGLUT1 by endocytosis, implicating the AP3 pathway specifically in compensatory endocytosis...
  3. ncbi request reprint Synaptic vesicles: half full or half empty?
    Thomas S Hnasko
    Department of Neurology, School of Medicine, University of California San Francisco, 600 16th Street, GH N272B, San Francisco, CA 94158, USA
    Neuron 51:523-4. 2006
    ..In this issue of Neuron, Prado et al. pursue this line of investigation and show that changes in transporter expression that alter quantal size can affect behavior...
  4. pmc Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions
    Juliette Johnson
    Department of Ophthalmology, University of California School of Medicine, San Francisco, California 94143, USA
    J Neurosci 27:7245-55. 2007
    ..Furthermore, melanopsin and VGLUT2 expression in a subset of RGCs immediately after birth strongly supports the idea that intrinsic vision can function well before rod- and cone-mediated signaling has matured...
  5. pmc Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3
    Rebecca P Seal
    Department of Physiology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 57:263-75. 2008
    ..The glutamate release conferred by expression of VGLUT3 thus has an essential role in both function and development of the auditory pathway, as well as in the control of cortical excitability...
  6. pmc Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors
    Rebecca P Seal
    Department of Physiology, University of California, San Francisco School of Medicine, California 94143, USA
    Nature 462:651-5. 2009
    ..The analysis of Vglut3(-/-) mice now indicates a critical role for C-LTMRs in the mechanical hypersensitivity caused by injury...
  7. pmc Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport
    Germaine Y Goh
    Department of Physiology, Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, California, USA
    Nat Neurosci 14:1285-92. 2011
    ..Manipulating presynaptic K(+) at a glutamatergic synapse influenced quantal size, indicating that synaptic vesicle K(+)/H(+) exchange regulates glutamate release and synaptic transmission...
  8. pmc RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway
    Cédric S Asensio
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 191:1173-87. 2010
    ..Although vesicles with a dense core still form in the absence of AP-3, they contain substantially less synaptotagmin 1, indicating that AP-3 concentrates the proteins required for regulated exocytosis...
  9. pmc Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3
    Daniel W Sirkis
    Graduate Program in Pharmaceutical Sciences and Pharmacogenomics, University of California San Francisco, San Francisco, California, United States of America Departments of Physiology and Neurology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 9:e1003812. 2013
    ..In addition, we show that loss of the related adaptor protein AP-1 has a similar effect on regulated secretion but exacerbates the effect of AP-3 RNAi, suggesting distinct roles for the two adaptors in the regulated secretory pathway. ..
  10. doi request reprint What the neuron tells glia
    Robert Edwards
    Department of Neurology, University of California, San Francisco, School of Medicine, San Francisco, CA 94158, USA
    Neuron 61:811-2. 2009
    ..In this issue of Neuron, Yang et al. show that presynaptic input induces expression of the predominant glial transporter involved in glutamate clearance, and this induction involves the transcription factor kappa B-binding protein...
  11. ncbi request reprint The neurotransmitter cycle and quantal size
    Robert H Edwards
    Department of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA 94158 2517, USA
    Neuron 55:835-58. 2007
    ..This review will summarize current understanding of the neurotransmitter cycle and indicate basic, unanswered questions about the presynaptic regulation of quantal size...
  12. ncbi request reprint Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites
    Robert T Fremeau
    Department of Neurology, Graduate Programs in Neuroscience and Cell Biology, University of California San Francisco School of Medicine, CA 94143, USA
    Science 304:1815-9. 2004
    ..The loss of VGLUT1 also reduced the reserve pool of synaptic vesicles. Thus, VGLUT1 plays an unanticipated role in membrane trafficking at the nerve terminal...
  13. pmc Synaptic and extrasynaptic factors governing glutamatergic retinal waves
    Aaron G Blankenship
    Neurosciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 62:230-41. 2009
    ....
  14. pmc Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo
    Thomas S Hnasko
    Departments of Physiology and Neurology, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 65:643-56. 2010
    ..Remarkably, low concentrations of glutamate acidify synaptic vesicles more slowly but to a greater extent than equimolar Cl(-), indicating a distinct, presynaptic mechanism to regulate quantal size...
  15. ncbi request reprint Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis
    Kristin E Larsen
    Department of Neurology, Columbia University, and New York Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 22:8951-60. 2002
    ....
  16. ncbi request reprint VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate
    Robert T Fremeau
    Department of Neurology, Graduate Program in Neuroscience, UCSF School of Medicine, 600 16th Street, San Francisco, CA 94143 2140, USA
    Trends Neurosci 27:98-103. 2004
    ..VGLUT3 also differs from VGLUT1 and VGLUT2 in its subcellular location, with somatodendritic as well as axonal expression...
  17. ncbi request reprint Glutamine uptake by neurons: interaction of protons with system a transporters
    Farrukh A Chaudhry
    Department of Neurology, University of California San Francisco School of Medicine, San Francisco, California 94143 0435, USA
    J Neurosci 22:62-72. 2002
    ..Differences between System N and A transporters in coupling to H+ thus contribute to the delivery of glutamine from glia to neurons. Nonetheless, although they are not transported, H+ inhibit SA1 and SA2 by competing with Na+...
  18. pmc Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate
    Garret D Stuber
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 30:8229-33. 2010
    ..Thus, the unique ability of NAc-projecting dopamine neurons to synchronously activate both dopamine and glutamate receptors may have crucial implications for the ability to respond to motivationally significant stimuli...
  19. pmc Vesicular glutamate transporter 3 expression identifies glutamatergic amacrine cells in the rodent retina
    Juliette Johnson
    Department of Ophthalmology, University of California School of Medicine, San Francisco, San Francisco, California 94143, USA
    J Comp Neurol 477:386-98. 2004
    ..Furthermore, a subset of VGLUT3 cells expressed the circadian clock gene period 1, implicating VGLUT3 cells as part of the light-entrainable retina-based circadian system...
  20. pmc Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
    Venu M Nemani
    Departments of Neurology and Physiology, Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 65:66-79. 2010
    ..Increased levels of alpha-synuclein thus produce a specific, physiological defect in synaptic vesicle recycling that precedes detectable neuropathology...
  21. ncbi request reprint Vesicular neurotransmitter transporter expression in developing postnatal rodent retina: GABA and glycine precede glutamate
    Juliette Johnson
    Department of Ophthalmology, University of California School of Medicine, San Francisco, California 94143 0730, USA
    J Neurosci 23:518-29. 2003
    ..Furthermore, vesicular glutamate transmission likely occurs before ribbon synapse formation in the inner retina...
  22. ncbi request reprint Functional implications of neurotransmitter co-release: glutamate and GABA share the load
    Rebecca P Seal
    Department of Neurology, UCSF School of Medicine, 600 16th St, GH N272B, San Francisco, CA 94143 2140, USA
    Curr Opin Pharmacol 6:114-9. 2006
    ..Moreover, dynamic regulation of neurotransmitter phenotypes increases the plasticity of neurotransmission, indicating potential avenues for therapeutic intervention...
  23. ncbi request reprint Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis
    Kristin E Larsen
    Department of Neurology, Columbia University School of Medicine, New York, New York 10032, USA
    J Neurosci 26:11915-22. 2006
    ..We conclude that alpha-syn overexpression inhibits a vesicle "priming" step, after secretory vesicle trafficking to "docking" sites but before calcium-dependent vesicle membrane fusion...
  24. ncbi request reprint Neural activity controls the synaptic accumulation of alpha-synuclein
    Doris L Fortin
    Department of Neurology, Graduate Program in Biomedical Sciences, University of California, San Francisco, California 94143 2140, USA
    J Neurosci 25:10913-21. 2005
    ..Furthermore, the dispersion of alpha-synuclein is graded with respect to stimulus intensity. Neural activity thus controls the normal function of alpha-synuclein at the nerve terminal and may influence its role in PD...
  25. pmc The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate
    Robert T Fremeau
    Department of Neurology, University of California School of Medicine, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 99:14488-93. 2002
    ..The dendritic expression of VGLUT3 by particular neurons also indicates the potential for retrograde synaptic signaling. The distribution and subcellular location of VGLUT3 thus suggest novel modes of signaling by glutamate...
  26. ncbi request reprint Do different endocytic pathways make different synaptic vesicles?
    Susan M Voglmaier
    Department of Psychiatry, UCSF School of Medicine, 600 16th Street, San Francisco, CA 94158 2517, USA
    Curr Opin Neurobiol 17:374-80. 2007
    ..These observations might begin to account for differences in the properties of different vesicle pools...
  27. ncbi request reprint The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons
    Christopher C Wreden
    Department of Neurology and Physiology, University of California San Francisco School of Medicine, San Francisco, California 94143 0435, USA
    J Neurosci 23:1265-75. 2003
    ..A protease protection assay and measurements of intracellular pH further indicate abundant expression at the plasma membrane, raising the possibility of physiological roles for LYAAT1 on the cell surface as well as in lysosomes...
  28. pmc Vesicular monoamine and glutamate transporters select distinct synaptic vesicle recycling pathways
    Bibiana Onoa
    Department of Neurology, University of California, San Francisco School of Medicine, San Francisco, California 94158 2517, USA
    J Neurosci 30:7917-27. 2010
    ..Even when expressed in the same neuron, the two vesicular transporters thus target to distinct populations of synaptic vesicles, presumably due to their selection of distinct recycling pathways...
  29. ncbi request reprint The effect of rare human sequence variants on the function of vesicular monoamine transporter 2
    Jonathon Burman
    Department of Neurology, UCSF School of Medicine, San Francisco, CA 94143 2140, USA
    Pharmacogenetics 14:587-94. 2004
    ..The results illustrate the relationship between conservation of the affected residue, the nature of the substitution and effects on substrate versus inhibitor interaction...
  30. ncbi request reprint Lipid rafts mediate the synaptic localization of alpha-synuclein
    Doris L Fortin
    Department of Neurology, Graduate Programs in Biomedical Sciences, Cell Biology and Neuroscience, University of California San Francisco School of Medicine, San Francisco, California 94143 2140, USA
    J Neurosci 24:6715-23. 2004
    ....
  31. ncbi request reprint Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines
    Haiyan Li
    Graduate Programs in Neuroscience and Cell Biology, Department of Neurology and Physiology, UCSF School of Medicine, 600 16th Street, San Francisco, California 94143, USA
    Neuron 48:619-33. 2005
    ..VMAT2 thus defines a population of secretory vesicles that mediate the activity-dependent somatodendritic release of multiple retrograde signals involved in synaptic function, growth, and plasticity...
  32. pmc Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons
    Eugene V Mosharov
    Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 62:218-29. 2009
    ..Thus, an interaction between Ca2+, DA(cyt), and alpha-synuclein may underlie the susceptibility of SN neurons in PD, suggesting multiple therapeutic targets...
  33. doi request reprint Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria
    Ken Nakamura
    Graduate Program in Neuroscience, Department of Neurology, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 28:12305-17. 2008
    ..We find that the conformation of alpha-synuclein responds selectively to mitochondria, indicating a direct link between alpha-synuclein and an organelle strongly implicated in the pathogenesis of PD...
  34. pmc The glutamine commute: take the N line and transfer to the A
    Farrukh A Chaudhry
    Graduate Program in Neuroscience, Department of Neurology, University of California at San Francisco School of Medicine, San Francisco, CA 94143, USA
    J Cell Biol 157:349-55. 2002
    ....
  35. ncbi request reprint Thyronamines inhibit plasma membrane and vesicular monoamine transport
    Aaron N Snead
    Graduate Program in Chemistry and Chemical Biology, University of California at San Francisco, San Francisco, California 94143, USA
    ACS Chem Biol 2:390-8. 2007
    ..These observations expand the nontranscriptional role of thyroid hormone derivatives and may help to explain the pharmacological effects of thyronamines in vivo...
  36. pmc Physiology versus pathology in Parkinson's disease
    Ken Nakamura
    Departments of Neurology and Physiology, University of California School of Medicine, 600 16th Street, GH N272B, San Francisco, CA 94158 2517, USA
    Proc Natl Acad Sci U S A 104:11867-8. 2007
  37. doi request reprint The behavior of alpha-synuclein in neurons
    Doris L Fortin
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA
    Mov Disord 25:S21-6. 2010
    ..In addition to the presumed role of alpha-synuclein dynamics in synaptic function, changes in its physiological behavior may underlie the pathological changes associated with Parkinson's disease...
  38. ncbi request reprint A combinatorial code for the interaction of alpha-synuclein with membranes
    Shin Ichiro Kubo
    Department of Neurology, Graduate Program in Biomedical Sciences, University of California, San Francisco, California 94143 2140, USA
    J Biol Chem 280:31664-72. 2005
    ....
  39. ncbi request reprint Antidepressants and the monoamine masquerade
    David Sulzer
    Department of Neurology, Columbia University, New York State Psychiatric Institute, New York, New York 10032, USA
    Neuron 46:1-2. 2005
    ..The results suggest that release of serotonin by dopamine neurons may contribute to the effects of multiple major classes of antidepressants...
  40. ncbi request reprint Cellular localization of three vesicular glutamate transporter mRNAs and proteins in rat spinal cord and dorsal root ganglia
    Alexandre L R Oliveira
    Department of Neuroscience, The Retzius Laboratory, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Synapse 50:117-29. 2003
    ..VGLUT1 is mainly present in primary afferents from large, CGRP-negative DRG neurons, VGLUT2 has mainly a local origin, and VGLUT3 fibers probably have a supraspinal origin...
  41. ncbi request reprint Postnatal development of the glutamate vesicular transporter VGLUT1 in rat cerebral cortex
    Andrea Minelli
    Istituto di Fisiologia Umana, Universita di Ancona, Via Tronto 10 A, Torrette di Ancona, I 60020, Ancona, Italy
    Brain Res Dev Brain Res 140:309-14. 2003
    ..Its spatial and temporal maturation patterns suggest that VGLUT1 may be the vesicular transporter in developing corticocortical connections...
  42. ncbi request reprint Cell-specific expression of the glutamine transporter SN1 suggests differences in dependence on the glutamine cycle
    Jean Luc Boulland
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, P O Box 1105 Blindern, Norway
    Eur J Neurosci 15:1615-31. 2002
    ....
  43. ncbi request reprint Complementary distribution of vesicular glutamate transporters 1 and 2 in the nucleus accumbens of rat: Relationship to calretinin-containing extrinsic innervation and calbindin-immunoreactive neurons
    Wolfgang Hartig
    Paul Flechsig Institute for Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    J Comp Neurol 465:1-10. 2003
    ....
  44. ncbi request reprint Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight
    Maria Collin
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, B3, 5th Floor, Room 514, SE 171 77 Stockholm, Sweden
    Eur J Neurosci 18:1265-78. 2003
    ....
  45. ncbi request reprint Vesicular neurotransmitter transporters as targets for endogenous and exogenous toxic substances
    Farrukh A Chaudhry
    Centre for Molecular Biology and Neuroscience, The Biotechnology Centre of Oslo, University of Oslo, Oslo, Norway
    Annu Rev Pharmacol Toxicol 48:277-301. 2008
    ..Thus, specific inhibitors have helped to characterize both the physiological role and mechanism of vesicular neurotransmitter transport...
  46. ncbi request reprint Evidence that certain retinal bipolar cells use both glutamate and GABA
    Yen Hong Kao
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6058, USA
    J Comp Neurol 478:207-18. 2004
    ..By "targeted injection," we identified two types of OFF bipolar cell with the machinery to make and package both transmitters. One of these types costratifies with a dopamine plexus...
  47. ncbi request reprint Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra
    Raquel Martín-Ibáñez
    Laboratory for Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1
    Eur J Neurosci 23:1063-70. 2006
    ..Collectively, our data indicate that VGLUT3 identifies a novel excitatory terminal subset that contributes to the tuning of DA cell excitability in the substantia nigra...
  48. ncbi request reprint Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3
    Tibor Harkany
    Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17177 Stockholm, Sweden
    J Neurosci 24:4978-88. 2004
    ....
  49. ncbi request reprint Electrochemical monitoring of transport by a vesicular monoamine transporter expressed in Xenopus oocytes
    Janet Whitley
    Medical Science, Indiana University School of Medicine, Jordan Hall 104, Bloomington, IN 47405 6401, USA
    J Neurosci Methods 133:191-9. 2004
    ..These results suggest that expression of VMATs in oocytes may provide a useful model system for mechanistic and regulatory studies that would not be feasible using traditional methods...
  50. pmc Secretion of L-glutamate from osteoclasts through transcytosis
    Riyo Morimoto
    Laboratory of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    EMBO J 25:4175-86. 2006
    ..Glutamate signaling may play an important role in the bone homeostasis...
  51. ncbi request reprint Complementary distribution of type 1 cannabinoid receptors and vesicular glutamate transporter 3 in basal forebrain suggests input-specific retrograde signalling by cholinergic neurons
    Tibor Harkany
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
    Eur J Neurosci 18:1979-92. 2003
    ....
  52. pmc Normal biogenesis and cycling of empty synaptic vesicles in dopamine neurons of vesicular monoamine transporter 2 knockout mice
    Benjamin G Croft
    Centre for Neuronal Survival and Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    Mol Biol Cell 16:306-15. 2005
    ....
  53. ncbi request reprint Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures
    Gunther Sperk
    Department of Pharmacology, University of Innsbruck, Innsbruck, Austria
    Hippocampus 13:806-15. 2003
    ..GABA could then act on GABA-A receptors, protecting granule cells from overexcitation...
  54. pmc Regulation of the glutamine transporter SN1 by extracellular pH and intracellular sodium ions
    Angelika Bröer
    School of Biochemistry and Molecular Biology, Australian National University, Canberra ACT 0200, Australia
    J Physiol 539:3-14. 2002
    ..A slippage mode in the transporter mechanism and pH-regulated endogenous oocyte cation channels are likely to contribute to the observed currents...
  55. ncbi request reprint Organic anion transport is the primary function of the SLC17/type I phosphate transporter family
    Richard J Reimer
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, CA 94305, Stanford, USA
    Pflugers Arch 447:629-35. 2004
    ....
  56. ncbi request reprint Distribution of vesicular glutamate transporters 1 and 2 in the rat spinal cord, with a note on the spinocervical tract
    Stefan Persson
    Department of Experimental Medical Science, Division for Neuroscience, and Lund University Pain Research Center, Lund University, S 221 84 Lund, Sweden
    J Comp Neurol 497:683-701. 2006
    ..The mediolateral differences in VGLUT1 distribution in laminae I-II suggest dual origins of VGLUT1-immunoreactive varicosities in this region...
  57. ncbi request reprint Changes in purinergic signaling after cerebral injury -- involvement of glutamatergic mechanisms?
    Heike Franke
    Rudolf Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany
    Int J Dev Neurosci 24:123-32. 2006
    ..It can be assumed, that the enhanced sensitivity of neurons to purinergic signaling may be related directly or indirectly to changes of the glutamatergic transmission...
  58. pmc Fast subplasma membrane Ca2+ transients control exo-endocytosis of synaptic-like microvesicles in astrocytes
    Julie Marchaland
    Department of Cell Biology and Morphology, Faculty of Biology and Medicine, University of Lausanne, 1005 Lausanne, Switzerland
    J Neurosci 28:9122-32. 2008
    ..Overall, the above characteristics of transmitter exocytosis from astrocytes support a role of this process in fast synaptic modulation...

Research Grants18

  1. TRANSPORT OF NEUROTRANSMITTER INTO SYNAPTIC VESICLES
    Robert Edwards; Fiscal Year: 2007
    ..We will also produce a conditional knock-out to distinguish among the behavioral effects of VGLUTS expressed by different neurons. ..
  2. TRANSPORT OF NEUROTRANSMITTER INTO SYNAPTIC VESICLES
    Robert H Edwards; Fiscal Year: 2010
    ..We will also produce a conditional knock-out to distinguish among the behavioral effects of VGLUTS expressed by different neurons. ..
  3. Alpha-Synuclein and the Synaptic Vesicle Cycle
    Robert Edwards; Fiscal Year: 2009
    ..In addition to exploring a mechanism to prevent the degeneration observed in Parkinson's, the experiments will suggest therapeutic strategies to improve the function of neurons that remain. ..
  4. TRANSPORT OF NEUROTRANSMITTER INTO SYNAPTIC VESICLES
    Robert Edwards; Fiscal Year: 2009
    ..We will also produce a conditional knock-out to distinguish among the behavioral effects of VGLUTS expressed by different neurons. ..
  5. TRANSPORT OF NEUROTRANSMITTER INTO SYNAPTIC VESICLES
    Robert Edwards; Fiscal Year: 2006
    ..We will also produce a conditional knock-out to distinguish among the behavioral effects of VGLUTS expressed by different neurons. ..
  6. TRANSPORT OF NEUROTRANSMITTER INTO SYNAPTIC VESICLES
    Robert Edwards; Fiscal Year: 2005
    ..These experiments will help to understand the transport of glutamate at the nerve terminal and its role in transmitter release, synaptic plasticity, excitotoxicity and behavior. ..
  7. TRANSPORT OF NEUROTRANSMITTER INTO SYNAPTIC VESICLES
    Robert Edwards; Fiscal Year: 2004
    ..These experiments will help to understand the transport of glutamate at the nerve terminal and its role in transmitter release, synaptic plasticity, excitotoxicity and behavior. ..
  8. TRANSPORT OF NEUROTRANSMITTER INTO SYNAPTIC VESICLES
    Robert Edwards; Fiscal Year: 2003
    ..These experiments will help to understand the transport of glutamate at the nerve terminal and its role in transmitter release, synaptic plasticity, excitotoxicity and behavior. ..
  9. TRANSPORT OF NEUROTRANSMITTER INTO SYNAPTIC VESICLES
    Robert Edwards; Fiscal Year: 2002
    ..These experiments will help to understand the transport of glutamate at the nerve terminal and its role in transmitter release, synaptic plasticity, excitotoxicity and behavior. ..
  10. TRANSPORT OF NEUROTRANSMITTER INTO SYNAPTIC VESICLES
    Robert Edwards; Fiscal Year: 2001
    ..These experiments will help to understand the transport of glutamate at the nerve terminal and its role in transmitter release, synaptic plasticity, excitotoxicity and behavior. ..
  11. TRANSPORT OF NEUROTRANSMITTER INTO SYNAPTIC VESICLES
    Robert Edwards; Fiscal Year: 2000
    ..These studies will both help to understand the molecular mechanism for neurotransmitter packaging and begin to reveal its role in quantal size, drug abuse and neural degeneration. ..
  12. TRANSPORT OF NEUROTRANSMITTER INTO SYNAPTIC VESICLES
    Robert Edwards; Fiscal Year: 1999
    ..These studies will both help to understand the molecular mechanism for neurotransmitter packaging and begin to reveal its role in quantal size, drug abuse and neural degeneration. ..
  13. Alpha-Synuclein and the Synaptic Vesicle Cycle
    Robert H Edwards; Fiscal Year: 2011
    ..In addition to exploring a mechanism to prevent the degeneration observed in Parkinson's, the experiments will suggest therapeutic strategies to improve the function of neurons that remain. ..